Incidental Mutation 'IGL03106:Pkn3'
ID 418979
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pkn3
Ensembl Gene ENSMUSG00000026785
Gene Name protein kinase N3
Synonyms
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03106
Quality Score
Status
Chromosome 2
Chromosomal Location 29967696-29981034 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 29975257 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Leucine at position 506 (R506L)
Ref Sequence ENSEMBL: ENSMUSP00000041025 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045246] [ENSMUST00000125346]
AlphaFold Q8K045
Predicted Effect probably damaging
Transcript: ENSMUST00000045246
AA Change: R506L

PolyPhen 2 Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000041025
Gene: ENSMUSG00000026785
AA Change: R506L

DomainStartEndE-ValueType
Hr1 15 78 3.45e-17 SMART
Hr1 98 166 6.19e-19 SMART
Hr1 171 239 3.32e-19 SMART
low complexity region 528 537 N/A INTRINSIC
S_TKc 548 807 2.52e-93 SMART
S_TK_X 808 872 9.58e-16 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000125346
SMART Domains Protein: ENSMUSP00000120268
Gene: ENSMUSG00000026785

DomainStartEndE-ValueType
Hr1 19 82 3.45e-17 SMART
Hr1 102 170 6.19e-19 SMART
Hr1 175 238 6.4e-12 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126838
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134591
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137240
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148650
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156197
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null mutation are viable, fertile and healthy. Mice with conditional loss of this gene and Pten in hematopoietic cells show a delay in leukemia development. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam3 G T 8: 25,205,135 (GRCm39) probably benign Het
Adgrv1 T C 13: 81,621,018 (GRCm39) N3911S probably benign Het
Alox12b C T 11: 69,059,702 (GRCm39) Q585* probably null Het
Amtn A G 5: 88,525,944 (GRCm39) Q36R probably benign Het
Arg2 G A 12: 79,196,665 (GRCm39) G129S probably damaging Het
Arhgef28 A C 13: 98,094,301 (GRCm39) Y948D probably damaging Het
Atp10b T C 11: 43,138,304 (GRCm39) V1195A probably benign Het
Bet1l G T 7: 140,434,523 (GRCm39) T42K probably benign Het
Cabin1 G A 10: 75,569,462 (GRCm39) T875I probably benign Het
Ccdc17 A G 4: 116,454,033 (GRCm39) probably null Het
Crebrf A G 17: 26,990,293 (GRCm39) E612G probably damaging Het
Cyp2c67 A T 19: 39,632,119 (GRCm39) M83K probably benign Het
Dgkz A G 2: 91,771,204 (GRCm39) S414P probably damaging Het
Dock10 G T 1: 80,546,551 (GRCm39) H411N probably damaging Het
Dpyd A T 3: 118,988,783 (GRCm39) T749S probably benign Het
Dsc1 C T 18: 20,219,701 (GRCm39) probably null Het
Echdc1 A T 10: 29,198,276 (GRCm39) M74L probably damaging Het
Edn1 C A 13: 42,458,499 (GRCm39) T104K possibly damaging Het
Fat2 T A 11: 55,202,727 (GRCm39) T116S probably benign Het
