Incidental Mutation 'IGL03088:Fbxo38'
ID 418196
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fbxo38
Ensembl Gene ENSMUSG00000042211
Gene Name F-box protein 38
Synonyms SP329, 6030410I24Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03088
Quality Score
Status
Chromosome 18
Chromosomal Location 62637226-62681766 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 62655543 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 381 (V381A)
Ref Sequence ENSEMBL: ENSMUSP00000047541 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048688]
AlphaFold Q8BMI0
Predicted Effect possibly damaging
Transcript: ENSMUST00000048688
AA Change: V381A

PolyPhen 2 Score 0.858 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000047541
Gene: ENSMUSG00000042211
AA Change: V381A

DomainStartEndE-ValueType
Pfam:F-box 29 66 2.6e-5 PFAM
SCOP:d1fqva2 127 357 6e-4 SMART
low complexity region 493 525 N/A INTRINSIC
low complexity region 598 610 N/A INTRINSIC
low complexity region 705 728 N/A INTRINSIC
low complexity region 736 753 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930438A08Rik T G 11: 58,184,210 (GRCm39) L299R unknown Het
Abca9 T G 11: 110,035,087 (GRCm39) R693S probably benign Het
Adamts20 A T 15: 94,227,795 (GRCm39) probably null Het
Afg1l T A 10: 42,302,493 (GRCm39) D169V probably damaging Het
Agbl1 T A 7: 76,369,890 (GRCm39) M663K probably benign Het
Angpt2 T A 8: 18,791,039 (GRCm39) I86F probably benign Het
Ankrd2 G A 19: 42,030,424 (GRCm39) E160K probably null Het
As3mt G T 19: 46,696,233 (GRCm39) V14F probably damaging Het
Atp6v0a2 T C 5: 124,791,171 (GRCm39) probably benign Het
Atp6v0d1 T A 8: 106,257,591 (GRCm39) I113F probably damaging Het
Bank1 A G 3: 135,799,123 (GRCm39) I406T probably damaging Het
Bicdl1 A G 5: 115,801,881 (GRCm39) V59A possibly damaging Het
Brsk1 A G 7: 4,713,453 (GRCm39) probably benign Het
Cdh17 T A 4: 11,810,473 (GRCm39) N721K probably damaging Het
Cercam A G 2: 29,771,699 (GRCm39) probably benign Het
Clpb T A 7: 101,434,656 (GRCm39) L484* probably null Het
Creb3l1 T A 2: 91,825,739 (GRCm39) M127L probably benign Het
Cstdc1 A T 2: 148,625,327 (GRCm39) H87L possibly damaging Het
Ctla2b A C 13: 61,043,874 (GRCm39) D122E probably damaging Het
Cyb5rl C A 4: 106,938,225 (GRCm39) Y12* probably null Het
Dennd5a T C 7: 109,507,588 (GRCm39) Y800C probably damaging Het
Dmrt3 T G 19: 25,600,411 (GRCm39) S419A probably benign Het
Elapor1 A G 3: 108,443,674 (GRCm39) W31R probably damaging Het
Flg2 A T 3: 93,110,498 (GRCm39) H842L unknown Het
Fn1 A T 1: 71,653,197 (GRCm39) probably null Het
Fos A C 12: 85,522,630 (GRCm39) T181P possibly damaging Het
Fzd10 A G 5: 128,679,669 (GRCm39) Y463C possibly damaging Het
Gprc5b T C 7: 118,582,856 (GRCm39) M338V probably benign Het
Gsta4 T C 9: 78,113,345 (GRCm39) probably benign Het
Gstm2 T A 3: 107,893,362 (GRCm39) T34S probably benign Het
Haspin C T 11: 73,027,451 (GRCm39) R546Q probably damaging Het
Itgad G A 7: 127,802,204 (GRCm39) R958H probably benign Het
Kansl1l A T 1: 66,774,884 (GRCm39) H647Q probably damaging Het
Kif5c A C 2: 49,634,455 (GRCm39) R762S probably benign Het
Klf4 C A 4: 55,530,758 (GRCm39) A68S possibly damaging Het
Klf4 A G 4: 55,530,811 (GRCm39) L50P probably damaging Het
Kmt2c T C 5: 25,504,802 (GRCm39) E3502G probably damaging Het
