Incidental Mutation 'IGL03095:Vmn2r92'
| ID |
418514 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r92
|
| Ensembl Gene |
ENSMUSG00000091350 |
| Gene Name |
vomeronasal 2, receptor 92 |
| Synonyms |
EG627111 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.082)
|
| Stock # |
IGL03095
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
17 |
| Chromosomal Location |
18372192-18405440 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 18386972 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Threonine
at position 104
(S104T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128685
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000169686]
|
| AlphaFold |
L7N2A4 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000169686
AA Change: S104T
PolyPhen 2
Score 0.546 (Sensitivity: 0.88; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000128685
Gene: ENSMUSG00000091350
AA Change: S104T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
463 |
4.7e-38 |
PFAM |
|
Pfam:NCD3G
|
510 |
564 |
2.5e-19 |
PFAM |
|
Pfam:7tm_3
|
597 |
832 |
1.1e-52 |
PFAM |
|
low complexity region
|
843 |
855 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 40 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Bche |
A |
G |
3: 73,609,216 (GRCm39) |
L70P |
probably damaging |
Het |
| Cacna1h |
C |
A |
17: 25,602,752 (GRCm39) |
|
probably benign |
Het |
| Ccdc60 |
A |
T |
5: 116,284,274 (GRCm39) |
|
probably benign |
Het |
| Cep152 |
T |
C |
2: 125,460,371 (GRCm39) |
N194D |
probably benign |
Het |
| Chodl |
T |
A |
16: 78,738,321 (GRCm39) |
D96E |
probably damaging |
Het |
| Clca3b |
C |
A |
3: 144,552,671 (GRCm39) |
G122* |
probably null |
Het |
| Crybg1 |
T |
C |
10: 43,865,245 (GRCm39) |
I1411V |
probably damaging |
Het |
| Dock9 |
A |
C |
14: 121,876,940 (GRCm39) |
V477G |
probably damaging |
Het |
| Fam149a |
T |
A |
8: 45,794,265 (GRCm39) |
E632D |
probably damaging |
Het |
| Gabra4 |
A |
G |
5: 71,781,358 (GRCm39) |
V351A |
probably damaging |
Het |
| Gen1 |
T |
A |
12: 11,298,265 (GRCm39) |
I319L |
probably benign |
Het |
| Gne |
C |
A |
4: 44,055,211 (GRCm39) |
D255Y |
probably damaging |
Het |
| Gpr146 |
A |
G |
5: 139,378,705 (GRCm39) |
H169R |
probably benign |
Het |
| Htatip2 |
A |
G |
7: 49,409,522 (GRCm39) |
E92G |
probably benign |
Het |
| Ipcef1 |
A |
G |
10: 6,869,732 (GRCm39) |
S223P |
probably damaging |
Het |
| Kcnmb2 |
T |
A |
3: 32,252,276 (GRCm39) |
*37R |
probably null |
Het |
| Lin54 |
A |
T |
5: 100,602,337 (GRCm39) |
V400E |
probably damaging |
Het |
| Ltbp1 |
C |
A |
17: 75,589,413 (GRCm39) |
Q511K |
possibly damaging |
Het |
| Lyg1 |
A |
G |
1: 37,989,849 (GRCm39) |
|
probably benign |
Het |
| Nampt |
T |
A |
12: 32,892,685 (GRCm39) |
V324D |
possibly damaging |
Het |
| Nat8b-ps |
T |
G |
6: 85,909,950 (GRCm39) |
|
probably benign |
Het |
| Neb |
G |
A |
2: 52,059,100 (GRCm39) |
H213Y |
probably damaging |
Het |
| Nfkb1 |
T |
C |
3: 135,324,591 (GRCm39) |
E179G |
possibly damaging |
Het |
| Nlrc5 |
T |
A |
8: 95,248,536 (GRCm39) |
|
probably benign |
Het |
| Or12d2 |
T |
A |
17: 37,624,664 (GRCm39) |
I204F |
probably benign |
Het |
| Or8k38 |
A |
T |
2: 86,488,775 (GRCm39) |
L9Q |
possibly damaging |
Het |
| Pcdh15 |
G |
A |
10: 74,191,706 (GRCm39) |
V601M |
probably damaging |
Het |
| Pigc |
G |
A |
1: 161,798,345 (GRCm39) |
R109Q |
possibly damaging |
Het |
| Plxna2 |
A |
G |
1: 194,483,435 (GRCm39) |
N1582S |
probably damaging |
Het |
| Pros1 |
C |
T |
16: 62,728,132 (GRCm39) |
Q279* |
probably null |
Het |
| Psmb5 |
A |
G |
14: 54,854,014 (GRCm39) |
S155P |
probably damaging |
Het |
| Rock2 |
T |
A |
12: 17,003,341 (GRCm39) |
D393E |
probably benign |
Het |
| Slc25a21 |
T |
C |
12: 56,785,410 (GRCm39) |
T156A |
probably benign |
Het |
| Slc44a1 |
T |
A |
4: 53,536,374 (GRCm39) |
Y183* |
probably null |
Het |
| Sytl2 |
C |
T |
7: 90,041,642 (GRCm39) |
P580L |
probably damaging |
Het |
| Tktl2 |
G |
T |
8: 66,964,936 (GRCm39) |
V165F |
probably damaging |
Het |
| Trim55 |
A |
G |
3: 19,728,629 (GRCm39) |
E480G |
probably benign |
Het |
| Vps51 |
C |
T |
19: 6,120,078 (GRCm39) |
R490H |
probably damaging |
Het |
| Wdr43 |
G |
A |
17: 71,948,282 (GRCm39) |
V391I |
probably benign |
Het |
| Zranb1 |
T |
G |
7: 132,551,635 (GRCm39) |
Y121* |
probably null |
Het |
|
| Other mutations in Vmn2r92 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01591:Vmn2r92
|
APN |
17 |
18,405,423 (GRCm39) |
missense |
unknown |
|
|
IGL01758:Vmn2r92
|
APN |
17 |
18,372,275 (GRCm39) |
nonsense |
probably null |
|
|
IGL02614:Vmn2r92
|
APN |
17 |
18,387,503 (GRCm39) |
splice site |
probably benign |
