Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03089:Vmn2r107'

418270

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r107

Ensembl Gene

ENSMUSG00000056910

Gene Name

vomeronasal 2, receptor 107

Synonyms

V2r6

Accession Numbers

Genbank: NM_001104569; MGI: 1316664

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

IGL03089

Quality Score

Status

Chromosome

Chromosomal Location

20345425-20375772 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 20375712 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Glutamine at position 842 (H842Q)

Ref Sequence

ENSEMBL: ENSMUSP00000048706 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042090]

AlphaFold

E9PZJ7

Predicted Effect

probably benign
Transcript: ENSMUST00000042090
AA Change: H842Q

PolyPhen 2 Score 0.047 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000048706
Gene: ENSMUSG00000056910
AA Change: H842Q

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	466	3.6e-40	PFAM
Pfam:NCD3G	509	562	5.1e-21	PFAM
Pfam:7tm_3	593	830	8e-51	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamtsl4	A	G	3: 95,677,246	S947P	probably damaging	Het
Agl	T	A	3: 116,781,023	H709L	probably damaging	Het
Alpi	T	A	1: 87,100,108	D250V	probably benign	Het
Anapc4	A	G	5: 52,866,398	S735G	probably benign	Het
Ank1	A	T	8: 23,104,832	I611L	probably benign	Het
Canx	A	G	11: 50,304,482	V253A	possibly damaging	Het
Cbfa2t3	A	T	8: 122,635,134	I383N	probably damaging	Het
Cdc23	T	C	18: 34,634,460	Y519C	probably damaging	Het
Celsr3	T	A	9: 108,826,607	N96K	probably benign	Het
Clptm1	A	G	7: 19,637,147	Y355H	probably damaging	Het
Col6a5	C	T	9: 105,933,839	S827N	unknown	Het
Cyp21a1	G	T	17: 34,803,446		probably null	Het
Cyp24a1	T	G	2: 170,485,966	H452P	probably damaging	Het
Cyp2c39	T	A	19: 39,563,851	H329Q	probably benign	Het
D630003M21Rik	C	T	2: 158,216,744	R412Q	probably benign	Het
Dennd1b	G	A	1: 139,102,029	R308Q	possibly damaging	Het
Deup1	T	C	9: 15,607,800	S137G	possibly damaging	Het
Dmbt1	T	A	7: 131,111,049	I1583N	probably damaging	Het
Dvl1	G	A	4: 155,855,152	V320M	probably damaging	Het
Elmod3	A	G	6: 72,569,316	S254P	probably damaging	Het
Emsy	G	A	7: 98,637,266	Q226*	probably null	Het
Ephb6	C	A	6: 41,614,174	D88E	probably damaging	Het
Exoc1	A	G	5: 76,542,158	M182V	possibly damaging	Het
Fbxw4	T	G	19: 45,591,721		probably benign	Het
Fgr	A	G	4: 132,986,266	D35G	probably damaging	Het
Gm13078	A	G	4: 143,726,133	T45A	probably benign	Het
Gm20547	A	T	17: 34,861,032	D366E	probably damaging	Het
Gucy1a1	T	C	3: 82,097,681	N599S	probably damaging	Het
Ighg2b	G	A	12: 113,306,678	P240L	probably damaging	Het
Jak3	A	G	8: 71,686,083	D975G	probably benign	Het
Klhl26	A	T	8: 70,455,633	N24K	probably benign	Het
Letm1	T	A	5: 33,760,858	E314D	probably damaging	Het
Lin54	A	T	5: 100,450,993	F319L	probably damaging	Het
Lrp5	A	T	19: 3,620,314		probably null	Het
Lvrn	T	C	18: 46,880,709	F486S	probably damaging	Het
Nov	C	T	15: 54,749,284	R230C	possibly damaging	Het
Olfr1218	T	C	2: 89,055,013	R138G	probably benign	Het
Olfr378	T	C	11: 73,425,183	T267A	probably benign	Het
Olfr631	A	C	7: 103,929,122	I100L	probably benign	Het
Olfr93	A	G	17: 37,151,643	C110R	probably damaging	Het
Olfr969	A	T	9: 39,795,681	Y102F	probably benign	Het
Sap30bp	T	A	11: 115,957,388	M112K	possibly damaging	Het
Sbno1	A	G	5: 124,387,311		probably benign	Het
Slc30a5	T	C	13: 100,813,830	I307V	probably benign	Het
Trim37	T	A	11: 87,190,137	D21E	probably damaging	Het
Usp34	T	C	11: 23,446,958	F614S	possibly damaging	Het
Usp39	A	C	6: 72,328,639	F387C	probably damaging	Het
Vipas39	C	T	12: 87,253,254	C149Y	probably damaging	Het
Vps18	T	A	2: 119,293,177	V195E	probably benign	Het
Vsx1	A	G	2: 150,685,590		probably benign	Het