Krt8 A G 15: 101,909,022 (GRCm39) I202T possibly damaging Het
Lmcd1 A T 6: 112,287,649 (GRCm39) T112S probably damaging Het
Lpxn T C 19: 12,810,575 (GRCm39) C340R probably damaging Het
Man2a2 C T 7: 80,009,082 (GRCm39) V844M possibly damaging Het
Map10 G A 8: 126,397,809 (GRCm39) E401K probably benign Het
Mark4 A T 7: 19,185,509 (GRCm39) L75Q probably damaging Het
Mlf2 T G 6: 124,910,945 (GRCm39) M81R probably damaging Het
Mup3 A G 4: 62,005,079 (GRCm39) I67T probably damaging Het
Mycbpap T C 11: 94,404,769 (GRCm39) probably null Het
Myt1l T C 12: 29,970,476 (GRCm39) V1185A probably benign Het
Ncoa7 C T 10: 30,574,121 (GRCm39) probably null Het
Nos1 C A 5: 118,005,323 (GRCm39) N14K probably damaging Het
Nova2 G T 7: 18,684,494 (GRCm39) V116F unknown Het
Obox3 G A 7: 15,360,927 (GRCm39) probably benign Het
Or10h1 A T 17: 33,418,534 (GRCm39) T171S probably benign Het
Or2t46 T A 11: 58,472,653 (GRCm39) probably benign Het
Or5v1 A G 17: 37,809,539 (GRCm39) probably benign Het
Or8b50 A T 9: 38,518,597 (GRCm39) S279C probably damaging Het
P2rx5 T A 11: 73,056,446 (GRCm39) probably benign Het
Parvb T A 15: 84,193,044 (GRCm39) probably benign Het
Popdc2 A T 16: 38,194,184 (GRCm39) T202S probably damaging Het
Ppm1j T A 3: 104,692,725 (GRCm39) Y411* probably null Het
Rapgefl1 C A 11: 98,740,058 (GRCm39) L484M probably damaging Het
Septin14 A G 5: 129,774,797 (GRCm39) probably benign Het
Slf1 A G 13: 77,232,554 (GRCm39) C517R probably damaging Het
Smyd3 A G 1: 178,921,898 (GRCm39) probably null Het
Snx9 A G 17: 5,974,885 (GRCm39) T458A probably benign Het
Srgap1 T C 10: 121,661,598 (GRCm39) D514G possibly damaging Het
Tbc1d14 A G 5: 36,682,308 (GRCm39) S311P probably damaging Het
Timd6 C A 11: 46,475,244 (GRCm39) F146L probably benign Het
Tmem150c T G 5: 100,234,076 (GRCm39) K91N probably damaging Het
Traf3 T A 12: 111,228,277 (GRCm39) M471K probably damaging Het
Tubd1 G T 11: 86,443,825 (GRCm39) G178C probably damaging Het
Vav2 T C 2: 27,157,262 (GRCm39) K847E possibly damaging Het
Vmn2r100 A T 17: 19,742,301 (GRCm39) H225L probably benign Het
Wrn A T 8: 33,758,851 (GRCm39) probably benign Het
Xpo7 T G 14: 70,918,702 (GRCm39) S710R probably benign Het
Zfp780b C T 7: 27,662,417 (GRCm39) V713I possibly damaging Het
Zkscan17 A T 11: 59,378,592 (GRCm39) I197N probably damaging Het
Other mutations in Fbxo38
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00911:Fbxo38 APN 18 62,663,871 (GRCm39) missense possibly damaging 0.59
IGL01384:Fbxo38 APN 18 62,655,487 (GRCm39) missense probably damaging 0.98
IGL01443:Fbxo38 APN 18 62,666,741 (GRCm39) missense probably damaging 1.00
IGL01515:Fbxo38 APN 18 62,651,642 (GRCm39) missense probably benign 0.00
IGL01621:Fbxo38 APN 18 62,655,595 (GRCm39) splice site probably benign
IGL01975:Fbxo38 APN 18 62,648,484 (GRCm39) missense probably damaging 1.00
IGL02148:Fbxo38 APN 18 62,669,298 (GRCm39) missense probably benign 0.02
IGL02390:Fbxo38 APN 18 62,666,660 (GRCm39) missense probably damaging 1.00
IGL03040:Fbxo38 APN 18 62,660,323 (GRCm39) missense probably damaging 1.00
IGL03290:Fbxo38 APN 18 62,659,234 (GRCm39) missense probably benign 0.08
FR4976:Fbxo38 UTSW 18 62,648,418 (GRCm39) small deletion probably benign
