Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03107:Scaper'

419049

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Scaper

Ensembl Gene

ENSMUSG00000034007

Gene Name

S phase cyclin A-associated protein in the ER

Synonyms

Zfp291, D530014O03Rik

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.713) question?

Stock #

IGL03107

Quality Score

Status

Chromosome

Chromosomal Location

55457163-55845403 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 55765686 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000149750 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000037408] [ENSMUST00000214747] [ENSMUST00000216595] [ENSMUST00000217647]

AlphaFold

F8VQ70

Predicted Effect

probably benign
Transcript: ENSMUST00000037408

SMART Domains

Protein: ENSMUSP00000043411
Gene: ENSMUSG00000034007

Domain	Start	End	E-Value	Type
Pfam:SCAPER_N	88	185	3.4e-47	PFAM
low complexity region	323	338	N/A	INTRINSIC
coiled coil region	415	466	N/A	INTRINSIC
coiled coil region	535	597	N/A	INTRINSIC
SCOP:d1eq1a_	605	769	3e-6	SMART
ZnF_C2H2	791	815	1.16e1	SMART
low complexity region	866	883	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000214747

Predicted Effect

probably benign
Transcript: ENSMUST00000216595

Predicted Effect

probably benign
Transcript: ENSMUST00000217647

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A930003A15Rik	T	C	16: 19,702,518 (GRCm39)		noncoding transcript	Het
Angpt4	A	G	2: 151,785,342 (GRCm39)	M453V	probably benign	Het
Atr	T	A	9: 95,779,783 (GRCm39)	D1380E	probably benign	Het
Carmil1	A	T	13: 24,278,438 (GRCm39)	M177K	probably damaging	Het
Cenpk	T	A	13: 104,379,280 (GRCm39)	I203N	probably damaging	Het
Cerk	A	T	15: 86,027,014 (GRCm39)	N165K	probably benign	Het
Col27a1	G	A	4: 63,242,869 (GRCm39)		probably benign	Het
Crb2	A	T	2: 37,681,428 (GRCm39)	D757V	probably benign	Het
Csnk1a1	A	G	18: 61,701,376 (GRCm39)	D91G	probably damaging	Het
Dnajc6	G	T	4: 101,474,057 (GRCm39)	W486L	probably damaging	Het
Elmod1	C	T	9: 53,841,507 (GRCm39)		probably benign	Het
Ercc3	G	T	18: 32,381,360 (GRCm39)	R392L	possibly damaging	Het
Fam135b	C	T	15: 71,335,410 (GRCm39)	V595I	probably benign	Het
Fem1al	T	A	11: 29,774,360 (GRCm39)	I366F	probably damaging	Het
Fermt1	A	T	2: 132,775,059 (GRCm39)	S256T	probably damaging	Het
Fstl5	G	T	3: 76,443,618 (GRCm39)	C321F	probably damaging	Het
Gpatch1	T	G	7: 35,002,742 (GRCm39)	N256T	probably benign	Het
Gpd2	T	A	2: 57,245,581 (GRCm39)	S425R	probably damaging	Het
Igkv4-57-1	T	G	6: 69,521,574 (GRCm39)	M43L	probably benign	Het
Itgae	A	G	11: 73,004,427 (GRCm39)	Q238R	probably damaging	Het
Lats1	T	A	10: 7,588,510 (GRCm39)	D1042E	probably benign	Het
Lcn8	G	A	2: 25,545,377 (GRCm39)	G156D	probably damaging	Het
Loxl4	A	C	19: 42,593,718 (GRCm39)	V224G	probably benign	Het
Lrp2	T	A	2: 69,285,177 (GRCm39)	D3827V	probably damaging	Het
Neb	C	A	2: 52,073,837 (GRCm39)	R231S	probably benign	Het
Or2g1	G	A	17: 38,106,679 (GRCm39)	V115I	probably benign	Het
Or5b105	A	T	19: 13,080,401 (GRCm39)	M89K	probably benign	Het
Or6c211	A	G	10: 129,505,809 (GRCm39)	M193T	probably benign	Het
Or6d13	T	G	6: 116,517,900 (GRCm39)	M162R	possibly damaging	Het
Or8g54	T	G	9: 39,707,475 (GRCm39)	M268R	probably benign	Het
Pappa	T	G	4: 65,122,940 (GRCm39)	S758R	probably damaging	Het
Pced1a	G	A	2: 130,264,755 (GRCm39)	T61I	possibly damaging	Het
Pik3cg	T	C	12: 32,250,594 (GRCm39)	D731G	probably damaging	Het
Plxnb1	G	A	9: 108,934,054 (GRCm39)	D761N	probably benign	Het
Pmp22	T	C	11: 63,049,135 (GRCm39)	V126A	probably benign	Het
Ppp6r2	G	T	15: 89,152,748 (GRCm39)	R296S	probably damaging	Het
Prkcq	A	C	2: 11,265,597 (GRCm39)	H438P	probably damaging	Het
Ryr1	T	A	7: 28,774,624 (GRCm39)	Y2339F	probably damaging	Het
Scp2	T	A	4: 107,955,312 (GRCm39)	I144F	probably benign	Het
Secisbp2	T	C	13: 51,806,793 (GRCm39)		probably null	Het
Sema5a	T	A	15: 32,669,554 (GRCm39)	Y693N	probably damaging	Het
Sin3b	T	A	8: 73,480,213 (GRCm39)	I905K	probably damaging	Het
Slc13a3	T	A	2: 165,279,227 (GRCm39)	M195L	probably benign	Het
Strada	A	G	11: 106,054,863 (GRCm39)		probably benign	Het
Stx18	G	A	5: 38,293,655 (GRCm39)	V294M	probably damaging	Het
Tbpl2	A	T	2: 23,983,845 (GRCm39)	N197K	probably benign	Het
Tdrd9	A	T	12: 112,009,274 (GRCm39)	H1060L	probably damaging	Het
Tm4sf5	G	A	11: 70,396,223 (GRCm39)	V23M	possibly damaging	Het
Tmem54	C	A	4: 129,004,705 (GRCm39)	L187I	probably damaging	Het
Tmprss5	A	G	9: 49,024,528 (GRCm39)	H281R	possibly damaging	Het
Trim30c	A	G	7: 104,031,820 (GRCm39)	Y332H	possibly damaging	Het
Uba6	T	A	5: 86,275,633 (GRCm39)		probably benign	Het
Unc80	C	A	1: 66,670,613 (GRCm39)	P1912Q	probably damaging	Het

