Incidental Mutation 'IGL03087:Septin4'
| ID |
418182 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Septin4
|
| Ensembl Gene |
ENSMUSG00000020486 |
| Gene Name |
septin 4 |
| Synonyms |
Gm11492, ARTS, septin H5, cell division control-related protein 2b, Sept4, Bh5, Pnutl2 |
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.796)
|
| Stock # |
IGL03087
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
11 |
| Chromosomal Location |
87457515-87481365 bp(+) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
T to A
at 87476071 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000115790
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000018544]
[ENSMUST00000063156]
[ENSMUST00000107960]
[ENSMUST00000107961]
[ENSMUST00000107962]
[ENSMUST00000122067]
[ENSMUST00000122945]
[ENSMUST00000133202]
|
| AlphaFold |
P28661
Q5ND19 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000018544
|
| SMART Domains |
Protein: ENSMUSP00000018544
Gene: ENSMUSG00000020486
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
94 |
108 |
N/A |
INTRINSIC |
|
Pfam:Septin
|
141 |
421 |
1.8e-130 |
PFAM |
|
Pfam:MMR_HSR1
|
146 |
290 |
1.3e-7 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000063156
|
| SMART Domains |
Protein: ENSMUSP00000060127
Gene: ENSMUSG00000020486
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF258
|
26 |
142 |
7.5e-7 |
PFAM |
|
Pfam:Septin
|
42 |
322 |
7.5e-131 |
PFAM |
|
Pfam:MMR_HSR1
|
47 |
211 |
5.4e-7 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107960
|
| SMART Domains |
Protein: ENSMUSP00000103594
Gene: ENSMUSG00000020486
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
94 |
108 |
N/A |
INTRINSIC |
|
Pfam:Septin
|
141 |
421 |
1.1e-130 |
PFAM |
|
Pfam:MMR_HSR1
|
146 |
293 |
7.3e-7 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107961
|
| SMART Domains |
Protein: ENSMUSP00000103595
Gene: ENSMUSG00000020486
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF258
|
19 |
135 |
1e-7 |
PFAM |
|
Pfam:Septin
|
35 |
232 |
1.9e-89 |
PFAM |
|
Pfam:MMR_HSR1
|
40 |
204 |
1.2e-7 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107962
|
| SMART Domains |
Protein: ENSMUSP00000103596
Gene: ENSMUSG00000020486
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
75 |
89 |
N/A |
INTRINSIC |
|
Pfam:Septin
|
122 |
402 |
1.3e-130 |
PFAM |
|
Pfam:MMR_HSR1
|
127 |
273 |
8.3e-7 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000122067
|
| SMART Domains |
Protein: ENSMUSP00000112960
Gene: ENSMUSG00000020486
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF258
|
8 |
124 |
5.3e-7 |
PFAM |
|
Pfam:Septin
|
23 |
303 |
3.9e-131 |
PFAM |
|
Pfam:MMR_HSR1
|
28 |
172 |
4e-7 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000122945
|
| SMART Domains |
Protein: ENSMUSP00000115682
Gene: ENSMUSG00000020486
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
87 |
101 |
N/A |
INTRINSIC |
|
Pfam:DUF258
|
116 |
212 |
2.4e-7 |
PFAM |
|
Pfam:Septin
|
134 |
213 |
9.1e-31 |
PFAM |
|
Pfam:MMR_HSR1
|
139 |
213 |
5.5e-7 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000148216
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000132723
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000134923
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000140398
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000133202
|
| SMART Domains |
Protein: ENSMUSP00000115790
Gene: ENSMUSG00000020486
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
84 |
98 |
N/A |
INTRINSIC |
|
Pfam:DUF258
|
114 |
232 |
1.4e-7 |
PFAM |
|
Pfam:Septin
|
131 |
280 |
1.2e-72 |
PFAM |
|
Pfam:MMR_HSR1
