Incidental Mutation 'IGL03106:Olfr1095'
ID418947
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1095
Ensembl Gene ENSMUSG00000075171
Gene Nameolfactory receptor 1095
SynonymsGA_x6K02T2Q125-48336843-48335917, MOR179-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.061) question?
Stock #IGL03106
Quality Score
Status
Chromosome2
Chromosomal Location86850770-86851696 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 86851614 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Arginine at position 28 (L28R)
Ref Sequence ENSEMBL: ENSMUSP00000097459 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099874]
Predicted Effect possibly damaging
Transcript: ENSMUST00000099874
AA Change: L28R

PolyPhen 2 Score 0.920 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000097459
Gene: ENSMUSG00000075171
AA Change: L28R

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.7e-47 PFAM
Pfam:7tm_1 39 288 9.8e-21 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam3 G T 8: 24,715,119 probably benign Het
Adgrv1 T C 13: 81,472,899 N3911S probably benign Het
Alox12b C T 11: 69,168,876 Q585* probably null Het
Amtn A G 5: 88,378,085 Q36R probably benign Het
Arg2 G A 12: 79,149,891 G129S probably damaging Het
Arhgef28 A C 13: 97,957,793 Y948D probably damaging Het
Atp10b T C 11: 43,247,477 V1195A probably benign Het
Bet1l G T 7: 140,854,610 T42K probably benign Het
Cabin1 G A 10: 75,733,628 T875I probably benign Het
Ccdc17 A G 4: 116,596,836 probably null Het
Crebrf A G 17: 26,771,319 E612G probably damaging Het
Cyp2c67 A T 19: 39,643,675 M83K probably benign Het
Dgkz A G 2: 91,940,859 S414P probably damaging Het
Dock10 G T 1: 80,568,834 H411N probably damaging Het
Dpyd A T 3: 119,195,134 T749S probably benign Het
Dsc1 C T 18: 20,086,644 probably null Het
Echdc1 A T 10: 29,322,280 M74L probably damaging Het
Edn1 C A 13: 42,305,023 T104K possibly damaging Het
Fat2 T A 11: 55,311,901 T116S probably benign Het
Fcrl5 A T 3: 87,435,883 probably null Het
Fpgt C T 3: 155,087,122 G423R probably damaging Het
Gprc5b A T 7: 118,984,193 V151E probably damaging Het
Grm5 A G 7: 88,036,070 Y465C probably damaging Het
Idh3b T A 2: 130,284,401 N6I probably benign Het
Ighmbp2 T C 19: 3,273,022 K308R possibly damaging Het
Lrch1 A T 14: 74,835,762 S146T possibly damaging Het
Lyl1 C T 8: 84,702,671 P3L possibly damaging Het
Mterf3 T C 13: 66,930,157 K16R probably damaging Het
Ncapg T A 5: 45,695,668 H825Q probably damaging Het
Olfr1138 A T 2: 87,738,118 S69T probably benign Het
Olfr1392 T A 11: 49,294,161 I280N probably damaging Het
Olfr1443 G A 19: 12,680,923 V272M possibly damaging Het
Olfr31 G A 14: 14,328,851 V247I probably damaging Het
Olfr984 A G 9: 40,100,734 V252A probably damaging Het
Pald1 A T 10: 61,347,105 M355K probably benign Het
Phc1 A G 6: 122,323,469 probably benign Het
Phkb T A 8: 86,018,466 probably benign Het
Pkn3 G T 2: 30,085,245 R506L probably damaging Het
Plod2 T C 9: 92,573,567 Y100H probably damaging Het
Prl7b1 G T 13: 27,606,935 Q56K probably benign Het
Rhot1 T A 11: 80,242,581 C229* probably null Het
Sema3a G A 5: 13,599,488 R735Q probably damaging Het
Slc18b1 A G 10: 23,826,659 *460W probably null Het
Slco6c1 T A 1: 97,066,023 probably benign Het
Slu7 T A 11: 43,442,630 V359D possibly damaging Het
Suco T C 1: 161,834,480 Y794C possibly damaging Het
Sult3a2 T C 10: 33,779,773 N70S probably benign Het
Taar2 A T 10: 23,941,297 D245V probably damaging Het
Taf1d A G 9: 15,309,941 H181R possibly damaging Het
Tmem33 T C 5: 67,263,796 S38P probably damaging Het
Traf3ip1 T C 1: 91,522,887 S519P probably benign Het
Ttc12 T C 9: 49,458,062 K253E possibly damaging Het
Other mutations in Olfr1095
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02010:Olfr1095 APN 2 86851197 missense possibly damaging 0.77
IGL02947:Olfr1095 APN 2 86850786 missense probably benign 0.00
R0631:Olfr1095 UTSW 2 86850967 missense probably benign 0.07
R1640:Olfr1095 UTSW 2 86851227 missense probably benign 0.05
R1718:Olfr1095 UTSW 2 86851187 missense probably benign 0.22
R1936:Olfr1095 UTSW 2 86851401 missense probably benign 0.01
R3720:Olfr1095 UTSW 2 86851591 missense probably benign 0.16
R4177:Olfr1095 UTSW 2 86851401 missense possibly damaging 0.56
R5378:Olfr1095 UTSW 2 86851463 missense probably benign
R5589:Olfr1095 UTSW 2 86850774 missense unknown
R6158:Olfr1095 UTSW 2 86851515 missense possibly damaging 0.92
R6326:Olfr1095 UTSW 2 86850994 missense probably benign 0.00
R6637:Olfr1095 UTSW 2 86851440 missense probably benign 0.01
Z1176:Olfr1095 UTSW 2 86850940 missense
Posted On2016-08-02