Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03092:Zfp641'

418409

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp641

Ensembl Gene

ENSMUSG00000022987

Gene Name

zinc finger protein 641

Synonyms

9930016F01Rik

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03092

Quality Score

Status

Chromosome

Chromosomal Location

98285585-98296161 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 98290516 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 161 (D161G)

Ref Sequence

ENSEMBL: ENSMUSP00000133212 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023722] [ENSMUST00000169721]

AlphaFold

Q8BZ34

Predicted Effect

possibly damaging
Transcript: ENSMUST00000023722
AA Change: D147G

PolyPhen 2 Score 0.904 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000023722
Gene: ENSMUSG00000022987
AA Change: D147G

Domain	Start	End	E-Value	Type
KRAB	91	142	2.16e-10	SMART
ZnF_C2H2	236	258	1.58e-3	SMART
ZnF_C2H2	264	286	1.67e-2	SMART
ZnF_C2H2	292	314	1.33e-1	SMART
ZnF_C2H2	342	364	8.94e-3	SMART
ZnF_C2H2	370	392	3.83e-2	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000169721
AA Change: D161G

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000133212
Gene: ENSMUSG00000022987
AA Change: D161G

Domain	Start	End	E-Value	Type
low complexity region	83	89	N/A	INTRINSIC
KRAB	95	156	2.56e-21	SMART
ZnF_C2H2	250	272	1.58e-3	SMART
ZnF_C2H2	278	300	1.67e-2	SMART
ZnF_C2H2	306	328	1.33e-1	SMART
ZnF_C2H2	356	378	8.94e-3	SMART
ZnF_C2H2	384	406	3.83e-2	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700006A11Rik	A	G	3: 124,406,470	L491P	probably damaging	Het
5430419D17Rik	G	T	7: 131,201,798		probably null	Het
Abcc6	T	A	7: 45,986,470	D1051V	probably damaging	Het
Aqr	T	A	2: 114,158,943	E133V	probably benign	Het
Bag6	A	G	17: 35,145,627	N911D	probably damaging	Het
BC024978	T	C	7: 27,201,136	M180T	probably damaging	Het
Ces4a	C	T	8: 105,148,204		probably benign	Het
Clec3b	A	T	9: 123,151,035		probably benign	Het
Cnot1	T	C	8: 95,769,615		probably benign	Het
Ctsg	T	A	14: 56,099,960	*262L	probably null	Het
Cyp17a1	T	A	19: 46,672,611	H78L	possibly damaging	Het
Dcaf13	C	A	15: 39,127,976		probably benign	Het
Dcun1d1	G	T	3: 35,920,992	Q52K	possibly damaging	Het
Ddb1	C	T	19: 10,612,945	R279W	probably damaging	Het
Dock1	A	G	7: 134,765,216		probably benign	Het
Dsel	A	G	1: 111,860,063	L914P	probably damaging	Het
Fbxo31	A	G	8: 121,560,018	F174L	probably benign	Het
Gm9116	A	G	3: 93,910,206		noncoding transcript	Het
Gspt1	C	T	16: 11,238,899	V211I	probably benign	Het
Hmgb1	A	T	5: 149,050,698	S14T	probably benign	Het
Igsf8	A	G	1: 172,312,529		probably benign	Het
Klf13	A	G	7: 63,891,669	F237L	probably damaging	Het
Mon2	A	T	10: 123,018,100	I962N	probably damaging	Het
Nfx1	A	G	4: 41,024,851	D1108G	probably damaging	Het
Nr2e1	T	C	10: 42,571,482	Y178C	probably damaging	Het
Olfr1426	C	A	19: 12,087,866	E309*	probably null	Het
Olfr646	A	T	7: 104,106,647	I123F	probably damaging	Het
Pde3b	A	T	7: 114,523,348	H717L	probably damaging	Het
Polr1b	T	C	2: 129,123,129	Y712H	probably damaging	Het
Pramef25	C	A	4: 143,950,197	K112N	probably damaging	Het
Rnf157	T	A	11: 116,347,969		probably null	Het
Ros1	T	C	10: 52,098,806	E1561G	probably damaging	Het
Serpina6	A	G	12: 103,653,895		probably null	Het
St18	A	G	1: 6,768,894		probably benign	Het
Ugp2	A	G	11: 21,329,722		probably benign	Het
Vmn1r70	T	C	7: 10,634,259	S225P	probably benign	Het

Other mutations in Zfp641

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01639:Zfp641	APN	15	98291185	missense	possibly damaging	0.85
IGL03191:Zfp641	APN	15	98288687	missense	probably damaging	0.98
R0079:Zfp641	UTSW	15	98289089	missense	probably benign	0.28
R0243:Zfp641	UTSW	15	98289127	missense	possibly damaging	0.82
R0487:Zfp641	UTSW	15	98289179	missense	probably benign
R2092:Zfp641	UTSW	15	98293712	missense	probably benign
R3415:Zfp641	UTSW	15	98290540	missense	probably benign	0.28
R4834:Zfp641	UTSW	15	98293704	missense	probably damaging	1.00
R4851:Zfp641	UTSW	15	98288717	missense	probably damaging	0.99
R5776:Zfp641	UTSW	15	98289010	missense	probably damaging	1.00
R6057:Zfp641	UTSW	15	98292935	missense	probably benign	0.00
R6896:Zfp641	UTSW	15	98293803	start codon destroyed	probably benign	0.06
R6958:Zfp641	UTSW	15	98292951	missense	possibly damaging	0.46
R6969:Zfp641	UTSW	15	98290567	missense	possibly damaging	0.46
R8117:Zfp641	UTSW	15	98288975	missense	probably damaging	1.00
R8314:Zfp641	UTSW	15	98290583	missense	probably damaging	0.97
R9130:Zfp641	UTSW	15	98288851	missense	probably benign	0.12
Z1177:Zfp641	UTSW	15	98288535	missense	probably damaging	1.00

Posted On

2016-08-02