|
136 |
279 |
2.2e-7 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000133638
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000135175
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000143950
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000123081
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136229
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000127414
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. [provided by RefSeq, Nov 2010]
PHENOTYPE: Homozygous null males are sterile and have immotile and structurally defective sperm that is bent and lacks the annulus. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 59 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1500035N22Rik |
C |
T |
5: 25,202,630 (GRCm39) |
|
probably benign |
Het |
| Acbd5 |
A |
G |
2: 22,979,722 (GRCm39) |
T261A |
probably benign |
Het |
| Ap1g2 |
G |
A |
14: 55,340,493 (GRCm39) |
T331I |
probably damaging |
Het |
| Ap4m1 |
A |
G |
5: 138,173,066 (GRCm39) |
T150A |
probably benign |
Het |
| Arid4a |
G |
T |
12: 71,122,019 (GRCm39) |
R478L |
possibly damaging |
Het |
| Bard1 |
T |
C |
1: 71,106,289 (GRCm39) |
D446G |
probably damaging |
Het |
| Baz2a |
T |
C |
10: 127,958,182 (GRCm39) |
L1087P |
probably damaging |
Het |
| Bnc1 |
A |
G |
7: 81,624,390 (GRCm39) |
L279P |
possibly damaging |
Het |
| Bphl |
A |
T |
13: 34,257,694 (GRCm39) |
H275L |
probably damaging |
Het |
| Ces1c |
T |
C |
8: 93,845,042 (GRCm39) |
I120V |
probably benign |
Het |
| Csmd3 |
T |
A |
15: 47,840,429 (GRCm39) |
Y946F |
probably damaging |
Het |
| Dnah8 |
G |
A |
17: 31,003,118 (GRCm39) |
V3606I |
probably benign |
Het |
| Eef2 |
A |
G |
10: 81,017,081 (GRCm39) |
N696S |
probably benign |
Het |
| Eno4 |
A |
G |
19: 58,951,248 (GRCm39) |
H420R |
possibly damaging |
Het |
| Enpp1 |
T |
A |
10: 24,531,779 (GRCm39) |
|
probably benign |
Het |
| Fbxo25 |
T |
C |
8: 13,974,019 (GRCm39) |
|
probably null |
Het |
| Glt8d1 |
T |
A |
14: 30,732,053 (GRCm39) |
F155I |
probably damaging |
Het |
| Golim4 |
A |
T |
3: 75,785,980 (GRCm39) |
H598Q |
possibly damaging |
Het |
| Hnrnpdl |
T |
A |
5: 100,185,460 (GRCm39) |
E149D |
probably damaging |
Het |
| Ifngr2 |
G |
T |
16: 91,359,892 (GRCm39) |
*333L |
probably null |
Het |
| Ift88 |
T |
C |
14: 57,715,414 (GRCm39) |
S486P |
probably benign |
Het |
| Igsf9 |
T |
C |
1: 172,318,310 (GRCm39) |
I150T |
probably benign |
Het |
| Jag2 |
G |
A |
12: 112,877,568 (GRCm39) |
L670F |
possibly damaging |
Het |
| Kcnc2 |
T |
A |
10: 112,291,652 (GRCm39) |
I280N |
probably benign |
Het |
| Kif18a |
A |
G |
2: 109,148,462 (GRCm39) |
|
probably benign |
Het |
| Lct |
A |
G |
1: 128,228,112 (GRCm39) |
L1127P |
possibly damaging |
Het |
| Lonrf1 |
A |
T |
8: 36,692,705 (GRCm39) |
|
probably null |
Het |
| Lyst |
T |
A |
13: 13,809,641 (GRCm39) |
I437N |
probably damaging |
Het |
| Map3k1 |
A |
G |
13: 111,885,559 (GRCm39) |
S1453P |
probably benign |
Het |
| Mcmdc2 |
A |
G |
1: 10,001,170 (GRCm39) |
M482V |
possibly damaging |
Het |
| Mical1 |
T |
C |
10: 41,358,686 (GRCm39) |
S535P |
probably damaging |
Het |
| Myh3 |
T |
C |
11: 66,981,798 (GRCm39) |
F765L |
probably damaging |
Het |
| Nat8f6 |
A |
T |
6: 85,785,499 (GRCm39) |
Y217N |
probably damaging |
Het |
| Ndufaf1 |
A |
G |
2: 119,486,280 (GRCm39) |
|
probably benign |
Het |
| Neurod6 |
A |
T |
6: 55,655,760 (GRCm39) |
C292* |
probably null |
Het |
| Or12j3 |
T |
A |
7: 139,953,005 (GRCm39) |
I173F |
probably damaging |
Het |
| Or4c12b |
A |
G |
2: 89,647,015 (GRCm39) |
E109G |
probably damaging |
Het |
| Or5j1 |
A |
