Incidental Mutation 'IGL03092:Dcaf13'
| ID |
418428 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Dcaf13
|
| Ensembl Gene |
ENSMUSG00000022300 |
| Gene Name |
DDB1 and CUL4 associated factor 13 |
| Synonyms |
LOC223499, Wdsof1 |
| Accession Numbers |
Genbank: NM_198606; MGI: 2684929 |
| Essential gene? |
Probably essential
(E-score: 0.961)
|
| Stock # |
IGL03092
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
15 |
| Chromosomal Location |
39112865-39146856 bp(+) (GRCm38) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
C to A
at 39127976 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000022909
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000022909]
|
| AlphaFold |
Q6PAC3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000022909
|
| SMART Domains |
Protein: ENSMUSP00000022909
Gene: ENSMUSG00000022300
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
55 |
95 |
5.77e-5 |
SMART |
|
WD40
|
98 |
137 |
4.38e-5 |
SMART |
|
WD40
|
185 |
225 |
5.97e-1 |
SMART |
|
Blast:WD40
|
228 |
267 |
1e-18 |
BLAST |
|
WD40
|
271 |
310 |
2.69e-5 |
SMART |
|
WD40
|
312 |
353 |
2.96e-2 |
SMART |
|
Pfam:Sof1
|
354 |
440 |
7.2e-38 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226224
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000228436
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
All alleles(9) : Targeted, other(2) Gene trapped(7) |
| Other mutations in this stock |
Total: 36 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700006A11Rik |
A |
G |
3: 124,406,470 (GRCm38) |
L491P |
probably damaging |
Het |
| 5430419D17Rik |
G |
T |
7: 131,201,798 (GRCm38) |
|
probably null |
Het |
| Abcc6 |
T |
A |
7: 45,986,470 (GRCm38) |
D1051V |
probably damaging |
Het |
| Aqr |
T |
A |
2: 114,158,943 (GRCm38) |
E133V |
probably benign |
Het |
| Bag6 |
A |
G |
17: 35,145,627 (GRCm38) |
N911D |
probably damaging |
Het |
| BC024978 |
T |
C |
7: 27,201,136 (GRCm38) |
M180T |
probably damaging |
Het |
| Ces4a |
C |
T |
8: 105,148,204 (GRCm38) |
|
probably benign |
Het |
| Clec3b |
A |
T |
9: 123,151,035 (GRCm38) |
|
probably benign |
Het |
| Cnot1 |
T |
C |
8: 95,769,615 (GRCm38) |
|
probably benign |
Het |
| Ctsg |
T |
A |
14: 56,099,960 (GRCm38) |
*262L |
probably null |
Het |
| Cyp17a1 |
T |
A |
19: 46,672,611 (GRCm38) |
H78L |
possibly damaging |
Het |
| Dcun1d1 |
G |
T |
3: 35,920,992 (GRCm38) |
Q52K |
possibly damaging |
Het |
| Ddb1 |
C |
T |
19: 10,612,945 (GRCm38) |
R279W |
probably damaging |
Het |
| Dock1 |
A |
G |
7: 134,765,216 (GRCm38) |
|
probably benign |
Het |
| Dsel |
A |
G |
1: 111,860,063 (GRCm38) |
L914P |
probably damaging |
Het |
| Fbxo31 |
A |
G |
8: 121,560,018 (GRCm38) |
F174L |
probably benign |
Het |
| Gm9116 |
A |
G |
3: 93,910,206 (GRCm38) |
|
noncoding transcript |
Het |
| Gspt1 |
C |
T |
16: 11,238,899 (GRCm38) |
V211I |
probably benign |
Het |
| Hmgb1 |
A |
T |
5: 149,050,698 (GRCm38) |
S14T |
probably benign |
Het |
| Igsf8 |
A |
G |
1: 172,312,529 (GRCm38) |
|
probably benign |
Het |
| Klf13 |
A |
G |
7: 63,891,669 (GRCm38) |
F237L |
probably damaging |
Het |
| Mon2 |
A |
T |
10: 123,018,100 (GRCm38) |
I962N |
probably damaging |
Het |
| Nfx1 |
A |
G |
4: 41,024,851 (GRCm38) |
D1108G |
probably damaging |
Het |
| Nr2e1 |
T |
C |
10: 42,571,482 (GRCm38) |
Y178C |
probably damaging |
Het |
| Olfr1426 |
C |
A |
19: 12,087,866 (GRCm38) |
E309* |
probably null |
Het |
| Olfr646 |
A |
T |
7: 104,106,647 (GRCm38) |
I123F |
probably damaging |
Het |
| Pde3b |
A |
T |
7: 114,523,348 (GRCm38) |
H717L |
probably damaging |
Het |
| Polr1b |
T |
C |
2: 129,123,129 (GRCm38) |
Y712H |
probably damaging |
Het |
| Pramef25 |
C |
A |
4: 143,950,197 (GRCm38) |
K112N |
probably damaging |
Het |
| Rnf157 |
T |
A |
11: 116,347,969 (GRCm38) |
|
