Incidental Mutation 'IGL03101:Zfp943'
ID 418720
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp943
Ensembl Gene ENSMUSG00000053347
Gene Name zinc finger prtoein 943
Synonyms 4930432O21Rik
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.250) question?
Stock # IGL03101
Quality Score
Status
Chromosome 17
Chromosomal Location 22181540-22213347 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 22211156 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 81 (S81P)
Ref Sequence ENSEMBL: ENSMUSP00000059554 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055349] [ENSMUST00000153985] [ENSMUST00000174015]
AlphaFold Q6NZP4
Predicted Effect probably damaging
Transcript: ENSMUST00000055349
AA Change: S81P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000059554
Gene: ENSMUSG00000053347
AA Change: S81P

DomainStartEndE-ValueType
KRAB 13 72 2.62e-18 SMART
ZnF_C2H2 180 202 1.6e-4 SMART
ZnF_C2H2 208 230 1.38e-3 SMART
ZnF_C2H2 236 258 1.13e-4 SMART
ZnF_C2H2 264 286 1.03e-2 SMART
ZnF_C2H2 292 314 2.24e-3 SMART
ZnF_C2H2 320 342 9.58e-3 SMART
ZnF_C2H2 348 370 5.67e-5 SMART
ZnF_C2H2 376 398 4.54e-4 SMART
ZnF_C2H2 404 426 2.15e-5 SMART
ZnF_C2H2 432 454 5.59e-4 SMART
ZnF_C2H2 460 482 3.34e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000153985
SMART Domains Protein: ENSMUSP00000115817
Gene: ENSMUSG00000053347

DomainStartEndE-ValueType
KRAB 13 73 3.51e-19 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000174015
SMART Domains Protein: ENSMUSP00000133735
Gene: ENSMUSG00000053347

