Incidental Mutation 'IGL03107:Or2g1'
ID 419015
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2g1
Ensembl Gene ENSMUSG00000045202
Gene Name olfactory receptor family 2 subfamily G member 1
Synonyms MOR256-9, GA_x6K02T2PSCP-2255106-2256035, Olfr123
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # IGL03107
Quality Score
Status
Chromosome 17
Chromosomal Location 38106337-38107266 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 38106679 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 115 (V115I)
Ref Sequence ENSEMBL: ENSMUSP00000149802 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054748] [ENSMUST00000214770] [ENSMUST00000215168] [ENSMUST00000216051] [ENSMUST00000216478]
AlphaFold Q8VFQ1
Predicted Effect probably benign
Transcript: ENSMUST00000054748
AA Change: V115I

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000058678
Gene: ENSMUSG00000045202
AA Change: V115I

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srv 23 163 2.9e-6 PFAM
Pfam:7tm_4 29 306 2.3e-44 PFAM
Pfam:7TM_GPCR_Srsx 33 144 2.4e-5 PFAM
Pfam:7tm_1 39 288 1.1e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174446
Predicted Effect probably benign
Transcript: ENSMUST00000214770
AA Change: V115I

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
Predicted Effect probably benign
Transcript: ENSMUST00000215168
Predicted Effect probably benign
Transcript: ENSMUST00000216051
AA Change: V115I

