Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03093:Vmn2r53'

418438

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r53

Ensembl Gene

ENSMUSG00000096002

Gene Name

vomeronasal 2, receptor 53

Synonyms

EG637908

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.099) question?

Stock #

IGL03093

Quality Score

Status

Chromosome

Chromosomal Location

12315397-12342583 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 12334791 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 290 (T290S)

Ref Sequence

ENSEMBL: ENSMUSP00000126979 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170412]

AlphaFold

A0A3B2W4A7

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000118665

Predicted Effect

probably benign
Transcript: ENSMUST00000170412
AA Change: T290S

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000126979
Gene: ENSMUSG00000096002
AA Change: T290S

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	5	397	3.6e-58	PFAM
Pfam:NCD3G	442	495	2.2e-19	PFAM
Pfam:7tm_3	526	763	3.1e-53	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Add3	A	G	19: 53,219,638 (GRCm39)	D121G	probably damaging	Het
Cacna1s	A	G	1: 136,043,802 (GRCm39)	D1380G	probably benign	Het
Clca3a1	T	C	3: 144,453,262 (GRCm39)	Y487C	probably damaging	Het
Coro2a	A	G	4: 46,544,158 (GRCm39)	S278P	possibly damaging	Het
Creb3l3	A	G	10: 80,927,047 (GRCm39)	S128P	probably benign	Het
Dab2	A	G	15: 6,465,892 (GRCm39)	R697G	probably damaging	Het
Erap1	T	C	13: 74,823,399 (GRCm39)	F811S	probably benign	Het
Fam170b	A	G	14: 32,557,482 (GRCm39)	S106G	probably damaging	Het
Galk2	T	C	2: 125,771,563 (GRCm39)	L196P	probably damaging	Het
Gan	T	C	8: 117,910,314 (GRCm39)	M81T	probably benign	Het
Gemin2	A	G	12: 59,068,511 (GRCm39)	T197A	probably benign	Het
Hemgn	A	T	4: 46,396,504 (GRCm39)	M244K	probably benign	Het
Htr6	A	G	4: 138,789,080 (GRCm39)	F325S	probably damaging	Het
Igkv9-120	A	G	6: 68,027,398 (GRCm39)	D104G	probably damaging	Het
Itpr2	A	C	6: 146,281,008 (GRCm39)	I216S	probably damaging	Het
Lingo1	T	C	9: 56,526,748 (GRCm39)	I614V	possibly damaging	Het
Mep1b	C	T	18: 21,226,710 (GRCm39)	T524M	probably benign	Het
Mtif2	A	G	11: 29,480,702 (GRCm39)		probably benign	Het
Mylk	G	A	16: 34,732,562 (GRCm39)	R614H	possibly damaging	Het
Or2ag2	T	C	7: 106,485,410 (GRCm39)	T205A	probably benign	Het
Or52s19	T	C	7: 103,007,446 (GRCm39)		probably benign	Het
Pabpc4	G	A	4: 123,180,502 (GRCm39)	D75N	probably damaging	Het
Paics	T	A	5: 77,109,355 (GRCm39)		probably null	Het
Prl	T	A	13: 27,248,870 (GRCm39)	I172N	probably benign	Het
Ripk2	A	G	4: 16,152,056 (GRCm39)	S168P	probably damaging	Het
Siglecf	T	C	7: 43,001,865 (GRCm39)	V225A	probably damaging	Het
Slc36a1	A	G	11: 55,110,430 (GRCm39)	I86V	probably benign	Het
Slc6a13	A	G	6: 121,309,407 (GRCm39)	Y306C	probably damaging	Het
Soat2	T	A	15: 102,066,078 (GRCm39)	L250Q	probably damaging	Het
Tex38	A	G	4: 115,637,762 (GRCm39)	S14P	probably damaging	Het
Tm2d1	A	T	4: 98,268,921 (GRCm39)	C59S	possibly damaging	Het
Tmco1	A	G	1: 167,143,848 (GRCm39)	D82G	probably damaging	Het
Tmem245	G	A	4: 56,886,019 (GRCm39)	R866W	probably damaging	Het
Tnip1	G	T	11: 54,831,652 (GRCm39)	Y7*	probably null	Het
Trp73	A	G	4: 154,189,330 (GRCm39)	M48T	probably benign	Het
Tslp	T	C	18: 32,948,612 (GRCm39)		probably benign	Het
Usp47	T	C	7: 111,688,827 (GRCm39)	F745L	probably damaging	Het
Wdr1	T	C	5: 38,718,472 (GRCm39)	D30G	probably benign	Het
Zkscan2	T	C	7: 123,094,073 (GRCm39)	Y247C	probably benign	Het