Fcrl5 A T 3: 87,343,190 (GRCm39) probably null Het
Fpgt C T 3: 154,792,759 (GRCm39) G423R probably damaging Het
Gprc5b A T 7: 118,583,416 (GRCm39) V151E probably damaging Het
Grm5 A G 7: 87,685,278 (GRCm39) Y465C probably damaging Het
Idh3b T A 2: 130,126,321 (GRCm39) N6I probably benign Het
Ighmbp2 T C 19: 3,323,022 (GRCm39) K308R possibly damaging Het
Lrch1 A T 14: 75,073,202 (GRCm39) S146T possibly damaging Het
Lyl1 C T 8: 85,429,300 (GRCm39) P3L possibly damaging Het
Mterf3 T C 13: 67,078,221 (GRCm39) K16R probably damaging Het
Ncapg T A 5: 45,853,010 (GRCm39) H825Q probably damaging Het
Or2t1 G A 14: 14,328,851 (GRCm38) V247I probably damaging Het
Or2y1f T A 11: 49,184,988 (GRCm39) I280N probably damaging Het
Or4d5 A G 9: 40,012,030 (GRCm39) V252A probably damaging Het
Or5b95 G A 19: 12,658,287 (GRCm39) V272M possibly damaging Het
Or5t15 A C 2: 86,681,958 (GRCm39) L28R possibly damaging Het
Or5w15 A T 2: 87,568,462 (GRCm39) S69T probably benign Het
Pald1 A T 10: 61,182,884 (GRCm39) M355K probably benign Het
Phc1 A G 6: 122,300,428 (GRCm39) probably benign Het
Phkb T A 8: 86,745,095 (GRCm39) probably benign Het
Plod2 T C 9: 92,455,620 (GRCm39) Y100H probably damaging Het
Prl7b1 G T 13: 27,790,918 (GRCm39) Q56K probably benign Het
Rhot1 T A 11: 80,133,407 (GRCm39) C229* probably null Het
Sema3a G A 5: 13,649,456 (GRCm39) R735Q probably damaging Het
Slc18b1 A G 10: 23,702,557 (GRCm39) *460W probably null Het
Slco6c1 T A 1: 96,993,748 (GRCm39) probably benign Het
Slu7 T A 11: 43,333,457 (GRCm39) V359D possibly damaging Het
Suco T C 1: 161,662,049 (GRCm39) Y794C possibly damaging Het
Sult3a2 T C 10: 33,655,769 (GRCm39) N70S probably benign Het
Taar2 A T 10: 23,817,195 (GRCm39) D245V probably damaging Het
Taf1d A G 9: 15,221,237 (GRCm39) H181R possibly damaging Het
Tmem33 T C 5: 67,421,139 (GRCm39) S38P probably damaging Het
Traf3ip1 T C 1: 91,450,609 (GRCm39) S519P probably benign Het
Ttc12 T C 9: 49,369,362 (GRCm39) K253E possibly damaging Het
Other mutations in Pkn3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00422:Pkn3 APN 2 29,971,116 (GRCm39) missense probably damaging 0.97
IGL00781:Pkn3 APN 2 29,973,402 (GRCm39) unclassified probably benign
IGL00815:Pkn3 APN 2 29,971,212 (GRCm39) missense possibly damaging 0.88
IGL01576:Pkn3 APN 2 29,977,054 (GRCm39) missense probably damaging 1.00
IGL01897:Pkn3 APN 2 29,972,824 (GRCm39) unclassified probably benign
IGL02513:Pkn3 APN 2 29,973,149 (GRCm39) missense probably damaging 0.98
IGL02552:Pkn3 APN 2 29,970,879 (GRCm39) missense probably damaging 1.00
IGL02622:Pkn3 APN 2 29,973,158 (GRCm39) missense probably benign 0.28
IGL02689:Pkn3 APN 2 29,970,858 (GRCm39) missense probably damaging 1.00
IGL02996:Pkn3 APN 2 29,970,627 (GRCm39) missense probably benign 0.39
Enflamme UTSW 2 29,973,049 (GRCm39) unclassified probably benign
Wrath UTSW 2 29,978,596 (GRCm39) critical splice donor site probably null
PIT4151001:Pkn3 UTSW 2 29,980,539 (GRCm39) missense probably damaging 1.00
