Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03100:Zfp961'

418681

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp961

Ensembl Gene

ENSMUSG00000052446

Gene Name

zinc finger protein 961

Synonyms

A230105L22Rik, BC049349

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03100

Quality Score

Status

Chromosome

Chromosomal Location

72704910-72724177 bp(+) (GRCm39)

Type of Mutation

makesense

DNA Base Change (assembly)

T to C at 72721754 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Stop codon to Glutamine at position 69 (*69Q)

Ref Sequence

ENSEMBL: ENSMUSP00000122589 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000109997] [ENSMUST00000131237] [ENSMUST00000132848] [ENSMUST00000136516] [ENSMUST00000138304] [ENSMUST00000145256]

AlphaFold

E9Q4R5

Predicted Effect

probably benign
Transcript: ENSMUST00000109997
AA Change: V89A

PolyPhen 2 Score 0.183 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000105623
Gene: ENSMUSG00000052446
AA Change: V89A

Domain	Start	End	E-Value	Type
KRAB	25	82	1.14e-18	SMART
ZnF_C2H2	144	166	1.69e-3	SMART
ZnF_C2H2	172	194	3.07e-1	SMART
ZnF_C2H2	199	221	1.36e-2	SMART
ZnF_C2H2	226	248	3.29e-1	SMART
ZnF_C2H2	254	276	3.34e-2	SMART
ZnF_C2H2	282	304	9.58e-3	SMART
ZnF_C2H2	310	332	2.17e-1	SMART
ZnF_C2H2	338	360	1.04e-3	SMART
ZnF_C2H2	366	388	2.24e-3	SMART
ZnF_C2H2	394	416	2.24e-3	SMART
ZnF_C2H2	421	443	4.61e-5	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000131237
AA Change: V70A

PolyPhen 2 Score 0.326 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000122942
Gene: ENSMUSG00000052446
AA Change: V70A

Domain	Start	End	E-Value	Type
KRAB	6	63	1.14e-18	SMART
ZnF_C2H2	125	147	1.69e-3	SMART
ZnF_C2H2	153	175	3.07e-1	SMART
ZnF_C2H2	180	202	1.36e-2	SMART
ZnF_C2H2	207	229	3.29e-1	SMART
ZnF_C2H2	235	257	3.34e-2	SMART
ZnF_C2H2	263	285	9.58e-3	SMART
ZnF_C2H2	291	313	2.17e-1	SMART
ZnF_C2H2	319	341	1.04e-3	SMART
ZnF_C2H2	347	369	2.24e-3	SMART
ZnF_C2H2	375	397	2.24e-3	SMART
ZnF_C2H2	402	424	4.61e-5	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000132848
AA Change: V89A

PolyPhen 2 Score 0.651 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000114730
Gene: ENSMUSG00000052446
AA Change: V89A

Domain	Start	End	E-Value	Type
KRAB	25	82	1.14e-18	SMART
ZnF_C2H2	144	166	1.69e-3	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000136516
AA Change: *69Q

SMART Domains

Protein: ENSMUSP00000122589
Gene: ENSMUSG00000052446
AA Change: *69Q

Domain	Start	End	E-Value	Type
KRAB	25	82	1.14e-18	SMART
ZnF_C2H2	144	166	1.69e-3	SMART
ZnF_C2H2	172	194	3.07e-1	SMART
ZnF_C2H2	199	221	1.36e-2	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000136878

