Mutagenetix > Incidental Mutations

Incidental Mutation 'R0470:Vmn2r109'

41822

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r109

Ensembl Gene

ENSMUSG00000090572

Gene Name

vomeronasal 2, receptor 109

Synonyms

EG627814

MMRRC Submission

038670-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.067) question?

Stock #

R0470 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

20540517-20564756 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 20552886 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Arginine at position 491 (Q491R)

Ref Sequence

ENSEMBL: ENSMUSP00000132641 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167093]

AlphaFold

K7N747

Predicted Effect

probably benign
Transcript: ENSMUST00000167093
AA Change: Q491R

PolyPhen 2 Score 0.063 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000132641
Gene: ENSMUSG00000090572
AA Change: Q491R

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	467	1.4e-35	PFAM
Pfam:NCD3G	510	563	3.1e-21	PFAM
Pfam:7tm_3	596	831	7.4e-52	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.3%
20x: 93.0%

Validation Efficiency

98% (55/56)

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A730017C20Rik	C	T	18: 59,075,639	R120C	probably damaging	Het
Ahnak	T	G	19: 9,008,967	D2538E	probably benign	Het
Akr1c13	T	A	13: 4,198,501	L235H	probably damaging	Het
Ank	G	A	15: 27,571,635	C331Y	probably damaging	Het
Ankrd12	T	C	17: 65,986,134	E768G	probably benign	Het
Atm	A	T	9: 53,460,966	V2172E	probably damaging	Het
Atp10b	T	A	11: 43,203,039	L470Q	possibly damaging	Het
Bcl2	G	A	1: 106,712,562	R107C	probably damaging	Het
Cdadc1	A	T	14: 59,573,841		probably benign	Het
Cfhr2	A	T	1: 139,821,779	V155E	probably damaging	Het
Chp1	C	T	2: 119,560,763	R34C	probably damaging	Het
Cilp2	A	T	8: 69,885,405	V192E	possibly damaging	Het
Cyth1	T	C	11: 118,132,248		probably benign	Het
Dnah8	T	A	17: 30,708,540		probably benign	Het
Gja3	T	C	14: 57,036,427	T163A	probably damaging	Het
Gsdmcl1	C	T	15: 63,850,431		noncoding transcript	Het
Herc6	C	T	6: 57,619,452	T459M	probably damaging	Het
Hexb	A	G	13: 97,177,999	L412P	probably damaging	Het
Il17ra	T	G	6: 120,481,806	D639E	probably benign	Het
Kcnh5	G	A	12: 75,114,414	T240I	probably benign	Het
Lef1	T	C	3: 131,112,826		probably benign	Het
Lilrb4a	T	A	10: 51,494,827	N282K	possibly damaging	Het
Mbnl2	A	T	14: 120,404,650	H342L	probably damaging	Het
Nipal3	A	G	4: 135,447,372	V356A	probably damaging	Het
Olfr441	C	G	6: 43,116,624	A294G	probably null	Het
Olfr640	A	T	7: 104,021,670	I216N	probably damaging	Het
Plekha6	G	A	1: 133,272,307	R208Q	probably benign	Het
Prkar1b	A	G	5: 139,050,749	I82T	probably damaging	Het
Prrc1	C	T	18: 57,363,397	T140M	probably damaging	Het
Psg22	A	C	7: 18,719,664	S95R	probably damaging	Het
Ptk6	T	C	2: 181,195,939	T396A	probably benign	Het
Ptov1	A	G	7: 44,864,811	S9P	probably damaging	Het
Scin	A	C	12: 40,073,292		probably benign	Het
Sec13	T	C	6: 113,740,632		probably benign	Het
Setd1a	G	A	7: 127,785,057		probably benign	Het
Sf3a2	G	A	10: 80,804,554		probably benign	Het
Shmt1	T	C	11: 60,792,963	Y341C	possibly damaging	Het
Slc27a4	T	A	2: 29,804,185	L7Q	probably benign	Het
Slc41a2	T	C	10: 83,316,222	M130V	possibly damaging	Het
Sorcs3	T	C	19: 48,797,517		probably null	Het
Tex24	C	T	8: 27,344,908	R155*	probably null	Het
Tgfb1	T	A	7: 25,687,930		probably benign	Het
Tmc5	A	G	7: 118,639,931	D349G	possibly damaging	Het
Trappc13	C	T	13: 104,161,004	V131I	possibly damaging	Het
Trim66	A	G	7: 109,457,542		probably benign	Het
Tspoap1	T	C	11: 87,776,162	S1027P	probably damaging	Het
Usp34	C	T	11: 23,436,001	H2143Y	possibly damaging	Het
Vmn1r179	A	C	7: 23,928,393	Y3S	probably benign	Het
Vmn1r231	G	A	17: 20,890,003	Q217*	probably null	Het
Vmn1r62	T	A	7: 5,676,067	L249*	probably null	Het
Vmn1r71	G	C	7: 10,748,092	S223C	possibly damaging	Het
Vwf	G	A	6: 125,628,428	V925M	possibly damaging	Het
Wisp1	A	G	15: 66,917,378	I238V	probably benign	Het
Zbtb6	A	C	2: 37,429,493	L141W	probably damaging	Het
Zranb1	G	T	7: 132,982,771	L615F	probably damaging	Het

