Incidental Mutation 'IGL03092:Or4d10c'
ID 418403
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or4d10c
Ensembl Gene ENSMUSG00000044994
Gene Name olfactory receptor family 4 subfamily D member 10C
Synonyms Olfr1426, MOR239-1, GA_x6K02T2RE5P-2447610-2446675
Accession Numbers
Essential gene? Probably non essential (E-score: 0.139) question?
Stock # IGL03092
Quality Score
Status
Chromosome 19
Chromosomal Location 12064974-12069211 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 12065230 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Stop codon at position 309 (E309*)
Ref Sequence ENSEMBL: ENSMUSP00000151988 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000112952] [ENSMUST00000208703] [ENSMUST00000217952] [ENSMUST00000219005] [ENSMUST00000219155] [ENSMUST00000219996] [ENSMUST00000220005]
AlphaFold Q8VG74
Predicted Effect probably null
Transcript: ENSMUST00000112952
AA Change: E309*
SMART Domains Protein: ENSMUSP00000108575
Gene: ENSMUSG00000044994
AA Change: E309*

DomainStartEndE-ValueType
Pfam:7tm_4 29 302 2.1e-49 PFAM
Pfam:7tm_1 39 300 1.1e-21 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000208703
AA Change: E309*
Predicted Effect probably null
Transcript: ENSMUST00000217952
AA Change: E309*
Predicted Effect probably null
Transcript: ENSMUST00000219005
AA Change: E309*
Predicted Effect probably null
Transcript: ENSMUST00000219155
AA Change: E309*
Predicted Effect probably null
Transcript: ENSMUST00000219996
AA Change: E309*
Predicted Effect probably null
Transcript: ENSMUST00000220005
AA Change: E309*
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700006A11Rik A G 3: 124,200,119 (GRCm39) L491P probably damaging Het
Abcc6 T A 7: 45,635,894 (GRCm39) D1051V probably damaging Het
Actmap T C 7: 26,900,561 (GRCm39) M180T probably damaging Het
Aqr T A 2: 113,989,424 (GRCm39) E133V probably benign Het
Bag6 A G 17: 35,364,603 (GRCm39) N911D probably damaging Het
Cdcp3 G T 7: 130,803,527 (GRCm39) probably null Het
Ces4a C T 8: 105,874,836 (GRCm39) probably benign Het
Clec3b A T 9: 122,980,100 (GRCm39) probably benign Het
Cnot1 T C 8: 96,496,243 (GRCm39) probably benign Het
Ctsg T A 14: 56,337,417 (GRCm39) *262L probably null Het
Cyp17a1 T A 19: 46,661,050 (GRCm39) H78L possibly damaging Het
Dcaf13 C A 15: 38,991,371 (GRCm39) probably benign Het
Dcun1d1 G T 3: 35,975,141 (GRCm39) Q52K possibly damaging Het
Ddb1 C T 19: 10,590,309 (GRCm39) R279W probably damaging Het
Dock1 A G 7: 134,366,945 (GRCm39) probably benign Het
Dsel A G 1: 111,787,793 (GRCm39) L914P probably damaging Het
Fbxo31 A G 8: 122,286,757 (GRCm39) F174L probably benign Het
Gm9116 A G 3: 93,817,513 (GRCm39) noncoding transcript Het
Gspt1 C T 16: 11,056,763 (GRCm39) V211I probably benign Het
Hmgb1 A T 5: 148,987,508 (GRCm39) S14T probably benign Het
Igsf8 A G 1: 172,140,096 (GRCm39) probably benign Het
Klf13 A G 7: 63,541,417 (GRCm39) F237L probably damaging Het
Mon2 A T 10: 122,854,005 (GRCm39) I962N probably damaging Het
