Incidental Mutation 'IGL03105:Zfp263'
ID418926
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp263
Ensembl Gene ENSMUSG00000022529
Gene Namezinc finger protein 263
SynonymsmFPM315, 1200014J04Rik, NT2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.146) question?
Stock #IGL03105
Quality Score
Status
Chromosome16
Chromosomal Location3744093-3750790 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 3748960 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Arginine at position 380 (C380R)
Ref Sequence ENSEMBL: ENSMUSP00000023176 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023176] [ENSMUST00000161630] [ENSMUST00000162207]
Predicted Effect probably damaging
Transcript: ENSMUST00000023176
AA Change: C380R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000023176
Gene: ENSMUSG00000022529
AA Change: C380R

DomainStartEndE-ValueType
SCAN 39 151 5.15e-71 SMART
KRAB 219 279 1.86e-9 SMART
ZnF_C2H2 378 400 1.45e-2 SMART
ZnF_C2H2 434 456 3.11e-2 SMART
ZnF_C2H2 462 484 1.2e-3 SMART
ZnF_C2H2 490 512 6.52e-5 SMART
ZnF_C2H2 518 540 1.98e-4 SMART
ZnF_C2H2 572 594 2.4e-3 SMART
ZnF_C2H2 600 622 4.87e-4 SMART
ZnF_C2H2 628 650 1.1e-2 SMART
ZnF_C2H2 656 678 1.72e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159060
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159425
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159469
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160923
Predicted Effect probably benign
Transcript: ENSMUST00000161630
SMART Domains Protein: ENSMUSP00000123725
Gene: ENSMUSG00000022529

DomainStartEndE-ValueType
SCAN 39 143 1.61e-63 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000162207
AA Change: C92R

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000124433
Gene: ENSMUSG00000022529
AA Change: C92R

