Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03104:Gm17455'

418878

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm17455

Ensembl Gene

ENSMUSG00000090439

Gene Name

predicted gene, 17455

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.136) question?

Stock #

IGL03104

Quality Score

Status

Chromosome

Chromosomal Location

60399726-60403559 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 60403281 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 108 (C108*)

Ref Sequence

ENSEMBL: ENSMUSP00000129705 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000073242] [ENSMUST00000105461] [ENSMUST00000105462] [ENSMUST00000105463] [ENSMUST00000105464] [ENSMUST00000164428]

AlphaFold

G3UW87

Predicted Effect

probably benign
Transcript: ENSMUST00000073242

SMART Domains

Protein: ENSMUSP00000072973
Gene: ENSMUSG00000012819

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
CA	55	130	5.15e-13	SMART
CA	154	234	3.19e-18	SMART
CA	258	346	2.03e-11	SMART
CA	371	458	8.11e-11	SMART
CA	482	559	1.04e-22	SMART
CA	583	669	3.55e-25	SMART
CA	693	776	2.04e-25	SMART
CA	800	888	5.03e-16	SMART
CA	912	993	1.05e-27	SMART
CA	1017	1100	1.99e-19	SMART
CA	1124	1206	6.94e-19	SMART
CA	1231	1311	1.99e-19	SMART
CA	1335	1415	1.21e-18	SMART
CA	1440	1524	2.38e-26	SMART
CA	1549	1631	6.27e-26	SMART
CA	1656	1741	6.99e-24	SMART
CA	1765	1848	3.49e-24	SMART
CA	1872	1956	2.78e-18	SMART
CA	1984	2066	5.6e-14	SMART
CA	2090	2171	2.59e-27	SMART
CA	2195	2290	2.87e-11	SMART
CA	2317	2399	1.01e-20	SMART
CA	2423	2506	1.09e-25	SMART
CA	2530	2608	7.91e-23	SMART
CA	2634	2719	1.06e-23	SMART
CA	2750	2843	2e-10	SMART
Blast:CA	2867	2956	4e-51	BLAST
transmembrane domain	3067	3089	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000105461

SMART Domains

Protein: ENSMUSP00000101101
Gene: ENSMUSG00000012819

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
CA	55	130	5.15e-13	SMART
CA	154	234	3.19e-18	SMART
CA	258	346	2.03e-11	SMART
CA	371	458	1.25e-11	SMART
CA	482	559	1.04e-22	SMART
CA	583	669	3.55e-25	SMART
CA	693	776	2.04e-25	SMART
CA	800	888	5.03e-16	SMART
CA	912	993	1.05e-27	SMART
CA	1017	1100	1.99e-19	SMART
CA	1124	1206	6.94e-19	SMART
CA	1231	1311	1.99e-19	SMART
CA	1335	1416	5.26e-19	SMART
CA	1441	1525	2.38e-26	SMART
CA	1550	1632	6.27e-26	SMART
CA	1657	1742	6.99e-24	SMART
CA	1766	1849	3.49e-24	SMART
CA	1873	1957	2.78e-18	SMART
CA	1985	2067	5.6e-14	SMART
CA	2091	2172	2.59e-27	SMART
CA	2196	2291	2.87e-11	SMART
CA	2318	2400	1.01e-20	SMART
CA	2424	2507	1.09e-25	SMART
CA	2531	2609	7.91e-23	SMART
CA	2635	2720	1.06e-23	SMART
CA	2751	2844	2e-10	SMART
Blast:CA	2868	2957	4e-51	BLAST
transmembrane domain	3068	3090	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000105462

