Incidental Mutation 'IGL03095:Olfr1085'
ID418541
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1085
Ensembl Gene ENSMUSG00000075176
Gene Nameolfactory receptor 1085
SynonymsGA_x6K02T2Q125-48147264-48146323, MOR191-1
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL03095
Quality Score
Status
Chromosome2
Chromosomal Location86653665-86662019 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 86658431 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Glutamine at position 9 (L9Q)
Ref Sequence ENSEMBL: ENSMUSP00000150955 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099879] [ENSMUST00000213279] [ENSMUST00000214566]
Predicted Effect possibly damaging
Transcript: ENSMUST00000099879
AA Change: L9Q

PolyPhen 2 Score 0.500 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000097464
Gene: ENSMUSG00000075176
AA Change: L9Q

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 4.6e-49 PFAM
Pfam:7tm_1 41 290 1.1e-18 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213279
AA Change: L9Q

PolyPhen 2 Score 0.500 (Sensitivity: 0.88; Specificity: 0.90)
Predicted Effect possibly damaging
Transcript: ENSMUST00000214566
AA Change: L9Q

PolyPhen 2 Score 0.500 (Sensitivity: 0.88; Specificity: 0.90)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bche A G 3: 73,701,883 L70P probably damaging Het
Cacna1h C A 17: 25,383,778 probably benign Het
Ccdc60 A T 5: 116,146,215 probably benign Het
Cep152 T C 2: 125,618,451 N194D probably benign Het
Chodl T A 16: 78,941,433 D96E probably damaging Het
Clca3b C A 3: 144,846,910 G122* probably null Het
Crybg1 T C 10: 43,989,249 I1411V probably damaging Het
Dock9 A C 14: 121,639,528 V477G probably damaging Het
Fam149a T A 8: 45,341,228 E632D probably damaging Het
Gabra4 A G 5: 71,624,015 V351A probably damaging Het
Gen1 T A 12: 11,248,264 I319L probably benign Het
Gne C A 4: 44,055,211 D255Y probably damaging Het
Gpr146 A G 5: 139,392,950 H169R probably benign Het
Htatip2 A G 7: 49,759,774 E92G probably benign Het
Ipcef1 A G 10: 6,919,732 S223P probably damaging Het
Kcnmb2 T A 3: 32,198,127 *37R probably null Het
Lin54 A T 5: 100,454,478 V400E probably damaging Het
Ltbp1 C A 17: 75,282,418 Q511K possibly damaging Het
Lyg1 A G 1: 37,950,768 probably benign Het
Nampt T A 12: 32,842,686 V324D possibly damaging Het
Nat8b-ps T G 6: 85,932,968 probably benign Het
Neb G A 2: 52,169,088 H213Y probably damaging Het
Nfkb1 T C 3: 135,618,830 E179G possibly damaging Het
Nlrc5 T A 8: 94,521,908 probably benign Het
Olfr102 T A 17: 37,313,773 I204F probably benign Het
Pcdh15 G A 10: 74,355,874 V601M probably damaging Het
Pigc G A 1: 161,970,776 R109Q possibly damaging Het
Plxna2 A G 1: 194,801,127 N1582S probably damaging Het
Pros1 C T 16: 62,907,769 Q279* probably null Het
Psmb5 A G 14: 54,616,557 S155P probably damaging Het
Rock2 T A 12: 16,953,340 D393E probably benign Het
Slc25a21 T C 12: 56,738,625 T156A probably benign Het
Slc44a1 T A 4: 53,536,374 Y183* probably null Het
Sytl2 C T 7: 90,392,434 P580L probably damaging Het
Tktl2 G T 8: 66,512,284 V165F probably damaging Het
Trim55 A G 3: 19,674,465 E480G probably benign Het
Vmn2r92 T A 17: 18,166,710 S104T possibly damaging Het
Vps51 C T 19: 6,070,048 R490H probably damaging Het
Wdr43 G A 17: 71,641,287 V391I probably benign Het
Zranb1 T G 7: 132,949,906 Y121* probably null Het
Other mutations in Olfr1085
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00940:Olfr1085 APN 2 86657726 missense probably damaging 0.98
IGL01137:Olfr1085 APN 2 86657711 missense possibly damaging 0.92
IGL01329:Olfr1085 APN 2 86658207 missense probably benign 0.31
IGL01398:Olfr1085 APN 2 86657688 missense probably damaging 1.00
IGL02248:Olfr1085 APN 2 86657717 missense probably damaging 1.00
IGL02699:Olfr1085 APN 2 86658347 missense probably benign 0.34
IGL02818:Olfr1085 APN 2 86657784 missense probably damaging 1.00
IGL03218:Olfr1085 APN 2 86658359 missense probably benign 0.32
R0121:Olfr1085 UTSW 2 86657819 missense probably benign 0.42
R0546:Olfr1085 UTSW 2 86657891 missense possibly damaging 0.91
R0583:Olfr1085 UTSW 2 86658360 missense probably benign 0.20
R0980:Olfr1085 UTSW 2 86657865 missense probably benign 0.39
R2067:Olfr1085 UTSW 2 86658437 missense probably damaging 1.00
R2111:Olfr1085 UTSW 2 86658437 missense probably damaging 1.00
R3760:Olfr1085 UTSW 2 86657888 missense possibly damaging 0.91
R4530:Olfr1085 UTSW 2 86657561 missense probably benign 0.00
R4809:Olfr1085 UTSW 2 86657685 missense possibly damaging 0.95
R5940:Olfr1085 UTSW 2 86658050 missense probably damaging 0.98
R6027:Olfr1085 UTSW 2 86657804 missense probably damaging 1.00
R6417:Olfr1085 UTSW 2 86658166 nonsense probably null
R6420:Olfr1085 UTSW 2 86658166 nonsense probably null
R6619:Olfr1085 UTSW 2 86658062 missense probably damaging 1.00
R6762:Olfr1085 UTSW 2 86657844 missense probably benign 0.22
R6946:Olfr1085 UTSW 2 86657588 missense probably damaging 1.00
R7673:Olfr1085 UTSW 2 86657726 missense probably damaging 1.00
R7718:Olfr1085 UTSW 2 86658029 missense probably benign 0.26
Posted On2016-08-02