DomainStartEndE-ValueType
ZnF_C2H2 90 112 1.45e-2 SMART
ZnF_C2H2 146 168 3.11e-2 SMART
ZnF_C2H2 174 196 1.2e-3 SMART
ZnF_C2H2 202 224 6.52e-5 SMART
ZnF_C2H2 230 252 1.98e-4 SMART
ZnF_C2H2 284 306 2.4e-3 SMART
ZnF_C2H2 312 334 4.87e-4 SMART
ZnF_C2H2 340 362 1.1e-2 SMART
ZnF_C2H2 368 390 1.72e-4 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adssl1 A G 12: 112,632,721 I129V probably benign Het
Ankrd35 A G 3: 96,684,057 H553R probably benign Het
Brca2 A G 5: 150,560,485 K2923R probably benign Het
Cadm3 A T 1: 173,345,016 L174M probably damaging Het
Car10 T C 11: 93,100,275 V17A probably benign Het
Cep290 A G 10: 100,551,824 K1956E possibly damaging Het
Cfhr1 T A 1: 139,547,827 probably benign Het
Crim1 A T 17: 78,315,750 probably benign Het
Dedd G A 1: 171,340,918 R224H probably damaging Het
F7 A T 8: 13,034,001 I229L probably null Het
Fam208a T A 14: 27,442,552 C272S probably damaging Het
Igkv17-121 A T 6: 68,037,300 Q112L probably damaging Het
Kcnk13 G A 12: 100,061,110 R148Q probably damaging Het
Klk13 T C 7: 43,721,480 L51P probably benign Het
Ldb2 A G 5: 44,799,373 S41P possibly damaging Het
Magi2 A G 5: 20,543,618 D767G probably damaging Het
Mical3 T C 6: 121,042,238 T8A probably benign Het
Mkln1 G T 6: 31,459,059 E318* probably null Het
Mx1 C T 16: 97,456,354 V68I possibly damaging Het
Mylk2 T C 2: 152,917,359 V350A possibly damaging Het
Nav2 T A 7: 49,464,879 S870R probably damaging Het
Olfr19 T C 16: 16,673,526 T152A probably benign Het
Olfr66 A G 7: 103,882,132 I37T possibly damaging Het
Olfr668 A T 7: 104,925,764 probably benign Het
Olfr828 T C 9: 18,815,389 R302G probably benign Het
Onecut2 A T 18: 64,341,508 K358* probably null Het
Orai3 A G 7: 127,773,553 probably benign Het
Ppp1r32 A G 19: 10,477,020 probably benign Het
Rad54b A G 4: 11,615,569 N859S probably benign Het
Sec23b C T 2: 144,582,020 R530W probably damaging Het
Slc25a35 T C 11: 68,968,670 F3S probably damaging Het
Slc7a11 A T 3: 50,372,339 I491K possibly damaging Het
Srrt A T 5: 137,299,844 N317K possibly damaging Het
Sspo T C 6: 48,473,658 probably benign Het
Taf2 A C 15: 55,045,799 D683E probably benign Het
Tcerg1l G T 7: 138,248,444 probably benign Het
Tg G T 15: 66,715,106 V1578F probably benign Het
Tmem43 G A 6: 91,480,700 G188D probably damaging Het
Tnfrsf8 T C 4: 145,298,784 Y73C probably damaging Het
Ttc21a A G 9: 119,942,576 Y147C probably benign Het
Ttn T A 2: 76,812,177 D11592V probably damaging Het
Ttn T C 2: 76,778,050 D17843G probably damaging Het
Tubgcp5 T A 7: 55,825,581 I842N probably damaging Het
Unc80 A T 1: 66,472,099 T89S probably damaging Het
Usp28 T C 9: 49,039,055 M928T probably damaging Het
Usp43 A G 11: 67,879,976 S611P possibly damaging Het
Utp20 A G 10: 88,791,096 V1000A probably benign Het
Zfyve1 A C 12: 83,558,639 C14G probably damaging Het
Other mutations in Zfp263
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00489:Zfp263 APN 16 3745846 missense probably benign 0.00
IGL01112:Zfp263 APN 16 3748912 missense probably benign 0.09
IGL02049:Zfp263 APN 16 3744618 missense probably damaging 0.97
IGL02534:Zfp263 APN 16 3746415 unclassified probably benign
IGL02674:Zfp263 APN 16 3746765 unclassified probably benign
IGL03065:Zfp263 APN 16 3746480 missense probably benign
IGL03153:Zfp263 APN 16 3746880 missense possibly damaging 0.56
IGL02796:Zfp263 UTSW 16 3746876 missense probably benign 0.03
R1201:Zfp263 UTSW 16 3749430 missense probably damaging 1.00
R1414:Zfp263 UTSW 16 3749296 missense probably damaging 1.00
R1448:Zfp263 UTSW 16 3746459 missense probably benign 0.18
R3085:Zfp263 UTSW 16 3749716 missense probably damaging 1.00
R4368:Zfp263 UTSW 16 3744906 unclassified probably benign
R4989:Zfp263 UTSW 16 3749128 missense probably damaging 1.00
R5072:Zfp263 UTSW 16 3746840 missense possibly damaging 0.84
R5073:Zfp263 UTSW 16 3746840 missense possibly damaging 0.84
R5074:Zfp263 UTSW 16 3746840 missense possibly damaging 0.84
R5122:Zfp263 UTSW 16 3749855 missense probably damaging 0.99
R5705:Zfp263 UTSW 16 3746454 missense probably benign 0.00
R6140:Zfp263 UTSW 16 3748217 missense probably benign 0.10
R6879:Zfp263 UTSW 16 3749855 missense probably damaging 0.99
R7133:Zfp263 UTSW 16 3749391 nonsense probably null
R7216:Zfp263 UTSW 16 3744571 missense probably damaging 1.00
R8517:Zfp263 UTSW 16 3746896 critical splice donor site probably null
R8822:Zfp263 UTSW 16 3744140 unclassified probably benign
Posted On2016-08-02