Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03085:Trim66'

418067

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trim66

Ensembl Gene

ENSMUSG00000031026

Gene Name

tripartite motif-containing 66

Synonyms

Tif1d, D7H11orf29

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.177) question?

Stock #

IGL03085

Quality Score

Status

Chromosome

Chromosomal Location

109449006-109508134 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 109458745 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 877 (I877F)

Ref Sequence

ENSEMBL: ENSMUSP00000102350 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000033339] [ENSMUST00000106739] [ENSMUST00000106741]

AlphaFold

Q924W6

Predicted Effect

probably benign
Transcript: ENSMUST00000033339
AA Change: I877F

PolyPhen 2 Score 0.170 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000033339
Gene: ENSMUSG00000031026
AA Change: I877F

Domain	Start	End	E-Value	Type
PHD	4	69	7.77e0	SMART
BBC	108	234	1.61e-39	SMART
low complexity region	318	333	N/A	INTRINSIC
low complexity region	452	486	N/A	INTRINSIC
low complexity region	517	530	N/A	INTRINSIC
low complexity region	568	581	N/A	INTRINSIC
PHD	998	1041	4.09e-10	SMART
BROMO	1069	1175	8.22e-27	SMART
low complexity region	1185	1199	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000106739
AA Change: I877F

PolyPhen 2 Score 0.170 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000102350
Gene: ENSMUSG00000031026
AA Change: I877F

Domain	Start	End	E-Value	Type
PHD	4	69	7.77e0	SMART
BBC	108	234	1.61e-39	SMART
low complexity region	318	333	N/A	INTRINSIC
low complexity region	452	486	N/A	INTRINSIC
low complexity region	517	530	N/A	INTRINSIC
low complexity region	568	581	N/A	INTRINSIC
PHD	998	1041	4.09e-10	SMART
BROMO	1069	1175	8.22e-27	SMART
low complexity region	1185	1199	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000106741
AA Change: I979F

PolyPhen 2 Score 0.053 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000102352
Gene: ENSMUSG00000031026
AA Change: I979F