T |
2: 86,879,356 (GRCm39) |
S75T |
possibly damaging |
Het |
| Or6c76 |
A |
T |
10: 129,612,130 (GRCm39) |
M116L |
probably damaging |
Het |
| Or7g16 |
T |
C |
9: 18,727,380 (GRCm39) |
D70G |
probably damaging |
Het |
| Pcdhac2 |
A |
G |
18: 37,278,735 (GRCm39) |
N572D |
probably damaging |
Het |
| Pfpl |
A |
G |
19: 12,406,241 (GRCm39) |
N164S |
probably benign |
Het |
| Pi4kb |
A |
G |
3: 94,892,075 (GRCm39) |
R264G |
probably benign |
Het |
| Pla2g2c |
T |
A |
4: 138,458,923 (GRCm39) |
F10I |
probably benign |
Het |
| Rag2 |
G |
A |
2: 101,460,559 (GRCm39) |
V290I |
probably benign |
Het |
| Rhot2 |
G |
A |
17: 26,060,115 (GRCm39) |
|
probably benign |
Het |
| Rps6kc1 |
T |
C |
1: 190,603,908 (GRCm39) |
Y238C |
probably damaging |
Het |
| Scyl2 |
G |
T |
10: 89,488,830 (GRCm39) |
A495D |
possibly damaging |
Het |
| Serpina5 |
G |
T |
12: 104,067,992 (GRCm39) |
A18S |
probably benign |
Het |
| Slc25a11 |
T |
C |
11: 70,536,033 (GRCm39) |
T234A |
probably benign |
Het |
| Slc44a2 |
C |
T |
9: 21,258,061 (GRCm39) |
T435I |
probably benign |
Het |
| Tekt2 |
T |
A |
4: 126,218,660 (GRCm39) |
Q31L |
possibly damaging |
Het |
| Tfpi |
A |
G |
2: 84,274,389 (GRCm39) |
V199A |
possibly damaging |
Het |
| Trap1 |
G |
T |
16: 3,862,565 (GRCm39) |
|
probably null |
Het |
| Trmt1 |
A |
G |
8: 85,421,862 (GRCm39) |
Y213C |
probably damaging |
Het |
| Ubr4 |
C |
T |
4: 139,177,668 (GRCm39) |
R3184* |
probably null |
Het |
| Uroc1 |
G |
T |
6: 90,340,085 (GRCm39) |
|
probably benign |
Het |
| Vmn1r19 |
A |
G |
6: 57,381,476 (GRCm39) |
I10V |
probably benign |
Het |
| Zfhx2 |
G |
A |
14: 55,310,302 (GRCm39) |
A748V |
possibly damaging |
Het |
|
| Other mutations in Septin4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00941:Septin4
|
APN |
11 |
87,480,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00963:Septin4
|
APN |
11 |
87,474,199 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL01803:Septin4
|
APN |
11 |
87,459,075 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL01993:Septin4
|
APN |
11 |
87,458,555 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL02566:Septin4
|
APN |
11 |
87,458,468 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03213:Septin4
|
APN |
11 |
87,458,184 (GRCm39) |
splice site |
probably null |
|
|
IGL03268:Septin4
|
APN |
11 |
87,480,529 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03388:Septin4
|
APN |
11 |
87,459,042 (GRCm39) |
nonsense |
probably null |
|
|
R0050:Septin4
|
UTSW |
11 |
87,458,172 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0077:Septin4
|
UTSW |
11 |
87,472,022 (GRCm39) |
missense |
probably benign |
|
|
R1479:Septin4
|
UTSW |
11 |
87,458,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1729:Septin4
|
UTSW |
11 |
87,474,262 (GRCm39) |
missense |
probably benign |
0.26 |
|
R1730:Septin4
|
UTSW |
11 |
87,474,262 (GRCm39) |
missense |
probably benign |
0.26 |
|
R1739:Septin4
|
UTSW |
11 |
87,474,262 (GRCm39) |
missense |
probably benign |
0.26 |
|
R1762:Septin4
|
UTSW |
11 |
87,474,262 (GRCm39) |
missense |
probably benign |
0.26 |
|
R1783:Septin4
|
UTSW |
11 |
87,474,262 (GRCm39) |
missense |
probably benign |
0.26 |
|
R1784:Septin4
|
UTSW |
11 |
87,474,262 (GRCm39) |
missense |
probably benign |
0.26 |
|
R1785:Septin4
|
UTSW |
11 |
87,474,262 (GRCm39) |
missense |
probably benign |
0.26 |
|
R1851:Septin4
|
UTSW |
11 |
87,459,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1862:Septin4
|
UTSW |
11 |
87,458,061 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R1913:Septin4
|
UTSW |
11 |
87,457,838 (GRCm39) |