R0279:Pkn3 UTSW 2 29,973,309 (GRCm39) missense probably benign 0.16
R0370:Pkn3 UTSW 2 29,977,184 (GRCm39) missense probably damaging 1.00
R0491:Pkn3 UTSW 2 29,979,889 (GRCm39) missense probably damaging 1.00
R0600:Pkn3 UTSW 2 29,971,146 (GRCm39) missense probably benign 0.06
R1418:Pkn3 UTSW 2 29,973,059 (GRCm39) missense probably damaging 1.00
R1510:Pkn3 UTSW 2 29,969,776 (GRCm39) critical splice donor site probably null
R1535:Pkn3 UTSW 2 29,977,065 (GRCm39) missense probably benign
R1540:Pkn3 UTSW 2 29,974,703 (GRCm39) missense probably damaging 1.00
R1808:Pkn3 UTSW 2 29,969,663 (GRCm39) missense probably damaging 1.00
R1884:Pkn3 UTSW 2 29,972,840 (GRCm39) missense probably damaging 1.00
R1995:Pkn3 UTSW 2 29,979,989 (GRCm39) missense probably damaging 1.00
R3745:Pkn3 UTSW 2 29,980,353 (GRCm39) missense probably damaging 1.00
R4119:Pkn3 UTSW 2 29,973,049 (GRCm39) unclassified probably benign
R4258:Pkn3 UTSW 2 29,978,572 (GRCm39) missense probably damaging 0.99
R4665:Pkn3 UTSW 2 29,975,469 (GRCm39) unclassified probably benign
R4772:Pkn3 UTSW 2 29,974,692 (GRCm39) splice site probably null
R4808:Pkn3 UTSW 2 29,980,093 (GRCm39) missense probably damaging 1.00
R5038:Pkn3 UTSW 2 29,975,293 (GRCm39) critical splice donor site probably null
R5388:Pkn3 UTSW 2 29,971,086 (GRCm39) missense probably damaging 0.99
R5488:Pkn3 UTSW 2 29,978,596 (GRCm39) critical splice donor site probably null
R5611:Pkn3 UTSW 2 29,969,673 (GRCm39) missense probably damaging 1.00
R6001:Pkn3 UTSW 2 29,978,596 (GRCm39) critical splice donor site probably null
R6277:Pkn3 UTSW 2 29,972,957 (GRCm39) missense possibly damaging 0.93
R6562:Pkn3 UTSW 2 29,970,699 (GRCm39) critical splice donor site probably null
R6724:Pkn3 UTSW 2 29,980,562 (GRCm39) missense possibly damaging 0.94
R7061:Pkn3 UTSW 2 29,973,548 (GRCm39) splice site probably null
R7128:Pkn3 UTSW 2 29,973,327 (GRCm39) missense probably damaging 1.00
R7249:Pkn3 UTSW 2 29,974,773 (GRCm39) missense probably benign 0.00
R7475:Pkn3 UTSW 2 29,977,122 (GRCm39) missense probably benign 0.01
R7746:Pkn3 UTSW 2 29,980,596 (GRCm39) missense probably benign 0.00
R7747:Pkn3 UTSW 2 29,980,596 (GRCm39) missense probably benign 0.00
R7783:Pkn3 UTSW 2 29,969,634 (GRCm39) missense probably damaging 1.00
R8401:Pkn3 UTSW 2 29,970,071 (GRCm39) missense probably benign 0.00
R8425:Pkn3 UTSW 2 29,976,513 (GRCm39) critical splice donor site probably null
R8535:Pkn3 UTSW 2 29,969,936 (GRCm39) critical splice acceptor site probably null
R8720:Pkn3 UTSW 2 29,975,196 (GRCm39) missense probably benign 0.01
R8743:Pkn3 UTSW 2 29,973,318 (GRCm39) missense probably benign 0.00
R9415:Pkn3 UTSW 2 29,968,332 (GRCm39) missense probably benign 0.20
R9437:Pkn3 UTSW 2 29,973,267 (GRCm39) missense possibly damaging 0.93
R9583:Pkn3 UTSW 2 29,976,723 (GRCm39) missense probably null 0.99
R9800:Pkn3 UTSW 2 29,973,290 (GRCm39) nonsense probably null
Posted On 2016-08-02