Incidental Mutation 'IGL03083:Trim58'
ID 417965
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trim58
Ensembl Gene ENSMUSG00000037124
Gene Name tripartite motif-containing 58
Synonyms LOC386443, LOC216781
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # IGL03083
Quality Score
Status
Chromosome 11
Chromosomal Location 58531291-58543230 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 58542216 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 392 (M392K)
Ref Sequence ENSEMBL: ENSMUSP00000074594 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075084]
AlphaFold Q5NCC9
Predicted Effect probably benign
Transcript: ENSMUST00000075084
AA Change: M392K

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000074594
Gene: ENSMUSG00000037124
AA Change: M392K

DomainStartEndE-ValueType
RING 15 58 2.95e-7 SMART
BBOX 90 131 2.93e-11 SMART
coiled coil region 192 241 N/A INTRINSIC
PRY 289 341 5.33e-23 SMART
SPRY 342 461 6.16e-29 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 T A 3: 121,932,261 (GRCm39) probably null Het
Acadsb A C 7: 131,042,922 (GRCm39) probably benign Het
Ankk1 A G 9: 49,333,166 (GRCm39) L106P probably benign Het
Ankrd24 G A 10: 81,474,483 (GRCm39) A72T probably benign Het
Ankrd35 A T 3: 96,592,117 (GRCm39) Q801L probably damaging Het
Avil A G 10: 126,852,193 (GRCm39) I659M probably benign Het
Ccnc A G 4: 21,742,683 (GRCm39) D170G possibly damaging Het
Cfap57 T C 4: 118,441,936 (GRCm39) K711E probably damaging Het
Dctn1 T C 6: 83,174,466 (GRCm39) probably benign Het
Dpp6 T C 5: 27,914,548 (GRCm39) probably null Het
Efhb A T 17: 53,706,087 (GRCm39) W817R probably damaging Het
Emilin3 G A 2: 160,750,649 (GRCm39) Q320* probably null Het
Fer1l4 A G 2: 155,881,286 (GRCm39) probably benign Het
Fgf8 T C 19: 45,725,667 (GRCm39) N137S probably damaging Het
Fndc3b T C 3: 27,521,576 (GRCm39) D533G probably benign Het
Fshb A G 2: 106,887,812 (GRCm39) V69A probably benign Het
Galnt7 A T 8: 57,979,223 (GRCm39) H633Q probably damaging Het
Gm5458 A G 14: 19,652,451 (GRCm39) probably null Het
Hjv T A 3: 96,435,922 (GRCm39) D393E probably benign Het
Hpca A C 4: 129,012,319 (GRCm39) F72L probably damaging Het
Inpp5d A T 1: 87,638,863 (GRCm39) D552V probably damaging Het
Lepr C T 4: 101,671,876 (GRCm39) Q967* probably null Het
Lgr5 A G 10: 115,288,937 (GRCm39) V497A probably benign Het
Matr3 A G 18: 35,705,471 (GRCm39) K132R probably damaging Het
Mib1 T G 18: 10,752,029 (GRCm39) probably null Het
Mios T A 6: 8,215,156 (GRCm39) N117K probably damaging Het
Nab1 T C 1: 52,529,429 (GRCm39) D156G probably benign Het
Nfxl1 C T 5: 72,698,005 (GRCm39) probably benign Het
Nutm2 G A 13: 50,621,480 (GRCm39) G15E probably damaging Het
Oca2 A G 7: 55,945,232 (GRCm39) H280R probably benign Het
Or10al2 C A 17: 37,983,551 (GRCm39) C212* probably null Het
Or4d1 T C 11: 87,804,914 (GRCm39) I273V probably benign Het
P2ry1 A G 3: 60,911,736 (GRCm39) T292A probably benign Het
Pcna C T 2: 132,093,673 (GRCm39) E109K probably benign Het
Pidd1 A G 7: 141,020,369 (GRCm39) probably null Het
Pitpnm2 T C 5: 124,271,445 (GRCm39) E376G possibly damaging Het
Pkd1l2 G A 8: 117,792,484 (GRCm39) T436I probably benign Het
Polr2a T C 11: 69,635,872 (GRCm39) probably null Het
Sbno2 A T 10: 79,893,368 (GRCm39) M1311K probably damaging Het
Senp7 A G 16: 55,992,228 (GRCm39) N701S probably benign Het
Sirpa T A 2: 129,471,848 (GRCm39) I211N probably damaging Het
Slc9a4 A G 1: 40,668,562 (GRCm39) E735G probably benign Het
Sorbs1 C T 19: 40,302,820 (GRCm39) M790I probably damaging Het
Sult1e1 T A 5: 87,737,983 (GRCm39) M33L probably benign Het
Tapbpl G A 6: 125,205,191 (GRCm39) probably null Het