SMART Domains

Protein: ENSMUSP00000101102
Gene: ENSMUSG00000012819

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
CA	55	130	5.15e-13	SMART
CA	154	234	3.19e-18	SMART
CA	261	349	2.03e-11	SMART
CA	374	461	8.11e-11	SMART
CA	485	562	1.04e-22	SMART
CA	586	672	3.55e-25	SMART
CA	696	779	2.04e-25	SMART
CA	803	891	5.03e-16	SMART
CA	915	996	1.05e-27	SMART
CA	1020	1103	1.99e-19	SMART
CA	1127	1209	6.94e-19	SMART
CA	1234	1314	1.99e-19	SMART
CA	1338	1418	1.21e-18	SMART
CA	1443	1527	2.38e-26	SMART
CA	1552	1634	6.27e-26	SMART
CA	1659	1744	6.99e-24	SMART
CA	1768	1851	3.49e-24	SMART
CA	1875	1959	2.78e-18	SMART
CA	1987	2069	5.6e-14	SMART
CA	2093	2174	2.59e-27	SMART
CA	2198	2293	2.87e-11	SMART
CA	2320	2402	1.01e-20	SMART
CA	2426	2509	1.09e-25	SMART
CA	2533	2611	7.91e-23	SMART
CA	2637	2722	1.06e-23	SMART
CA	2753	2846	2e-10	SMART
Blast:CA	2870	2959	4e-51	BLAST
transmembrane domain	3070	3092	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000105463

SMART Domains

Protein: ENSMUSP00000101103
Gene: ENSMUSG00000012819

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
CA	55	130	5.15e-13	SMART
CA	154	234	3.19e-18	SMART
CA	258	346	2.03e-11	SMART
CA	371	458	1.25e-11	SMART
CA	482	559	1.04e-22	SMART
CA	583	669	3.55e-25	SMART
CA	693	776	2.04e-25	SMART
CA	800	888	5.03e-16	SMART
CA	912	993	1.05e-27	SMART
CA	1017	1100	1.99e-19	SMART
CA	1124	1206	6.94e-19	SMART
CA	1231	1311	1.99e-19	SMART
CA	1335	1416	5.26e-19	SMART
CA	1441	1525	2.38e-26	SMART
CA	1550	1632	6.27e-26	SMART
CA	1657	1742	6.99e-24	SMART
CA	1766	1849	3.49e-24	SMART
CA	1873	1957	2.78e-18	SMART
CA	1985	2067	5.6e-14	SMART
CA	2091	2172	2.59e-27	SMART
CA	2196	2291	2.87e-11	SMART
CA	2318	2400	1.01e-20	SMART
CA	2424	2507	1.09e-25	SMART
CA	2531	2609	7.91e-23	SMART
CA	2635	2720	1.06e-23	SMART
CA	2751	2844	2e-10	SMART
Blast:CA	2868	2957	4e-51	BLAST
transmembrane domain	3068	3090	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000105464

SMART Domains

Protein: ENSMUSP00000101104
Gene: ENSMUSG00000012819

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
CA	55	130	5.15e-13	SMART
CA	154	234	3.19e-18	SMART
CA	258	346	2.03e-11	SMART
CA	371	456	3.58e-12	SMART
CA	480	557	1.04e-22	SMART
CA	581	667	3.55e-25	SMART
CA	691	774	2.04e-25	SMART
CA	798	886	5.03e-16	SMART
CA	910	991	1.05e-27	SMART
CA	1015	1098	1.99e-19	SMART
CA	1122	1204	6.94e-19	SMART
CA	1229	1309	1.99e-19	SMART
CA	1333	1414	5.26e-19	SMART
CA	1439	1523	2.38e-26	SMART
CA	1548	1630	6.27e-26	SMART
CA	1655	1740	6.99e-24	SMART
CA	1764	1847	3.49e-24	SMART
CA	1871	1955	2.78e-18	SMART
CA	1983	2065	5.6e-14	SMART
CA	2089	2170	2.59e-27	SMART
CA	2194	2289	2.87e-11	SMART
CA	2316	2398	1.01e-20	SMART
CA	2422	2505	1.09e-25	SMART
CA	2529	2607	7.91e-23	SMART
CA	2633	2718	1.06e-23	SMART
CA	2749	2842	2e-10	SMART
Blast:CA	2866	2955	3e-51	BLAST
transmembrane domain	3066	3088	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000128249

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000135638

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000144462

Predicted Effect

probably null
Transcript: ENSMUST00000164428
AA Change: C108*

SMART Domains

Protein: ENSMUSP00000129705
Gene: ENSMUSG00000090439
AA Change: C108*

Domain	Start	End	E-Value	Type
SCOP:d1ji1a3	36	101	7e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000218360

