Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03104:Armt1'

418883

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Armt1

Ensembl Gene

ENSMUSG00000061759

Gene Name

acidic residue methyltransferase 1

Synonyms

1700052N19Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.152) question?

Stock #

IGL03104

Quality Score

Status

Chromosome

Chromosomal Location

4382572-4405140 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 4389615 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Asparagine at position 91 (Y91N)

Ref Sequence

ENSEMBL: ENSMUSP00000114073 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095893] [ENSMUST00000117489] [ENSMUST00000118544] [ENSMUST00000152294]

AlphaFold

A6H630

Predicted Effect

possibly damaging
Transcript: ENSMUST00000095893
AA Change: Y91N

PolyPhen 2 Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000093581
Gene: ENSMUSG00000061759
AA Change: Y91N

Domain	Start	End	E-Value	Type
Pfam:DUF89	20	417	1.3e-125	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000117489
AA Change: Y91N

PolyPhen 2 Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000114025
Gene: ENSMUSG00000061759
AA Change: Y91N

Domain	Start	End	E-Value	Type
Pfam:DUF89	20	136	7.2e-25	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000118544
AA Change: Y91N

PolyPhen 2 Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000114073
Gene: ENSMUSG00000061759
AA Change: Y91N

Domain	Start	End	E-Value	Type
Pfam:DUF89	20	187	1.2e-33	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000131636

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134484

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000143037

Predicted Effect

probably benign
Transcript: ENSMUST00000152294

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aox1	C	A	1: 58,321,918 (GRCm39)	T70K	probably benign	Het
Atp1a2	A	G	1: 172,120,934 (GRCm39)	L46S	probably damaging	Het
Baz1a	A	G	12: 54,941,743 (GRCm39)	S1488P	probably damaging	Het
Coro7	T	A	16: 4,446,990 (GRCm39)	E793V	probably damaging	Het
Ctnnbl1	G	T	2: 157,732,885 (GRCm39)	R555L	probably damaging	Het
Dclk2	A	G	3: 86,743,666 (GRCm39)	C268R	probably damaging	Het
Dock7	A	T	4: 98,847,260 (GRCm39)	M1684K	possibly damaging	Het
Dock8	T	A	19: 25,178,384 (GRCm39)	C2092*	probably null	Het
Dtx1	T	A	5: 120,833,030 (GRCm39)	Q136L	possibly damaging	Het
Egln3	C	T	12: 54,249,981 (GRCm39)		probably benign	Het
Eml5	A	T	12: 98,827,504 (GRCm39)	Y575*	probably null	Het
Entpd5	A	T	12: 84,431,022 (GRCm39)	V310E	probably damaging	Het
Fkbp5	A	G	17: 28,634,946 (GRCm39)	F188L	probably damaging	Het
Frrs1	T	C	3: 116,675,431 (GRCm39)	S120P	probably benign	Het
Gadl1	T	C	9: 115,903,108 (GRCm39)	I479T	possibly damaging	Het
Gfra2	A	T	14: 71,205,725 (GRCm39)	M106L	probably benign	Het
Gm17455	T	A	10: 60,239,060 (GRCm39)	C108*	probably null	Het
Grhpr	A	G	4: 44,983,867 (GRCm39)		probably benign	Het
Hsp90ab1	G	A	17: 45,882,449 (GRCm39)	R82C	probably damaging	Het
Igsf10	T	C	3: 59,226,905 (GRCm39)	Y2256C	probably damaging	Het
Ivd	A	T	2: 118,703,384 (GRCm39)	I160F	probably benign	Het
Krtap5-5	A	G	7: 141,783,450 (GRCm39)	C67R	unknown	Het
Lhx4	A	T	1: 155,580,967 (GRCm39)	V186E	probably damaging	Het
Lrrk2	T	C	15: 91,631,958 (GRCm39)	I1294T	possibly damaging	Het
Map3k5	C	T	10: 20,007,801 (GRCm39)	S1202L	probably benign	Het
Mdfic	T	A	6: 15,770,319 (GRCm39)	N108K	probably damaging	Het
Mov10	G	A	3: 104,704,623 (GRCm39)	R763W	probably damaging	Het
Mto1	T	C	9: 78,356,802 (GRCm39)	S106P	probably damaging	Het
Naca	C	T	10: 127,876,233 (GRCm39)		probably benign	Het
Or10j27	A	G	1: 172,958,526 (GRCm39)	V86A	probably benign	Het
Or8s10	A	G	15: 98,336,127 (GRCm39)	Y259C	possibly damaging	Het
Pan2	T	C	10: 128,151,532 (GRCm39)		probably benign	Het
Pold1	T	C	7: 44,190,004 (GRCm39)	Y394C	probably damaging	Het
Sipa1l1	T	A	12: 82,388,904 (GRCm39)	S377T	probably benign	Het
Sirpd	G	T	3: 15,397,283 (GRCm39)		probably benign	Het
Slc36a3	A	G	11: 55,015,946 (GRCm39)	S403P	probably damaging	Het
Slc4a4	A	G	5: 89,297,231 (GRCm39)	T480A	probably damaging	Het
Slu7	G	A	11: 43,332,883 (GRCm39)	V315I	probably benign	Het
St6galnac3	T	C	3: 152,911,115 (GRCm39)	E282G	probably damaging	Het
Tlr12	A	G	4: 128,509,685 (GRCm39)	V855A	probably benign	Het
Tut7	T	C	13: 59,962,717 (GRCm39)	D350G	probably benign	Het
Vmn1r53	T	A	6: 90,200,944 (GRCm39)	K127*	probably null	Het
Vmn1r72	T	G	7: 11,403,812 (GRCm39)	H212P	probably damaging	Het
Vmn2r86	T	A	10: 130,282,501 (GRCm39)	Q705L	probably damaging	Het
Vps33b	C	T	7: 79,925,831 (GRCm39)	R93C	probably damaging	Het
Wdr91	T	A	6: 34,882,491 (GRCm39)	E219D	probably benign	Het
Zan	G	A	5: 137,461,762 (GRCm39)	T1139I	unknown	Het
Zc3hav1	T	A	6: 38,317,278 (GRCm39)	K107N	probably damaging	Het
Zmym2	A	G	14: 57,187,784 (GRCm39)	E1150G	possibly damaging	Het