Nfx1 A G 4: 41,024,851 (GRCm39) D1108G probably damaging Het
Nr2e1 T C 10: 42,447,478 (GRCm39) Y178C probably damaging Het
Or52d1 A T 7: 103,755,854 (GRCm39) I123F probably damaging Het
Pde3b A T 7: 114,122,583 (GRCm39) H717L probably damaging Het
Polr1b T C 2: 128,965,049 (GRCm39) Y712H probably damaging Het
Pramel16 C A 4: 143,676,767 (GRCm39) K112N probably damaging Het
Rnf157 T A 11: 116,238,795 (GRCm39) probably null Het
Ros1 T C 10: 51,974,902 (GRCm39) E1561G probably damaging Het
Serpina6 A G 12: 103,620,154 (GRCm39) probably null Het
St18 A G 1: 6,839,118 (GRCm39) probably benign Het
Ugp2 A G 11: 21,279,722 (GRCm39) probably benign Het
Vmn1r70 T C 7: 10,368,186 (GRCm39) S225P probably benign Het
Zfp641 T C 15: 98,188,397 (GRCm39) D161G probably damaging Het
Other mutations in Or4d10c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00092:Or4d10c APN 19 12,065,357 (GRCm39) missense probably benign 0.28
IGL01549:Or4d10c APN 19 12,065,329 (GRCm39) missense probably benign 0.20
IGL02479:Or4d10c APN 19 12,065,269 (GRCm39) missense probably benign 0.01
IGL03065:Or4d10c APN 19 12,065,975 (GRCm39) missense possibly damaging 0.91
IGL03046:Or4d10c UTSW 19 12,065,391 (GRCm39) missense probably damaging 0.98
R0734:Or4d10c UTSW 19 12,065,483 (GRCm39) missense probably benign 0.12
R1190:Or4d10c UTSW 19 12,066,051 (GRCm39) missense possibly damaging 0.82
R1990:Or4d10c UTSW 19 12,065,620 (GRCm39) missense probably damaging 0.98
R2331:Or4d10c UTSW 19 12,065,522 (GRCm39) missense probably benign 0.00
R3500:Or4d10c UTSW 19 12,065,421 (GRCm39) missense possibly damaging 0.58
R3768:Or4d10c UTSW 19 12,065,304 (GRCm39) missense probably damaging 1.00
R3825:Or4d10c UTSW 19 12,065,391 (GRCm39) missense probably damaging 0.98
R4589:Or4d10c UTSW 19 12,065,305 (GRCm39) missense possibly damaging 0.61
R5175:Or4d10c UTSW 19 12,065,926 (GRCm39) missense probably damaging 1.00
R6436:Or4d10c UTSW 19 12,065,299 (GRCm39) missense probably benign 0.24
R6729:Or4d10c UTSW 19 12,065,860 (GRCm39) missense probably benign 0.04
R6965:Or4d10c UTSW 19 12,066,120 (GRCm39) missense possibly damaging 0.95
R7099:Or4d10c UTSW 19 12,065,530 (GRCm39) missense possibly damaging 0.78
R7393:Or4d10c UTSW 19 12,065,992 (GRCm39) missense probably benign 0.13
R7582:Or4d10c UTSW 19 12,065,370 (GRCm39) missense probably benign 0.01
R8000:Or4d10c UTSW 19 12,065,358 (GRCm39) missense probably damaging 0.98
R8803:Or4d10c UTSW 19 12,065,469 (GRCm39) missense probably benign 0.07
R8833:Or4d10c UTSW 19 12,065,643 (GRCm39) missense possibly damaging 0.92
R8846:Or4d10c UTSW 19 12,065,433 (GRCm39) missense probably damaging 0.96
R8951:Or4d10c UTSW 19 12,066,056 (GRCm39) nonsense probably null
R9469:Or4d10c UTSW 19 12,065,434 (GRCm39) missense probably benign 0.20
RF011:Or4d10c UTSW 19 12,065,611 (GRCm39) missense probably benign 0.09
Z1177:Or4d10c UTSW 19 12,065,308 (GRCm39) missense probably benign 0.01
Posted On 2016-08-02