Domain	Start	End	E-Value	Type
RING	28	78	2.38e-2	SMART
BBOX	102	140	1.48e0	SMART
PHD	106	171	7.77e0	SMART
RING	107	170	4.38e0	SMART
BBOX	162	203	4.21e-3	SMART
BBC	210	336	1.61e-39	SMART
low complexity region	420	435	N/A	INTRINSIC
low complexity region	554	588	N/A	INTRINSIC
low complexity region	619	632	N/A	INTRINSIC
low complexity region	670	683	N/A	INTRINSIC
PHD	1100	1143	4.09e-10	SMART
BROMO	1171	1277	8.22e-27	SMART
low complexity region	1287	1301	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930578I06Rik	A	T	14: 63,971,432	H230Q	probably benign	Het
Aagab	T	A	9: 63,639,034		probably benign	Het
Actl11	G	T	9: 107,929,550	K357N	probably damaging	Het
Aktip	A	G	8: 91,126,023		probably null	Het
Amtn	A	G	5: 88,381,642		probably benign	Het
Arhgap21	T	A	2: 20,914,721	M58L	probably benign	Het
Art2b	T	A	7: 101,580,578	Y38F	probably damaging	Het
Asb10	T	C	5: 24,539,603		probably benign	Het
Atm	A	T	9: 53,484,171	D1699E	possibly damaging	Het
Azi2	A	C	9: 118,059,146	K259T	probably damaging	Het
Bcas3	A	G	11: 85,476,783	D77G	probably damaging	Het
Birc6	G	A	17: 74,596,950	R1246H	probably damaging	Het
Cdh13	C	A	8: 119,288,724	D559E	probably damaging	Het
Chrm3	C	T	13: 9,877,534	A489T	probably damaging	Het
Ckap2l	A	T	2: 129,285,047	Y404N	probably benign	Het
Col18a1	A	G	10: 77,059,181		probably benign	Het
Col4a1	T	A	8: 11,222,198	K731*	probably null	Het
Corin	A	T	5: 72,353,930	C360S	probably damaging	Het
Cyp1a1	A	C	9: 57,701,712	H292P	possibly damaging	Het
Dennd5b	A	G	6: 149,027,395	V760A	probably damaging	Het
Dhx57	T	C	17: 80,258,097	D842G	possibly damaging	Het
Emp2	C	A	16: 10,288,046		probably benign	Het
Eral1	G	A	11: 78,078,267	R136C	probably damaging	Het
Fat2	T	A	11: 55,283,246	M2214L	probably benign	Het
Flnb	G	A	14: 7,882,211	R304H	probably benign	Het
G6pd2	A	T	5: 61,810,302	E473D	probably benign	Het
Gpx8	A	G	13: 113,043,261	Y169H	probably damaging	Het
Ighv1-64	A	G	12: 115,507,841	S19P	possibly damaging	Het
Ikbkb	G	T	8: 22,682,786	N139K	probably benign	Het
Inpp5b	A	T	4: 124,792,322	T720S	probably benign	Het
Kmt2d	C	A	15: 98,839,940		probably benign	Het
Lrig2	G	A	3: 104,467,259	P169S	probably damaging	Het
Magi3	T	A	3: 104,015,339	K1354I	possibly damaging	Het
Mapk9	A	T	11: 49,867,038	D103V	probably damaging	Het
Mrpl46	A	T	7: 78,781,585	I75N	probably damaging	Het
Olfr402	T	A	11: 74,155,685	I177N	probably damaging	Het
Olfr890	A	G	9: 38,143,183	E16G	probably damaging	Het
Olfr926	G	A	9: 38,877,663	M162I	probably benign	Het
Otog	G	T	7: 46,305,922		probably null	Het
Pex11a	A	G	7: 79,737,775	L103P	probably damaging	Het
Pnpla8	A	G	12: 44,311,522	T687A	probably benign	Het
Ppm1d	A	G	11: 85,337,163	I302V	probably null	Het
Prdm11	C	A	2: 92,974,959	V549F	possibly damaging	Het
Prss54	G	A	8: 95,565,630	P107L	probably benign	Het
Rasa3	T	A	8: 13,585,690	N422I	probably benign	Het
Rbm27	T	C	18: 42,327,524		probably benign	Het
Rpl13-ps3	A	T	14: 58,893,707		noncoding transcript	Het
Rps6ka2	G	A	17: 7,295,280		probably null	Het
Sphkap	T	A	1: 83,280,354	I223F	possibly damaging	Het
Srm	T	C	4: 148,593,381	F159L	probably damaging	Het
Stt3a	A	G	9: 36,732,970		probably benign	Het
Tacr3	T	C	3: 134,932,266	S395P	possibly damaging	Het
Tecpr2	A	G	12: 110,954,826		probably benign	Het
Tmub1	C	T	5: 24,446,098	G188S	probably damaging	Het
Ubr5	T	C	15: 38,029,568	E471G	probably damaging	Het
Vmn1r218	A	T	13: 23,137,311	Y196F	possibly damaging	Het
Vmn2r89	T	A	14: 51,452,158	D39E	probably damaging	Het
Wee1	C	A	7: 110,124,598	P240Q	probably damaging	Het
Zc3h12a	A	T	4: 125,127,020	V10D	probably benign	Het
Zzef1	T	C	11: 72,855,524		probably benign	Het