R0526:Fbxo38 UTSW 18 62,639,051 (GRCm39) missense probably damaging 1.00
R0529:Fbxo38 UTSW 18 62,639,057 (GRCm39) missense probably damaging 1.00
R0789:Fbxo38 UTSW 18 62,648,570 (GRCm39) missense possibly damaging 0.84
R1232:Fbxo38 UTSW 18 62,643,882 (GRCm39) missense probably damaging 1.00
R1857:Fbxo38 UTSW 18 62,648,489 (GRCm39) missense probably damaging 1.00
R1859:Fbxo38 UTSW 18 62,648,489 (GRCm39) missense probably damaging 1.00
R1872:Fbxo38 UTSW 18 62,650,094 (GRCm39) missense probably benign 0.01
R2114:Fbxo38 UTSW 18 62,639,711 (GRCm39) missense possibly damaging 0.71
R2910:Fbxo38 UTSW 18 62,652,878 (GRCm39) missense probably benign 0.01
R2911:Fbxo38 UTSW 18 62,652,878 (GRCm39) missense probably benign 0.01
R3406:Fbxo38 UTSW 18 62,647,914 (GRCm39) missense probably damaging 0.99
R3731:Fbxo38 UTSW 18 62,648,399 (GRCm39) small deletion probably benign
R3792:Fbxo38 UTSW 18 62,666,533 (GRCm39) splice site probably null
R3848:Fbxo38 UTSW 18 62,648,144 (GRCm39) missense possibly damaging 0.87
R3948:Fbxo38 UTSW 18 62,662,615 (GRCm39) splice site probably benign
R4151:Fbxo38 UTSW 18 62,648,399 (GRCm39) small deletion probably benign
R4323:Fbxo38 UTSW 18 62,648,232 (GRCm39) missense probably benign
R4456:Fbxo38 UTSW 18 62,659,320 (GRCm39) missense probably damaging 1.00
R4786:Fbxo38 UTSW 18 62,662,745 (GRCm39) missense probably damaging 1.00
R4829:Fbxo38 UTSW 18 62,651,662 (GRCm39) missense probably benign
R4959:Fbxo38 UTSW 18 62,655,578 (GRCm39) missense probably benign 0.45
R5274:Fbxo38 UTSW 18 62,648,140 (GRCm39) missense probably damaging 0.98
R5288:Fbxo38 UTSW 18 62,674,042 (GRCm39) missense probably benign
R5384:Fbxo38 UTSW 18 62,674,042 (GRCm39) missense probably benign
R5385:Fbxo38 UTSW 18 62,674,042 (GRCm39) missense probably benign
R5448:Fbxo38 UTSW 18 62,655,528 (GRCm39) missense possibly damaging 0.59
R5540:Fbxo38 UTSW 18 62,647,864 (GRCm39) critical splice donor site probably null
R5588:Fbxo38 UTSW 18 62,659,248 (GRCm39) missense probably damaging 1.00
R5617:Fbxo38 UTSW 18 62,639,042 (GRCm39) missense probably damaging 1.00
R5636:Fbxo38 UTSW 18 62,644,089 (GRCm39) missense possibly damaging 0.80
R5769:Fbxo38 UTSW 18 62,648,036 (GRCm39) missense probably benign 0.10
R6254:Fbxo38 UTSW 18 62,638,571 (GRCm39) splice site probably null
R6315:Fbxo38 UTSW 18 62,669,218 (GRCm39) nonsense probably null
R6517:Fbxo38 UTSW 18 62,666,634 (GRCm39) missense probably damaging 1.00
R6673:Fbxo38 UTSW 18 62,666,986 (GRCm39) missense probably damaging 1.00
R6974:Fbxo38 UTSW 18 62,639,740 (GRCm39) missense possibly damaging 0.95
R7022:Fbxo38 UTSW 18 62,669,295 (GRCm39) missense probably damaging 1.00
R7175:Fbxo38 UTSW 18 62,648,544 (GRCm39) missense probably benign 0.11
R8013:Fbxo38 UTSW 18 62,663,882 (GRCm39) missense possibly damaging 0.63
R8815:Fbxo38 UTSW 18 62,666,587 (GRCm39) missense probably damaging 1.00
R8885:Fbxo38 UTSW 18 62,659,272 (GRCm39) missense probably damaging 0.99
R9240:Fbxo38 UTSW 18 62,651,632 (GRCm39) nonsense probably null
R9427:Fbxo38 UTSW 18 62,644,160 (GRCm39) missense probably benign 0.00
R9750:Fbxo38 UTSW 18 62,674,061 (GRCm39) missense probably benign 0.14
R9796:Fbxo38 UTSW 18 62,674,055 (GRCm39) missense possibly damaging 0.92
Z1177:Fbxo38 UTSW 18 62,648,535 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02