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
Predicted Effect probably benign
Transcript: ENSMUST00000216478
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930003A15Rik T C 16: 19,702,518 (GRCm39) noncoding transcript Het
Angpt4 A G 2: 151,785,342 (GRCm39) M453V probably benign Het
Atr T A 9: 95,779,783 (GRCm39) D1380E probably benign Het
Carmil1 A T 13: 24,278,438 (GRCm39) M177K probably damaging Het
Cenpk T A 13: 104,379,280 (GRCm39) I203N probably damaging Het
Cerk A T 15: 86,027,014 (GRCm39) N165K probably benign Het
Col27a1 G A 4: 63,242,869 (GRCm39) probably benign Het
Crb2 A T 2: 37,681,428 (GRCm39) D757V probably benign Het
Csnk1a1 A G 18: 61,701,376 (GRCm39) D91G probably damaging Het
Dnajc6 G T 4: 101,474,057 (GRCm39) W486L probably damaging Het
Elmod1 C T 9: 53,841,507 (GRCm39) probably benign Het
Ercc3 G T 18: 32,381,360 (GRCm39) R392L possibly damaging Het
Fam135b C T 15: 71,335,410 (GRCm39) V595I probably benign Het
Fem1al T A 11: 29,774,360 (GRCm39) I366F probably damaging Het
Fermt1 A T 2: 132,775,059 (GRCm39) S256T probably damaging Het
Fstl5 G T 3: 76,443,618 (GRCm39) C321F probably damaging Het
Gpatch1 T G 7: 35,002,742 (GRCm39) N256T probably benign Het
Gpd2 T A 2: 57,245,581 (GRCm39) S425R probably damaging Het
Igkv4-57-1 T G 6: 69,521,574 (GRCm39) M43L probably benign Het
Itgae A G 11: 73,004,427 (GRCm39) Q238R probably damaging Het
Lats1 T A 10: 7,588,510 (GRCm39) D1042E probably benign Het
Lcn8 G A 2: 25,545,377 (GRCm39) G156D probably damaging Het
Loxl4 A C 19: 42,593,718 (GRCm39) V224G probably benign Het
Lrp2 T A 2: 69,285,177 (GRCm39) D3827V probably damaging Het
Neb C A 2: 52,073,837 (GRCm39) R231S probably benign Het
Or5b105 A T 19: 13,080,401 (GRCm39) M89K probably benign Het
Or6c211 A G 10: 129,505,809 (GRCm39) M193T probably benign Het
Or6d13 T G 6: 116,517,900 (GRCm39) M162R possibly damaging Het
Or8g54 T G 9: 39,707,475 (GRCm39) M268R probably benign Het
Pappa T G 4: 65,122,940 (GRCm39) S758R probably damaging Het
Pced1a G A 2: 130,264,755 (GRCm39) T61I possibly damaging Het
Pik3cg T C 12: 32,250,594 (GRCm39) D731G probably damaging Het
Plxnb1 G A 9: 108,934,054 (GRCm39) D761N probably benign Het
Pmp22 T C 11: 63,049,135 (GRCm39) V126A probably benign Het
Ppp6r2 G T 15: 89,152,748 (GRCm39) R296S probably damaging Het
Prkcq A C 2: 11,265,597 (GRCm39) H438P probably damaging Het
Ryr1 T A 7: 28,774,624 (GRCm39) Y2339F probably damaging Het
Scaper T C 9: 55,765,686 (GRCm39) probably benign Het
Scp2 T A 4: 107,955,312 (GRCm39) I144F probably benign Het
Secisbp2 T C 13: 51,806,793 (GRCm39) probably null Het
Sema5a T A 15: 32,669,554 (GRCm39) Y693N probably damaging Het
Sin3b T A 8: 73,480,213 (GRCm39) I905K probably damaging Het
Slc13a3 T A 2: 165,279,227 (GRCm39) M195L probably benign Het
Strada A G 11: 106,054,863 (GRCm39) probably benign Het
Stx18 G A 5: 38,293,655 (GRCm39) V294M probably damaging Het
Tbpl2 A T 2: 23,983,845 (GRCm39) N197K probably benign Het
Tdrd9 A T 12: 112,009,274 (GRCm39) H1060L probably damaging Het
Tm4sf5 G A 11: 70,396,223 (GRCm39) V23M possibly damaging Het
Tmem54 C A 4: 129,004,705 (GRCm39) L187I probably damaging Het
Tmprss5 A G 9: 49,024,528 (GRCm39) H281R possibly damaging Het
Trim30c A G 7: 104,031,820 (GRCm39) Y332H possibly damaging Het
Uba6 T A 5: 86,275,633 (GRCm39) probably benign Het
Unc80 C A 1: 66,670,613 (GRCm39) P1912Q probably damaging Het
Other mutations in Or2g1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01409:Or2g1 APN 17 38,106,413 (GRCm39) missense probably damaging 0.99
IGL03030:Or2g1 APN 17 38,107,162 (GRCm39) missense probably damaging 1.00
R0329:Or2g1 UTSW 17 38,106,880 (GRCm39) missense probably benign 0.01
R0330:Or2g1 UTSW 17 38,106,880 (GRCm39) missense probably benign 0.01
R0524:Or2g1 UTSW 17 38,106,496 (GRCm39) nonsense probably null
R0581:Or2g1 UTSW 17 38,106,993 (GRCm39) missense probably damaging 1.00
R1288:Or2g1 UTSW 17 38,106,584 (GRCm39) missense probably damaging 0.98
R1897:Or2g1 UTSW 17 38,107,075 (GRCm39) missense probably benign 0.22
R3751:Or2g1 UTSW 17 38,107,123 (GRCm39) missense possibly damaging 0.95
R3753:Or2g1 UTSW 17 38,107,123 (GRCm39) missense possibly damaging 0.95
R3780:Or2g1 UTSW 17 38,106,895 (GRCm39) missense probably damaging 1.00
R3947:Or2g1 UTSW 17 38,107,006 (GRCm39) missense probably benign
R5925:Or2g1 UTSW 17 38,106,482 (GRCm39) missense probably benign 0.00
R5987:Or2g1 UTSW 17 38,107,248 (GRCm39) missense probably benign
R6369:Or2g1 UTSW 17 38,106,387 (GRCm39) missense probably benign 0.02
R6891:Or2g1 UTSW 17 38,106,395 (GRCm39) missense probably benign
R7320:Or2g1 UTSW 17 38,107,248 (GRCm39) missense probably benign
R7997:Or2g1 UTSW 17 38,107,053 (GRCm39) nonsense probably null
R8153:Or2g1 UTSW 17 38,106,367 (GRCm39) missense probably benign 0.00
R8793:Or2g1 UTSW 17 38,107,255 (GRCm39) missense probably benign 0.21
R9348:Or2g1 UTSW 17 38,106,992 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02