Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03105:Zfp263'

418926

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp263

Ensembl Gene

ENSMUSG00000022529

Gene Name

zinc finger protein 263

Synonyms

mFPM315, NT2, 1200014J04Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.119) question?

Stock #

IGL03105

Quality Score

Status

Chromosome

Chromosomal Location

3561957-3568654 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 3566824 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Arginine at position 380 (C380R)

Ref Sequence

ENSEMBL: ENSMUSP00000023176 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023176] [ENSMUST00000161630] [ENSMUST00000162207]

AlphaFold

Q8CF60

Predicted Effect

probably damaging
Transcript: ENSMUST00000023176
AA Change: C380R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000023176
Gene: ENSMUSG00000022529
AA Change: C380R

Domain	Start	End	E-Value	Type
SCAN	39	151	5.15e-71	SMART
KRAB	219	279	1.86e-9	SMART
ZnF_C2H2	378	400	1.45e-2	SMART
ZnF_C2H2	434	456	3.11e-2	SMART
ZnF_C2H2	462	484	1.2e-3	SMART
ZnF_C2H2	490	512	6.52e-5	SMART
ZnF_C2H2	518	540	1.98e-4	SMART
ZnF_C2H2	572	594	2.4e-3	SMART
ZnF_C2H2	600	622	4.87e-4	SMART
ZnF_C2H2	628	650	1.1e-2	SMART
ZnF_C2H2	656	678	1.72e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000159060

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000159425

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000159469

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000160923

Predicted Effect

probably benign
Transcript: ENSMUST00000161630

SMART Domains

Protein: ENSMUSP00000123725
Gene: ENSMUSG00000022529

Domain	Start	End	E-Value	Type
SCAN	39	143	1.61e-63	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000162207
AA Change: C92R

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000124433
Gene: ENSMUSG00000022529
AA Change: C92R

Domain	Start	End	E-Value	Type
ZnF_C2H2	90	112	1.45e-2	SMART
ZnF_C2H2	146	168	3.11e-2	SMART
ZnF_C2H2	174	196	1.2e-3	SMART
ZnF_C2H2	202	224	6.52e-5	SMART
ZnF_C2H2	230	252	1.98e-4	SMART
ZnF_C2H2	284	306	2.4e-3	SMART
ZnF_C2H2	312	334	4.87e-4	SMART
ZnF_C2H2	340	362	1.1e-2	SMART
ZnF_C2H2	368	390	1.72e-4	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adss1	A	G	12: 112,599,155 (GRCm39)	I129V	probably benign	Het
Ankrd35	A	G	3: 96,591,373 (GRCm39)	H553R	probably benign	Het
Brca2	A	G	5: 150,483,950 (GRCm39)	K2923R	probably benign	Het
Cadm3	A	T	1: 173,172,583 (GRCm39)	L174M	probably damaging	Het
Car10	T	C	11: 92,991,101 (GRCm39)	V17A	probably benign	Het
Cep290	A	G	10: 100,387,686 (GRCm39)	K1956E	possibly damaging	Het
Cfhr1	T	A	1: 139,475,565 (GRCm39)		probably benign	Het
Crim1	A	T	17: 78,623,179 (GRCm39)		probably benign	Het
Dedd	G	A	1: 171,168,486 (GRCm39)	R224H	probably damaging	Het
F7	A	T	8: 13,084,001 (GRCm39)	I229L	probably null	Het
Igkv17-121	A	T	6: 68,014,284 (GRCm39)	Q112L	probably damaging	Het
Kcnk13	G	A	12: 100,027,369 (GRCm39)	R148Q	probably damaging	Het
Klk13	T	C	7: 43,370,904 (GRCm39)	L51P	probably benign	Het
Ldb2	A	G	5: 44,956,715 (GRCm39)	S41P	possibly damaging	Het
Magi2	A	G	5: 20,748,616 (GRCm39)	D767G	probably damaging	Het
Mical3	T	C	6: 121,019,199 (GRCm39)	T8A	probably benign	Het
Mkln1	G	T	6: 31,435,994 (GRCm39)	E318*	probably null	Het
Mx1	C	T	16: 97,257,554 (GRCm39)	V68I	possibly damaging	Het
Mylk2	T	C	2: 152,759,279 (GRCm39)	V350A	possibly damaging	Het
Nav2	T	A	7: 49,114,627 (GRCm39)	S870R	probably damaging	Het
Onecut2	A	T	18: 64,474,579 (GRCm39)	K358*	probably null	Het
Or51b4	A	G	7: 103,531,339 (GRCm39)	I37T	possibly damaging	Het
Or52n2c	A	T	7: 104,574,971 (GRCm39)		probably benign	Het
Or7a40	T	C	16: 16,491,390 (GRCm39)	T152A	probably benign	Het
Or7g16	T	C	9: 18,726,685 (GRCm39)	R302G	probably benign	Het
Orai3	A	G	7: 127,372,725 (GRCm39)		probably benign	Het
Rad54b	A	G	4: 11,615,569 (GRCm39)	N859S	probably benign	Het
Saxo4	A	G	19: 10,454,384 (GRCm39)		probably benign	Het
Sec23b	C	T	2: 144,423,940 (GRCm39)	R530W	probably damaging	Het
Slc25a35	T	C	11: 68,859,496 (GRCm39)	F3S	probably damaging	Het
Slc7a11	A	T	3: 50,326,788 (GRCm39)	I491K	possibly damaging	Het
Srrt	A	T	5: 137,298,106 (GRCm39)	N317K	possibly damaging	Het
Sspo	T	C	6: 48,450,592 (GRCm39)		probably benign	Het
Taf2	A	C	15: 54,909,195 (GRCm39)	D683E	probably benign	Het
Tasor	T	A	14: 27,164,509 (GRCm39)	C272S	probably damaging	Het
Tcerg1l	G	T	7: 137,850,173 (GRCm39)		probably benign	Het
Tg	G	T	15: 66,586,955 (GRCm39)	V1578F	probably benign	Het
Tmem43	G	A	6: 91,457,682 (GRCm39)	G188D	probably damaging	Het
Tnfrsf8	T	C	4: 145,025,354 (GRCm39)	Y73C	probably damaging	Het
Ttc21a	A	G	9: 119,771,642 (GRCm39)	Y147C	probably benign	Het
Ttn	T	C	2: 76,608,394 (GRCm39)	D17843G	probably damaging	Het
Ttn	T	A	2: 76,642,521 (GRCm39)	D11592V	probably damaging	Het
Tubgcp5	T	A	7: 55,475,329 (GRCm39)	I842N	probably damaging	Het
Unc80	A	T	1: 66,511,258 (GRCm39)	T89S	probably damaging	Het
Usp28	T	C	9: 48,950,355 (GRCm39)	M928T	probably damaging	Het
Usp43	A	G	11: 67,770,802 (GRCm39)	S611P	possibly damaging	Het
Utp20	A	G	10: 88,626,958 (GRCm39)	V1000A	probably benign	Het
Zfyve1	A	C	12: 83,605,413 (GRCm39)	C14G	probably damaging	Het

