Incidental Mutation 'IGL03080:Adgrf3'
ID 417820
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Adgrf3
Ensembl Gene ENSMUSG00000067642
Gene Name adhesion G protein-coupled receptor F3
Synonyms Gpr113, LOC381628, PGR23
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03080
Quality Score
Status
Chromosome 5
Chromosomal Location 30193431-30205722 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 30196829 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 734 (M734V)
Ref Sequence ENSEMBL: ENSMUSP00000085440 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088117] [ENSMUST00000125367]
AlphaFold Q58Y75
Predicted Effect probably benign
Transcript: ENSMUST00000088117
AA Change: M734V

PolyPhen 2 Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000085440
Gene: ENSMUSG00000067642
AA Change: M734V

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
low complexity region 85 97 N/A INTRINSIC
Blast:IG 163 252 2e-20 BLAST
Blast:CCP 341 399 1e-6 BLAST
low complexity region 403 415 N/A INTRINSIC
low complexity region 471 483 N/A INTRINSIC
GPS 632 684 2.68e-17 SMART
Pfam:7tm_2 687 935 1e-30 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000125367
SMART Domains Protein: ENSMUSP00000120958
Gene: ENSMUSG00000067642

DomainStartEndE-ValueType
transmembrane domain 21 43 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932415D10Rik T C 10: 82,283,982 D428G probably damaging Het
Abce1 T C 8: 79,703,001 probably null Het
Aqp8 T G 7: 123,466,579 probably benign Het
Ces1d C A 8: 93,169,718 probably null Het
Cntn4 A G 6: 106,655,539 D508G probably damaging Het
Cyp11b1 A T 15: 74,839,436 probably null Het
Dnah8 A G 17: 30,719,006 D1619G probably benign Het
Ephb4 T A 5: 137,354,083 probably benign Het
Ffar3 A T 7: 30,855,322 V191E probably damaging Het
Galnt1 T A 18: 24,269,517 D310E probably damaging Het
Gm2075 A T 12: 88,011,845 probably benign Het
Igf2r T C 17: 12,726,676 Y342C probably benign Het
Jade1 T A 3: 41,600,075 C251* probably null Het
Jhy T C 9: 40,944,357 E278G probably damaging Het
Kif24 A C 4: 41,394,417 S819A probably benign Het
Lrp8 T C 4: 107,855,799 L344P probably damaging Het
Lrrc27 A G 7: 139,230,237 T375A probably benign Het
Mbd3 C T 10: 80,393,251 R204Q probably damaging Het
Nab2 T C 10: 127,664,794 N143S possibly damaging Het
Nkiras2 T C 11: 100,624,279 probably null Het
Olfr868 A T 9: 20,101,409 I217F probably damaging Het
Palm C A 10: 79,819,117 H74Q probably damaging Het
Pros1 T A 16: 62,918,143 N408K probably damaging Het
Psg23 T A 7: 18,606,985 Y448F probably damaging Het
Ranbp2 C A 10: 58,476,791 P1111Q probably benign Het
Rims2 A G 15: 39,535,903 S1115G probably damaging Het
Scn7a T C 2: 66,697,816 T777A probably benign Het
Stard3nl A T 13: 19,370,478 probably null Het
Sult1d1 T C 5: 87,556,988 D214G probably benign Het
Tmprss12 T C 15: 100,292,648 W300R probably damaging Het
Tmprss2 T C 16: 97,596,844 Y44C probably damaging Het
Ttk A G 9: 83,843,083 N154D probably damaging Het
Tyw1 T C 5: 130,267,055 Y108H probably damaging Het
Vmn2r44 C A 7: 8,383,245 probably benign Het
Zcchc11 T A 4: 108,505,824 S444R probably damaging Het
Zfand1 A G 3: 10,340,737 *269Q probably null Het
Zfp142 A T 1: 74,571,209 D1039E probably benign Het
Zkscan5 G T 5: 145,218,650 S377I probably damaging Het
