Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03104:Mov10'

418888

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mov10

Ensembl Gene

ENSMUSG00000002227

Gene Name

Moloney leukemia virus 10

Synonyms

Mov-10

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.381) question?

Stock #

IGL03104

Quality Score

Status

Chromosome

Chromosomal Location

104794836-104818563 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 104797307 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Tryptophan at position 763 (R763W)

Ref Sequence

ENSEMBL: ENSMUSP00000002297 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000002297] [ENSMUST00000002303] [ENSMUST00000106774] [ENSMUST00000106775] [ENSMUST00000106787] [ENSMUST00000166979] [ENSMUST00000168015] [ENSMUST00000176347] [ENSMUST00000196817] [ENSMUST00000199824]

AlphaFold

P23249

Predicted Effect

probably damaging
Transcript: ENSMUST00000002297
AA Change: R763W

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000002297
Gene: ENSMUSG00000002227
AA Change: R763W

Domain	Start	End	E-Value	Type
low complexity region	297	312	N/A	INTRINSIC
low complexity region	338	353	N/A	INTRINSIC
AAA	517	699	5.72e-3	SMART
low complexity region	953	970	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000002303

SMART Domains

Protein: ENSMUSP00000002303
Gene: ENSMUSG00000002233

Domain	Start	End	E-Value	Type
RHO	8	181	9.45e-130	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000106774

SMART Domains

Protein: ENSMUSP00000102386
Gene: ENSMUSG00000002227

Domain	Start	End	E-Value	Type
low complexity region	297	312	N/A	INTRINSIC
low complexity region	338	353	N/A	INTRINSIC
AAA	517	699	5.72e-3	SMART
low complexity region	953	970	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000106775
AA Change: R836W

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000102387
Gene: ENSMUSG00000002227
AA Change: R836W

Domain	Start	End	E-Value	Type
low complexity region	297	312	N/A	INTRINSIC
low complexity region	338	353	N/A	INTRINSIC
AAA	517	699	5.72e-3	SMART
low complexity region	953	970	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000106787

SMART Domains

Protein: ENSMUSP00000102399
Gene: ENSMUSG00000002233

Domain	Start	End	E-Value	Type
RHO	8	181	9.45e-130	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000132721

Predicted Effect

probably damaging
Transcript: ENSMUST00000166979
AA Change: R836W

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000126897
Gene: ENSMUSG00000002227
AA Change: R836W

Domain	Start	End	E-Value	Type
low complexity region	61	75	N/A	INTRINSIC
low complexity region	370	385	N/A	INTRINSIC
low complexity region	411	426	N/A	INTRINSIC
AAA	590	772	5.72e-3	SMART
low complexity region	1026	1043	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000168015
AA Change: R763W

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000128246
Gene: ENSMUSG00000002227
AA Change: R763W

Domain	Start	End	E-Value	Type
low complexity region	297	312	N/A	INTRINSIC
low complexity region	338	353	N/A	INTRINSIC
AAA	517	699	5.72e-3	SMART
low complexity region	953	970	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000176347

SMART Domains

Protein: ENSMUSP00000135659
Gene: ENSMUSG00000002233

Domain	Start	End	E-Value	Type
RHO	8	148	7.45e-87	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000196817

SMART Domains

Protein: ENSMUSP00000142697
Gene: ENSMUSG00000002233

Domain	Start	End	E-Value	Type
RHO	8	181	9.45e-130	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000199824

SMART Domains

Protein: ENSMUSP00000142855
Gene: ENSMUSG00000002233

Domain	Start	End	E-Value	Type
RHO	8	118	1.4e-68	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous knockout is embryonic lethal. Heterozygous knockout leads to reduced dendritic branching of neurons, which affects anxiety- and/or activity-related behavior. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aox2	C	A	1: 58,282,759	T70K	probably benign	Het
Armt1	T	A	10: 4,439,615	Y91N	possibly damaging	Het
Atp1a2	A	G	1: 172,293,367	L46S	probably damaging	Het
Baz1a	A	G	12: 54,894,958	S1488P	probably damaging	Het
Coro7	T	A	16: 4,629,126	E793V	probably damaging	Het
Ctnnbl1	G	T	2: 157,890,965	R555L	probably damaging	Het
Dclk2	A	G	3: 86,836,359	C268R	probably damaging	Het
Dock7	A	T	4: 98,959,023	M1684K	possibly damaging	Het
Dock8	T	A	19: 25,201,020	C2092*	probably null	Het
Dtx1	T	A	5: 120,694,965	Q136L	possibly damaging	Het
Egln3	C	T	12: 54,203,195		probably benign	Het
Eml5	A	T	12: 98,861,245	Y575*	probably null	Het
Entpd5	A	T	12: 84,384,248	V310E	probably damaging	Het
Fkbp5	A	G	17: 28,415,972	F188L	probably damaging	Het
Frrs1	T	C	3: 116,881,782	S120P	probably benign	Het
Gadl1	T	C	9: 116,074,040	I479T	possibly damaging	Het
Gfra2	A	T	14: 70,968,285	M106L	probably benign	Het
Gm17455	T	A	10: 60,403,281	C108*	probably null	Het
Gm9733	G	T	3: 15,332,223		probably benign	Het
Grhpr	A	G	4: 44,983,867		probably benign	Het
Hsp90ab1	G	A	17: 45,571,523	R82C	probably damaging	Het
Igsf10	T	C	3: 59,319,484	Y2256C	probably damaging	Het
Ivd	A	T	2: 118,872,903	I160F	probably benign	Het
Krtap5-5	A	G	7: 142,229,713	C67R	unknown	Het
Lhx4	A	T	1: 155,705,221	V186E	probably damaging	Het
Lrrk2	T	C	15: 91,747,755	I1294T	possibly damaging	Het
Map3k5	C	T	10: 20,132,055	S1202L	probably benign	Het
Mdfic	T	A	6: 15,770,320	N108K	probably damaging	Het
Mto1	T	C	9: 78,449,520	S106P	probably damaging	Het
Naca	C	T	10: 128,040,364		probably benign	Het
Olfr1408	A	G	1: 173,130,959	V86A	probably benign	Het
Olfr282	A	G	15: 98,438,246	Y259C	possibly damaging	Het
Pan2	T	C	10: 128,315,663		probably benign	Het
Pold1	T	C	7: 44,540,580	Y394C	probably damaging	Het
Sipa1l1	T	A	12: 82,342,130	S377T	probably benign	Het
Slc36a3	A	G	11: 55,125,120	S403P	probably damaging	Het
Slc4a4	A	G	5: 89,149,372	T480A	probably damaging	Het
Slu7	G	A	11: 43,442,056	V315I	probably benign	Het
St6galnac3	T	C	3: 153,205,478	E282G	probably damaging	Het
Tlr12	A	G	4: 128,615,892	V855A	probably benign	Het
Vmn1r53	T	A	6: 90,223,962	K127*	probably null	Het
Vmn1r72	T	G	7: 11,669,885	H212P	probably damaging	Het
Vmn2r86	T	A	10: 130,446,632	Q705L	probably damaging	Het
Vps33b	C	T	7: 80,276,083	R93C	probably damaging	Het
Wdr91	T	A	6: 34,905,556	E219D	probably benign	Het
Zan	G	A	5: 137,463,500	T1139I	unknown	Het
Zc3hav1	T	A	6: 38,340,343	K107N	probably damaging	Het
Zcchc6	T	C	13: 59,814,903	D350G	probably benign	Het
Zmym2	A	G	14: 56,950,327	E1150G	possibly damaging	Het

