Incidental Mutation 'IGL03107:Tdrd9'
ID 419025
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tdrd9
Ensembl Gene ENSMUSG00000054003
Gene Name tudor domain containing 9
Synonyms 4930441E05Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.192) question?
Stock # IGL03107
Quality Score
Status
Chromosome 12
Chromosomal Location 111937993-112035288 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 112009274 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 1060 (H1060L)
Ref Sequence ENSEMBL: ENSMUSP00000078022 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079009]
AlphaFold Q14BI7
Predicted Effect probably damaging
Transcript: ENSMUST00000079009
AA Change: H1060L

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000078022
Gene: ENSMUSG00000054003
AA Change: H1060L

DomainStartEndE-ValueType
low complexity region 29 40 N/A INTRINSIC
low complexity region 70 81 N/A INTRINSIC
DEXDc 132 327 5.64e-21 SMART
HELICc 404 502 3.22e-16 SMART
low complexity region 547 561 N/A INTRINSIC
HA2 565 666 1.9e-20 SMART
TUDOR 944 1003 1.52e-7 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000191808
Predicted Effect probably benign
Transcript: ENSMUST00000192125
Predicted Effect noncoding transcript
Transcript: ENSMUST00000193586
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Male homozygous mice are sterile, displaying small testis, arrest of male meiosis and abnormal spermatocyte morphology. Females are fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930003A15Rik T C 16: 19,702,518 (GRCm39) noncoding transcript Het
Angpt4 A G 2: 151,785,342 (GRCm39) M453V probably benign Het
Atr T A 9: 95,779,783 (GRCm39) D1380E probably benign Het
Carmil1 A T 13: 24,278,438 (GRCm39) M177K probably damaging Het
Cenpk T A 13: 104,379,280 (GRCm39) I203N probably damaging Het
Cerk A T 15: 86,027,014 (GRCm39) N165K probably benign Het
Col27a1 G A 4: 63,242,869 (GRCm39) probably benign Het
Crb2 A T 2: 37,681,428 (GRCm39) D757V probably benign Het
Csnk1a1 A G 18: 61,701,376 (GRCm39) D91G probably damaging Het
Dnajc6 G T 4: 101,474,057 (GRCm39) W486L probably damaging Het
Elmod1 C T 9: 53,841,507 (GRCm39) probably benign Het
Ercc3 G T 18: 32,381,360 (GRCm39) R392L possibly damaging Het
Fam135b C T 15: 71,335,410 (GRCm39) V595I probably benign Het
Fem1al T A 11: 29,774,360 (GRCm39) I366F probably damaging Het
Fermt1 A T 2: 132,775,059 (GRCm39) S256T probably damaging Het
Fstl5 G T 3: 76,443,618 (GRCm39) C321F probably damaging Het
Gpatch1 T G 7: 35,002,742 (GRCm39) N256T probably benign Het
Gpd2 T A 2: 57,245,581 (GRCm39) S425R probably damaging Het
Igkv4-57-1 T G 6: 69,521,574 (GRCm39) M43L probably benign Het
Itgae A G 11: 73,004,427 (GRCm39) Q238R probably damaging Het
Lats1 T A 10: 7,588,510 (GRCm39) D1042E probably benign Het
Lcn8 G A 2: 25,545,377 (GRCm39) G156D probably damaging Het
Loxl4 A C 19: 42,593,718 (GRCm39) V224G probably benign Het
Lrp2 T A 2: 69,285,177 (GRCm39) D3827V probably damaging Het
Neb C A 2: 52,073,837 (GRCm39) R231S probably benign Het
Or2g1 G A 17: 38,106,679 (GRCm39) V115I probably benign Het
Or5b105 A T 19: 13,080,401 (GRCm39) M89K probably benign Het
Or6c211 A G 10: 129,505,809 (GRCm39) M193T probably benign Het
Or6d13 T G 6: 116,517,900 (GRCm39) M162R possibly damaging Het
Or8g54 T G 9: 39,707,475 (GRCm39) M268R probably benign Het
Pappa T G 4: 65,122,940 (GRCm39) S758R probably damaging Het
Pced1a G A 2: 130,264,755 (GRCm39) T61I possibly damaging Het