Other mutations in Vmn2r109

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01313:Vmn2r109	APN	17	20550157	missense	probably damaging	1.00
IGL01383:Vmn2r109	APN	17	20541121	missense	possibly damaging	0.89
IGL01469:Vmn2r109	APN	17	20541409	missense	probably damaging	1.00
IGL01762:Vmn2r109	APN	17	20554392	missense	probably benign
IGL01864:Vmn2r109	APN	17	20541134	missense	probably benign	0.28
IGL02028:Vmn2r109	APN	17	20541080	missense	probably benign	0.28
IGL02074:Vmn2r109	APN	17	20554341	missense	probably benign	0.05
IGL02162:Vmn2r109	APN	17	20554160	missense	probably benign	0.01
IGL02474:Vmn2r109	APN	17	20540888	missense	probably benign
IGL02490:Vmn2r109	APN	17	20540984	missense	possibly damaging	0.78
IGL02604:Vmn2r109	APN	17	20540701	missense	probably damaging	1.00
IGL02669:Vmn2r109	APN	17	20554256	missense	possibly damaging	0.64
IGL02705:Vmn2r109	APN	17	20553800	missense	probably benign
IGL02745:Vmn2r109	APN	17	20541250	missense	probably damaging	0.99
PIT4142001:Vmn2r109	UTSW	17	20554577	critical splice acceptor site	probably null
R0389:Vmn2r109	UTSW	17	20541074	missense	probably damaging	1.00
R0570:Vmn2r109	UTSW	17	20540675	missense	probably damaging	0.99
R0855:Vmn2r109	UTSW	17	20541408	nonsense	probably null
R0882:Vmn2r109	UTSW	17	20554580	splice site	probably benign
R1241:Vmn2r109	UTSW	17	20555241	missense	possibly damaging	0.86
R1587:Vmn2r109	UTSW	17	20540740	missense	probably damaging	1.00
R1931:Vmn2r109	UTSW	17	20553810	nonsense	probably null
R1957:Vmn2r109	UTSW	17	20564707	missense	probably benign	0.11
R1962:Vmn2r109	UTSW	17	20553923	missense	probably damaging	0.99
R2020:Vmn2r109	UTSW	17	20541186	nonsense	probably null
R2073:Vmn2r109	UTSW	17	20564712	missense	probably benign	0.00
R2436:Vmn2r109	UTSW	17	20554536	missense	probably damaging	0.99
R3123:Vmn2r109	UTSW	17	20540986	missense	probably damaging	1.00
R3839:Vmn2r109	UTSW	17	20554442	missense	probably damaging	1.00
R4019:Vmn2r109	UTSW	17	20553812	missense	probably benign
R4428:Vmn2r109	UTSW	17	20553024	missense	probably benign
R4584:Vmn2r109	UTSW	17	20554558	nonsense	probably null
R4652:Vmn2r109	UTSW	17	20541394	missense	probably damaging	1.00
R4708:Vmn2r109	UTSW	17	20541343	missense	probably damaging	0.97
R4823:Vmn2r109	UTSW	17	20553891	missense	probably damaging	1.00
