Incidental Mutation 'IGL03082:Slc35f1'
| ID |
417898 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Slc35f1
|
| Ensembl Gene |
ENSMUSG00000038602 |
| Gene Name |
solute carrier family 35, member F1 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL03082
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
10 |
| Chromosomal Location |
52690533-53111622 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 52933138 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Isoleucine
at position 74
(V74I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000101113
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000105473]
|
| AlphaFold |
Q8BGK5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105473
AA Change: V74I
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000101113
Gene: ENSMUSG00000038602
AA Change: V74I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
20 |
N/A |
INTRINSIC |
|
Pfam:SLC35F
|
56 |
355 |
1.4e-151 |
PFAM |
|
Pfam:CRT-like
|
66 |
315 |
2.3e-13 |
PFAM |
|
Pfam:EamA
|
217 |
355 |
1.7e-9 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit no detectable phenotypic abnormalities. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 37 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Asic1 |
T |
A |
15: 99,696,547 (GRCm38) |
N324K |
probably benign |
Het |
| Atpaf2 |
T |
C |
11: 60,403,844 (GRCm38) |
E251G |
probably damaging |
Het |
| Cacna1d |
T |
C |
14: 30,099,233 (GRCm38) |
K1109E |
probably damaging |
Het |
| Ces1d |
C |
A |
8: 93,169,718 (GRCm38) |
|
probably null |
Het |
| Chst1 |
C |
T |
2: 92,613,933 (GRCm38) |
T250I |
possibly damaging |
Het |
| Cpne6 |
T |
C |
14: 55,516,303 (GRCm38) |
L406P |
probably damaging |
Het |
| Cryz |
A |
G |
3: 154,604,926 (GRCm38) |
M8V |
probably damaging |
Het |
| Dpysl2 |
T |
C |
14: 66,808,010 (GRCm38) |
E438G |
probably damaging |
Het |
| Elovl1 |
T |
C |
4: 118,430,880 (GRCm38) |
I71T |
probably benign |
Het |
| Eml2 |
T |
A |
7: 19,201,877 (GRCm38) |
Y679N |
probably damaging |
Het |
| Fam185a |
G |
A |
5: 21,455,838 (GRCm38) |
V284I |
possibly damaging |
Het |
| Fpgs |
C |
T |
2: 32,685,757 (GRCm38) |
W391* |
probably null |
Het |
| Hdac11 |
C |
T |
6: 91,173,103 (GRCm38) |
P295S |
probably damaging |
Het |
| Herc2 |
A |
T |
7: 56,185,923 (GRCm38) |
I3260F |
probably benign |
Het |
| Hltf |
G |
A |
3: 20,064,559 (GRCm38) |
|
probably benign |
Het |
| Immp2l |
T |
G |
12: 41,110,901 (GRCm38) |
V66G |
possibly damaging |
Het |
| Lrrc4c |
T |
C |
2: 97,630,586 (GRCm38) |
I519T |
probably benign |
Het |
| Megf8 |
A |
G |
7: 25,330,236 (GRCm38) |
T402A |
probably benign |
Het |
| Mttp |
T |
G |
3: 138,123,795 (GRCm38) |
I111L |
probably benign |
Het |
| Mycbp2 |
T |
A |
14: 103,204,369 (GRCm38) |
I1987F |
probably benign |
Het |
| Ncr1 |
T |
A |
7: 4,341,242 (GRCm38) |
|
probably benign |
Het |
| Nedd4 |
G |
A |
9: 72,677,394 (GRCm38) |
|
probably null |
Het |
| Nnt |
A |
G |
13: 119,396,868 (GRCm38) |
F87S |
probably damaging |
Het |
| Nol6 |
A |
G |
4: 41,115,878 (GRCm38) |
|
probably benign |
Het |
| Pdzd3 |
A |
T |
9: 44,250,786 (GRCm38) |
S39T |
possibly damaging |
Het |
| Pkhd1 |
A |
T |
1: 20,565,633 (GRCm38) |
I491N |
probably damaging |
Het |
| Plcxd2 |
T |
C |
16: 45,965,110 (GRCm38) |
I311V |
probably damaging |
Het |
| Pou2f3 |
C |
A |
9: 43,146,915 (GRCm38) |
|
probably null |
Het |
| Rgsl1 |
G |
A |
1: 153,799,947 (GRCm38) |
T836I |
possibly damaging |
Het |
| Rttn |
G |
A |
18: 88,983,948 (GRCm38) |
G328D |
probably damaging |
Het |
| Serpina11 |
T |
C |