|
|
IGL03403:Vmn2r92
|
APN |
17 |
18,387,114 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0133:Vmn2r92
|
UTSW |
17 |
18,388,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0225:Vmn2r92
|
UTSW |
17 |
18,388,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0227:Vmn2r92
|
UTSW |
17 |
18,388,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0265:Vmn2r92
|
UTSW |
17 |
18,388,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0266:Vmn2r92
|
UTSW |
17 |
18,388,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0267:Vmn2r92
|
UTSW |
17 |
18,388,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0420:Vmn2r92
|
UTSW |
17 |
18,389,183 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0426:Vmn2r92
|
UTSW |
17 |
18,388,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0494:Vmn2r92
|
UTSW |
17 |
18,388,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1253:Vmn2r92
|
UTSW |
17 |
18,387,028 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1497:Vmn2r92
|
UTSW |
17 |
18,387,625 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1571:Vmn2r92
|
UTSW |
17 |
18,372,352 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1656:Vmn2r92
|
UTSW |
17 |
18,372,198 (GRCm39) |
missense |
probably benign |
|
|
R1816:Vmn2r92
|
UTSW |
17 |
18,386,939 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2229:Vmn2r92
|
UTSW |
17 |
18,387,654 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2909:Vmn2r92
|
UTSW |
17 |
18,405,377 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R3694:Vmn2r92
|
UTSW |
17 |
18,372,205 (GRCm39) |
nonsense |
probably null |
|
|
R4207:Vmn2r92
|
UTSW |
17 |
18,404,523 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R4548:Vmn2r92
|
UTSW |
17 |
18,391,578 (GRCm39) |
missense |
probably benign |
|
|
R4612:Vmn2r92
|
UTSW |
17 |
18,387,132 (GRCm39) |
missense |
probably benign |
0.25 |
|
R4742:Vmn2r92
|
UTSW |
17 |
18,387,119 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4824:Vmn2r92
|
UTSW |
17 |
18,372,183 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R4865:Vmn2r92
|
UTSW |
17 |
18,387,634 (GRCm39) |
missense |
probably benign |
0.16 |
|
R4900:Vmn2r92
|
UTSW |
17 |
18,404,605 (GRCm39) |
missense |
probably benign |
0.27 |
|
R5084:Vmn2r92
|
UTSW |
17 |
18,405,439 (GRCm39) |
makesense |
probably null |
|
|
R5140:Vmn2r92
|
UTSW |
17 |
18,372,312 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5995:Vmn2r92
|
UTSW |
17 |
18,389,213 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6045:Vmn2r92
|
UTSW |
17 |
18,388,305 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6269:Vmn2r92
|
UTSW |
17 |
18,387,036 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6877:Vmn2r92
|
UTSW |
17 |
18,389,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7151:Vmn2r92
|
UTSW |
17 |
18,387,005 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7260:Vmn2r92
|
UTSW |
17 |
18,387,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7344:Vmn2r92
|
UTSW |
17 |
18,387,513 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7514:Vmn2r92
|
UTSW |
17 |
18,391,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7576:Vmn2r92
|
UTSW |
17 |
18,387,621 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7584:Vmn2r92
|
UTSW |
17 |
18,387,028 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7912:Vmn2r92
|
UTSW |
17 |
18,404,970 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7941:Vmn2r92
|
UTSW |
17 |
18,405,099 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8178:Vmn2r92
|
UTSW |
17 |
18,386,988 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R8238:Vmn2r92
|
UTSW |
17 |
18,405,278 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8239:Vmn2r92
|
UTSW |
17 |
18,405,278 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8252:Vmn2r92
|
UTSW |
17 |
18,387,134 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8322:Vmn2r92
|
UTSW |
17 |
18,386,886 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8355:Vmn2r92
|
UTSW |
17 |
18,405,061 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9399:Vmn2r92
|
UTSW |
17 |
18,389,137 (GRCm39) |
missense |
probably benign |
0.29 |
|
R9639:Vmn2r92
|
UTSW |
17 |
18,372,352 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9747:Vmn2r92
|
UTSW |
17 |
18,405,201 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9773:Vmn2r92
|
UTSW |
17 |
18,386,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0066:Vmn2r92
|
UTSW |
17 |
18,405,157 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Vmn2r92
|
UTSW |
17 |
18,404,795 (GRCm39) |
missense |
probably damaging |
0.96 |
|
| Posted On |
2016-08-02 |
Incidental Mutation