DomainStartEndE-ValueType
KRAB 13 60 3.79e-15 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AA474408 A T 7: 109,660,177 (GRCm39) probably benign Het
Abcc1 T A 16: 14,207,732 (GRCm39) V23D probably damaging Het
Adam8 G T 7: 139,568,456 (GRCm39) N260K possibly damaging Het
Ap3b1 A T 13: 94,591,906 (GRCm39) I457L probably benign Het
Apaf1 T C 10: 90,867,421 (GRCm39) N808S possibly damaging Het
Arhgef26 A G 3: 62,327,082 (GRCm39) T532A possibly damaging Het
Cfap65 G T 1: 74,967,592 (GRCm39) T162N possibly damaging Het
Clec12b A G 6: 129,356,480 (GRCm39) probably null Het
Creb3 T C 4: 43,563,081 (GRCm39) V60A probably benign Het
Cyp11b1 A G 15: 74,707,703 (GRCm39) F469L probably benign Het
Defb28 A T 2: 152,362,047 (GRCm39) E69V possibly damaging Het
Etnppl T C 3: 130,415,967 (GRCm39) L118S probably damaging Het
Fsip1 T C 2: 118,072,144 (GRCm39) Y213C probably damaging Het
Glb1l2 A G 9: 26,676,421 (GRCm39) W480R probably damaging Het
Herc1 A T 9: 66,395,279 (GRCm39) M4205L probably benign Het
Kif5a A T 10: 127,071,478 (GRCm39) probably benign Het
Lmbrd2 C T 15: 9,186,695 (GRCm39) R557C probably damaging Het
Map4k3 A G 17: 80,963,284 (GRCm39) probably null Het
Npc1 A G 18: 12,331,596 (GRCm39) I858T probably benign Het
Or7e173 T C 9: 19,938,725 (GRCm39) T170A probably benign Het
Pecam1 A G 11: 106,588,177 (GRCm39) V92A probably damaging Het
Rbm43 A T 2: 51,816,757 (GRCm39) I70N probably benign Het
Rps6kb1 T C 11: 86,393,708 (GRCm39) Y474C probably benign Het
Slco2a1 G A 9: 102,954,205 (GRCm39) G459R possibly damaging Het
Snca T A 6: 60,804,595 (GRCm39) probably benign Het
Spata31f1e T C 4: 42,793,424 (GRCm39) D236G possibly damaging Het
Stap2 T A 17: 56,309,029 (GRCm39) I113F probably damaging Het
Tas2r140 T C 6: 40,468,764 (GRCm39) M198T probably benign Het
Trim9 T C 12: 70,393,428 (GRCm39) E172G probably damaging Het
Ttll7 T C 3: 146,602,445 (GRCm39) V81A possibly damaging Het
Vmn2r103 A G 17: 19,993,782 (GRCm39) Y53C probably damaging Het
Vmn2r22 C A 6: 123,614,295 (GRCm39) A432S probably benign Het
Other mutations in Zfp943
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0019:Zfp943 UTSW 17 22,211,070 (GRCm39) intron probably benign
R0827:Zfp943 UTSW 17 22,211,071 (GRCm39) critical splice acceptor site probably null
R1824:Zfp943 UTSW 17 22,211,361 (GRCm39) missense probably benign 0.32
R1958:Zfp943 UTSW 17 22,211,979 (GRCm39) missense probably damaging 0.99
R2174:Zfp943 UTSW 17 22,211,804 (GRCm39) missense probably damaging 1.00
R3790:Zfp943 UTSW 17 22,211,403 (GRCm39) missense possibly damaging 0.81
R4093:Zfp943 UTSW 17 22,211,963 (GRCm39) missense probably damaging 1.00
R4094:Zfp943 UTSW 17 22,211,963 (GRCm39) missense probably damaging 1.00
R4352:Zfp943 UTSW 17 22,212,104 (GRCm39) missense probably damaging 0.98
R4677:Zfp943 UTSW 17 22,212,176 (GRCm39) missense probably benign 0.17
R4735:Zfp943 UTSW 17 22,211,391 (GRCm39) missense probably benign 0.03
R5201:Zfp943 UTSW 17 22,211,794 (GRCm39) missense probably damaging 1.00
R5492:Zfp943 UTSW 17 22,212,056 (GRCm39) missense probably damaging 1.00
R5642:Zfp943 UTSW 17 22,211,813 (GRCm39) missense probably damaging 1.00
R6031:Zfp943 UTSW 17 22,212,357 (GRCm39) missense probably benign
R6031:Zfp943 UTSW 17 22,212,357 (GRCm39) missense probably benign
R6667:Zfp943 UTSW 17 22,211,889 (GRCm39) missense probably damaging 1.00
R6864:Zfp943 UTSW 17 22,211,593 (GRCm39) missense probably damaging 1.00
R6976:Zfp943 UTSW 17 22,209,922 (GRCm39) missense possibly damaging 0.47
R7837:Zfp943 UTSW 17 22,211,346 (GRCm39) missense probably benign 0.39
R7934:Zfp943 UTSW 17 22,212,361 (GRCm39) missense probably damaging 0.97
R8302:Zfp943 UTSW 17 22,211,091 (GRCm39) missense probably benign 0.18
R8323:Zfp943 UTSW 17 22,211,763 (GRCm39) missense possibly damaging 0.95
R9025:Zfp943 UTSW 17 22,211,321 (GRCm39) missense possibly damaging 0.67
R9101:Zfp943 UTSW 17 22,212,392 (GRCm39) missense possibly damaging 0.83
R9279:Zfp943 UTSW 17 22,209,832 (GRCm39) missense possibly damaging 0.89
R9640:Zfp943 UTSW 17 22,209,899 (GRCm39) missense probably damaging 0.99
Z1176:Zfp943 UTSW 17 22,211,946 (GRCm39) missense probably damaging 1.00
Z1177:Zfp943 UTSW 17 22,207,063 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02