Incidental Mutation 'IGL03080:Sult1d1'
ID417826
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sult1d1
Ensembl Gene ENSMUSG00000029273
Gene Namesulfotransferase family 1D, member 1
Synonymstyrosine-ester sulfotransferase, Sultn, 5033411P13Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.053) question?
Stock #IGL03080
Quality Score
Status
Chromosome5
Chromosomal Location87554645-87569027 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 87556988 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 214 (D214G)
Ref Sequence ENSEMBL: ENSMUSP00000108940 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000113314]
PDB Structure
Crystal structure of mouse sulfotransferase SULT1D1 complex with PAP [X-RAY DIFFRACTION]
Crystal structure of mouse cytosolic sulfotransferase mSULT1D1 complex with PAP and p-nitrophenol [X-RAY DIFFRACTION]
Crystal structure of mouse cytosolic sulfotransferase mSULT1D1 complex with PAP and alpha-naphthol [X-RAY DIFFRACTION]
Crystal structure of mouse cytosolic sulfotransferase mSULT1D1 complex with PAPS [X-RAY DIFFRACTION]
Crystal structure of mouse cytosolic sulfotransferase mSULT1D1 complex with PAPS and p-nitrophenyl sulfate [X-RAY DIFFRACTION]
Crystal structure of mouse cytosolic sulfotransferase mSULT1D1 complex with PAPS/PAP and p-nitrophenol [X-RAY DIFFRACTION]
crystal structure of mouse cytosolic sulfotransferase mSULT1D1 complex with PAP and p-nitrophenol, obtained by two-step soaking method [X-RAY DIFFRACTION]
Predicted Effect probably benign
Transcript: ENSMUST00000113314
AA Change: D214G

PolyPhen 2 Score 0.158 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000108940
Gene: ENSMUSG00000029273
AA Change: D214G

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 38 288 6e-95 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000166996
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased benzylic DNA adduct formation in the liver and kidney but increased formation in the colon. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932415D10Rik T C 10: 82,283,982 D428G probably damaging Het
Abce1 T C 8: 79,703,001 probably null Het
Adgrf3 T C 5: 30,196,829 M734V probably benign Het
Aqp8 T G 7: 123,466,579 probably benign Het
Ces1d C A 8: 93,169,718 probably null Het
Cntn4 A G 6: 106,655,539 D508G probably damaging Het
Cyp11b1 A T 15: 74,839,436 probably null Het
Dnah8 A G 17: 30,719,006 D1619G probably benign Het
Ephb4 T A 5: 137,354,083 probably benign Het
Ffar3 A T 7: 30,855,322 V191E probably damaging Het
Galnt1 T A 18: 24,269,517 D310E probably damaging Het
Gm2075 A T 12: 88,011,845 probably benign Het
Igf2r T C 17: 12,726,676 Y342C probably benign Het
Jade1 T A 3: 41,600,075 C251* probably null Het
Jhy T C 9: 40,944,357 E278G probably damaging Het
Kif24 A C 4: 41,394,417 S819A probably benign Het
Lrp8 T C 4: 107,855,799 L344P probably damaging Het
Lrrc27 A G 7: 139,230,237 T375A probably benign Het
Mbd3 C T 10: 80,393,251 R204Q probably damaging Het
Nab2 T C 10: 127,664,794 N143S possibly damaging Het
Nkiras2 T C 11: 100,624,279 probably null Het
Olfr868 A T 9: 20,101,409 I217F probably damaging Het
Palm C A 10: 79,819,117 H74Q probably damaging Het
Pros1 T A 16: 62,918,143 N408K probably damaging Het
Psg23 T A 7: 18,606,985 Y448F probably damaging Het
Ranbp2 C A 10: 58,476,791 P1111Q probably benign Het
Rims2 A G 15: 39,535,903 S1115G probably damaging Het
Scn7a T C 2: 66,697,816 T777A probably benign Het
Stard3nl A T 13: 19,370,478 probably null Het
Tmprss12 T C 15: 100,292,648 W300R probably damaging Het
Tmprss2 T C 16: 97,596,844 Y44C probably damaging Het
Ttk A G 9: 83,843,083 N154D probably damaging Het
Tyw1 T C 5: 130,267,055 Y108H probably damaging Het
Vmn2r44 C A 7: 8,383,245 probably benign Het
Zcchc11 T A 4: 108,505,824 S444R probably damaging Het
Zfand1 A G 3: 10,340,737 *269Q probably null Het
Zfp142 A T 1: 74,571,209 D1039E probably benign Het
Zkscan5 G T 5: 145,218,650 S377I probably damaging Het
Other mutations in Sult1d1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02306:Sult1d1 APN 5 87556055 splice site probably benign
IGL02566:Sult1d1 APN 5 87564811 missense probably damaging 0.98
IGL03113:Sult1d1 APN 5 87559879 nonsense probably null
R0269:Sult1d1 UTSW 5 87564802 missense probably damaging 1.00
R1473:Sult1d1 UTSW 5 87564739 missense probably benign 0.13
R2105:Sult1d1 UTSW 5 87559802 missense probably damaging 1.00
R2273:Sult1d1 UTSW 5 87556028 missense probably damaging 1.00
R2919:Sult1d1 UTSW 5 87559755 splice site probably benign
R4416:Sult1d1 UTSW 5 87558576 missense probably damaging 1.00
R4648:Sult1d1 UTSW 5 87566095 missense probably benign 0.00
R5031:Sult1d1 UTSW 5 87559844 missense possibly damaging 0.77
R5108:Sult1d1 UTSW 5 87563869 critical splice donor site probably null
R5905:Sult1d1 UTSW 5 87559826 missense probably damaging 1.00
R5934:Sult1d1 UTSW 5 87559770 frame shift probably null
R6028:Sult1d1 UTSW 5 87559826 missense probably damaging 1.00
Posted On2016-08-02