Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03087:Or7g16'

418134

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or7g16

Ensembl Gene

ENSMUSG00000078116

Gene Name

olfactory receptor family 7 subfamily G member 16

Synonyms

GA_x6K02T2PVTD-12559294-12558356, Olfr828, MOR149-1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.136) question?

Stock #

IGL03087

Quality Score

Status

Chromosome

Chromosomal Location

18726650-18727588 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 18727380 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 70 (D70G)

Ref Sequence

ENSEMBL: ENSMUSP00000148853 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000104914] [ENSMUST00000213018] [ENSMUST00000215380]

AlphaFold

Q8VFM8

Predicted Effect

probably damaging
Transcript: ENSMUST00000104914
AA Change: D70G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000100514
Gene: ENSMUSG00000078116
AA Change: D70G

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	310	1e-48	PFAM
Pfam:7TM_GPCR_Srsx	35	305	1.4e-5	PFAM
Pfam:7tm_1	41	290	2.1e-21	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000213018
AA Change: D70G

Predicted Effect

probably damaging
Transcript: ENSMUST00000215380
AA Change: D70G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1500035N22Rik	C	T	5: 25,202,630 (GRCm39)		probably benign	Het
Acbd5	A	G	2: 22,979,722 (GRCm39)	T261A	probably benign	Het
Ap1g2	G	A	14: 55,340,493 (GRCm39)	T331I	probably damaging	Het
Ap4m1	A	G	5: 138,173,066 (GRCm39)	T150A	probably benign	Het
Arid4a	G	T	12: 71,122,019 (GRCm39)	R478L	possibly damaging	Het
Bard1	T	C	1: 71,106,289 (GRCm39)	D446G	probably damaging	Het
Baz2a	T	C	10: 127,958,182 (GRCm39)	L1087P	probably damaging	Het
Bnc1	A	G	7: 81,624,390 (GRCm39)	L279P	possibly damaging	Het
Bphl	A	T	13: 34,257,694 (GRCm39)	H275L	probably damaging	Het
Ces1c	T	C	8: 93,845,042 (GRCm39)	I120V	probably benign	Het
Csmd3	T	A	15: 47,840,429 (GRCm39)	Y946F	probably damaging	Het
Dnah8	G	A	17: 31,003,118 (GRCm39)	V3606I	probably benign	Het
Eef2	A	G	10: 81,017,081 (GRCm39)	N696S	probably benign	Het
Eno4	A	G	19: 58,951,248 (GRCm39)	H420R	possibly damaging	Het
Enpp1	T	A	10: 24,531,779 (GRCm39)		probably benign	Het
Fbxo25	T	C	8: 13,974,019 (GRCm39)		probably null	Het
Glt8d1	T	A	14: 30,732,053 (GRCm39)	F155I	probably damaging	Het
Golim4	A	T	3: 75,785,980 (GRCm39)	H598Q	possibly damaging	Het
Hnrnpdl	T	A	5: 100,185,460 (GRCm39)	E149D	probably damaging	Het
Ifngr2	G	T	16: 91,359,892 (GRCm39)	*333L	probably null	Het
Ift88	T	C	14: 57,715,414 (GRCm39)	S486P	probably benign	Het
Igsf9	T	C	1: 172,318,310 (GRCm39)	I150T	probably benign	Het
Jag2	G	A	12: 112,877,568 (GRCm39)	L670F	possibly damaging	Het
Kcnc2	T	A	10: 112,291,652 (GRCm39)	I280N	probably benign	Het
Kif18a	A	G	2: 109,148,462 (GRCm39)		probably benign	Het
Lct	A	G	1: 128,228,112 (GRCm39)	L1127P	possibly damaging	Het
Lonrf1	A	T	8: 36,692,705 (GRCm39)		probably null	Het
Lyst	T	A	13: 13,809,641 (GRCm39)	I437N	probably damaging	Het
Map3k1	A	G	13: 111,885,559 (GRCm39)	S1453P	probably benign	Het
Mcmdc2	A	G	1: 10,001,170 (GRCm39)	M482V	possibly damaging	Het
Mical1	T	C	10: 41,358,686 (GRCm39)	S535P	probably damaging	Het
Myh3	T	C	11: 66,981,798 (GRCm39)	F765L	probably damaging	Het
Nat8f6	A	T	6: 85,785,499 (GRCm39)	Y217N	probably damaging	Het
Ndufaf1	A	G	2: 119,486,280 (GRCm39)		probably benign	Het
Neurod6	A	T	6: 55,655,760 (GRCm39)	C292*	probably null	Het
Or12j3	T	A	7: 139,953,005 (GRCm39)	I173F	probably damaging	Het
Or4c12b	A	G	2: 89,647,015 (GRCm39)	E109G	probably damaging	Het
Or5j1	A	T	2: 86,879,356 (GRCm39)	S75T	possibly damaging	Het
Or6c76	A	T	10: 129,612,130 (GRCm39)	M116L	probably damaging	Het
Pcdhac2	A	G	18: 37,278,735 (GRCm39)	N572D	probably damaging	Het
Pfpl	A	G	19: 12,406,241 (GRCm39)	N164S	probably benign	Het
Pi4kb	A	G	3: 94,892,075 (GRCm39)	R264G	probably benign	Het
Pla2g2c	T	A	4: 138,458,923 (GRCm39)	F10I	probably benign	Het
Rag2	G	A	2: 101,460,559 (GRCm39)	V290I	probably benign	Het
Rhot2	G	A	17: 26,060,115 (GRCm39)		probably benign	Het
Rps6kc1	T	C	1: 190,603,908 (GRCm39)	Y238C	probably damaging	Het
Scyl2	G	T	10: 89,488,830 (GRCm39)	A495D	possibly damaging	Het
Septin4	T	A	11: 87,476,071 (GRCm39)		probably benign	Het
Serpina5	G	T	12: 104,067,992 (GRCm39)	A18S	probably benign	Het
Slc25a11	T	C	11: 70,536,033 (GRCm39)	T234A	probably benign	Het
Slc44a2	C	T	9: 21,258,061 (GRCm39)	T435I	probably benign	Het
Tekt2	T	A	4: 126,218,660 (GRCm39)	Q31L	possibly damaging	Het
Tfpi	A	G	2: 84,274,389 (GRCm39)	V199A	possibly damaging	Het
Trap1	G	T	16: 3,862,565 (GRCm39)		probably null	Het
Trmt1	A	G	8: 85,421,862 (GRCm39)	Y213C	probably damaging	Het
Ubr4	C	T	4: 139,177,668 (GRCm39)	R3184*	probably null	Het
Uroc1	G	T	6: 90,340,085 (GRCm39)		probably benign	Het
Vmn1r19	A	G	6: 57,381,476 (GRCm39)	I10V	probably benign	Het
Zfhx2	G	A	14: 55,310,302 (GRCm39)	A748V	possibly damaging	Het