Other mutations in Trim66

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01539:Trim66	APN	7	109455066	missense	probably benign	0.02
IGL01758:Trim66	APN	7	109486045	critical splice donor site	probably null
IGL01982:Trim66	APN	7	109458763	missense	probably benign	0.00
IGL01983:Trim66	APN	7	109458251	nonsense	probably null
IGL02149:Trim66	APN	7	109460902	missense	possibly damaging	0.66
IGL02392:Trim66	APN	7	109460274	missense	probably benign	0.01
IGL02483:Trim66	APN	7	109477630	splice site	probably benign
IGL02832:Trim66	APN	7	109460497	missense	probably damaging	1.00
IGL02945:Trim66	APN	7	109460176	nonsense	probably null
PIT1430001:Trim66	UTSW	7	109475247	missense	probably damaging	0.99
R0326:Trim66	UTSW	7	109460172	missense	probably benign	0.00
R0358:Trim66	UTSW	7	109460176	nonsense	probably null
R0401:Trim66	UTSW	7	109475264	missense	probably damaging	0.98
R0470:Trim66	UTSW	7	109457542	splice site	probably benign
R0568:Trim66	UTSW	7	109460695	missense	probably benign	0.00
R0669:Trim66	UTSW	7	109454992	intron	probably benign
R0980:Trim66	UTSW	7	109455670	missense	probably damaging	1.00
R1015:Trim66	UTSW	7	109455233	missense	probably damaging	1.00
R1078:Trim66	UTSW	7	109472319	missense	probably damaging	1.00
R1099:Trim66	UTSW	7	109475454	missense	probably benign	0.34
R1181:Trim66	UTSW	7	109484577	critical splice donor site	probably null
R1497:Trim66	UTSW	7	109484619	missense	probably benign	0.00
R1583:Trim66	UTSW	7	109455080	missense	probably damaging	1.00
R1843:Trim66	UTSW	7	109475839	missense	probably damaging	0.99
R1998:Trim66	UTSW	7	109484577	critical splice donor site	probably null
R2016:Trim66	UTSW	7	109472232	critical splice donor site	probably null
R2143:Trim66	UTSW	7	109475113	missense	probably damaging	0.98
R2144:Trim66	UTSW	7	109475113	missense	probably damaging	0.98
R2145:Trim66	UTSW	7	109475113	missense	probably damaging	0.98
R3945:Trim66	UTSW	7	109472268	missense	possibly damaging	0.94
R4012:Trim66	UTSW	7	109458131	missense	probably damaging	0.98
R4464:Trim66	UTSW	7	109477690	missense	possibly damaging	0.51
R4473:Trim66	UTSW	7	109481995	missense	probably damaging	1.00
R4729:Trim66	UTSW	7	109456060	critical splice donor site	probably null
R4730:Trim66	UTSW	7	109483069	missense	probably damaging	1.00
R4775:Trim66	UTSW	7	109457589	nonsense	probably null
R4819:Trim66	UTSW	7	109457586	missense	probably damaging	1.00
R5269:Trim66	UTSW	7	109457590	missense	probably benign	0.00
R5557:Trim66	UTSW	7	109483737	missense	probably benign	0.06
R5832:Trim66	UTSW	7	109455202	missense	probably damaging	1.00
R6220:Trim66	UTSW	7	109483093	missense	probably damaging	0.97
R6243:Trim66	UTSW	7	109460274	missense	probably benign	0.01
R6374:Trim66	UTSW	7	109486062	missense	probably benign
R6450:Trim66	UTSW	7	109460738	missense	probably benign	0.09
R6543:Trim66	UTSW	7	109475879	missense	probably benign	0.01
R6788:Trim66	UTSW	7	109477754	missense	probably damaging	1.00
R6842:Trim66	UTSW	7	109460776	missense	probably benign	0.00
R7169:Trim66	UTSW	7	109455121	missense	probably benign	0.25
R7257:Trim66	UTSW	7	109460244	missense	probably damaging	1.00
R7328:Trim66	UTSW	7	109457751	missense	probably damaging	0.99
R7616:Trim66	UTSW	7	109483749	missense	probably damaging	0.99
R8423:Trim66	UTSW	7	109475392	missense	possibly damaging	0.77
R8855:Trim66	UTSW	7	109481981	missense	probably damaging	1.00
R9130:Trim66	UTSW	7	109477689	missense	possibly damaging	0.90
R9137:Trim66	UTSW	7	109475123	missense	probably damaging	0.99
R9640:Trim66	UTSW	7	109475618	missense	probably damaging	1.00
RF013:Trim66	UTSW	7	109460753	missense	probably damaging	0.99
RF024:Trim66	UTSW	7	109460740	missense	possibly damaging	0.62

Posted On

2016-08-02