Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03092:Zfp641'

418409

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp641

Ensembl Gene

ENSMUSG00000022987

Gene Name

zinc finger protein 641

Synonyms

9930016F01Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03092

Quality Score

Status

Chromosome

Chromosomal Location

98183466-98194042 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 98188397 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 161 (D161G)

Ref Sequence

ENSEMBL: ENSMUSP00000133212 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023722] [ENSMUST00000169721]

AlphaFold

Q8BZ34

Predicted Effect

possibly damaging
Transcript: ENSMUST00000023722
AA Change: D147G

PolyPhen 2 Score 0.904 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000023722
Gene: ENSMUSG00000022987
AA Change: D147G

Domain	Start	End	E-Value	Type
KRAB	91	142	2.16e-10	SMART
ZnF_C2H2	236	258	1.58e-3	SMART
ZnF_C2H2	264	286	1.67e-2	SMART
ZnF_C2H2	292	314	1.33e-1	SMART
ZnF_C2H2	342	364	8.94e-3	SMART
ZnF_C2H2	370	392	3.83e-2	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000169721
AA Change: D161G

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000133212
Gene: ENSMUSG00000022987
AA Change: D161G

Domain	Start	End	E-Value	Type
low complexity region	83	89	N/A	INTRINSIC
KRAB	95	156	2.56e-21	SMART
ZnF_C2H2	250	272	1.58e-3	SMART
ZnF_C2H2	278	300	1.67e-2	SMART
ZnF_C2H2	306	328	1.33e-1	SMART
ZnF_C2H2	356	378	8.94e-3	SMART
ZnF_C2H2	384	406	3.83e-2	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700006A11Rik	A	G	3: 124,200,119 (GRCm39)	L491P	probably damaging	Het
Abcc6	T	A	7: 45,635,894 (GRCm39)	D1051V	probably damaging	Het
Actmap	T	C	7: 26,900,561 (GRCm39)	M180T	probably damaging	Het
Aqr	T	A	2: 113,989,424 (GRCm39)	E133V	probably benign	Het
Bag6	A	G	17: 35,364,603 (GRCm39)	N911D	probably damaging	Het
Cdcp3	G	T	7: 130,803,527 (GRCm39)		probably null	Het
Ces4a	C	T	8: 105,874,836 (GRCm39)		probably benign	Het
Clec3b	A	T	9: 122,980,100 (GRCm39)		probably benign	Het
Cnot1	T	C	8: 96,496,243 (GRCm39)		probably benign	Het
Ctsg	T	A	14: 56,337,417 (GRCm39)	*262L	probably null	Het
Cyp17a1	T	A	19: 46,661,050 (GRCm39)	H78L	possibly damaging	Het
Dcaf13	C	A	15: 38,991,371 (GRCm39)		probably benign	Het
Dcun1d1	G	T	3: 35,975,141 (GRCm39)	Q52K	possibly damaging	Het
Ddb1	C	T	19: 10,590,309 (GRCm39)	R279W	probably damaging	Het
Dock1	A	G	7: 134,366,945 (GRCm39)		probably benign	Het
Dsel	A	G	1: 111,787,793 (GRCm39)	L914P	probably damaging	Het
Fbxo31	A	G	8: 122,286,757 (GRCm39)	F174L	probably benign	Het
Gm9116	A	G	3: 93,817,513 (GRCm39)		noncoding transcript	Het
Gspt1	C	T	16: 11,056,763 (GRCm39)	V211I	probably benign	Het
Hmgb1	A	T	5: 148,987,508 (GRCm39)	S14T	probably benign	Het
Igsf8	A	G	1: 172,140,096 (GRCm39)		probably benign	Het
Klf13	A	G	7: 63,541,417 (GRCm39)	F237L	probably damaging	Het
Mon2	A	T	10: 122,854,005 (GRCm39)	I962N	probably damaging	Het
Nfx1	A	G	4: 41,024,851 (GRCm39)	D1108G	probably damaging	Het
Nr2e1	T	C	10: 42,447,478 (GRCm39)	Y178C	probably damaging	Het
Or4d10c	C	A	19: 12,065,230 (GRCm39)	E309*	probably null	Het
Or52d1	A	T	7: 103,755,854 (GRCm39)	I123F	probably damaging	Het
Pde3b	A	T	7: 114,122,583 (GRCm39)	H717L	probably damaging	Het
Polr1b	T	C	2: 128,965,049 (GRCm39)	Y712H	probably damaging	Het
Pramel16	C	A	4: 143,676,767 (GRCm39)	K112N	probably damaging	Het
Rnf157	T	A	11: 116,238,795 (GRCm39)		probably null	Het
Ros1	T	C	10: 51,974,902 (GRCm39)	E1561G	probably damaging	Het
Serpina6	A	G	12: 103,620,154 (GRCm39)		probably null	Het
St18	A	G	1: 6,839,118 (GRCm39)		probably benign	Het
Ugp2	A	G	11: 21,279,722 (GRCm39)		probably benign	Het
Vmn1r70	T	C	7: 10,368,186 (GRCm39)	S225P	probably benign	Het

Other mutations in Zfp641

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01639:Zfp641	APN	15	98,189,066 (GRCm39)	missense	possibly damaging	0.85
IGL03191:Zfp641	APN	15	98,186,568 (GRCm39)	missense	probably damaging	0.98
R0079:Zfp641	UTSW	15	98,186,970 (GRCm39)	missense	probably benign	0.28
R0243:Zfp641	UTSW	15	98,187,008 (GRCm39)	missense	possibly damaging	0.82
R0487:Zfp641	UTSW	15	98,187,060 (GRCm39)	missense	probably benign
R2092:Zfp641	UTSW	15	98,191,593 (GRCm39)	missense	probably benign
R3415:Zfp641	UTSW	15	98,188,421 (GRCm39)	missense	probably benign	0.28
R4834:Zfp641	UTSW	15	98,191,585 (GRCm39)	missense	probably damaging	1.00
R4851:Zfp641	UTSW	15	98,186,598 (GRCm39)	missense	probably damaging	0.99
R5776:Zfp641	UTSW	15	98,186,891 (GRCm39)	missense	probably damaging	1.00
R6057:Zfp641	UTSW	15	98,190,816 (GRCm39)	missense	probably benign	0.00
R6896:Zfp641	UTSW	15	98,191,684 (GRCm39)	start codon destroyed	probably benign	0.06
R6958:Zfp641	UTSW	15	98,190,832 (GRCm39)	missense	possibly damaging	0.46
R6969:Zfp641	UTSW	15	98,188,448 (GRCm39)	missense	possibly damaging	0.46
R8117:Zfp641	UTSW	15	98,186,856 (GRCm39)	missense	probably damaging	1.00
R8314:Zfp641	UTSW	15	98,188,464 (GRCm39)	missense	probably damaging	0.97
R9130:Zfp641	UTSW	15	98,186,732 (GRCm39)	missense	probably benign	0.12
Z1177:Zfp641	UTSW	15	98,186,416 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02