Other mutations in Scaper

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00653:Scaper	APN	9	55,767,143 (GRCm39)	missense	probably damaging	0.99
IGL00912:Scaper	APN	9	55,593,239 (GRCm39)	missense	probably damaging	1.00
IGL01469:Scaper	APN	9	55,767,051 (GRCm39)	missense	probably damaging	1.00
IGL01626:Scaper	APN	9	55,819,335 (GRCm39)	missense	possibly damaging	0.61
IGL01779:Scaper	APN	9	55,799,524 (GRCm39)	missense	probably benign	0.20
IGL02011:Scaper	APN	9	55,487,606 (GRCm39)	missense	probably damaging	1.00
IGL02997:Scaper	APN	9	55,722,783 (GRCm39)	missense	probably damaging	1.00
IGL03167:Scaper	APN	9	55,767,108 (GRCm39)	missense	probably damaging	1.00
IGL03293:Scaper	APN	9	55,782,107 (GRCm39)	missense	probably benign
IGL03340:Scaper	APN	9	55,510,116 (GRCm39)	missense	possibly damaging	0.88
IGL03368:Scaper	APN	9	55,563,311 (GRCm39)	missense	possibly damaging	0.53
R0111:Scaper	UTSW	9	55,510,074 (GRCm39)	missense	probably benign	0.01
R0510:Scaper	UTSW	9	55,665,346 (GRCm39)	splice site	probably benign
R0531:Scaper	UTSW	9	55,517,158 (GRCm39)	missense	possibly damaging	0.91
R0558:Scaper	UTSW	9	55,593,207 (GRCm39)	missense	probably benign	0.08
R0605:Scaper	UTSW	9	55,722,802 (GRCm39)	splice site	probably benign
R0646:Scaper	UTSW	9	55,665,340 (GRCm39)	missense	probably damaging	1.00
R0837:Scaper	UTSW	9	55,766,326 (GRCm39)	nonsense	probably null
R1440:Scaper	UTSW	9	55,510,202 (GRCm39)	nonsense	probably null
R1548:Scaper	UTSW	9	55,723,954 (GRCm39)	missense	probably damaging	1.00
R1777:Scaper	UTSW	9	55,771,830 (GRCm39)	missense	probably benign	0.33
R1822:Scaper	UTSW	9	55,767,184 (GRCm39)	missense	probably damaging	0.99
R1834:Scaper	UTSW	9	55,724,018 (GRCm39)	missense	possibly damaging	0.90
R1870:Scaper	UTSW	9	55,593,222 (GRCm39)	missense	probably damaging	1.00
R2102:Scaper	UTSW	9	55,819,334 (GRCm39)	missense	probably benign	0.43
R2168:Scaper	UTSW	9	55,650,923 (GRCm39)	missense	probably damaging	1.00
R2174:Scaper	UTSW	9	55,766,321 (GRCm39)	missense	probably null	0.01
R3690:Scaper	UTSW	9	55,791,205 (GRCm39)	missense	probably benign	0.00
R4392:Scaper	UTSW	9	55,765,399 (GRCm39)	missense	probably damaging	0.99
R4418:Scaper	UTSW	9	55,745,464 (GRCm39)	missense	probably damaging	1.00
R4606:Scaper	UTSW	9	55,563,187 (GRCm39)	critical splice donor site	probably null
R4643:Scaper	UTSW	9	55,745,463 (GRCm39)	missense	probably damaging	0.99
R4665:Scaper	UTSW	9	55,819,339 (GRCm39)	missense	probably damaging	1.00
R4739:Scaper	UTSW	9	55,650,932 (GRCm39)	missense	probably damaging	1.00
R4921:Scaper	UTSW	9	55,799,519 (GRCm39)	missense	probably benign	0.02
R4934:Scaper	UTSW	9	55,716,459 (GRCm39)	missense	probably damaging	1.00
R4956:Scaper	UTSW	9	55,745,426 (GRCm39)	missense	probably damaging	1.00
