Incidental Mutation 'IGL03089:Olfr93'
ID418273
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr93
Ensembl Gene ENSMUSG00000091601
Gene Nameolfactory receptor 93
SynonymsGA_x6K02T2PSCP-1592036-1591098, MOR256-39P
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.115) question?
Stock #IGL03089
Quality Score
Status
Chromosome17
Chromosomal Location37140423-37161494 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 37151643 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Arginine at position 110 (C110R)
Ref Sequence ENSEMBL: ENSMUSP00000151672 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171679] [ENSMUST00000208003] [ENSMUST00000219235]
Predicted Effect probably damaging
Transcript: ENSMUST00000171679
AA Change: C110R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000125907
Gene: ENSMUSG00000091601
AA Change: C110R

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 5.7e-50 PFAM
Pfam:7tm_1 39 288 3.3e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000208003
Predicted Effect probably damaging
Transcript: ENSMUST00000219235
AA Change: C110R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl4 A G 3: 95,677,246 S947P probably damaging Het
Agl T A 3: 116,781,023 H709L probably damaging Het
Alpi T A 1: 87,100,108 D250V probably benign Het
Anapc4 A G 5: 52,866,398 S735G probably benign Het
Ank1 A T 8: 23,104,832 I611L probably benign Het
Canx A G 11: 50,304,482 V253A possibly damaging Het
Cbfa2t3 A T 8: 122,635,134 I383N probably damaging Het
Cdc23 T C 18: 34,634,460 Y519C probably damaging Het
Celsr3 T A 9: 108,826,607 N96K probably benign Het
Clptm1 A G 7: 19,637,147 Y355H probably damaging Het
Col6a5 C T 9: 105,933,839 S827N unknown Het
Cyp21a1 G T 17: 34,803,446 probably null Het
Cyp24a1 T G 2: 170,485,966 H452P probably damaging Het
Cyp2c39 T A 19: 39,563,851 H329Q probably benign Het
D630003M21Rik C T 2: 158,216,744 R412Q probably benign Het
Dennd1b G A 1: 139,102,029 R308Q possibly damaging Het
Deup1 T C 9: 15,607,800 S137G possibly damaging Het
Dmbt1 T A 7: 131,111,049 I1583N probably damaging Het
Dvl1 G A 4: 155,855,152 V320M probably damaging Het
Elmod3 A G 6: 72,569,316 S254P probably damaging Het
Emsy G A 7: 98,637,266 Q226* probably null Het
Ephb6 C A 6: 41,614,174 D88E probably damaging Het
Exoc1 A G 5: 76,542,158 M182V possibly damaging Het
Fbxw4 T G 19: 45,591,721 probably benign Het
Fgr A G 4: 132,986,266 D35G probably damaging Het
Gm13078 A G 4: 143,726,133 T45A probably benign Het
Gm20547 A T 17: 34,861,032 D366E probably damaging Het
Gucy1a1 T C 3: 82,097,681 N599S probably damaging Het
Ighg2b G A 12: 113,306,678 P240L probably damaging Het
Jak3 A G 8: 71,686,083 D975G probably benign Het
Klhl26 A T 8: 70,455,633 N24K probably benign Het
Letm1 T A 5: 33,760,858 E314D probably damaging Het
Lin54 A T 5: 100,450,993 F319L probably damaging Het
Lrp5 A T 19: 3,620,314 probably null Het
Lvrn T C 18: 46,880,709 F486S probably damaging Het
Nov C T 15: 54,749,284 R230C possibly damaging Het
Olfr1218 T C 2: 89,055,013 R138G probably benign Het
Olfr378 T C 11: 73,425,183 T267A probably benign Het
Olfr631 A C 7: 103,929,122 I100L probably benign Het
Olfr969 A T 9: 39,795,681 Y102F probably benign Het
Sap30bp T A 11: 115,957,388 M112K possibly damaging Het
Sbno1 A G 5: 124,387,311 probably benign Het
Slc30a5 T C 13: 100,813,830 I307V probably benign Het
Trim37 T A 11: 87,190,137 D21E probably damaging Het
Usp34 T C 11: 23,446,958 F614S possibly damaging Het
Usp39 A C 6: 72,328,639 F387C probably damaging Het
Vipas39 C T 12: 87,253,254 C149Y probably damaging Het
Vmn2r107 C A 17: 20,375,712 H842Q probably benign Het
Vps18 T A 2: 119,293,177 V195E probably benign Het
Vsx1 A G 2: 150,685,590 probably benign Het
Other mutations in Olfr93
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01087:Olfr93 APN 17 37151441 missense probably damaging 1.00
IGL02369:Olfr93 APN 17 37151774 missense probably damaging 1.00
IGL02392:Olfr93 APN 17 37151088 missense probably benign 0.03
IGL02516:Olfr93 APN 17 37151272 missense possibly damaging 0.95
PIT4515001:Olfr93 UTSW 17 37151379 missense probably benign
R0396:Olfr93 UTSW 17 37151555 missense probably damaging 1.00
R2276:Olfr93 UTSW 17 37151254 nonsense probably null
R2278:Olfr93 UTSW 17 37151254 nonsense probably null
R3419:Olfr93 UTSW 17 37151351 missense probably damaging 0.99
R4254:Olfr93 UTSW 17 37151639 missense possibly damaging 0.90
R4353:Olfr93 UTSW 17 37151337 missense probably damaging 1.00
R4530:Olfr93 UTSW 17 37151607 missense possibly damaging 0.84
R4666:Olfr93 UTSW 17 37151379 missense possibly damaging 0.61
R5583:Olfr93 UTSW 17 37151594 missense probably benign 0.00
R5834:Olfr93 UTSW 17 37151799 missense probably damaging 1.00
R6348:Olfr93 UTSW 17 37151606 missense probably damaging 0.96
R6461:Olfr93 UTSW 17 37151471 missense probably damaging 1.00
R6788:Olfr93 UTSW 17 37151822 missense probably damaging 0.98
R7969:Olfr93 UTSW 17 37151186 missense possibly damaging 0.95
R8374:Olfr93 UTSW 17 37151745 missense probably damaging 0.97
Z1177:Olfr93 UTSW 17 37151825 missense probably damaging 0.99
Posted On2016-08-02