Top1 A G 2: 160,545,498 (GRCm39) T289A probably damaging Het
Uaca A G 9: 60,770,945 (GRCm39) I371V probably benign Het
Vmn1r54 T C 6: 90,246,854 (GRCm39) I256T possibly damaging Het
Wdr19 T C 5: 65,388,319 (GRCm39) I668T probably benign Het
Other mutations in Trim58
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02351:Trim58 APN 11 58,542,176 (GRCm39) missense probably damaging 1.00
IGL02358:Trim58 APN 11 58,542,176 (GRCm39) missense probably damaging 1.00
IGL02792:Trim58 APN 11 58,531,292 (GRCm39) utr 5 prime probably benign
IGL02794:Trim58 APN 11 58,531,292 (GRCm39) utr 5 prime probably benign
IGL02875:Trim58 APN 11 58,531,292 (GRCm39) utr 5 prime probably benign
IGL02934:Trim58 APN 11 58,531,292 (GRCm39) utr 5 prime probably benign
IGL03213:Trim58 APN 11 58,541,993 (GRCm39) missense probably benign 0.00
R0011:Trim58 UTSW 11 58,533,946 (GRCm39) missense probably benign 0.02
R0011:Trim58 UTSW 11 58,533,946 (GRCm39) missense probably benign 0.02
R0735:Trim58 UTSW 11 58,542,219 (GRCm39) missense probably benign 0.16
R1294:Trim58 UTSW 11 58,533,953 (GRCm39) missense probably benign 0.28
R1929:Trim58 UTSW 11 58,531,493 (GRCm39) missense possibly damaging 0.84
R2104:Trim58 UTSW 11 58,533,964 (GRCm39) splice site probably benign
R2311:Trim58 UTSW 11 58,533,934 (GRCm39) missense probably benign 0.02
R2981:Trim58 UTSW 11 58,542,387 (GRCm39) missense probably damaging 1.00
R3432:Trim58 UTSW 11 58,537,787 (GRCm39) splice site probably benign
R4270:Trim58 UTSW 11 58,542,093 (GRCm39) missense probably damaging 1.00
R4450:Trim58 UTSW 11 58,542,191 (GRCm39) missense probably benign 0.03
R4841:Trim58 UTSW 11 58,542,150 (GRCm39) missense probably damaging 0.96
R4842:Trim58 UTSW 11 58,542,150 (GRCm39) missense probably damaging 0.96
R5262:Trim58 UTSW 11 58,542,494 (GRCm39) missense possibly damaging 0.88
R5979:Trim58 UTSW 11 58,536,909 (GRCm39) missense probably damaging 1.00
R6101:Trim58 UTSW 11 58,542,441 (GRCm39) missense probably benign 0.01
R6684:Trim58 UTSW 11 58,542,446 (GRCm39) missense probably benign 0.00
R6747:Trim58 UTSW 11 58,542,090 (GRCm39) missense probably benign 0.02
R7126:Trim58 UTSW 11 58,531,405 (GRCm39) missense probably damaging 1.00
R7981:Trim58 UTSW 11 58,542,138 (GRCm39) missense probably benign 0.26
R8307:Trim58 UTSW 11 58,537,909 (GRCm39) missense probably benign 0.00
R9221:Trim58 UTSW 11 58,542,075 (GRCm39) missense probably damaging 1.00
R9318:Trim58 UTSW 11 58,542,093 (GRCm39) missense probably damaging 1.00
X0026:Trim58 UTSW 11 58,536,795 (GRCm39) missense probably damaging 1.00
X0067:Trim58 UTSW 11 58,537,931 (GRCm39) missense possibly damaging 0.89
Z1186:Trim58 UTSW 11 58,542,486 (GRCm39) missense probably benign
Z1186:Trim58 UTSW 11 58,531,684 (GRCm39) missense possibly damaging 0.83
Z1187:Trim58 UTSW 11 58,542,486 (GRCm39) missense probably benign
Z1187:Trim58 UTSW 11 58,531,684 (GRCm39) missense possibly damaging 0.83
Z1188:Trim58 UTSW 11 58,542,486 (GRCm39) missense probably benign
Z1188:Trim58 UTSW 11 58,531,684 (GRCm39) missense possibly damaging 0.83
Z1189:Trim58 UTSW 11 58,542,486 (GRCm39) missense probably benign
Z1189:Trim58 UTSW 11 58,531,684 (GRCm39) missense possibly damaging 0.83
Z1190:Trim58 UTSW 11 58,542,486 (GRCm39) missense probably benign
Z1190:Trim58 UTSW 11 58,531,684 (GRCm39) missense possibly damaging 0.83
Z1191:Trim58 UTSW 11 58,542,486 (GRCm39) missense probably benign
Z1191:Trim58 UTSW 11 58,531,684 (GRCm39) missense possibly damaging 0.83
Z1192:Trim58 UTSW 11 58,542,486 (GRCm39) missense probably benign
Z1192:Trim58 UTSW 11 58,531,684 (GRCm39) missense possibly damaging 0.83
Posted On 2016-08-02