Other mutations in Zfp263

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00489:Zfp263	APN	16	3,563,710 (GRCm39)	missense	probably benign	0.00
IGL01112:Zfp263	APN	16	3,566,776 (GRCm39)	missense	probably benign	0.09
IGL02049:Zfp263	APN	16	3,562,482 (GRCm39)	missense	probably damaging	0.97
IGL02534:Zfp263	APN	16	3,564,279 (GRCm39)	unclassified	probably benign
IGL02674:Zfp263	APN	16	3,564,629 (GRCm39)	unclassified	probably benign
IGL03065:Zfp263	APN	16	3,564,344 (GRCm39)	missense	probably benign
IGL03153:Zfp263	APN	16	3,564,744 (GRCm39)	missense	possibly damaging	0.56
IGL02796:Zfp263	UTSW	16	3,564,740 (GRCm39)	missense	probably benign	0.03
R1201:Zfp263	UTSW	16	3,567,294 (GRCm39)	missense	probably damaging	1.00
R1414:Zfp263	UTSW	16	3,567,160 (GRCm39)	missense	probably damaging	1.00
R1448:Zfp263	UTSW	16	3,564,323 (GRCm39)	missense	probably benign	0.18
R3085:Zfp263	UTSW	16	3,567,580 (GRCm39)	missense	probably damaging	1.00
R4368:Zfp263	UTSW	16	3,562,770 (GRCm39)	unclassified	probably benign
R4989:Zfp263	UTSW	16	3,566,992 (GRCm39)	missense	probably damaging	1.00
R5072:Zfp263	UTSW	16	3,564,704 (GRCm39)	missense	possibly damaging	0.84
R5073:Zfp263	UTSW	16	3,564,704 (GRCm39)	missense	possibly damaging	0.84
R5074:Zfp263	UTSW	16	3,564,704 (GRCm39)	missense	possibly damaging	0.84
R5122:Zfp263	UTSW	16	3,567,719 (GRCm39)	missense	probably damaging	0.99
R5705:Zfp263	UTSW	16	3,564,318 (GRCm39)	missense	probably benign	0.00
R6140:Zfp263	UTSW	16	3,566,081 (GRCm39)	missense	probably benign	0.10
R6879:Zfp263	UTSW	16	3,567,719 (GRCm39)	missense	probably damaging	0.99
R7133:Zfp263	UTSW	16	3,567,255 (GRCm39)	nonsense	probably null
R7216:Zfp263	UTSW	16	3,562,435 (GRCm39)	missense	probably damaging	1.00
R8517:Zfp263	UTSW	16	3,564,760 (GRCm39)	critical splice donor site	probably null
R8822:Zfp263	UTSW	16	3,562,004 (GRCm39)	unclassified	probably benign
R9130:Zfp263	UTSW	16	3,567,701 (GRCm39)	missense	probably benign	0.06
R9172:Zfp263	UTSW	16	3,567,323 (GRCm39)	missense	probably benign	0.22
R9512:Zfp263	UTSW	16	3,564,306 (GRCm39)	missense	probably damaging	1.00
R9616:Zfp263	UTSW	16	3,567,482 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02