Pik3cg T C 12: 32,250,594 (GRCm39) D731G probably damaging Het
Plxnb1 G A 9: 108,934,054 (GRCm39) D761N probably benign Het
Pmp22 T C 11: 63,049,135 (GRCm39) V126A probably benign Het
Ppp6r2 G T 15: 89,152,748 (GRCm39) R296S probably damaging Het
Prkcq A C 2: 11,265,597 (GRCm39) H438P probably damaging Het
Ryr1 T A 7: 28,774,624 (GRCm39) Y2339F probably damaging Het
Scaper T C 9: 55,765,686 (GRCm39) probably benign Het
Scp2 T A 4: 107,955,312 (GRCm39) I144F probably benign Het
Secisbp2 T C 13: 51,806,793 (GRCm39) probably null Het
Sema5a T A 15: 32,669,554 (GRCm39) Y693N probably damaging Het
Sin3b T A 8: 73,480,213 (GRCm39) I905K probably damaging Het
Slc13a3 T A 2: 165,279,227 (GRCm39) M195L probably benign Het
Strada A G 11: 106,054,863 (GRCm39) probably benign Het
Stx18 G A 5: 38,293,655 (GRCm39) V294M probably damaging Het
Tbpl2 A T 2: 23,983,845 (GRCm39) N197K probably benign Het
Tm4sf5 G A 11: 70,396,223 (GRCm39) V23M possibly damaging Het
Tmem54 C A 4: 129,004,705 (GRCm39) L187I probably damaging Het
Tmprss5 A G 9: 49,024,528 (GRCm39) H281R possibly damaging Het
Trim30c A G 7: 104,031,820 (GRCm39) Y332H possibly damaging Het
Uba6 T A 5: 86,275,633 (GRCm39) probably benign Het
Unc80 C A 1: 66,670,613 (GRCm39) P1912Q probably damaging Het
Other mutations in Tdrd9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01339:Tdrd9 APN 12 112,006,868 (GRCm39) missense probably damaging 1.00
IGL01373:Tdrd9 APN 12 112,006,868 (GRCm39) missense probably damaging 1.00
IGL01542:Tdrd9 APN 12 112,013,423 (GRCm39) missense possibly damaging 0.94
IGL02967:Tdrd9 APN 12 111,958,922 (GRCm39) missense possibly damaging 0.50
IGL03063:Tdrd9 APN 12 112,010,733 (GRCm39) missense probably benign 0.00
R0433:Tdrd9 UTSW 12 111,992,015 (GRCm39) nonsense probably null
R0453:Tdrd9 UTSW 12 112,034,673 (GRCm39) missense probably benign
R0655:Tdrd9 UTSW 12 112,006,899 (GRCm39) missense probably damaging 1.00
R0666:Tdrd9 UTSW 12 111,974,014 (GRCm39) intron probably benign
R1073:Tdrd9 UTSW 12 111,989,693 (GRCm39) missense probably damaging 1.00
R1280:Tdrd9 UTSW 12 112,005,842 (GRCm39) missense probably damaging 1.00
R1386:Tdrd9 UTSW 12 112,011,238 (GRCm39) missense probably benign 0.21
R1521:Tdrd9 UTSW 12 112,002,844 (GRCm39) missense probably damaging 1.00
R1601:Tdrd9 UTSW 12 111,989,687 (GRCm39) nonsense probably null
R1651:Tdrd9 UTSW 12 111,991,140 (GRCm39) missense probably damaging 0.97
R1715:Tdrd9 UTSW 12 112,002,873 (GRCm39) missense possibly damaging 0.62
R1854:Tdrd9 UTSW 12 112,011,246 (GRCm39) missense probably damaging 1.00
R1905:Tdrd9 UTSW 12 112,030,061 (GRCm39) splice site probably benign
R2386:Tdrd9 UTSW 12 111,982,334 (GRCm39) missense probably damaging 1.00
R2863:Tdrd9 UTSW 12 111,997,695 (GRCm39) missense probably benign
R2915:Tdrd9 UTSW 12 112,006,895 (GRCm39) missense probably damaging 1.00
R2958:Tdrd9 UTSW 12 112,008,106 (GRCm39) missense probably damaging 0.97
R4033:Tdrd9 UTSW 12 111,958,973 (GRCm39) missense possibly damaging 0.58
R4087:Tdrd9 UTSW 12 111,979,920 (GRCm39) nonsense probably null
R4237:Tdrd9 UTSW 12 112,034,059 (GRCm39) nonsense probably null
R4482:Tdrd9 UTSW 12 111,980,935 (GRCm39) critical splice donor site probably null
R4501:Tdrd9 UTSW 12 112,009,243 (GRCm39) missense probably benign 0.00
R4502:Tdrd9 UTSW 12 111,960,259 (GRCm39) missense probably damaging 1.00
R4715:Tdrd9 UTSW 12 112,008,123 (GRCm39) missense probably benign 0.00
R4803:Tdrd9 UTSW 12 111,963,269 (GRCm39) nonsense probably null