probably null |
Het |
| Ros1 |
T |
C |
10: 52,098,806 (GRCm38) |
E1561G |
probably damaging |
Het |
| Serpina6 |
A |
G |
12: 103,653,895 (GRCm38) |
|
probably null |
Het |
| St18 |
A |
G |
1: 6,768,894 (GRCm38) |
|
probably benign |
Het |
| Ugp2 |
A |
G |
11: 21,329,722 (GRCm38) |
|
probably benign |
Het |
| Vmn1r70 |
T |
C |
7: 10,634,259 (GRCm38) |
S225P |
probably benign |
Het |
| Zfp641 |
T |
C |
15: 98,290,516 (GRCm38) |
D161G |
probably damaging |
Het |
|
| Other mutations in Dcaf13 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00787:Dcaf13
|
APN |
15 |
39,143,632 (GRCm38) |
nonsense |
probably null |
|
|
IGL01081:Dcaf13
|
APN |
15 |
39,118,806 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01766:Dcaf13
|
APN |
15 |
39,118,750 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02174:Dcaf13
|
APN |
15 |
39,138,149 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02262:Dcaf13
|
APN |
15 |
39,118,707 (GRCm38) |
splice site |
probably benign |
|
|
IGL02740:Dcaf13
|
APN |
15 |
39,145,100 (GRCm38) |
nonsense |
probably null |
|
|
IGL03374:Dcaf13
|
APN |
15 |
39,145,148 (GRCm38) |
nonsense |
probably null |
|
|
R0590:Dcaf13
|
UTSW |
15 |
39,145,085 (GRCm38) |
splice site |
probably benign |
|
|
R0594:Dcaf13
|
UTSW |
15 |
39,123,268 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0711:Dcaf13
|
UTSW |
15 |
39,138,089 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1036:Dcaf13
|
UTSW |
15 |
39,143,718 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1770:Dcaf13
|
UTSW |
15 |
39,130,238 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1826:Dcaf13
|
UTSW |
15 |
39,118,899 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1933:Dcaf13
|
UTSW |
15 |
39,138,088 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2508:Dcaf13
|
UTSW |
15 |
39,145,152 (GRCm38) |
missense |
probably benign |
|
|
R4113:Dcaf13
|
UTSW |
15 |
39,130,220 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4595:Dcaf13
|
UTSW |
15 |
39,118,893 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4649:Dcaf13
|
UTSW |
15 |
39,138,242 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R5431:Dcaf13
|
UTSW |
15 |
39,123,224 (GRCm38) |
missense |
probably benign |
0.16 |
|
R5454:Dcaf13
|
UTSW |
15 |
39,124,364 (GRCm38) |
missense |
probably benign |
|
|
R5834:Dcaf13
|
UTSW |
15 |
39,143,642 (GRCm38) |
nonsense |
probably null |
|
|
R5929:Dcaf13
|
UTSW |
15 |
39,143,653 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R5944:Dcaf13
|
UTSW |
15 |
39,146,677 (GRCm38) |
missense |
probably benign |
|
|
R6319:Dcaf13
|
UTSW |
15 |
39,143,672 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6394:Dcaf13
|
UTSW |
15 |
39,143,737 (GRCm38) |
missense |
probably benign |
0.04 |
|
R6664:Dcaf13
|
UTSW |
15 |
39,118,888 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6884:Dcaf13
|
UTSW |
15 |
39,123,240 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7419:Dcaf13
|
UTSW |
15 |
39,130,220 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R8750:Dcaf13
|
UTSW |
15 |
39,119,441 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8944:Dcaf13
|
UTSW |
15 |
39,138,217 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R9294:Dcaf13
|
UTSW |
15 |
39,130,292 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R9300:Dcaf13
|
UTSW |
15 |
39,146,707 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9663:Dcaf13
|
UTSW |
15 |
39,118,783 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R9696:Dcaf13
|
UTSW |
15 |
39,138,101 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R9778:Dcaf13
|
UTSW |
15 |
39,145,191 (GRCm38) |
missense |
probably damaging |
0.99 |
|
Z1088:Dcaf13
|
UTSW |
15 |
39,145,247 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2016-08-02 |
Incidental Mutation