Other mutations in Vmn2r107

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01402:Vmn2r107	APN	17	20375747	missense	probably damaging	0.98
IGL01768:Vmn2r107	APN	17	20345606	missense	probably benign	0.32
IGL02086:Vmn2r107	APN	17	20357800	missense	probably benign	0.00
IGL02136:Vmn2r107	APN	17	20374906	missense	probably benign	0.02
IGL02266:Vmn2r107	APN	17	20356777	missense	probably damaging	1.00
IGL02285:Vmn2r107	APN	17	20375561	missense	probably damaging	1.00
IGL02724:Vmn2r107	APN	17	20356744	missense	possibly damaging	0.49
IGL02998:Vmn2r107	APN	17	20357755	missense	probably damaging	0.99
IGL03284:Vmn2r107	APN	17	20356911	missense	probably benign	0.07
IGL03307:Vmn2r107	APN	17	20356776	missense	probably benign	0.09
IGL03399:Vmn2r107	APN	17	20357958	splice site	probably benign
3-1:Vmn2r107	UTSW	17	20345504	missense	probably benign
BB006:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
BB016:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
R0285:Vmn2r107	UTSW	17	20345611	missense	probably benign	0.00
R0455:Vmn2r107	UTSW	17	20374823	splice site	probably benign
R0497:Vmn2r107	UTSW	17	20375132	missense	probably damaging	1.00
R0506:Vmn2r107	UTSW	17	20357759	missense	probably benign
R0621:Vmn2r107	UTSW	17	20374990	missense	probably benign	0.01
R0667:Vmn2r107	UTSW	17	20355654	missense	possibly damaging	0.91
R1118:Vmn2r107	UTSW	17	20356598	missense	probably benign	0.03
R1204:Vmn2r107	UTSW	17	20357769	missense	probably benign
R1237:Vmn2r107	UTSW	17	20356685	nonsense	probably null
R1485:Vmn2r107	UTSW	17	20374847	missense	possibly damaging	0.95
R1783:Vmn2r107	UTSW	17	20356513	missense	possibly damaging	0.51
R1873:Vmn2r107	UTSW	17	20345578	missense	probably benign	0.10
R1974:Vmn2r107	UTSW	17	20355617	splice site	probably null
R2009:Vmn2r107	UTSW	17	20375467	missense	probably benign	0.01
R2029:Vmn2r107	UTSW	17	20375287	missense	probably benign	0.01
R2164:Vmn2r107	UTSW	17	20375642	missense	probably damaging	1.00
R2269:Vmn2r107	UTSW	17	20375555	missense	possibly damaging	0.58
R3087:Vmn2r107	UTSW	17	20360345	missense	probably benign	0.03
R3740:Vmn2r107	UTSW	17	20374889	missense	probably benign	0.00
R3961:Vmn2r107	UTSW	17	20375455	missense	probably damaging	1.00
R4031:Vmn2r107	UTSW	17	20375221	missense	probably benign	0.00
R4270:Vmn2r107	UTSW	17	20355779	missense	probably benign
R4963:Vmn2r107	UTSW	17	20375141	missense	probably damaging	1.00
R5121:Vmn2r107	UTSW	17	20355753	missense	probably benign	0.01
R5640:Vmn2r107	UTSW	17	20375164	missense	probably damaging	1.00
R6007:Vmn2r107	UTSW	17	20375054	missense	probably benign	0.19
R6238:Vmn2r107	UTSW	17	20345587	missense	probably benign	0.43
R6298:Vmn2r107	UTSW	17	20355782	missense	probably benign	0.00
R6467:Vmn2r107	UTSW	17	20375677	missense	probably damaging	0.99
R6726:Vmn2r107	UTSW	17	20375375	missense	probably damaging	0.96
R6782:Vmn2r107	UTSW	17	20356879	missense	probably damaging	1.00
R7299:Vmn2r107	UTSW	17	20345616	missense	probably benign	0.01
R7301:Vmn2r107	UTSW	17	20345616	missense	probably benign	0.01
R7375:Vmn2r107	UTSW	17	20355876	missense	probably benign
R7448:Vmn2r107	UTSW	17	20375732	missense	probably benign	0.00
R7495:Vmn2r107	UTSW	17	20375009	missense	possibly damaging	0.71
R7589:Vmn2r107	UTSW	17	20375372	missense	probably benign	0.05
R7594:Vmn2r107	UTSW	17	20360373	missense	probably benign	0.03
R7678:Vmn2r107	UTSW	17	20356639	missense	probably benign	0.01
R7929:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
R7974:Vmn2r107	UTSW	17	20357008	missense	probably benign	0.00
R8040:Vmn2r107	UTSW	17	20375546	missense	probably damaging	1.00
R8263:Vmn2r107	UTSW	17	20360352	missense	probably damaging	1.00
R8426:Vmn2r107	UTSW	17	20356977	missense	possibly damaging	0.91
R9175:Vmn2r107	UTSW	17	20356789	missense	possibly damaging	0.79
R9537:Vmn2r107	UTSW	17	20374887	missense	probably benign	0.00
R9642:Vmn2r107	UTSW	17	20360399	missense	probably damaging	1.00
R9711:Vmn2r107	UTSW	17	20357000	missense	probably damaging	1.00
X0022:Vmn2r107	UTSW	17	20356968	missense	possibly damaging	0.85

Posted On

2016-08-02