Incidental Mutation 'IGL03099:Srrm3'
ID418676
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Srrm3
Ensembl Gene ENSMUSG00000039860
Gene Nameserine/arginine repetitive matrix 3
Synonyms2900083I11Rik, Srrm2l, SRm300-like
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.429) question?
Stock #IGL03099
Quality Score
Status
Chromosome5
Chromosomal Location135806890-135874772 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) C to A at 135869298 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000115695 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000013615] [ENSMUST00000144211]
Predicted Effect probably benign
Transcript: ENSMUST00000013615
SMART Domains Protein: ENSMUSP00000013615
Gene: ENSMUSG00000039860

DomainStartEndE-ValueType
low complexity region 34 43 N/A INTRINSIC
cwf21 55 100 8.92e-17 SMART
low complexity region 160 186 N/A INTRINSIC
low complexity region 200 242 N/A INTRINSIC
low complexity region 253 276 N/A INTRINSIC
low complexity region 286 317 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000144211
SMART Domains Protein: ENSMUSP00000115695
Gene: ENSMUSG00000039860

DomainStartEndE-ValueType
low complexity region 34 43 N/A INTRINSIC
cwf21 55 100 8.92e-17 SMART
internal_repeat_1 122 142 4.3e-6 PROSPERO
low complexity region 160 186 N/A INTRINSIC
low complexity region 200 242 N/A INTRINSIC
low complexity region 253 276 N/A INTRINSIC
low complexity region 286 317 N/A INTRINSIC
internal_repeat_1 325 345 4.3e-6 PROSPERO
low complexity region 362 442 N/A INTRINSIC
low complexity region 451 478 N/A INTRINSIC
low complexity region 493 508 N/A INTRINSIC
Pfam:SRRM_C 520 584 1.9e-28 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150566
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akp3 C A 1: 87,127,606 F458L probably benign Het
Alpi A G 1: 87,098,631 L546P unknown Het
Arpc5l A G 2: 39,013,832 Y111C probably damaging Het
Atp11a T C 8: 12,827,462 F296S possibly damaging Het
Bbof1 C T 12: 84,426,765 Q290* probably null Het
Brinp3 A T 1: 146,902,097 T761S possibly damaging Het
Cyp2j6 A T 4: 96,536,091 M143K possibly damaging Het
Daw1 T C 1: 83,179,367 probably null Het
Dst A G 1: 34,275,781 N6498D probably damaging Het
Fbxo15 T C 18: 84,981,213 L380P possibly damaging Het
Glce A T 9: 62,060,062 F602L probably benign Het
Gpatch1 A G 7: 35,297,523 S417P possibly damaging Het
Hjurp T C 1: 88,266,289 K223R probably benign Het
Hnrnpm C T 17: 33,669,172 C113Y probably damaging Het
Igkv4-71 T C 6: 69,243,415 M11V probably benign Het
Insr G T 8: 3,258,715 T107K probably damaging Het
Mdm4 G A 1: 132,992,209 T306M probably damaging Het
Nek11 T C 9: 105,287,653 I425V probably benign Het
Otop3 T A 11: 115,339,582 V95E probably damaging Het
Scn3a G A 2: 65,536,672 A2V probably damaging Het
Snx10 T A 6: 51,579,860 M41K possibly damaging Het
Sos2 T A 12: 69,616,359 N588Y probably damaging Het
Tbc1d19 G T 5: 53,883,655 probably benign Het
Vmn2r68 T A 7: 85,222,240 K612* probably null Het
Other mutations in Srrm3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02479:Srrm3 APN 5 135835249 missense probably damaging 1.00
IGL02716:Srrm3 APN 5 135854433 splice site probably null
P0047:Srrm3 UTSW 5 135852926 splice site probably null
R0688:Srrm3 UTSW 5 135869276 utr 3 prime probably benign
R0811:Srrm3 UTSW 5 135873282 unclassified probably benign
R0812:Srrm3 UTSW 5 135873282 unclassified probably benign
R1083:Srrm3 UTSW 5 135854409 missense probably damaging 0.99
R1161:Srrm3 UTSW 5 135854392 small deletion probably benign
R1656:Srrm3 UTSW 5 135835038 critical splice acceptor site probably null
R1694:Srrm3 UTSW 5 135873225 unclassified probably benign
R1803:Srrm3 UTSW 5 135857129 missense probably damaging 0.99
R2037:Srrm3 UTSW 5 135854377 missense probably damaging 1.00
R2436:Srrm3 UTSW 5 135835176 nonsense probably null
R3826:Srrm3 UTSW 5 135857214 missense probably damaging 0.99
R3829:Srrm3 UTSW 5 135857214 missense probably damaging 0.99
R4840:Srrm3 UTSW 5 135854595 missense possibly damaging 0.81
R6526:Srrm3 UTSW 5 135835234 missense probably damaging 1.00
R6843:Srrm3 UTSW 5 135852281 missense probably benign 0.01
R7408:Srrm3 UTSW 5 135852206 missense probably benign 0.04
R7583:Srrm3 UTSW 5 135852281 missense probably benign 0.01
R8096:Srrm3 UTSW 5 135869240 missense unknown
Posted On2016-08-02