R5055:Scaper	UTSW	9	55,767,003 (GRCm39)	splice site	probably null
R5107:Scaper	UTSW	9	55,487,616 (GRCm39)	missense	probably damaging	1.00
R5155:Scaper	UTSW	9	55,463,370 (GRCm39)	missense	probably null	1.00
R5265:Scaper	UTSW	9	55,771,830 (GRCm39)	missense	probably benign
R5408:Scaper	UTSW	9	55,493,508 (GRCm39)	missense	probably damaging	0.99
R5623:Scaper	UTSW	9	55,771,791 (GRCm39)	missense	probably benign	0.02
R5665:Scaper	UTSW	9	55,714,916 (GRCm39)	missense	probably damaging	1.00
R5748:Scaper	UTSW	9	55,766,360 (GRCm39)	critical splice acceptor site	probably null
R5771:Scaper	UTSW	9	55,724,075 (GRCm39)	missense	probably damaging	1.00
R6534:Scaper	UTSW	9	55,791,260 (GRCm39)	missense	probably benign	0.00
R6557:Scaper	UTSW	9	55,458,134 (GRCm39)	missense	probably benign	0.02
R6651:Scaper	UTSW	9	55,765,788 (GRCm39)	missense	probably benign	0.05
R6796:Scaper	UTSW	9	55,771,711 (GRCm39)	missense	probably benign	0.00
R6962:Scaper	UTSW	9	55,767,055 (GRCm39)	missense	probably benign	0.01
R7145:Scaper	UTSW	9	55,819,395 (GRCm39)	missense	unknown
R7199:Scaper	UTSW	9	55,745,460 (GRCm39)	nonsense	probably null
R7356:Scaper	UTSW	9	55,799,495 (GRCm39)	missense	unknown
R7426:Scaper	UTSW	9	55,669,561 (GRCm39)	nonsense	probably null
R7503:Scaper	UTSW	9	55,715,038 (GRCm39)	missense	probably damaging	0.98
R7844:Scaper	UTSW	9	55,722,732 (GRCm39)	missense	probably benign	0.04
R7966:Scaper	UTSW	9	55,669,611 (GRCm39)	missense	probably damaging	0.98
R7992:Scaper	UTSW	9	55,765,438 (GRCm39)	missense	probably benign	0.02
R8081:Scaper	UTSW	9	55,823,330 (GRCm39)	missense	unknown
R8189:Scaper	UTSW	9	55,819,404 (GRCm39)	missense	probably damaging	1.00
R8294:Scaper	UTSW	9	55,517,280 (GRCm39)	missense	possibly damaging	0.62
R8351:Scaper	UTSW	9	55,724,088 (GRCm39)	missense	possibly damaging	0.92
R8451:Scaper	UTSW	9	55,724,088 (GRCm39)	missense	possibly damaging	0.92
R8473:Scaper	UTSW	9	55,458,131 (GRCm39)	missense	probably damaging	1.00
R8476:Scaper	UTSW	9	55,669,575 (GRCm39)	missense	probably damaging	1.00
R8504:Scaper	UTSW	9	55,771,722 (GRCm39)	missense	probably benign
R9058:Scaper	UTSW	9	55,722,762 (GRCm39)	missense	probably damaging	1.00
R9071:Scaper	UTSW	9	55,771,803 (GRCm39)	missense	probably benign
R9099:Scaper	UTSW	9	55,669,616 (GRCm39)	missense	probably damaging	0.98
R9104:Scaper	UTSW	9	55,819,400 (GRCm39)	missense	unknown
R9516:Scaper	UTSW	9	55,593,275 (GRCm39)	missense	probably benign	0.05
R9685:Scaper	UTSW	9	55,771,835 (GRCm39)	missense	probably benign	0.10
X0012:Scaper	UTSW	9	55,563,214 (GRCm39)	missense	probably damaging	0.98
X0052:Scaper	UTSW	9	55,723,948 (GRCm39)	missense	probably damaging	1.00
Z1176:Scaper	UTSW	9	55,463,532 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02