Incidental Mutation 'IGL03104:Zmym2'
ID 418850
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zmym2
Ensembl Gene ENSMUSG00000021945
Gene Name zinc finger, MYM-type 2
Synonyms SCLL, RAMP, Zfp198, FIM, MYM
Accession Numbers
Essential gene? Possibly essential (E-score: 0.569) question?
Stock # IGL03104
Quality Score
Status
Chromosome 14
Chromosomal Location 57123986-57199815 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 57187784 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 1150 (E1150G)
Ref Sequence ENSEMBL: ENSMUSP00000022511 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022511]
AlphaFold Q9CU65
Predicted Effect possibly damaging
Transcript: ENSMUST00000022511
AA Change: E1150G

PolyPhen 2 Score 0.876 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000022511
Gene: ENSMUSG00000021945
AA Change: E1150G

DomainStartEndE-ValueType
TRASH 330 366 1.55e-5 SMART
TRASH 372 412 7.69e-1 SMART
TRASH 424 459 7.5e1 SMART
TRASH 466 505 6.53e-4 SMART
Pfam:zf-FCS 527 569 1.8e-9 PFAM
TRASH 583 619 4.79e1 SMART
TRASH 638 674 8.49e-3 SMART
TRASH 680 715 7.28e-2 SMART
TRASH 726 761 1.95e-2 SMART
TRASH 767 802 3.89e1 SMART
low complexity region 881 895 N/A INTRINSIC
low complexity region 904 917 N/A INTRINSIC
low complexity region 1087 1111 N/A INTRINSIC
Pfam:DUF3504 1191 1359 7.3e-66 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223965
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224922
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225282
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226025
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a protein that contains nine MYM-type zinc finger motifs. Expression of this gene may mediate the inhibition of hematopoietic cell development during ontogeny, and the encoded protein may also play a role in transforming growth factor-beta signaling as a Smad binding protein. [provided by RefSeq, Feb 2011]
PHENOTYPE: Mice homozygous for an ENU-induced mutation exhibit prenatal lethality. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aox1 C A 1: 58,321,918 (GRCm39) T70K probably benign Het
Armt1 T A 10: 4,389,615 (GRCm39) Y91N possibly damaging Het
Atp1a2 A G 1: 172,120,934 (GRCm39) L46S probably damaging Het
Baz1a A G 12: 54,941,743 (GRCm39) S1488P probably damaging Het
Coro7 T A 16: 4,446,990 (GRCm39) E793V probably damaging Het
Ctnnbl1 G T 2: 157,732,885 (GRCm39) R555L probably damaging Het
Dclk2 A G 3: 86,743,666 (GRCm39) C268R probably damaging Het
Dock7 A T 4: 98,847,260 (GRCm39) M1684K possibly damaging Het
Dock8 T A 19: 25,178,384 (GRCm39) C2092* probably null Het
Dtx1 T A 5: 120,833,030 (GRCm39) Q136L possibly damaging Het
Egln3 C T 12: 54,249,981 (GRCm39) probably benign Het
Eml5 A T 12: 98,827,504 (GRCm39) Y575* probably null Het
Entpd5 A T 12: 84,431,022 (GRCm39) V310E probably damaging Het
Fkbp5 A G 17: 28,634,946 (GRCm39) F188L probably damaging Het
Frrs1 T C 3: 116,675,431 (GRCm39) S120P probably benign Het
Gadl1 T C 9: 115,903,108 (GRCm39) I479T possibly damaging Het
Gfra2 A T 14: 71,205,725 (GRCm39) M106L probably benign Het
Gm17455 T A 10: 60,239,060 (GRCm39) C108* probably null Het
Grhpr A G 4: 44,983,867 (GRCm39) probably benign Het