Other mutations in Armt1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00907:Armt1	APN	10	4,454,051 (GRCm38)	missense	possibly damaging	0.50
IGL01018:Armt1	APN	10	4,404,237 (GRCm39)	unclassified	probably benign
IGL01018:Armt1	APN	10	4,400,732 (GRCm39)	missense	probably benign
IGL02198:Armt1	APN	10	4,404,064 (GRCm39)	missense	possibly damaging	0.95
IGL02980:Armt1	APN	10	4,400,643 (GRCm39)	splice site	probably benign
R0620:Armt1	UTSW	10	4,382,689 (GRCm39)	missense	probably benign	0.38
R4248:Armt1	UTSW	10	4,389,687 (GRCm39)	missense	probably benign	0.00
R5709:Armt1	UTSW	10	4,384,903 (GRCm39)	missense	probably damaging	0.97
R6058:Armt1	UTSW	10	4,403,488 (GRCm39)	missense	probably damaging	1.00
R6318:Armt1	UTSW	10	4,400,859 (GRCm39)	missense	probably benign	0.01
R6410:Armt1	UTSW	10	4,403,826 (GRCm39)	missense	probably benign
R6998:Armt1	UTSW	10	4,403,937 (GRCm39)	missense	probably benign	0.03
R7242:Armt1	UTSW	10	4,403,475 (GRCm39)	missense	probably damaging	1.00
R7268:Armt1	UTSW	10	4,400,855 (GRCm39)	missense	possibly damaging	0.75
R7432:Armt1	UTSW	10	4,382,706 (GRCm39)	missense	probably benign	0.00
R7640:Armt1	UTSW	10	4,403,572 (GRCm39)	missense	probably damaging	0.97
R7715:Armt1	UTSW	10	4,400,751 (GRCm39)	missense	probably benign	0.01
R8877:Armt1	UTSW	10	4,400,864 (GRCm39)	missense	possibly damaging	0.66
R8968:Armt1	UTSW	10	4,404,150 (GRCm39)	missense	probably damaging	1.00
R8973:Armt1	UTSW	10	4,389,550 (GRCm39)	missense	probably damaging	0.99
R9096:Armt1	UTSW	10	4,384,829 (GRCm39)	missense	probably damaging	1.00
R9404:Armt1	UTSW	10	4,400,848 (GRCm39)	frame shift	probably null
R9405:Armt1	UTSW	10	4,400,848 (GRCm39)	frame shift	probably null
R9408:Armt1	UTSW	10	4,400,848 (GRCm39)	frame shift	probably null
R9563:Armt1	UTSW	10	4,400,848 (GRCm39)	frame shift	probably null
R9785:Armt1	UTSW	10	4,389,606 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02