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000218974

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000219863

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aox2	C	A	1: 58,282,759	T70K	probably benign	Het
Armt1	T	A	10: 4,439,615	Y91N	possibly damaging	Het
Atp1a2	A	G	1: 172,293,367	L46S	probably damaging	Het
Baz1a	A	G	12: 54,894,958	S1488P	probably damaging	Het
Coro7	T	A	16: 4,629,126	E793V	probably damaging	Het
Ctnnbl1	G	T	2: 157,890,965	R555L	probably damaging	Het
Dclk2	A	G	3: 86,836,359	C268R	probably damaging	Het
Dock7	A	T	4: 98,959,023	M1684K	possibly damaging	Het
Dock8	T	A	19: 25,201,020	C2092*	probably null	Het
Dtx1	T	A	5: 120,694,965	Q136L	possibly damaging	Het
Egln3	C	T	12: 54,203,195		probably benign	Het
Eml5	A	T	12: 98,861,245	Y575*	probably null	Het
Entpd5	A	T	12: 84,384,248	V310E	probably damaging	Het
Fkbp5	A	G	17: 28,415,972	F188L	probably damaging	Het
Frrs1	T	C	3: 116,881,782	S120P	probably benign	Het
Gadl1	T	C	9: 116,074,040	I479T	possibly damaging	Het
Gfra2	A	T	14: 70,968,285	M106L	probably benign	Het
Gm9733	G	T	3: 15,332,223		probably benign	Het
Grhpr	A	G	4: 44,983,867		probably benign	Het
Hsp90ab1	G	A	17: 45,571,523	R82C	probably damaging	Het
Igsf10	T	C	3: 59,319,484	Y2256C	probably damaging	Het
Ivd	A	T	2: 118,872,903	I160F	probably benign	Het
Krtap5-5	A	G	7: 142,229,713	C67R	unknown	Het
Lhx4	A	T	1: 155,705,221	V186E	probably damaging	Het
Lrrk2	T	C	15: 91,747,755	I1294T	possibly damaging	Het
Map3k5	C	T	10: 20,132,055	S1202L	probably benign	Het
Mdfic	T	A	6: 15,770,320	N108K	probably damaging	Het
Mov10	G	A	3: 104,797,307	R763W	probably damaging	Het
Mto1	T	C	9: 78,449,520	S106P	probably damaging	Het
Naca	C	T	10: 128,040,364		probably benign	Het
Olfr1408	A	G	1: 173,130,959	V86A	probably benign	Het
Olfr282	A	G	15: 98,438,246	Y259C	possibly damaging	Het
Pan2	T	C	10: 128,315,663		probably benign	Het
Pold1	T	C	7: 44,540,580	Y394C	probably damaging	Het
Sipa1l1	T	A	12: 82,342,130	S377T	probably benign	Het
Slc36a3	A	G	11: 55,125,120	S403P	probably damaging	Het
Slc4a4	A	G	5: 89,149,372	T480A	probably damaging	Het
Slu7	G	A	11: 43,442,056	V315I	probably benign	Het
St6galnac3	T	C	3: 153,205,478	E282G	probably damaging	Het
Tlr12	A	G	4: 128,615,892	V855A	probably benign	Het
Vmn1r53	T	A	6: 90,223,962	K127*	probably null	Het
Vmn1r72	T	G	7: 11,669,885	H212P	probably damaging	Het
Vmn2r86	T	A	10: 130,446,632	Q705L	probably damaging	Het
Vps33b	C	T	7: 80,276,083	R93C	probably damaging	Het
Wdr91	T	A	6: 34,905,556	E219D	probably benign	Het
Zan	G	A	5: 137,463,500	T1139I	unknown	Het
Zc3hav1	T	A	6: 38,340,343	K107N	probably damaging	Het
Zcchc6	T	C	13: 59,814,903	D350G	probably benign	Het
Zmym2	A	G	14: 56,950,327	E1150G	possibly damaging	Het

Other mutations in Gm17455

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02797:Gm17455	APN	10	60403328	missense	possibly damaging	0.82
R0454:Gm17455	UTSW	10	60402973	missense	probably benign	0.01
R0494:Gm17455	UTSW	10	60403235	missense	possibly damaging	0.94
Z1177:Gm17455	UTSW	10	60403015	missense	probably benign

Posted On

2016-08-02