Incidental Mutation 'IGL03105:Slc25a35'
ID 418908
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Slc25a35
Ensembl Gene ENSMUSG00000018740
Gene Name solute carrier family 25, member 35
Synonyms 1810012H11Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03105
Quality Score
Status
Chromosome 11
Chromosomal Location 68858954-68863342 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 68859496 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 3 (F3S)
Ref Sequence ENSEMBL: ENSMUSP00000099666 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000018884] [ENSMUST00000038644] [ENSMUST00000102606]
AlphaFold Q5SWT3
Predicted Effect probably damaging
Transcript: ENSMUST00000018884
AA Change: F3S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000018884
Gene: ENSMUSG00000018740
AA Change: F3S

DomainStartEndE-ValueType
Pfam:Mito_carr 1 90 4.5e-20 PFAM
Pfam:Mito_carr 98 193 2.2e-16 PFAM
Pfam:Mito_carr 197 295 6.8e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000038644
SMART Domains Protein: ENSMUSP00000038485
Gene: ENSMUSG00000032892

DomainStartEndE-ValueType
Pfam:Mog1 7 145 1.3e-41 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000102606
AA Change: F3S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000099666
Gene: ENSMUSG00000018740
AA Change: F3S

DomainStartEndE-ValueType
Pfam:Mito_carr 1 92 7.9e-17 PFAM
Pfam:Mito_carr 98 197 1.2e-16 PFAM
Pfam:Mito_carr 202 299 8.6e-18 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132093
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133099
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136520
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144271
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138362
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156178
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143444
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150017
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] SLC25A35 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adss1 A G 12: 112,599,155 (GRCm39) I129V probably benign Het
Ankrd35 A G 3: 96,591,373 (GRCm39) H553R probably benign Het
Brca2 A G 5: 150,483,950 (GRCm39) K2923R probably benign Het
Cadm3 A T 1: 173,172,583 (GRCm39) L174M probably damaging Het
Car10 T C 11: 92,991,101 (GRCm39) V17A probably benign Het
Cep290 A G 10: 100,387,686 (GRCm39) K1956E possibly damaging Het
Cfhr1 T A 1: 139,475,565 (GRCm39) probably benign Het
Crim1 A T 17: 78,623,179 (GRCm39) probably benign Het
Dedd G A 1: 171,168,486 (GRCm39) R224H probably damaging Het
F7 A T 8: 13,084,001 (GRCm39) I229L probably null Het
Igkv17-121 A T 6: 68,014,284 (GRCm39) Q112L probably damaging Het
Kcnk13 G A 12: 100,027,369 (GRCm39) R148Q probably damaging Het
Klk13 T C 7: 43,370,904 (GRCm39) L51P probably benign Het
Ldb2 A G 5: 44,956,715 (GRCm39) S41P possibly damaging Het
Magi2 A G 5: 20,748,616 (GRCm39) D767G probably damaging Het
Mical3 T C 6: 121,019,199 (GRCm39) T8A probably benign Het
Mkln1 G T 6: 31,435,994 (GRCm39) E318* probably null Het
Mx1 C T 16: 97,257,554 (GRCm39) V68I possibly damaging Het
Mylk2 T C 2: 152,759,279 (GRCm39) V350A possibly damaging Het
Nav2 T A 7: 49,114,627 (GRCm39) S870R probably damaging Het
Onecut2 A T 18: 64,474,579 (GRCm39) K358* probably null Het
Or51b4 A G 7: 103,531,339 (GRCm39) I37T possibly damaging Het
Or52n2c A T 7: 104,574,971 (GRCm39) probably benign Het
Or7a40 T C 16: 16,491,390 (GRCm39) T152A probably benign Het
Or7g16 T C 9: 18,726,685 (GRCm39) R302G probably benign Het
Orai3 A G 7: 127,372,725 (GRCm39) probably benign Het
Rad54b A G 4: 11,615,569 (GRCm39) N859S probably benign Het
Saxo4 A G 19: 10,454,384 (GRCm39) probably benign Het
Sec23b C T 2: 144,423,940 (GRCm39) R530W probably damaging Het
Slc7a11 A T 3: 50,326,788 (GRCm39) I491K possibly damaging Het
Srrt A T 5: 137,298,106 (GRCm39) N317K possibly damaging Het
Sspo T C 6: 48,450,592 (GRCm39) probably benign Het
Taf2 A C 15: 54,909,195 (GRCm39) D683E probably benign Het
Tasor T A 14: 27,164,509 (GRCm39) C272S probably damaging Het
Tcerg1l G T 7: 137,850,173 (GRCm39) probably benign Het
Tg G T 15: 66,586,955 (GRCm39) V1578F probably benign Het
Tmem43 G A 6: 91,457,682 (GRCm39) G188D probably damaging Het
Tnfrsf8 T C 4: 145,025,354 (GRCm39) Y73C probably damaging Het
Ttc21a A G 9: 119,771,642 (GRCm39) Y147C probably benign Het
Ttn T C 2: 76,608,394 (GRCm39) D17843G probably damaging Het
Ttn T A 2: 76,642,521 (GRCm39) D11592V probably damaging Het
Tubgcp5 T A 7: 55,475,329 (GRCm39) I842N probably damaging Het
Unc80 A T 1: 66,511,258 (GRCm39) T89S probably damaging Het
Usp28 T C 9: 48,950,355 (GRCm39) M928T probably damaging Het
Usp43 A G 11: 67,770,802 (GRCm39) S611P possibly damaging Het
Utp20 A G 10: 88,626,958 (GRCm39) V1000A probably benign Het
Zfp263 T C 16: 3,566,824 (GRCm39) C380R probably damaging Het
Zfyve1 A C 12: 83,605,413 (GRCm39) C14G probably damaging Het
Other mutations in Slc25a35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03146:Slc25a35 APN 11 68,859,678 (GRCm39) missense possibly damaging 0.90
R0131:Slc25a35 UTSW 11 68,862,786 (GRCm39) missense probably damaging 1.00
R0131:Slc25a35 UTSW 11 68,862,786 (GRCm39) missense probably damaging 1.00
R0132:Slc25a35 UTSW 11 68,862,786 (GRCm39) missense probably damaging 1.00
R2130:Slc25a35 UTSW 11 68,859,791 (GRCm39) missense possibly damaging 0.88
R6425:Slc25a35 UTSW 11 68,859,591 (GRCm39) missense possibly damaging 0.88
R8119:Slc25a35 UTSW 11 68,862,798 (GRCm39) missense probably benign 0.01
R9347:Slc25a35 UTSW 11 68,862,076 (GRCm39) missense probably benign
Posted On 2016-08-02