Incidental Mutation 'IGL03106:Prl7b1'
ID418968
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prl7b1
Ensembl Gene ENSMUSG00000021347
Gene Nameprolactin family 7, subfamily b, member 1
SynonymsPLP-N, Prlpn, 1600014J19Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL03106
Quality Score
Status
Chromosome13
Chromosomal Location27601819-27610582 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 27606935 bp
ZygosityHeterozygous
Amino Acid Change Glutamine to Lysine at position 56 (Q56K)
Ref Sequence ENSEMBL: ENSMUSP00000079431 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080595]
Predicted Effect probably benign
Transcript: ENSMUST00000080595
AA Change: Q56K

PolyPhen 2 Score 0.172 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000079431
Gene: ENSMUSG00000021347
AA Change: Q56K

DomainStartEndE-ValueType
Pfam:Hormone_1 16 241 3.1e-60 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit enhanced fetal growth and survival following exposure of dams to low oxygen conditions. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam3 G T 8: 24,715,119 probably benign Het
Adgrv1 T C 13: 81,472,899 N3911S probably benign Het
Alox12b C T 11: 69,168,876 Q585* probably null Het
Amtn A G 5: 88,378,085 Q36R probably benign Het
Arg2 G A 12: 79,149,891 G129S probably damaging Het
Arhgef28 A C 13: 97,957,793 Y948D probably damaging Het
Atp10b T C 11: 43,247,477 V1195A probably benign Het
Bet1l G T 7: 140,854,610 T42K probably benign Het
Cabin1 G A 10: 75,733,628 T875I probably benign Het
Ccdc17 A G 4: 116,596,836 probably null Het
Crebrf A G 17: 26,771,319 E612G probably damaging Het
Cyp2c67 A T 19: 39,643,675 M83K probably benign Het
Dgkz A G 2: 91,940,859 S414P probably damaging Het
Dock10 G T 1: 80,568,834 H411N probably damaging Het
Dpyd A T 3: 119,195,134 T749S probably benign Het
Dsc1 C T 18: 20,086,644 probably null Het
Echdc1 A T 10: 29,322,280 M74L probably damaging Het
Edn1 C A 13: 42,305,023 T104K possibly damaging Het
Fat2 T A 11: 55,311,901 T116S probably benign Het
Fcrl5 A T 3: 87,435,883 probably null Het
Fpgt C T 3: 155,087,122 G423R probably damaging Het
Gprc5b A T 7: 118,984,193 V151E probably damaging Het
Grm5 A G 7: 88,036,070 Y465C probably damaging Het
Idh3b T A 2: 130,284,401 N6I probably benign Het
Ighmbp2 T C 19: 3,273,022 K308R possibly damaging Het
Lrch1 A T 14: 74,835,762 S146T possibly damaging Het
Lyl1 C T 8: 84,702,671 P3L possibly damaging Het
Mterf3 T C 13: 66,930,157 K16R probably damaging Het
Ncapg T A 5: 45,695,668 H825Q probably damaging Het
Olfr1095 A C 2: 86,851,614 L28R possibly damaging Het
Olfr1138 A T 2: 87,738,118 S69T probably benign Het
Olfr1392 T A 11: 49,294,161 I280N probably damaging Het
Olfr1443 G A 19: 12,680,923 V272M possibly damaging Het
Olfr31 G A 14: 14,328,851 V247I probably damaging Het
Olfr984 A G 9: 40,100,734 V252A probably damaging Het
Pald1 A T 10: 61,347,105 M355K probably benign Het
Phc1 A G 6: 122,323,469 probably benign Het
Phkb T A 8: 86,018,466 probably benign Het
Pkn3 G T 2: 30,085,245 R506L probably damaging Het
Plod2 T C 9: 92,573,567 Y100H probably damaging Het
Rhot1 T A 11: 80,242,581 C229* probably null Het
Sema3a G A 5: 13,599,488 R735Q probably damaging Het
Slc18b1 A G 10: 23,826,659 *460W probably null Het
Slco6c1 T A 1: 97,066,023 probably benign Het
Slu7 T A 11: 43,442,630 V359D possibly damaging Het
Suco T C 1: 161,834,480 Y794C possibly damaging Het
Sult3a2 T C 10: 33,779,773 N70S probably benign Het
Taar2 A T 10: 23,941,297 D245V probably damaging Het
Taf1d A G 9: 15,309,941 H181R possibly damaging Het
Tmem33 T C 5: 67,263,796 S38P probably damaging Het
Traf3ip1 T C 1: 91,522,887 S519P probably benign Het
Ttc12 T C 9: 49,458,062 K253E possibly damaging Het
Other mutations in Prl7b1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00473:Prl7b1 APN 13 27604590 missense probably damaging 0.98
IGL01350:Prl7b1 APN 13 27602821 missense probably damaging 1.00
IGL01602:Prl7b1 APN 13 27602044 missense possibly damaging 0.70
IGL01605:Prl7b1 APN 13 27602044 missense possibly damaging 0.70
IGL03401:Prl7b1 APN 13 27601981 missense probably benign 0.02
fleshy UTSW 13 27602895 splice site probably null
R1169:Prl7b1 UTSW 13 27606904 missense possibly damaging 0.81
R1423:Prl7b1 UTSW 13 27602127 missense probably damaging 0.99
R1846:Prl7b1 UTSW 13 27602848 missense probably damaging 1.00
R2294:Prl7b1 UTSW 13 27602871 missense possibly damaging 0.93
R6049:Prl7b1 UTSW 13 27606178 missense probably benign 0.03
R6065:Prl7b1 UTSW 13 27604546 missense probably benign 0.01
R6324:Prl7b1 UTSW 13 27602895 splice site probably null
R6870:Prl7b1 UTSW 13 27604533 missense probably damaging 1.00
R7473:Prl7b1 UTSW 13 27602013 missense possibly damaging 0.70
R7742:Prl7b1 UTSW 13 27607048 missense probably benign 0.07
R8301:Prl7b1 UTSW 13 27602772 missense possibly damaging 0.69
Posted On2016-08-02