Other mutations in Adgrf3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03171:Adgrf3 APN 5 30196294 missense probably damaging 1.00
R0010:Adgrf3 UTSW 5 30205609 splice site probably benign
R0042:Adgrf3 UTSW 5 30197428 missense probably damaging 1.00
R0140:Adgrf3 UTSW 5 30196381 missense probably benign 0.19
R0617:Adgrf3 UTSW 5 30195080 missense probably benign 0.25
R0748:Adgrf3 UTSW 5 30196876 missense probably damaging 1.00
R1291:Adgrf3 UTSW 5 30199534 missense probably damaging 0.99
R1330:Adgrf3 UTSW 5 30195095 missense probably benign 0.24
R1468:Adgrf3 UTSW 5 30202229 splice site probably benign
R1695:Adgrf3 UTSW 5 30203555 missense probably benign 0.05
R1716:Adgrf3 UTSW 5 30197551 missense probably benign 0.03
R1844:Adgrf3 UTSW 5 30199213 missense probably damaging 0.96
R1935:Adgrf3 UTSW 5 30202306 missense probably benign 0.00
R1936:Adgrf3 UTSW 5 30202306 missense probably benign 0.00
R2059:Adgrf3 UTSW 5 30199491 missense possibly damaging 0.91
R2656:Adgrf3 UTSW 5 30196438 missense possibly damaging 0.96
R2913:Adgrf3 UTSW 5 30196994 missense probably damaging 1.00
R2914:Adgrf3 UTSW 5 30196994 missense probably damaging 1.00
R2987:Adgrf3 UTSW 5 30197360 missense probably damaging 1.00
R3797:Adgrf3 UTSW 5 30196823 missense possibly damaging 0.49
R3798:Adgrf3 UTSW 5 30196823 missense possibly damaging 0.49
R3799:Adgrf3 UTSW 5 30196823 missense possibly damaging 0.49
R3934:Adgrf3 UTSW 5 30200434 unclassified probably benign
R4043:Adgrf3 UTSW 5 30204362 missense probably benign 0.00
R4080:Adgrf3 UTSW 5 30197369 nonsense probably null
R4575:Adgrf3 UTSW 5 30202257 missense probably benign 0.00
R4754:Adgrf3 UTSW 5 30197617 critical splice acceptor site probably null
R4819:Adgrf3 UTSW 5 30198444 missense possibly damaging 0.66
R4893:Adgrf3 UTSW 5 30200478 missense probably benign 0.00
R4991:Adgrf3 UTSW 5 30199148 missense probably benign 0.26
R5686:Adgrf3 UTSW 5 30197306 missense probably damaging 1.00
R5965:Adgrf3 UTSW 5 30205639 missense probably benign 0.00
R5997:Adgrf3 UTSW 5 30198362 critical splice donor site probably null
R6103:Adgrf3 UTSW 5 30196267 missense probably damaging 1.00
R6244:Adgrf3 UTSW 5 30197533 missense probably benign 0.17
R6409:Adgrf3 UTSW 5 30197314 missense probably damaging 0.96
R6575:Adgrf3 UTSW 5 30196524 missense possibly damaging 0.72
R6745:Adgrf3 UTSW 5 30203603 missense probably benign 0.31
R6790:Adgrf3 UTSW 5 30196387 missense probably benign 0.00
R6813:Adgrf3 UTSW 5 30197521 missense probably damaging 0.96
R7202:Adgrf3 UTSW 5 30204380 nonsense probably null
R7250:Adgrf3 UTSW 5 30195682 missense probably damaging 1.00
R7353:Adgrf3 UTSW 5 30198497 missense probably damaging 0.98
R7634:Adgrf3 UTSW 5 30202247 missense probably benign 0.01
R7658:Adgrf3 UTSW 5 30197206 missense probably benign 0.41
R8037:Adgrf3 UTSW 5 30199512 missense probably damaging 1.00
R8281:Adgrf3 UTSW 5 30197303 missense possibly damaging 0.46
R8717:Adgrf3 UTSW 5 30198581 unclassified probably benign
R8857:Adgrf3 UTSW 5 30197067 nonsense probably null
R8926:Adgrf3 UTSW 5 30200448 missense possibly damaging 0.46
R9391:Adgrf3 UTSW 5 30195073 missense possibly damaging 0.94
R9446:Adgrf3 UTSW 5 30196959 missense probably benign 0.01
R9522:Adgrf3 UTSW 5 30199484 missense possibly damaging 0.90
Z1088:Adgrf3 UTSW 5 30199120 missense possibly damaging 0.90
Posted On 2016-08-02