Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03106:Cyp2c67'

418949

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp2c67

Ensembl Gene

ENSMUSG00000062624

Gene Name

cytochrome P450, family 2, subfamily c, polypeptide 67

Synonyms

C730004C24Rik

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.101) question?

Stock #

IGL03106

Quality Score

Status

Chromosome

Chromosomal Location

39608842-39649051 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 39643675 bp

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 83 (M83K)

Ref Sequence

ENSEMBL: ENSMUSP00000065796 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067328]

Predicted Effect

probably benign
Transcript: ENSMUST00000067328
AA Change: M83K

PolyPhen 2 Score 0.271 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000065796
Gene: ENSMUSG00000062624
AA Change: M83K

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:p450	30	487	8.5e-150	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam3	G	T	8: 24,715,119		probably benign	Het
Adgrv1	T	C	13: 81,472,899	N3911S	probably benign	Het
Alox12b	C	T	11: 69,168,876	Q585*	probably null	Het
Amtn	A	G	5: 88,378,085	Q36R	probably benign	Het
Arg2	G	A	12: 79,149,891	G129S	probably damaging	Het
Arhgef28	A	C	13: 97,957,793	Y948D	probably damaging	Het
Atp10b	T	C	11: 43,247,477	V1195A	probably benign	Het
Bet1l	G	T	7: 140,854,610	T42K	probably benign	Het
Cabin1	G	A	10: 75,733,628	T875I	probably benign	Het
Ccdc17	A	G	4: 116,596,836		probably null	Het
Crebrf	A	G	17: 26,771,319	E612G	probably damaging	Het
Dgkz	A	G	2: 91,940,859	S414P	probably damaging	Het
Dock10	G	T	1: 80,568,834	H411N	probably damaging	Het
Dpyd	A	T	3: 119,195,134	T749S	probably benign	Het
Dsc1	C	T	18: 20,086,644		probably null	Het
Echdc1	A	T	10: 29,322,280	M74L	probably damaging	Het
Edn1	C	A	13: 42,305,023	T104K	possibly damaging	Het
Fat2	T	A	11: 55,311,901	T116S	probably benign	Het
Fcrl5	A	T	3: 87,435,883		probably null	Het
Fpgt	C	T	3: 155,087,122	G423R	probably damaging	Het
Gprc5b	A	T	7: 118,984,193	V151E	probably damaging	Het
Grm5	A	G	7: 88,036,070	Y465C	probably damaging	Het
Idh3b	T	A	2: 130,284,401	N6I	probably benign	Het
Ighmbp2	T	C	19: 3,273,022	K308R	possibly damaging	Het
Lrch1	A	T	14: 74,835,762	S146T	possibly damaging	Het
Lyl1	C	T	8: 84,702,671	P3L	possibly damaging	Het
Mterf3	T	C	13: 66,930,157	K16R	probably damaging	Het
Ncapg	T	A	5: 45,695,668	H825Q	probably damaging	Het
Olfr1095	A	C	2: 86,851,614	L28R	possibly damaging	Het
Olfr1138	A	T	2: 87,738,118	S69T	probably benign	Het
Olfr1392	T	A	11: 49,294,161	I280N	probably damaging	Het
Olfr1443	G	A	19: 12,680,923	V272M	possibly damaging	Het
Olfr31	G	A	14: 14,328,851	V247I	probably damaging	Het
Olfr984	A	G	9: 40,100,734	V252A	probably damaging	Het
Pald1	A	T	10: 61,347,105	M355K	probably benign	Het
Phc1	A	G	6: 122,323,469		probably benign	Het
Phkb	T	A	8: 86,018,466		probably benign	Het
Pkn3	G	T	2: 30,085,245	R506L	probably damaging	Het
Plod2	T	C	9: 92,573,567	Y100H	probably damaging	Het
Prl7b1	G	T	13: 27,606,935	Q56K	probably benign	Het
Rhot1	T	A	11: 80,242,581	C229*	probably null	Het
Sema3a	G	A	5: 13,599,488	R735Q	probably damaging	Het
Slc18b1	A	G	10: 23,826,659	*460W	probably null	Het
Slco6c1	T	A	1: 97,066,023		probably benign	Het
Slu7	T	A	11: 43,442,630	V359D	possibly damaging	Het
Suco	T	C	1: 161,834,480	Y794C	possibly damaging	Het
Sult3a2	T	C	10: 33,779,773	N70S	probably benign	Het
Taar2	A	T	10: 23,941,297	D245V	probably damaging	Het
Taf1d	A	G	9: 15,309,941	H181R	possibly damaging	Het
Tmem33	T	C	5: 67,263,796	S38P	probably damaging	Het
Traf3ip1	T	C	1: 91,522,887	S519P	probably benign	Het
Ttc12	T	C	9: 49,458,062	K253E	possibly damaging	Het

