Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03092:Vmn1r70'

418406

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r70

Ensembl Gene

ENSMUSG00000045340

Gene Name

vomeronasal 1 receptor 70

Synonyms

V1rl1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.075) question?

Stock #

IGL03092

Quality Score

Status

Chromosome

Chromosomal Location

10631532-10636530 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 10634259 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 225 (S225P)

Ref Sequence

ENSEMBL: ENSMUSP00000154041 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055847] [ENSMUST00000226255] [ENSMUST00000228090]

AlphaFold

Q8R254

Predicted Effect

probably benign
Transcript: ENSMUST00000055847
AA Change: S225P

PolyPhen 2 Score 0.229 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000054445
Gene: ENSMUSG00000045340
AA Change: S225P

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	292	2.6e-9	PFAM
Pfam:V1R	33	295	3.1e-31	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000226182

Predicted Effect

probably benign
Transcript: ENSMUST00000226255
AA Change: S225P

PolyPhen 2 Score 0.229 (Sensitivity: 0.91; Specificity: 0.88)

Predicted Effect

probably benign
Transcript: ENSMUST00000228090
AA Change: S206P

PolyPhen 2 Score 0.104 (Sensitivity: 0.93; Specificity: 0.86)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700006A11Rik	A	G	3: 124,406,470	L491P	probably damaging	Het
5430419D17Rik	G	T	7: 131,201,798		probably null	Het
Abcc6	T	A	7: 45,986,470	D1051V	probably damaging	Het
Aqr	T	A	2: 114,158,943	E133V	probably benign	Het
Bag6	A	G	17: 35,145,627	N911D	probably damaging	Het
BC024978	T	C	7: 27,201,136	M180T	probably damaging	Het
Ces4a	C	T	8: 105,148,204		probably benign	Het
Clec3b	A	T	9: 123,151,035		probably benign	Het
Cnot1	T	C	8: 95,769,615		probably benign	Het
Ctsg	T	A	14: 56,099,960	*262L	probably null	Het
Cyp17a1	T	A	19: 46,672,611	H78L	possibly damaging	Het
Dcaf13	C	A	15: 39,127,976		probably benign	Het
Dcun1d1	G	T	3: 35,920,992	Q52K	possibly damaging	Het
Ddb1	C	T	19: 10,612,945	R279W	probably damaging	Het
Dock1	A	G	7: 134,765,216		probably benign	Het
Dsel	A	G	1: 111,860,063	L914P	probably damaging	Het
Fbxo31	A	G	8: 121,560,018	F174L	probably benign	Het
Gm9116	A	G	3: 93,910,206		noncoding transcript	Het
Gspt1	C	T	16: 11,238,899	V211I	probably benign	Het
Hmgb1	A	T	5: 149,050,698	S14T	probably benign	Het
Igsf8	A	G	1: 172,312,529		probably benign	Het
Klf13	A	G	7: 63,891,669	F237L	probably damaging	Het
Mon2	A	T	10: 123,018,100	I962N	probably damaging	Het
Nfx1	A	G	4: 41,024,851	D1108G	probably damaging	Het
Nr2e1	T	C	10: 42,571,482	Y178C	probably damaging	Het
Olfr1426	C	A	19: 12,087,866	E309*	probably null	Het
Olfr646	A	T	7: 104,106,647	I123F	probably damaging	Het
Pde3b	A	T	7: 114,523,348	H717L	probably damaging	Het
Polr1b	T	C	2: 129,123,129	Y712H	probably damaging	Het
Pramef25	C	A	4: 143,950,197	K112N	probably damaging	Het
Rnf157	T	A	11: 116,347,969		probably null	Het
Ros1	T	C	10: 52,098,806	E1561G	probably damaging	Het
Serpina6	A	G	12: 103,653,895		probably null	Het
St18	A	G	1: 6,768,894		probably benign	Het
Ugp2	A	G	11: 21,329,722		probably benign	Het
Zfp641	T	C	15: 98,290,516	D161G	probably damaging	Het

Other mutations in Vmn1r70

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03250:Vmn1r70	APN	7	10634281	missense	probably damaging	1.00
R0375:Vmn1r70	UTSW	7	10634060	missense	probably damaging	1.00
R0482:Vmn1r70	UTSW	7	10634277	missense	probably damaging	1.00
R0497:Vmn1r70	UTSW	7	10634026	missense	probably benign	0.19
R1964:Vmn1r70	UTSW	7	10633810	missense	possibly damaging	0.88
R2067:Vmn1r70	UTSW	7	10634337	missense	possibly damaging	0.61
R3807:Vmn1r70	UTSW	7	10633788	missense	probably benign	0.01
R4573:Vmn1r70	UTSW	7	10633629	splice site	probably null
R5070:Vmn1r70	UTSW	7	10634398	missense	probably benign	0.04
R5442:Vmn1r70	UTSW	7	10633950	missense	possibly damaging	0.69
R5558:Vmn1r70	UTSW	7	10634475	missense	probably benign	0.01
R6036:Vmn1r70	UTSW	7	10633903	missense	probably damaging	1.00
R6036:Vmn1r70	UTSW	7	10633903	missense	probably damaging	1.00
R6189:Vmn1r70	UTSW	7	10633671	missense	probably benign	0.04
R6976:Vmn1r70	UTSW	7	10634044	missense	probably benign	0.02
R7571:Vmn1r70	UTSW	7	10633944	missense	probably benign	0.00
R9236:Vmn1r70	UTSW	7	10634089	missense	probably damaging	1.00
R9568:Vmn1r70	UTSW	7	10634365	missense	probably benign	0.03
R9673:Vmn1r70	UTSW	7	10634437	missense	probably damaging	1.00
X0020:Vmn1r70	UTSW	7	10633590	missense	probably benign

Posted On

2016-08-02