Predicted Effect

probably benign
Transcript: ENSMUST00000138304

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000139781

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000147033

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000144807

Predicted Effect

probably benign
Transcript: ENSMUST00000145256

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000151168

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	A	T	11: 9,208,527 (GRCm39)	R233S	probably benign	Het
Abcc9	A	T	6: 142,640,270 (GRCm39)	W73R	probably damaging	Het
Ago1	A	G	4: 126,336,964 (GRCm39)	V247A	probably benign	Het
Anpep	T	A	7: 79,486,109 (GRCm39)	T538S	probably benign	Het
Asb14	A	G	14: 26,625,329 (GRCm39)	K228R	probably benign	Het
Atp6v0d2	C	T	4: 19,910,586 (GRCm39)		probably null	Het
B3gat2	A	T	1: 23,802,272 (GRCm39)	D186V	probably damaging	Het
Bmpr1a	A	T	14: 34,163,164 (GRCm39)		probably benign	Het
Carmil3	A	G	14: 55,732,175 (GRCm39)	D224G	probably damaging	Het
Cd6	T	C	19: 10,770,303 (GRCm39)	M463V	probably benign	Het
Clasp1	T	C	1: 118,395,626 (GRCm39)	I188T	possibly damaging	Het
Cldn17	G	T	16: 88,303,489 (GRCm39)	A80E	probably damaging	Het
Clptm1l	A	G	13: 73,760,509 (GRCm39)		probably benign	Het
Col6a5	A	T	9: 105,814,512 (GRCm39)	V500E	unknown	Het
Ctdspl2	C	T	2: 121,809,394 (GRCm39)	T115I	probably benign	Het
Dbh	G	T	2: 27,055,534 (GRCm39)	A3S	probably benign	Het
Fgd4	A	G	16: 16,295,383 (GRCm39)		probably benign	Het
Gm4952	T	A	19: 12,602,083 (GRCm39)		probably null	Het
Grik4	A	G	9: 42,461,751 (GRCm39)	M551T	probably damaging	Het
Hecw2	T	C	1: 53,870,815 (GRCm39)	I1389V	probably damaging	Het
Hkdc1	T	C	10: 62,253,608 (GRCm39)	T58A	probably benign	Het
Kcnh2	T	C	5: 24,527,682 (GRCm39)	K890R	probably damaging	Het
Kif24	T	C	4: 41,394,446 (GRCm39)	H809R	possibly damaging	Het
Knl1	A	G	2: 118,931,251 (GRCm39)	E1989G	probably damaging	Het
Muc15	A	G	2: 110,561,939 (GRCm39)	D125G	probably damaging	Het
Ogdhl	A	T	14: 32,064,029 (GRCm39)	M632L	probably benign	Het
Prkdc	T	C	16: 15,531,499 (GRCm39)	I1374T	probably benign	Het
Psmd1	T	A	1: 86,046,243 (GRCm39)	N670K	possibly damaging	Het
Ryr1	T	C	7: 28,804,018 (GRCm39)	H590R	probably damaging	Het
Scara3	A	C	14: 66,168,722 (GRCm39)	H298Q	probably damaging	Het
Sirt3	T	C	7: 140,445,030 (GRCm39)	D256G	probably damaging	Het
Slc13a2	T	C	11: 78,295,299 (GRCm39)	Q158R	probably damaging	Het
Slco5a1	T	A	1: 12,949,504 (GRCm39)	T629S	possibly damaging	Het
Speer4f2	A	G	5: 17,581,528 (GRCm39)	K157E	probably damaging	Het
Srsf1	T	A	11: 87,939,954 (GRCm39)	D155E	probably damaging	Het
Tln2	C	T	9: 67,203,019 (GRCm39)	R534H	probably damaging	Het
Ttn	A	G	2: 76,591,992 (GRCm39)		probably benign	Het
Ube2m	A	G	7: 12,771,562 (GRCm39)	L32P	probably benign	Het
Wdr24	T	A	17: 26,044,681 (GRCm39)	F179I	possibly damaging	Het

Other mutations in Zfp961

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00595:Zfp961	APN	8	72,722,272 (GRCm39)	missense	probably damaging	1.00
IGL00801:Zfp961	APN	8	72,719,732 (GRCm39)	missense	probably damaging	1.00
IGL00825:Zfp961	APN	8	72,721,888 (GRCm39)	missense	possibly damaging	0.91
IGL01405:Zfp961	APN	8	72,721,778 (GRCm39)	missense	possibly damaging	0.53
R0969:Zfp961	UTSW	8	72,722,139 (GRCm39)	missense	probably damaging	1.00
R4851:Zfp961	UTSW	8	72,722,847 (GRCm39)	unclassified	probably benign
R5502:Zfp961	UTSW	8	72,721,903 (GRCm39)	missense	probably damaging	0.99
R5813:Zfp961	UTSW	8	72,722,070 (GRCm39)	missense	probably damaging	1.00
R6762:Zfp961	UTSW	8	72,719,958 (GRCm39)	missense	possibly damaging	0.53
R6902:Zfp961	UTSW	8	72,722,522 (GRCm39)	missense	probably damaging	1.00
R7858:Zfp961	UTSW	8	72,704,949 (GRCm39)	missense	unknown
R8749:Zfp961	UTSW	8	72,719,686 (GRCm39)	missense	probably damaging	1.00
R9718:Zfp961	UTSW	8	72,721,933 (GRCm39)	missense	possibly damaging	0.81
X0027:Zfp961	UTSW	8	72,721,793 (GRCm39)	missense	possibly damaging	0.89

Posted On

2016-08-02