Other mutations in Cyp2c67

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00955:Cyp2c67	APN	19	39643385	missense	possibly damaging	0.95
IGL01025:Cyp2c67	APN	19	39639932	nonsense	probably null
IGL01363:Cyp2c67	APN	19	39639967	missense	probably damaging	0.99
IGL01819:Cyp2c67	APN	19	39615721	missense	probably damaging	0.98
IGL01902:Cyp2c67	APN	19	39649026	missense	probably damaging	1.00
IGL02172:Cyp2c67	APN	19	39649002	missense	possibly damaging	0.76
IGL02351:Cyp2c67	APN	19	39617417	missense	probably damaging	1.00
IGL02355:Cyp2c67	APN	19	39643405	missense	probably benign	0.34
IGL02355:Cyp2c67	APN	19	39617382	nonsense	probably null
IGL02358:Cyp2c67	APN	19	39617417	missense	probably damaging	1.00
IGL02362:Cyp2c67	APN	19	39643405	missense	probably benign	0.34
IGL02362:Cyp2c67	APN	19	39617382	nonsense	probably null
IGL02388:Cyp2c67	APN	19	39643355	missense	probably benign	0.20
IGL03219:Cyp2c67	APN	19	39643294	missense	possibly damaging	0.54
IGL03326:Cyp2c67	APN	19	39643269	critical splice donor site	probably null
IGL03349:Cyp2c67	APN	19	39643684	missense	probably damaging	1.00
IGL03356:Cyp2c67	APN	19	39639961	missense	probably damaging	1.00
IGL03052:Cyp2c67	UTSW	19	39648885	missense	possibly damaging	0.88
R0585:Cyp2c67	UTSW	19	39638694	missense	possibly damaging	0.59
R0975:Cyp2c67	UTSW	19	39609178	missense	possibly damaging	0.49
R0976:Cyp2c67	UTSW	19	39643374	missense	probably damaging	1.00
R1252:Cyp2c67	UTSW	19	39626141	missense	possibly damaging	0.93
R1398:Cyp2c67	UTSW	19	39638625	missense	probably damaging	0.96
R1411:Cyp2c67	UTSW	19	39638591	missense	probably damaging	1.00
R1505:Cyp2c67	UTSW	19	39648964	missense	probably benign	0.00
R1543:Cyp2c67	UTSW	19	39643264	splice site	probably benign
R1613:Cyp2c67	UTSW	19	39626199	missense	probably benign	0.00
R1618:Cyp2c67	UTSW	19	39643264	splice site	probably benign
R1667:Cyp2c67	UTSW	19	39643590	critical splice donor site	probably null
R1852:Cyp2c67	UTSW	19	39617367	missense	probably benign	0.01
R2005:Cyp2c67	UTSW	19	39643345	missense	probably damaging	1.00
R2105:Cyp2c67	UTSW	19	39626237	missense	probably benign	0.24
R2181:Cyp2c67	UTSW	19	39609097	missense	possibly damaging	0.94
R3817:Cyp2c67	UTSW	19	39638683	missense	probably benign	0.00
R4669:Cyp2c67	UTSW	19	39643654	missense	probably benign	0.00
R4689:Cyp2c67	UTSW	19	39638588	missense	probably benign	0.00
R4756:Cyp2c67	UTSW	19	39643744	missense	probably benign	0.03
R4823:Cyp2c67	UTSW	19	39615724	missense	probably benign	0.13
R5152:Cyp2c67	UTSW	19	39638688	missense	probably benign	0.00
R5345:Cyp2c67	UTSW	19	39626232	missense	probably benign	0.01
R5580:Cyp2c67	UTSW	19	39615650	missense	probably damaging	0.99
R5644:Cyp2c67	UTSW	19	39615694	missense	possibly damaging	0.84
R6116:Cyp2c67	UTSW	19	39617435	missense	probably damaging	1.00
R6516:Cyp2c67	UTSW	19	39617429	missense	probably damaging	1.00
R6550:Cyp2c67	UTSW	19	39617410	nonsense	probably null
R6939:Cyp2c67	UTSW	19	39643334	missense	possibly damaging	0.68
R6995:Cyp2c67	UTSW	19	39615679	missense	probably damaging	0.96
R7028:Cyp2c67	UTSW	19	39639897	missense	possibly damaging	0.68
R7144:Cyp2c67	UTSW	19	39615694	missense	probably benign	0.00
R7242:Cyp2c67	UTSW	19	39617339	missense	probably benign	0.30
R7335:Cyp2c67	UTSW	19	39640007	nonsense	probably null
R7337:Cyp2c67	UTSW	19	39609264	splice site	probably null
R7474:Cyp2c67	UTSW	19	39617432	missense	probably null	0.05
R7642:Cyp2c67	UTSW	19	39615640	missense	probably damaging	0.97
R7870:Cyp2c67	UTSW	19	39609225	missense	probably damaging	1.00
R8152:Cyp2c67	UTSW	19	39640008	missense	probably benign	0.21
R8367:Cyp2c67	UTSW	19	39638674	missense	probably benign	0.01
Z1177:Cyp2c67	UTSW	19	39643679	missense	possibly damaging	0.89

Posted On

2016-08-02