Incidental Mutation 'IGL03103:Tas2r110'
| ID |
418821 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Tas2r110
|
| Ensembl Gene |
ENSMUSG00000062952 |
| Gene Name |
taste receptor, type 2, member 110 |
| Synonyms |
T2R10, mt2r57, Tas2r10, STC 9-1 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.047)
|
| Stock # |
IGL03103
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
132844971-132845972 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 132845443 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Arginine
at position 158
(Q158R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000080674
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000082014]
|
| AlphaFold |
Q7M712 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000082014
AA Change: Q158R
PolyPhen 2
Score 0.091 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000080674
Gene: ENSMUSG00000062952
AA Change: Q158R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
6 |
322 |
3.1e-82 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 29 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Cdc27 |
A |
T |
11: 104,403,806 (GRCm39) |
F652Y |
probably benign |
Het |
| Cntn5 |
T |
C |
9: 9,972,817 (GRCm39) |
|
probably benign |
Het |
| Ctsc |
A |
G |
7: 87,959,013 (GRCm39) |
N431S |
probably benign |
Het |
| Ddi2 |
A |
G |
4: 141,430,479 (GRCm39) |
M235T |
probably damaging |
Het |
| Dgkg |
G |
A |
16: 22,399,275 (GRCm39) |
P220S |
probably damaging |
Het |
| Gpr180 |
A |
T |
14: 118,377,175 (GRCm39) |
I59F |
possibly damaging |
Het |
| Haspin |
A |
T |
11: 73,027,526 (GRCm39) |
V521D |
probably damaging |
Het |
| Itprid1 |
A |
G |
6: 55,945,144 (GRCm39) |
T622A |
possibly damaging |
Het |
| Kif16b |
G |
T |
2: 142,704,408 (GRCm39) |
T57N |
probably damaging |
Het |
| Lmbr1 |
A |
G |
5: 29,440,014 (GRCm39) |
F422S |
probably damaging |
Het |
| Lpcat2b |
A |
T |
5: 107,581,414 (GRCm39) |
N248Y |
probably damaging |
Het |
| Lrch3 |
T |
C |
16: 32,772,507 (GRCm39) |
V163A |
probably damaging |
Het |
| Lrrc49 |
A |
G |
9: 60,592,316 (GRCm39) |
|
probably null |
Het |
| Mon2 |
T |
A |
10: 122,866,008 (GRCm39) |
|
probably benign |
Het |
| Mroh4 |
T |
C |
15: 74,488,008 (GRCm39) |
S374G |
possibly damaging |
Het |
| Nr1h3 |
T |
A |
2: 91,022,360 (GRCm39) |
K89N |
probably damaging |
Het |
| Or4c29 |
A |
T |
2: 88,740,522 (GRCm39) |
S72T |
probably benign |
Het |
| Or52w1 |
A |
G |
7: 105,017,785 (GRCm39) |
D75G |
probably damaging |
Het |
| Or8b49 |
A |
G |
9: 38,505,823 (GRCm39) |
Y102C |
probably damaging |
Het |
| Phldb3 |
C |
T |
7: 24,323,601 (GRCm39) |
P445L |
possibly damaging |
Het |
| Pstpip1 |
G |
T |
9: 56,021,592 (GRCm39) |
V39L |
possibly damaging |
Het |
| Sbf1 |
A |
T |
15: 89,178,150 (GRCm39) |
L1560Q |
probably damaging |
Het |
| Sco1 |
C |
T |
11: 66,946,568 (GRCm39) |
Q114* |
probably null |
Het |
| Slc29a4 |
A |
G |
5: 142,697,835 (GRCm39) |
H96R |
probably damaging |
Het |
| Slitrk6 |
A |
G |
14: 110,987,373 (GRCm39) |
L778P |
probably benign |
Het |
| Tle3 |
A |
G |
9: 61,300,524 (GRCm39) |
I92V |
possibly damaging |
Het |
| Ttn |
T |
A |
2: 76,579,266 (GRCm39) |
M15549L |
possibly damaging |
Het |
| Urb2 |
T |
G |
8: 124,756,491 (GRCm39) |
S733A |
probably benign |
Het |
| Vcl |
T |
C |
14: 21,074,348 (GRCm39) |
W912R |
probably damaging |
Het |
|
| Other mutations in Tas2r110 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL03275:Tas2r110
|
APN |
6 |
132,845,061 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0111:Tas2r110
|
UTSW |
6 |
132,845,166 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0539:Tas2r110
|
UTSW |
6 |
132,845,334 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1432:Tas2r110
|
UTSW |
6 |
132,845,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1672:Tas2r110
|
UTSW |
6 |
132,845,029 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2483:Tas2r110
|
UTSW |
6 |
132,845,433 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3110:Tas2r110
|
UTSW |
6 |
132,844,987 (GRCm39) |
missense |
unknown |
|
|
R3112:Tas2r110
|
UTSW |
6 |
132,844,987 (GRCm39) |
missense |
unknown |
|
|
R3623:Tas2r110
|
UTSW |
6 |
132,845,433 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3847:Tas2r110
|
UTSW |
6 |
132,845,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3849:Tas2r110
|
UTSW |
6 |
132,845,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3850:Tas2r110
|
UTSW |
6 |
132,845,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4871:Tas2r110
|
UTSW |
6 |
132,845,091 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5010:Tas2r110
|
UTSW |
6 |
132,845,438 (GRCm39) |
nonsense |
probably null |
|
|
R5108:Tas2r110
|
UTSW |
6 |
132,845,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5289:Tas2r110
|
UTSW |
6 |
132,844,972 (GRCm39) |
start codon destroyed |
probably null |
|
|
R5938:Tas2r110
|
UTSW |
6 |
132,845,016 (GRCm39) |
missense |
probably benign |
0.39 |
|
R6262:Tas2r110
|
UTSW |
6 |
132,845,638 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6286:Tas2r110
|
UTSW |
6 |
132,845,490 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6582:Tas2r110
|
UTSW |
6 |
132,845,248 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7236:Tas2r110
|
UTSW |
6 |
132,845,667 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R8897:Tas2r110
|
UTSW |
6 |
132,845,374 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0024:Tas2r110
|
UTSW |
6 |
132,845,596 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tas2r110
|
UTSW |
6 |
132,845,574 (GRCm39) |
missense |
probably benign |
0.37 |
|
| Posted On |
2016-08-02 |
Incidental Mutation