Other mutations in Vmn2r53

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01090:Vmn2r53	APN	7	12,334,835 (GRCm39)	missense	possibly damaging	0.70
IGL01997:Vmn2r53	APN	7	12,316,373 (GRCm39)	missense	possibly damaging	0.54
IGL02442:Vmn2r53	APN	7	12,315,656 (GRCm39)	missense	probably damaging	1.00
IGL02449:Vmn2r53	APN	7	12,316,288 (GRCm39)	missense	probably damaging	1.00
IGL02589:Vmn2r53	APN	7	12,315,872 (GRCm39)	missense	possibly damaging	0.93
IGL02986:Vmn2r53	APN	7	12,315,393 (GRCm39)	unclassified	probably benign
IGL03064:Vmn2r53	APN	7	12,334,937 (GRCm39)	missense	possibly damaging	0.89
IGL03244:Vmn2r53	APN	7	12,340,435 (GRCm39)	missense	probably damaging	1.00
IGL03252:Vmn2r53	APN	7	12,340,318 (GRCm39)	missense	probably damaging	1.00
IGL03264:Vmn2r53	APN	7	12,315,819 (GRCm39)	missense	possibly damaging	0.95
IGL03293:Vmn2r53	APN	7	12,332,349 (GRCm39)	missense	probably benign	0.34
R0109:Vmn2r53	UTSW	7	12,315,993 (GRCm39)	missense	probably damaging	1.00
R0453:Vmn2r53	UTSW	7	12,316,338 (GRCm39)	missense	probably damaging	1.00
R0735:Vmn2r53	UTSW	7	12,315,707 (GRCm39)	missense	probably benign
R0881:Vmn2r53	UTSW	7	12,334,859 (GRCm39)	missense	probably benign	0.01
R0894:Vmn2r53	UTSW	7	12,335,141 (GRCm39)	missense	probably benign	0.00
R0973:Vmn2r53	UTSW	7	12,335,319 (GRCm39)	missense	probably damaging	1.00
R0973:Vmn2r53	UTSW	7	12,335,319 (GRCm39)	missense	probably damaging	1.00
R0974:Vmn2r53	UTSW	7	12,335,319 (GRCm39)	missense	probably damaging	1.00
R0990:Vmn2r53	UTSW	7	12,315,429 (GRCm39)	missense	probably benign
R1102:Vmn2r53	UTSW	7	12,332,410 (GRCm39)	missense	possibly damaging	0.94
R1141:Vmn2r53	UTSW	7	12,334,673 (GRCm39)	missense	possibly damaging	0.54
R1263:Vmn2r53	UTSW	7	12,315,533 (GRCm39)	missense	probably benign	0.41
R1343:Vmn2r53	UTSW	7	12,318,701 (GRCm39)	missense	probably benign	0.08
R1750:Vmn2r53	UTSW	7	12,315,632 (GRCm39)	missense	probably damaging	1.00
R1836:Vmn2r53	UTSW	7	12,334,812 (GRCm39)	missense	probably damaging	1.00
R2035:Vmn2r53	UTSW	7	12,332,438 (GRCm39)	missense	possibly damaging	0.76
R2202:Vmn2r53	UTSW	7	12,335,366 (GRCm39)	missense	probably damaging	1.00
R3707:Vmn2r53	UTSW	7	12,315,981 (GRCm39)	missense	possibly damaging	0.95
R4372:Vmn2r53	UTSW	7	12,315,656 (GRCm39)	missense	probably damaging	0.98
R4615:Vmn2r53	UTSW	7	12,316,229 (GRCm39)	missense	probably damaging	1.00
R4655:Vmn2r53	UTSW	7	12,315,932 (GRCm39)	missense	possibly damaging	0.83
R4663:Vmn2r53	UTSW	7	12,334,901 (GRCm39)	missense	probably benign	0.21