Other mutations in Mov10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00498:Mov10	APN	3	104800947	splice site	probably benign
IGL01111:Mov10	APN	3	104801405	missense	possibly damaging	0.71
IGL01315:Mov10	APN	3	104795945	missense	probably damaging	0.98
IGL01463:Mov10	APN	3	104800324	missense	probably damaging	1.00
IGL02114:Mov10	APN	3	104795318	unclassified	probably benign
IGL02354:Mov10	APN	3	104804121	splice site	probably benign
IGL02361:Mov10	APN	3	104804121	splice site	probably benign
IGL02692:Mov10	APN	3	104800803	nonsense	probably null
IGL03121:Mov10	APN	3	104801002	missense	probably benign
P0040:Mov10	UTSW	3	104804679	missense	probably damaging	1.00
R0025:Mov10	UTSW	3	104804603	missense	probably damaging	1.00
R0270:Mov10	UTSW	3	104795405	missense	probably benign	0.09
R0747:Mov10	UTSW	3	104802496	missense	probably benign	0.41
R1434:Mov10	UTSW	3	104795174	missense	probably damaging	1.00
R1482:Mov10	UTSW	3	104804546	missense	probably damaging	0.98
R1594:Mov10	UTSW	3	104795411	missense	probably damaging	1.00
R1656:Mov10	UTSW	3	104799596	missense	probably benign	0.03
R1739:Mov10	UTSW	3	104800282	missense	probably damaging	0.98
R1785:Mov10	UTSW	3	104818116	missense	possibly damaging	0.73
R1786:Mov10	UTSW	3	104818116	missense	possibly damaging	0.73
R1911:Mov10	UTSW	3	104801560	splice site	probably benign
R1962:Mov10	UTSW	3	104796977	missense	probably damaging	1.00
R1993:Mov10	UTSW	3	104799419	missense	probably damaging	1.00
R2095:Mov10	UTSW	3	104801531	missense	probably damaging	1.00
R2138:Mov10	UTSW	3	104804242	missense	probably benign	0.00
R3107:Mov10	UTSW	3	104799724	missense	probably damaging	1.00
R4241:Mov10	UTSW	3	104797276	missense	probably benign	0.45
R4280:Mov10	UTSW	3	104799779	missense	probably damaging	0.98
R4474:Mov10	UTSW	3	104818465	missense	probably damaging	1.00
R5227:Mov10	UTSW	3	104802578	missense	probably benign
R5391:Mov10	UTSW	3	104802533	missense	probably benign	0.12
R5704:Mov10	UTSW	3	104799596	missense	probably benign	0.03
R5819:Mov10	UTSW	3	104801512	missense	probably damaging	1.00
R5842:Mov10	UTSW	3	104799379	splice site	probably benign
R6059:Mov10	UTSW	3	104817950	utr 3 prime	probably benign
R6692:Mov10	UTSW	3	104818044	missense	probably damaging	0.97
R7226:Mov10	UTSW	3	104801012	missense	probably damaging	1.00
R7426:Mov10	UTSW	3	104800052	splice site	probably null
R7633:Mov10	UTSW	3	104797065	missense	possibly damaging	0.93
R7637:Mov10	UTSW	3	104795885	missense	probably benign	0.26
R7869:Mov10	UTSW	3	104804678	missense	probably damaging	1.00
R8684:Mov10	UTSW	3	104804374	missense	probably benign
R9008:Mov10	UTSW	3	104800016	missense	probably benign	0.09
R9127:Mov10	UTSW	3	104804343	nonsense	probably null
R9559:Mov10	UTSW	3	104800961	missense
R9587:Mov10	UTSW	3	104804583	missense	probably benign	0.11
R9602:Mov10	UTSW	3	104800968	missense	probably benign	0.18
R9606:Mov10	UTSW	3	104800348	missense	probably benign	0.00
R9708:Mov10	UTSW	3	104797297	missense	probably benign

Posted On

2016-08-02