Other mutations in Or7g16

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02088:Or7g16	APN	9	18,727,219 (GRCm39)	missense	probably benign	0.03
IGL02103:Or7g16	APN	9	18,727,005 (GRCm39)	missense	probably damaging	1.00
IGL02792:Or7g16	APN	9	18,727,254 (GRCm39)	missense	probably benign	0.00
IGL02964:Or7g16	APN	9	18,727,024 (GRCm39)	missense	probably damaging	1.00
IGL03105:Or7g16	APN	9	18,726,685 (GRCm39)	missense	probably benign	0.03
R0330:Or7g16	UTSW	9	18,726,937 (GRCm39)	missense	probably damaging	1.00
R0335:Or7g16	UTSW	9	18,727,290 (GRCm39)	missense	probably damaging	1.00
R0862:Or7g16	UTSW	9	18,727,002 (GRCm39)	missense	probably damaging	0.98
R1226:Or7g16	UTSW	9	18,727,266 (GRCm39)	missense	probably benign	0.34
R2004:Or7g16	UTSW	9	18,726,801 (GRCm39)	missense	probably benign	0.05
R2005:Or7g16	UTSW	9	18,726,801 (GRCm39)	missense	probably benign	0.05
R2006:Or7g16	UTSW	9	18,726,801 (GRCm39)	missense	probably benign	0.05
R2199:Or7g16	UTSW	9	18,727,219 (GRCm39)	missense	probably damaging	0.97
R2230:Or7g16	UTSW	9	18,727,021 (GRCm39)	missense	probably damaging	1.00
R2399:Or7g16	UTSW	9	18,727,323 (GRCm39)	missense	probably benign	0.07
R5652:Or7g16	UTSW	9	18,726,922 (GRCm39)	missense	probably damaging	1.00
R5738:Or7g16	UTSW	9	18,727,125 (GRCm39)	missense	possibly damaging	0.81
R6416:Or7g16	UTSW	9	18,727,188 (GRCm39)	missense	probably benign	0.21
R6813:Or7g16	UTSW	9	18,727,188 (GRCm39)	missense	probably benign	0.21
R7092:Or7g16	UTSW	9	18,727,353 (GRCm39)	missense	probably damaging	1.00
R7109:Or7g16	UTSW	9	18,726,904 (GRCm39)	missense	probably benign	0.01
R7292:Or7g16	UTSW	9	18,727,486 (GRCm39)	missense	probably damaging	1.00
R7429:Or7g16	UTSW	9	18,726,650 (GRCm39)	makesense	probably null
R7430:Or7g16	UTSW	9	18,726,650 (GRCm39)	makesense	probably null
R7490:Or7g16	UTSW	9	18,727,229 (GRCm39)	nonsense	probably null
R7835:Or7g16	UTSW	9	18,727,105 (GRCm39)	missense	probably benign	0.05
R8016:Or7g16	UTSW	9	18,727,588 (GRCm39)	start codon destroyed	probably null	0.56
R8809:Or7g16	UTSW	9	18,726,919 (GRCm39)	missense	probably damaging	0.99
R8859:Or7g16	UTSW	9	18,726,992 (GRCm39)	missense	possibly damaging	0.90
R9036:Or7g16	UTSW	9	18,727,569 (GRCm39)	missense	probably damaging	1.00
R9079:Or7g16	UTSW	9	18,726,731 (GRCm39)	missense	probably damaging	0.99
R9177:Or7g16	UTSW	9	18,726,742 (GRCm39)	missense	probably damaging	1.00
R9182:Or7g16	UTSW	9	18,726,742 (GRCm39)	missense	probably damaging	1.00
R9184:Or7g16	UTSW	9	18,727,138 (GRCm39)	missense	probably benign	0.10
RF003:Or7g16	UTSW	9	18,726,778 (GRCm39)	missense	probably benign	0.03
X0026:Or7g16	UTSW	9	18,727,059 (GRCm39)	missense	possibly damaging	0.95
Z1176:Or7g16	UTSW	9	18,727,276 (GRCm39)	frame shift	probably null
Z1177:Or7g16	UTSW	9	18,727,444 (GRCm39)	missense	probably benign	0.09

Posted On

2016-08-02