missense |
probably benign |
|
|
R1957:Septin4
|
UTSW |
11 |
87,481,193 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2131:Septin4
|
UTSW |
11 |
87,474,262 (GRCm39) |
missense |
probably benign |
0.26 |
|
R2133:Septin4
|
UTSW |
11 |
87,474,262 (GRCm39) |
missense |
probably benign |
0.26 |
|
R2140:Septin4
|
UTSW |
11 |
87,474,262 (GRCm39) |
missense |
probably benign |
0.26 |
|
R2141:Septin4
|
UTSW |
11 |
87,474,262 (GRCm39) |
missense |
probably benign |
0.26 |
|
R2252:Septin4
|
UTSW |
11 |
87,480,637 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R3149:Septin4
|
UTSW |
11 |
87,458,070 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R3176:Septin4
|
UTSW |
11 |
87,458,070 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R3276:Septin4
|
UTSW |
11 |
87,458,070 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R3696:Septin4
|
UTSW |
11 |
87,476,060 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R4018:Septin4
|
UTSW |
11 |
87,475,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4021:Septin4
|
UTSW |
11 |
87,458,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4117:Septin4
|
UTSW |
11 |
87,459,108 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4193:Septin4
|
UTSW |
11 |
87,474,142 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4196:Septin4
|
UTSW |
11 |
87,479,598 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4332:Septin4
|
UTSW |
11 |
87,458,730 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4515:Septin4
|
UTSW |
11 |
87,458,883 (GRCm39) |
missense |
probably benign |
|
|
R4663:Septin4
|
UTSW |
11 |
87,458,429 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4952:Septin4
|
UTSW |
11 |
87,458,598 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5012:Septin4
|
UTSW |
11 |
87,475,230 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R5015:Septin4
|
UTSW |
11 |
87,458,043 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5149:Septin4
|
UTSW |
11 |
87,480,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5176:Septin4
|
UTSW |
11 |
87,458,358 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5711:Septin4
|
UTSW |
11 |
87,458,723 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5891:Septin4
|
UTSW |
11 |
87,479,750 (GRCm39) |
unclassified |
probably benign |
|
|
R6090:Septin4
|
UTSW |
11 |
87,480,343 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6145:Septin4
|
UTSW |
11 |
87,476,072 (GRCm39) |
splice site |
probably null |
|
|
R6257:Septin4
|
UTSW |
11 |
87,481,175 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6305:Septin4
|
UTSW |
11 |
87,458,145 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6704:Septin4
|
UTSW |
11 |
87,479,856 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7064:Septin4
|
UTSW |
11 |
87,481,193 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7090:Septin4
|
UTSW |
11 |
87,475,264 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7784:Septin4
|
UTSW |
11 |
87,469,834 (GRCm39) |
missense |
probably benign |
|
|
R7790:Septin4
|
UTSW |
11 |
87,480,065 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8320:Septin4
|
UTSW |
11 |
87,480,560 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R9289:Septin4
|
UTSW |
11 |
87,459,792 (GRCm39) |
nonsense |
probably null |
|
|
R9613:Septin4
|
UTSW |
11 |
87,469,823 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
T0970:Septin4
|
UTSW |
11 |
87,458,558 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1177:Septin4
|
UTSW |
11 |
87,458,748 (GRCm39) |
missense |
probably benign |
|
|
| Posted On |
2016-08-02 |
Incidental Mutation