R5218:Tdrd9 UTSW 12 112,029,909 (GRCm39) intron probably benign
R5275:Tdrd9 UTSW 12 112,018,346 (GRCm39) nonsense probably null
R5295:Tdrd9 UTSW 12 112,018,346 (GRCm39) nonsense probably null
R5301:Tdrd9 UTSW 12 112,002,963 (GRCm39) critical splice donor site probably null
R5339:Tdrd9 UTSW 12 111,993,556 (GRCm39) missense probably damaging 1.00
R5500:Tdrd9 UTSW 12 111,989,702 (GRCm39) missense probably benign 0.02
R5573:Tdrd9 UTSW 12 111,964,336 (GRCm39) splice site probably null
R5590:Tdrd9 UTSW 12 112,018,414 (GRCm39) missense probably benign 0.01
R5891:Tdrd9 UTSW 12 112,009,153 (GRCm39) missense probably damaging 1.00
R6056:Tdrd9 UTSW 12 111,951,475 (GRCm39) missense probably damaging 1.00
R6057:Tdrd9 UTSW 12 111,979,720 (GRCm39) missense possibly damaging 0.85
R6125:Tdrd9 UTSW 12 112,034,632 (GRCm39) missense possibly damaging 0.89
R6254:Tdrd9 UTSW 12 111,992,334 (GRCm39) splice site probably null
R6335:Tdrd9 UTSW 12 112,008,186 (GRCm39) critical splice donor site probably null
R6345:Tdrd9 UTSW 12 112,001,042 (GRCm39) missense probably damaging 0.99
R6792:Tdrd9 UTSW 12 111,993,547 (GRCm39) missense probably benign 0.01
R6956:Tdrd9 UTSW 12 112,002,788 (GRCm39) splice site probably benign
R6987:Tdrd9 UTSW 12 111,992,027 (GRCm39) missense possibly damaging 0.82
R7090:Tdrd9 UTSW 12 111,958,904 (GRCm39) missense probably benign
R7158:Tdrd9 UTSW 12 112,002,800 (GRCm39) missense probably benign 0.08
R7220:Tdrd9 UTSW 12 111,980,888 (GRCm39) missense probably damaging 1.00
R7478:Tdrd9 UTSW 12 111,951,476 (GRCm39) missense probably damaging 1.00
R7489:Tdrd9 UTSW 12 112,034,071 (GRCm39) missense probably benign 0.00
R7751:Tdrd9 UTSW 12 111,958,982 (GRCm39) missense probably benign 0.09
R7809:Tdrd9 UTSW 12 111,999,155 (GRCm39) missense probably damaging 0.99
R7844:Tdrd9 UTSW 12 111,964,386 (GRCm39) missense possibly damaging 0.63
R7854:Tdrd9 UTSW 12 112,013,395 (GRCm39) missense probably benign 0.00
R7903:Tdrd9 UTSW 12 112,018,410 (GRCm39) missense possibly damaging 0.95
R7938:Tdrd9 UTSW 12 111,997,649 (GRCm39) missense possibly damaging 0.86
R8018:Tdrd9 UTSW 12 112,010,822 (GRCm39) missense probably damaging 0.99
R8018:Tdrd9 UTSW 12 111,999,180 (GRCm39) missense probably benign 0.12
R8090:Tdrd9 UTSW 12 111,982,369 (GRCm39) missense probably damaging 1.00
R8157:Tdrd9 UTSW 12 111,951,500 (GRCm39) missense probably benign 0.44
R8198:Tdrd9 UTSW 12 112,006,863 (GRCm39) missense probably damaging 1.00
R8203:Tdrd9 UTSW 12 111,992,064 (GRCm39) missense probably damaging 1.00
R8512:Tdrd9 UTSW 12 112,012,627 (GRCm39) missense probably benign
R8721:Tdrd9 UTSW 12 112,002,889 (GRCm39) missense probably damaging 1.00
R8889:Tdrd9 UTSW 12 111,979,718 (GRCm39) missense probably benign 0.07
R8892:Tdrd9 UTSW 12 111,979,718 (GRCm39) missense probably benign 0.07
R9276:Tdrd9 UTSW 12 111,980,935 (GRCm39) critical splice donor site probably null
R9459:Tdrd9 UTSW 12 111,992,007 (GRCm39) missense probably damaging 1.00
R9484:Tdrd9 UTSW 12 112,012,684 (GRCm39) missense probably damaging 0.97
R9657:Tdrd9 UTSW 12 112,002,824 (GRCm39) missense possibly damaging 0.50
R9745:Tdrd9 UTSW 12 112,009,130 (GRCm39) missense probably damaging 0.99
X0018:Tdrd9 UTSW 12 112,005,763 (GRCm39) missense probably benign 0.24
Z1177:Tdrd9 UTSW 12 111,982,355 (GRCm39) missense probably damaging 1.00
Z1177:Tdrd9 UTSW 12 111,960,325 (GRCm39) missense probably damaging 0.96
Z1177:Tdrd9 UTSW 12 111,938,088 (GRCm39) missense probably benign 0.08
Posted On 2016-08-02