R4708:Vmn2r53	UTSW	7	12,335,129 (GRCm39)	missense	probably benign
R4710:Vmn2r53	UTSW	7	12,335,129 (GRCm39)	missense	probably benign
R4774:Vmn2r53	UTSW	7	12,334,692 (GRCm39)	nonsense	probably null
R4859:Vmn2r53	UTSW	7	12,335,330 (GRCm39)	missense	probably damaging	1.00
R5061:Vmn2r53	UTSW	7	12,315,741 (GRCm39)	missense	probably benign	0.01
R5561:Vmn2r53	UTSW	7	12,335,347 (GRCm39)	missense	probably damaging	1.00
R5729:Vmn2r53	UTSW	7	12,334,733 (GRCm39)	missense	probably damaging	1.00
R6004:Vmn2r53	UTSW	7	12,316,328 (GRCm39)	missense	probably benign	0.12
R6083:Vmn2r53	UTSW	7	12,315,808 (GRCm39)	missense	probably benign
R6312:Vmn2r53	UTSW	7	12,332,566 (GRCm39)	critical splice acceptor site	probably null
R6700:Vmn2r53	UTSW	7	12,315,633 (GRCm39)	missense	probably damaging	0.96
R6783:Vmn2r53	UTSW	7	12,335,360 (GRCm39)	missense	probably damaging	1.00
R6852:Vmn2r53	UTSW	7	12,340,441 (GRCm39)	missense	probably damaging	0.99
R6889:Vmn2r53	UTSW	7	12,335,069 (GRCm39)	missense	probably benign	0.10
R6940:Vmn2r53	UTSW	7	12,316,343 (GRCm39)	missense	probably benign	0.19
R7100:Vmn2r53	UTSW	7	12,315,513 (GRCm39)	nonsense	probably null
R7174:Vmn2r53	UTSW	7	12,315,628 (GRCm39)	missense	probably benign	0.01
R7213:Vmn2r53	UTSW	7	12,334,983 (GRCm39)	missense	probably benign	0.17
R7276:Vmn2r53	UTSW	7	12,340,359 (GRCm39)	missense	probably damaging	0.99
R7515:Vmn2r53	UTSW	7	12,315,846 (GRCm39)	missense	probably benign	0.05
R7678:Vmn2r53	UTSW	7	12,332,425 (GRCm39)	missense	probably benign	0.04
R7714:Vmn2r53	UTSW	7	12,340,418 (GRCm39)	missense	probably damaging	1.00
R7843:Vmn2r53	UTSW	7	12,316,026 (GRCm39)	missense	probably damaging	1.00
R8208:Vmn2r53	UTSW	7	12,335,322 (GRCm39)	missense	probably damaging	1.00
R8211:Vmn2r53	UTSW	7	12,315,843 (GRCm39)	missense	probably benign	0.01
R8478:Vmn2r53	UTSW	7	12,340,281 (GRCm39)	missense	probably benign	0.01
R8853:Vmn2r53	UTSW	7	12,315,737 (GRCm39)	missense	probably damaging	1.00
R8924:Vmn2r53	UTSW	7	12,334,752 (GRCm39)	missense	probably benign	0.17
R8963:Vmn2r53	UTSW	7	12,315,926 (GRCm39)	missense	probably damaging	1.00
R9042:Vmn2r53	UTSW	7	12,315,435 (GRCm39)	missense	probably benign
R9076:Vmn2r53	UTSW	7	12,340,231 (GRCm39)	missense	probably damaging	1.00
R9407:Vmn2r53	UTSW	7	12,335,124 (GRCm39)	missense	probably damaging	0.99
R9690:Vmn2r53	UTSW	7	12,315,912 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r53	UTSW	7	12,335,231 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02