Incidental Mutation 'IGL03104:Olfr1408'
ID 418851
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1408
Ensembl Gene ENSMUSG00000062527
Gene Name olfactory receptor 1408
Synonyms MOR267-4, GA_x6K02T2R7CC-715776-716708
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # IGL03104
Quality Score
Status
Chromosome 1
Chromosomal Location 173128049-173137374 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 173130959 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 86 (V86A)
Ref Sequence ENSEMBL: ENSMUSP00000143864 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073663] [ENSMUST00000200689]
AlphaFold Q8VG32
Predicted Effect probably benign
Transcript: ENSMUST00000073663
AA Change: V86A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000073345
Gene: ENSMUSG00000062527
AA Change: V86A

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.5e-55 PFAM
Pfam:7tm_1 41 289 9.4e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000200689
AA Change: V86A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000143864
Gene: ENSMUSG00000062527
AA Change: V86A

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.5e-55 PFAM
Pfam:7tm_1 41 289 9.4e-19 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aox2 C A 1: 58,282,759 T70K probably benign Het
Armt1 T A 10: 4,439,615 Y91N possibly damaging Het
Atp1a2 A G 1: 172,293,367 L46S probably damaging Het
Baz1a A G 12: 54,894,958 S1488P probably damaging Het
Coro7 T A 16: 4,629,126 E793V probably damaging Het
Ctnnbl1 G T 2: 157,890,965 R555L probably damaging Het
Dclk2 A G 3: 86,836,359 C268R probably damaging Het
Dock7 A T 4: 98,959,023 M1684K possibly damaging Het
Dock8 T A 19: 25,201,020 C2092* probably null Het
Dtx1 T A 5: 120,694,965 Q136L possibly damaging Het
Egln3 C T 12: 54,203,195 probably benign Het
Eml5 A T 12: 98,861,245 Y575* probably null Het
Entpd5 A T 12: 84,384,248 V310E probably damaging Het
Fkbp5 A G 17: 28,415,972 F188L probably damaging Het
Frrs1 T C 3: 116,881,782 S120P probably benign Het
Gadl1 T C 9: 116,074,040 I479T possibly damaging Het
Gfra2 A T 14: 70,968,285 M106L probably benign Het
Gm17455 T A 10: 60,403,281 C108* probably null Het
Gm9733 G T 3: 15,332,223 probably benign Het
Grhpr A G 4: 44,983,867 probably benign Het
Hsp90ab1 G A 17: 45,571,523 R82C probably damaging Het
Igsf10 T C 3: 59,319,484 Y2256C probably damaging Het
Ivd A T 2: 118,872,903 I160F probably benign Het
Krtap5-5 A G 7: 142,229,713 C67R unknown Het
Lhx4 A T 1: 155,705,221 V186E probably damaging Het
Lrrk2 T C 15: 91,747,755 I1294T possibly damaging Het
Map3k5 C T 10: 20,132,055 S1202L probably benign Het
Mdfic T A 6: 15,770,320 N108K probably damaging Het
Mov10 G A 3: 104,797,307 R763W probably damaging Het
Mto1 T C 9: 78,449,520 S106P probably damaging Het
Naca C T 10: 128,040,364 probably benign Het
Olfr282 A G 15: 98,438,246 Y259C possibly damaging Het
Pan2 T C 10: 128,315,663 probably benign Het
Pold1 T C 7: 44,540,580 Y394C probably damaging Het
Sipa1l1 T A 12: 82,342,130 S377T probably benign Het
Slc36a3 A G 11: 55,125,120 S403P probably damaging Het
Slc4a4 A G 5: 89,149,372 T480A probably damaging Het
Slu7 G A 11: 43,442,056 V315I probably benign Het
St6galnac3 T C 3: 153,205,478 E282G probably damaging Het
Tlr12 A G 4: 128,615,892 V855A probably benign Het
Vmn1r53 T A 6: 90,223,962 K127* probably null Het
Vmn1r72 T G 7: 11,669,885 H212P probably damaging Het
Vmn2r86 T A 10: 130,446,632 Q705L probably damaging Het
Vps33b C T 7: 80,276,083 R93C probably damaging Het
Wdr91 T A 6: 34,905,556 E219D probably benign Het
Zan G A 5: 137,463,500 T1139I unknown Het
Zc3hav1 T A 6: 38,340,343 K107N probably damaging Het
Zcchc6 T C 13: 59,814,903 D350G probably benign Het
Zmym2 A G 14: 56,950,327 E1150G possibly damaging Het
Other mutations in Olfr1408
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00323:Olfr1408 APN 1 173130411 nonsense probably null
IGL01371:Olfr1408 APN 1 173130531 missense possibly damaging 0.67
IGL01816:Olfr1408 APN 1 173130273 utr 3 prime probably benign
IGL02543:Olfr1408 APN 1 173130334 missense probably damaging 0.99
IGL03183:Olfr1408 APN 1 173130858 missense probably damaging 0.97
R0940:Olfr1408 UTSW 1 173130453 missense probably benign 0.42
R1835:Olfr1408 UTSW 1 173130815 missense probably benign 0.00
R1993:Olfr1408 UTSW 1 173130851 missense possibly damaging 0.65
R1994:Olfr1408 UTSW 1 173130851 missense possibly damaging 0.65
R4438:Olfr1408 UTSW 1 173130302 missense probably benign 0.02
R4948:Olfr1408 UTSW 1 173130959 missense probably benign 0.00
R5088:Olfr1408 UTSW 1 173131039 missense probably damaging 1.00
R5117:Olfr1408 UTSW 1 173130917 missense possibly damaging 0.91
R5118:Olfr1408 UTSW 1 173130917 missense possibly damaging 0.91
R5344:Olfr1408 UTSW 1 173131106 missense probably benign 0.16
R8176:Olfr1408 UTSW 1 173130816 missense probably benign 0.00
X0018:Olfr1408 UTSW 1 173130699 missense probably benign 0.02
Posted On 2016-08-02