R4831:Vmn2r109	UTSW	17	20541232	missense	probably benign	0.01
R4907:Vmn2r109	UTSW	17	20550086	missense	probably damaging	1.00
R5011:Vmn2r109	UTSW	17	20555189	missense	probably damaging	1.00
R5296:Vmn2r109	UTSW	17	20554341	missense	possibly damaging	0.90
R5600:Vmn2r109	UTSW	17	20540927	missense	probably damaging	1.00
R5602:Vmn2r109	UTSW	17	20540671	missense	possibly damaging	0.94
R5652:Vmn2r109	UTSW	17	20540519	makesense	probably null
R5702:Vmn2r109	UTSW	17	20554145	missense	probably benign	0.42
R5706:Vmn2r109	UTSW	17	20554305	missense	probably benign	0.16
R5714:Vmn2r109	UTSW	17	20552859	missense	probably damaging	1.00
R5832:Vmn2r109	UTSW	17	20541056	missense	probably benign	0.10
R6008:Vmn2r109	UTSW	17	20540719	missense	probably damaging	1.00
R6334:Vmn2r109	UTSW	17	20541178	missense	probably benign	0.18
R6377:Vmn2r109	UTSW	17	20564534	critical splice donor site	probably null
R6738:Vmn2r109	UTSW	17	20554523	missense	possibly damaging	0.52
R6857:Vmn2r109	UTSW	17	20540670	missense	probably benign	0.45
R6953:Vmn2r109	UTSW	17	20540711	missense	possibly damaging	0.95
R7108:Vmn2r109	UTSW	17	20564744	missense	probably benign	0.03
R7229:Vmn2r109	UTSW	17	20540963	missense	possibly damaging	0.80
R7238:Vmn2r109	UTSW	17	20541074	missense	probably damaging	1.00
R7244:Vmn2r109	UTSW	17	20540683	missense	possibly damaging	0.70
R7292:Vmn2r109	UTSW	17	20541438	missense	probably benign	0.05
R7354:Vmn2r109	UTSW	17	20540781	missense	probably damaging	1.00
R7357:Vmn2r109	UTSW	17	20541274	missense	probably damaging	1.00
R7522:Vmn2r109	UTSW	17	20554403	missense	probably benign	0.11
R7596:Vmn2r109	UTSW	17	20540680	missense	probably damaging	0.98
R7728:Vmn2r109	UTSW	17	20552855	missense	probably damaging	0.99
R7859:Vmn2r109	UTSW	17	20541174	missense	probably damaging	1.00
R7871:Vmn2r109	UTSW	17	20540520	missense	probably benign	0.08
R8113:Vmn2r109	UTSW	17	20554467	missense	probably benign	0.01
R8153:Vmn2r109	UTSW	17	20564707	missense	probably benign	0.11
R8977:Vmn2r109	UTSW	17	20554269	missense	possibly damaging	0.96
Z1176:Vmn2r109	UTSW	17	20552994	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TTGGCAAACCAGTAGATTCTCCACG -3'
(R):5'- TCAATTCTGCTTCTTGGACACAGTGTAA -3'

Sequencing Primer
(F):5'- ccttcatacttctgaagtcataacc -3'
(R):5'- TCCTGAAGGACATTGATGAGAG -3'

Posted On

2013-05-23