12: 103,986,301 (GRCm38) |
E77G |
probably benign |
Het |
| Slc7a6 |
A |
G |
8: 106,193,222 (GRCm38) |
|
probably null |
Het |
| Smco2 |
A |
G |
6: 146,860,044 (GRCm38) |
T154A |
possibly damaging |
Het |
| Tcerg1 |
A |
G |
18: 42,573,357 (GRCm38) |
Y1033C |
probably damaging |
Het |
| Tmem87a |
A |
G |
2: 120,397,366 (GRCm38) |
F100S |
possibly damaging |
Het |
| Tssk4 |
T |
C |
14: 55,651,061 (GRCm38) |
F129S |
probably damaging |
Het |
| Wdr43 |
C |
T |
17: 71,638,341 (GRCm38) |
T315I |
probably damaging |
Het |
|
| Other mutations in Slc35f1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00434:Slc35f1
|
APN |
10 |
53,062,452 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01073:Slc35f1
|
APN |
10 |
53,021,960 (GRCm38) |
missense |
probably benign |
0.16 |
|
IGL01433:Slc35f1
|
APN |
10 |
53,073,446 (GRCm38) |
splice site |
probably benign |
|
|
IGL01566:Slc35f1
|
APN |
10 |
53,089,455 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02693:Slc35f1
|
APN |
10 |
52,933,128 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02870:Slc35f1
|
APN |
10 |
52,933,207 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R0884:Slc35f1
|
UTSW |
10 |
53,089,347 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1340:Slc35f1
|
UTSW |
10 |
53,089,454 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1781:Slc35f1
|
UTSW |
10 |
53,062,436 (GRCm38) |
splice site |
probably null |
|
|
R1813:Slc35f1
|
UTSW |
10 |
52,933,195 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1908:Slc35f1
|
UTSW |
10 |
53,021,904 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R2044:Slc35f1
|
UTSW |
10 |
53,089,347 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2518:Slc35f1
|
UTSW |
10 |
53,073,534 (GRCm38) |
missense |
probably benign |
0.07 |
|
R3872:Slc35f1
|
UTSW |
10 |
53,021,910 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R3934:Slc35f1
|
UTSW |
10 |
53,108,218 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3935:Slc35f1
|
UTSW |
10 |
53,108,218 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3936:Slc35f1
|
UTSW |
10 |
53,108,218 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4118:Slc35f1
|
UTSW |
10 |
53,089,368 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4921:Slc35f1
|
UTSW |
10 |
53,062,602 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5116:Slc35f1
|
UTSW |
10 |
53,021,895 (GRCm38) |
missense |
probably benign |
0.39 |
|
R5378:Slc35f1
|
UTSW |
10 |
52,691,061 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R5387:Slc35f1
|
UTSW |
10 |
53,108,164 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5500:Slc35f1
|
UTSW |
10 |
52,933,222 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5590:Slc35f1
|
UTSW |
10 |
53,108,178 (GRCm38) |
missense |
possibly damaging |
0.63 |
|
R5743:Slc35f1
|
UTSW |
10 |
53,089,450 (GRCm38) |
missense |
probably benign |
0.06 |
|
R5916:Slc35f1
|
UTSW |
10 |
52,933,221 (GRCm38) |
nonsense |
probably null |
|
|
R6985:Slc35f1
|
UTSW |
10 |
53,021,911 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7068:Slc35f1
|
UTSW |
10 |
53,062,500 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7295:Slc35f1
|
UTSW |
10 |
53,062,541 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7427:Slc35f1
|
UTSW |
10 |
53,089,414 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7428:Slc35f1
|
UTSW |
10 |
53,089,414 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8334:Slc35f1
|
UTSW |
10 |
53,108,148 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
| Posted On |
2016-08-02 |
Incidental Mutation