Hsp90ab1 G A 17: 45,882,449 (GRCm39) R82C probably damaging Het
Igsf10 T C 3: 59,226,905 (GRCm39) Y2256C probably damaging Het
Ivd A T 2: 118,703,384 (GRCm39) I160F probably benign Het
Krtap5-5 A G 7: 141,783,450 (GRCm39) C67R unknown Het
Lhx4 A T 1: 155,580,967 (GRCm39) V186E probably damaging Het
Lrrk2 T C 15: 91,631,958 (GRCm39) I1294T possibly damaging Het
Map3k5 C T 10: 20,007,801 (GRCm39) S1202L probably benign Het
Mdfic T A 6: 15,770,319 (GRCm39) N108K probably damaging Het
Mov10 G A 3: 104,704,623 (GRCm39) R763W probably damaging Het
Mto1 T C 9: 78,356,802 (GRCm39) S106P probably damaging Het
Naca C T 10: 127,876,233 (GRCm39) probably benign Het
Or10j27 A G 1: 172,958,526 (GRCm39) V86A probably benign Het
Or8s10 A G 15: 98,336,127 (GRCm39) Y259C possibly damaging Het
Pan2 T C 10: 128,151,532 (GRCm39) probably benign Het
Pold1 T C 7: 44,190,004 (GRCm39) Y394C probably damaging Het
Sipa1l1 T A 12: 82,388,904 (GRCm39) S377T probably benign Het
Sirpd G T 3: 15,397,283 (GRCm39) probably benign Het
Slc36a3 A G 11: 55,015,946 (GRCm39) S403P probably damaging Het
Slc4a4 A G 5: 89,297,231 (GRCm39) T480A probably damaging Het
Slu7 G A 11: 43,332,883 (GRCm39) V315I probably benign Het
St6galnac3 T C 3: 152,911,115 (GRCm39) E282G probably damaging Het
Tlr12 A G 4: 128,509,685 (GRCm39) V855A probably benign Het
Tut7 T C 13: 59,962,717 (GRCm39) D350G probably benign Het
Vmn1r53 T A 6: 90,200,944 (GRCm39) K127* probably null Het
Vmn1r72 T G 7: 11,403,812 (GRCm39) H212P probably damaging Het
Vmn2r86 T A 10: 130,282,501 (GRCm39) Q705L probably damaging Het
Vps33b C T 7: 79,925,831 (GRCm39) R93C probably damaging Het
Wdr91 T A 6: 34,882,491 (GRCm39) E219D probably benign Het
Zan G A 5: 137,461,762 (GRCm39) T1139I unknown Het
Zc3hav1 T A 6: 38,317,278 (GRCm39) K107N probably damaging Het
Other mutations in Zmym2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00516:Zmym2 APN 14 57,185,394 (GRCm39) splice site probably benign
IGL00587:Zmym2 APN 14 57,140,817 (GRCm39) missense possibly damaging 0.86
IGL00736:Zmym2 APN 14 57,140,668 (GRCm39) missense probably benign 0.01
IGL00753:Zmym2 APN 14 57,194,517 (GRCm39) nonsense probably null
IGL01608:Zmym2 APN 14 57,185,472 (GRCm39) missense possibly damaging 0.57
IGL01744:Zmym2 APN 14 57,184,029 (GRCm39) missense probably benign 0.24
IGL02150:Zmym2 APN 14 57,148,526 (GRCm39) splice site probably benign
IGL02186:Zmym2 APN 14 57,180,808 (GRCm39) missense probably benign 0.09
IGL02654:Zmym2 APN 14 57,148,772 (GRCm39) missense probably damaging 1.00
IGL02960:Zmym2 APN 14 57,175,870 (GRCm39) missense probably benign 0.09
IGL03162:Zmym2 APN 14 57,151,500 (GRCm39) missense probably benign 0.24
IGL03356:Zmym2 APN 14 57,194,517 (GRCm39) nonsense probably null
IGL03412:Zmym2 APN 14 57,197,176 (GRCm39) nonsense probably null
R5038_Zmym2_756 UTSW 14 57,193,637 (GRCm39) missense possibly damaging 0.86
R0131:Zmym2 UTSW 14 57,180,715 (GRCm39) missense probably benign
R0131:Zmym2 UTSW 14 57,180,715 (GRCm39) missense probably benign
R0132:Zmym2 UTSW 14 57,180,715 (GRCm39) missense probably benign
R0270:Zmym2 UTSW 14 57,187,141 (GRCm39) splice site probably null
