Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03083:Trim58'

417965

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trim58

Ensembl Gene

ENSMUSG00000037124

Gene Name

tripartite motif-containing 58

Synonyms

LOC386443, LOC216781

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

IGL03083

Quality Score

Status

Chromosome

Chromosomal Location

58640465-58652404 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 58651390 bp

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 392 (M392K)

Ref Sequence

ENSEMBL: ENSMUSP00000074594 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075084]

Predicted Effect

probably benign
Transcript: ENSMUST00000075084
AA Change: M392K

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)

SMART Domains

Protein: ENSMUSP00000074594
Gene: ENSMUSG00000037124
AA Change: M392K

Domain	Start	End	E-Value	Type
RING	15	58	2.95e-7	SMART
BBOX	90	131	2.93e-11	SMART
coiled coil region	192	241	N/A	INTRINSIC
PRY	289	341	5.33e-23	SMART
SPRY	342	461	6.16e-29	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca4	T	A	3: 122,138,612		probably null	Het
Acadsb	A	C	7: 131,441,193		probably benign	Het
Ankk1	A	G	9: 49,421,866	L106P	probably benign	Het
Ankrd24	G	A	10: 81,638,649	A72T	probably benign	Het
Ankrd35	A	T	3: 96,684,801	Q801L	probably damaging	Het
Avil	A	G	10: 127,016,324	I659M	probably benign	Het
Ccnc	A	G	4: 21,742,683	D170G	possibly damaging	Het
Cfap57	T	C	4: 118,584,739	K711E	probably damaging	Het
Dctn1	T	C	6: 83,197,484		probably benign	Het
Dpp6	T	C	5: 27,709,550		probably null	Het
Efhb	A	T	17: 53,399,059	W817R	probably damaging	Het
Emilin3	G	A	2: 160,908,729	Q320*	probably null	Het
Fer1l4	A	G	2: 156,039,366		probably benign	Het
Fgf8	T	C	19: 45,737,228	N137S	probably damaging	Het
Fndc3b	T	C	3: 27,467,427	D533G	probably benign	Het
Fshb	A	G	2: 107,057,467	V69A	probably benign	Het
Galnt7	A	T	8: 57,526,189	H633Q	probably damaging	Het
Gm5458	A	G	14: 19,602,383		probably null	Het
Hfe2	T	A	3: 96,528,606	D393E	probably benign	Het
Hpca	A	C	4: 129,118,526	F72L	probably damaging	Het
Inpp5d	A	T	1: 87,711,141	D552V	probably damaging	Het
Lepr	C	T	4: 101,814,679	Q967*	probably null	Het
Lgr5	A	G	10: 115,453,032	V497A	probably benign	Het
Matr3	A	G	18: 35,572,418	K132R	probably damaging	Het
Mib1	T	G	18: 10,752,029		probably null	Het
Mios	T	A	6: 8,215,156	N117K	probably damaging	Het
Nab1	T	C	1: 52,490,270	D156G	probably benign	Het
Nfxl1	C	T	5: 72,540,662		probably benign	Het
Nutm2	G	A	13: 50,467,444	G15E	probably damaging	Het
Oca2	A	G	7: 56,295,484	H280R	probably benign	Het
Olfr118	C	A	17: 37,672,660	C212*	probably null	Het
Olfr464	T	C	11: 87,914,088	I273V	probably benign	Het
P2ry1	A	G	3: 61,004,315	T292A	probably benign	Het
Pcna	C	T	2: 132,251,753	E109K	probably benign	Het
Pidd1	A	G	7: 141,440,456		probably null	Het
Pitpnm2	T	C	5: 124,133,382	E376G	possibly damaging	Het
Pkd1l2	G	A	8: 117,065,745	T436I	probably benign	Het
Polr2a	T	C	11: 69,745,046		probably null	Het
Sbno2	A	T	10: 80,057,534	M1311K	probably damaging	Het
Senp7	A	G	16: 56,171,865	N701S	probably benign	Het
Sirpa	T	A	2: 129,629,928	I211N	probably damaging	Het
Slc9a4	A	G	1: 40,629,402	E735G	probably benign	Het
Sorbs1	C	T	19: 40,314,376	M790I	probably damaging	Het
Sult1e1	T	A	5: 87,590,124	M33L	probably benign	Het
Tapbpl	G	A	6: 125,228,228		probably null	Het
Top1	A	G	2: 160,703,578	T289A	probably damaging	Het
Uaca	A	G	9: 60,863,663	I371V	probably benign	Het
Vmn1r54	T	C	6: 90,269,872	I256T	possibly damaging	Het
Wdr19	T	C	5: 65,230,976	I668T	probably benign	Het

Other mutations in Trim58

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02351:Trim58	APN	11	58651350	missense	probably damaging	1.00
IGL02358:Trim58	APN	11	58651350	missense	probably damaging	1.00
IGL02792:Trim58	APN	11	58640466	utr 5 prime	probably benign
IGL02794:Trim58	APN	11	58640466	utr 5 prime	probably benign
IGL02875:Trim58	APN	11	58640466	utr 5 prime	probably benign
IGL02934:Trim58	APN	11	58640466	utr 5 prime	probably benign
IGL03213:Trim58	APN	11	58651167	missense	probably benign	0.00
R0011:Trim58	UTSW	11	58643120	missense	probably benign	0.02
R0011:Trim58	UTSW	11	58643120	missense	probably benign	0.02
R0735:Trim58	UTSW	11	58651393	missense	probably benign	0.16
R1294:Trim58	UTSW	11	58643127	missense	probably benign	0.28
R1929:Trim58	UTSW	11	58640667	missense	possibly damaging	0.84
R2104:Trim58	UTSW	11	58643138	splice site	probably benign
R2311:Trim58	UTSW	11	58643108	missense	probably benign	0.02
R2981:Trim58	UTSW	11	58651561	missense	probably damaging	1.00
R3432:Trim58	UTSW	11	58646961	splice site	probably benign
R4270:Trim58	UTSW	11	58651267	missense	probably damaging	1.00
R4450:Trim58	UTSW	11	58651365	missense	probably benign	0.03
R4841:Trim58	UTSW	11	58651324	missense	probably damaging	0.96
R4842:Trim58	UTSW	11	58651324	missense	probably damaging	0.96
R5262:Trim58	UTSW	11	58651668	missense	possibly damaging	0.88
R5979:Trim58	UTSW	11	58646083	missense	probably damaging	1.00
R6101:Trim58	UTSW	11	58651615	missense	probably benign	0.01
R6684:Trim58	UTSW	11	58651620	missense	probably benign	0.00
R6747:Trim58	UTSW	11	58651264	missense	probably benign	0.02
R7126:Trim58	UTSW	11	58640579	missense	probably damaging	1.00
X0026:Trim58	UTSW	11	58645969	missense	probably damaging	1.00
X0067:Trim58	UTSW	11	58647105	missense	possibly damaging	0.89

Posted On

2016-08-02