Incidental Mutation 'IGL03104:Or8s10'
ID 418862
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or8s10
Ensembl Gene ENSMUSG00000063780
Gene Name olfactory receptor family 8 subfamily S member 1
Synonyms MOR160-2, Olfr282, GA_x6K02T2NBG7-5293798-5292872
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # IGL03104
Quality Score
Status
Chromosome 15
Chromosomal Location 98335351-98336278 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 98336127 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 259 (Y259C)
Ref Sequence ENSEMBL: ENSMUSP00000151156 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075851] [ENSMUST00000205491] [ENSMUST00000213608] [ENSMUST00000215320]
AlphaFold A1L1B4
Predicted Effect possibly damaging
Transcript: ENSMUST00000075851
AA Change: Y259C

PolyPhen 2 Score 0.926 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000075248
Gene: ENSMUSG00000063780
AA Change: Y259C

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 7.6e-55 PFAM
Pfam:7TM_GPCR_Srsx 35 217 5.7e-6 PFAM
Pfam:7tm_1 41 288 2.2e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205491
Predicted Effect possibly damaging
Transcript: ENSMUST00000213608
AA Change: Y259C

PolyPhen 2 Score 0.926 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000215320
AA Change: Y259C

PolyPhen 2 Score 0.926 (Sensitivity: 0.81; Specificity: 0.94)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aox1 C A 1: 58,321,918 (GRCm39) T70K probably benign Het
Armt1 T A 10: 4,389,615 (GRCm39) Y91N possibly damaging Het
Atp1a2 A G 1: 172,120,934 (GRCm39) L46S probably damaging Het
Baz1a A G 12: 54,941,743 (GRCm39) S1488P probably damaging Het
Coro7 T A 16: 4,446,990 (GRCm39) E793V probably damaging Het
Ctnnbl1 G T 2: 157,732,885 (GRCm39) R555L probably damaging Het
Dclk2 A G 3: 86,743,666 (GRCm39) C268R probably damaging Het
Dock7 A T 4: 98,847,260 (GRCm39) M1684K possibly damaging Het
Dock8 T A 19: 25,178,384 (GRCm39) C2092* probably null Het
Dtx1 T A 5: 120,833,030 (GRCm39) Q136L possibly damaging Het
Egln3 C T 12: 54,249,981 (GRCm39) probably benign Het
Eml5 A T 12: 98,827,504 (GRCm39) Y575* probably null Het
Entpd5 A T 12: 84,431,022 (GRCm39) V310E probably damaging Het
Fkbp5 A G 17: 28,634,946 (GRCm39) F188L probably damaging Het
Frrs1 T C 3: 116,675,431 (GRCm39) S120P probably benign Het
Gadl1 T C 9: 115,903,108 (GRCm39) I479T possibly damaging Het
Gfra2 A T 14: 71,205,725 (GRCm39) M106L probably benign Het
Gm17455 T A 10: 60,239,060 (GRCm39) C108* probably null Het
Grhpr A G 4: 44,983,867 (GRCm39) probably benign Het
Hsp90ab1 G A 17: 45,882,449 (GRCm39) R82C probably damaging Het
Igsf10 T C 3: 59,226,905 (GRCm39) Y2256C probably damaging Het
Ivd A T 2: 118,703,384 (GRCm39) I160F probably benign Het
Krtap5-5 A G 7: 141,783,450 (GRCm39) C67R unknown Het
Lhx4 A T 1: 155,580,967 (GRCm39) V186E probably damaging Het
Lrrk2 T C 15: 91,631,958 (GRCm39) I1294T possibly damaging Het
Map3k5 C T 10: 20,007,801 (GRCm39) S1202L probably benign Het
Mdfic T A 6: 15,770,319 (GRCm39) N108K probably damaging Het
Mov10 G A 3: 104,704,623 (GRCm39) R763W probably damaging Het
Mto1 T C 9: 78,356,802 (GRCm39) S106P probably damaging Het
Naca C T 10: 127,876,233 (GRCm39) probably benign Het
Or10j27 A G 1: 172,958,526 (GRCm39) V86A probably benign Het
Pan2 T C 10: 128,151,532 (GRCm39) probably benign Het
Pold1 T C 7: 44,190,004 (GRCm39) Y394C probably damaging Het
Sipa1l1 T A 12: 82,388,904 (GRCm39) S377T probably benign Het
Sirpd G T 3: 15,397,283 (GRCm39) probably benign Het
Slc36a3 A G 11: 55,015,946 (GRCm39) S403P probably damaging Het
Slc4a4 A G 5: 89,297,231 (GRCm39) T480A probably damaging Het
Slu7 G A 11: 43,332,883 (GRCm39) V315I probably benign Het
St6galnac3 T C 3: 152,911,115 (GRCm39) E282G probably damaging Het
Tlr12 A G 4: 128,509,685 (GRCm39) V855A probably benign Het
Tut7 T C 13: 59,962,717 (GRCm39) D350G probably benign Het
Vmn1r53 T A 6: 90,200,944 (GRCm39) K127* probably null Het
Vmn1r72 T G 7: 11,403,812 (GRCm39) H212P probably damaging Het
Vmn2r86 T A 10: 130,282,501 (GRCm39) Q705L probably damaging Het
Vps33b C T 7: 79,925,831 (GRCm39) R93C probably damaging Het
Wdr91 T A 6: 34,882,491 (GRCm39) E219D probably benign Het
Zan G A 5: 137,461,762 (GRCm39) T1139I unknown Het
Zc3hav1 T A 6: 38,317,278 (GRCm39) K107N probably damaging Het
Zmym2 A G 14: 57,187,784 (GRCm39) E1150G possibly damaging Het
Other mutations in Or8s10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01813:Or8s10 APN 15 98,335,530 (GRCm39) missense possibly damaging 0.95
IGL02724:Or8s10 APN 15 98,335,660 (GRCm39) missense probably benign 0.09
R0611:Or8s10 UTSW 15 98,336,168 (GRCm39) missense possibly damaging 0.95
R3008:Or8s10 UTSW 15 98,335,857 (GRCm39) missense probably damaging 1.00
R4093:Or8s10 UTSW 15 98,335,563 (GRCm39) missense probably damaging 1.00
R4094:Or8s10 UTSW 15 98,335,563 (GRCm39) missense probably damaging 1.00
R4095:Or8s10 UTSW 15 98,335,563 (GRCm39) missense probably damaging 1.00
R4579:Or8s10 UTSW 15 98,335,560 (GRCm39) missense probably damaging 1.00
R4647:Or8s10 UTSW 15 98,335,457 (GRCm39) missense probably benign 0.00
R5290:Or8s10 UTSW 15 98,336,213 (GRCm39) missense probably damaging 1.00
R7991:Or8s10 UTSW 15 98,335,419 (GRCm39) missense probably benign 0.00
R8927:Or8s10 UTSW 15 98,336,519 (GRCm39) splice site probably benign
R9208:Or8s10 UTSW 15 98,335,614 (GRCm39) missense probably benign
Posted On 2016-08-02