R0834:Zmym2 UTSW 14 57,194,420 (GRCm39) missense probably damaging 1.00
R1071:Zmym2 UTSW 14 57,197,278 (GRCm39) missense possibly damaging 0.93
R1386:Zmym2 UTSW 14 57,150,548 (GRCm39) missense probably damaging 1.00
R1442:Zmym2 UTSW 14 57,180,784 (GRCm39) missense probably damaging 0.99
R1472:Zmym2 UTSW 14 57,148,640 (GRCm39) missense probably benign 0.20
R1595:Zmym2 UTSW 14 57,158,187 (GRCm39) missense probably benign 0.25
R1598:Zmym2 UTSW 14 57,151,524 (GRCm39) missense probably damaging 1.00
R1598:Zmym2 UTSW 14 57,140,226 (GRCm39) missense possibly damaging 0.94
R1916:Zmym2 UTSW 14 57,197,299 (GRCm39) missense probably damaging 1.00
R2261:Zmym2 UTSW 14 57,165,719 (GRCm39) missense probably damaging 1.00
R2393:Zmym2 UTSW 14 57,158,180 (GRCm39) missense probably benign 0.17
R2866:Zmym2 UTSW 14 57,165,705 (GRCm39) missense probably damaging 1.00
R3727:Zmym2 UTSW 14 57,156,806 (GRCm39) splice site probably benign
R3847:Zmym2 UTSW 14 57,158,956 (GRCm39) splice site probably benign
R4043:Zmym2 UTSW 14 57,195,765 (GRCm39) splice site probably benign
R4074:Zmym2 UTSW 14 57,140,461 (GRCm39) missense probably damaging 0.99
R4343:Zmym2 UTSW 14 57,159,019 (GRCm39) missense probably damaging 0.99
R4420:Zmym2 UTSW 14 57,194,335 (GRCm39) missense probably damaging 0.98
R4645:Zmym2 UTSW 14 57,165,764 (GRCm39) missense probably damaging 1.00
R5015:Zmym2 UTSW 14 57,159,051 (GRCm39) missense probably damaging 1.00
R5038:Zmym2 UTSW 14 57,193,637 (GRCm39) missense possibly damaging 0.86
R5223:Zmym2 UTSW 14 57,183,971 (GRCm39) missense probably benign
R5364:Zmym2 UTSW 14 57,158,102 (GRCm39) missense possibly damaging 0.58
R5488:Zmym2 UTSW 14 57,193,712 (GRCm39) missense possibly damaging 0.56
R5489:Zmym2 UTSW 14 57,193,712 (GRCm39) missense possibly damaging 0.56
R5818:Zmym2 UTSW 14 57,183,986 (GRCm39) missense probably benign
R6160:Zmym2 UTSW 14 57,187,766 (GRCm39) missense probably damaging 1.00
R6437:Zmym2 UTSW 14 57,140,461 (GRCm39) missense probably damaging 1.00
R7107:Zmym2 UTSW 14 57,140,169 (GRCm39) missense probably benign 0.01
R7153:Zmym2 UTSW 14 57,187,659 (GRCm39) missense probably benign 0.16
R7337:Zmym2 UTSW 14 57,181,557 (GRCm39) missense probably benign 0.04
R7535:Zmym2 UTSW 14 57,194,536 (GRCm39) missense probably damaging 1.00
R7730:Zmym2 UTSW 14 57,193,638 (GRCm39) missense possibly damaging 0.95
R7779:Zmym2 UTSW 14 57,165,740 (GRCm39) missense probably damaging 1.00
R7849:Zmym2 UTSW 14 57,184,020 (GRCm39) missense probably benign 0.03
R8219:Zmym2 UTSW 14 57,163,316 (GRCm39) missense probably benign 0.07
R8493:Zmym2 UTSW 14 57,151,606 (GRCm39) missense probably damaging 1.00
R8885:Zmym2 UTSW 14 57,185,329 (GRCm39) intron probably benign
R9162:Zmym2 UTSW 14 57,163,361 (GRCm39) missense probably benign 0.02
R9165:Zmym2 UTSW 14 57,185,464 (GRCm39) missense probably damaging 0.98
R9250:Zmym2 UTSW 14 57,148,732 (GRCm39) missense probably damaging 1.00
R9453:Zmym2 UTSW 14 57,180,770 (GRCm39) missense probably damaging 1.00
R9677:Zmym2 UTSW 14 57,187,115 (GRCm39) missense probably benign 0.01
Z1176:Zmym2 UTSW 14 57,150,456 (GRCm39) missense possibly damaging 0.94
Z1177:Zmym2 UTSW 14 57,151,419 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02