Incidental Mutation 'IGL03107:Strada'
ID 419051
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Strada
Ensembl Gene ENSMUSG00000069631
Gene Name STE20-related kinase adaptor alpha
Synonyms 6030402H20Rik, 2610019A05Rik
Accession Numbers
Essential gene? Possibly essential (E-score: 0.521) question?
Stock # IGL03107
Quality Score
Status
Chromosome 11
Chromosomal Location 106053739-106084460 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to G at 106054863 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000115555 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000007444] [ENSMUST00000045923] [ENSMUST00000064545] [ENSMUST00000100326] [ENSMUST00000103072] [ENSMUST00000106875] [ENSMUST00000152008]
AlphaFold Q3UUJ4
Predicted Effect probably benign
Transcript: ENSMUST00000007444
SMART Domains Protein: ENSMUSP00000007444
Gene: ENSMUSG00000069631

DomainStartEndE-ValueType
Pfam:Pkinase 69 379 2.4e-37 PFAM
Pfam:Pkinase_Tyr 70 302 2.1e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000045923
SMART Domains Protein: ENSMUSP00000045357
Gene: ENSMUSG00000040699

DomainStartEndE-ValueType
LIM 40 92 3.93e-13 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000064545
SMART Domains Protein: ENSMUSP00000067070
Gene: ENSMUSG00000040699

DomainStartEndE-ValueType
LIM 40 92 3.93e-13 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000100326
SMART Domains Protein: ENSMUSP00000097900
Gene: ENSMUSG00000075480

DomainStartEndE-ValueType
low complexity region 39 54 N/A INTRINSIC
low complexity region 61 74 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000103072
SMART Domains Protein: ENSMUSP00000099361
Gene: ENSMUSG00000069631

DomainStartEndE-ValueType
Pfam:Pkinase 32 342 2.2e-35 PFAM
Pfam:Pkinase_Tyr 33 266 2.5e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106875
SMART Domains Protein: ENSMUSP00000102488
Gene: ENSMUSG00000040699

DomainStartEndE-ValueType
LIM 40 92 3.93e-13 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138094
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122989
Predicted Effect probably benign
Transcript: ENSMUST00000152008
SMART Domains Protein: ENSMUSP00000115555
Gene: ENSMUSG00000069631

DomainStartEndE-ValueType
Pfam:Pkinase 32 159 7.4e-16 PFAM
Pfam:Pkinase_Tyr 33 159 1.5e-10 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930003A15Rik T C 16: 19,702,518 (GRCm39) noncoding transcript Het
Angpt4 A G 2: 151,785,342 (GRCm39) M453V probably benign Het
Atr T A 9: 95,779,783 (GRCm39) D1380E probably benign Het
Carmil1 A T 13: 24,278,438 (GRCm39) M177K probably damaging Het
Cenpk T A 13: 104,379,280 (GRCm39) I203N probably damaging Het
Cerk A T 15: 86,027,014 (GRCm39) N165K probably benign Het
Col27a1 G A 4: 63,242,869 (GRCm39) probably benign Het
Crb2 A T 2: 37,681,428 (GRCm39) D757V probably benign Het
Csnk1a1 A G 18: 61,701,376 (GRCm39) D91G probably damaging Het
Dnajc6 G T 4: 101,474,057 (GRCm39) W486L probably damaging Het
Elmod1 C T 9: 53,841,507 (GRCm39) probably benign Het
Ercc3 G T 18: 32,381,360 (GRCm39) R392L possibly damaging Het
Fam135b C T 15: 71,335,410 (GRCm39) V595I probably benign Het
Fem1al T A 11: 29,774,360 (GRCm39) I366F probably damaging Het
Fermt1 A T 2: 132,775,059 (GRCm39) S256T probably damaging Het
Fstl5 G T 3: 76,443,618 (GRCm39) C321F probably damaging Het
Gpatch1 T G 7: 35,002,742 (GRCm39) N256T probably benign Het
Gpd2 T A 2: 57,245,581 (GRCm39) S425R probably damaging Het
Igkv4-57-1 T G 6: 69,521,574 (GRCm39) M43L probably benign Het
Itgae A G 11: 73,004,427 (GRCm39) Q238R probably damaging Het
Lats1 T A 10: 7,588,510 (GRCm39) D1042E probably benign Het
Lcn8 G A 2: 25,545,377 (GRCm39) G156D probably damaging Het
Loxl4 A C 19: 42,593,718 (GRCm39) V224G probably benign Het
Lrp2 T A 2: 69,285,177 (GRCm39) D3827V probably damaging Het
Neb C A 2: 52,073,837 (GRCm39) R231S probably benign Het
Or2g1 G A 17: 38,106,679 (GRCm39) V115I probably benign Het
Or5b105 A T 19: 13,080,401 (GRCm39) M89K probably benign Het
Or6c211 A G 10: 129,505,809 (GRCm39) M193T probably benign Het
Or6d13 T G 6: 116,517,900 (GRCm39) M162R possibly damaging Het
Or8g54 T G 9: 39,707,475 (GRCm39) M268R probably benign Het
Pappa T G 4: 65,122,940 (GRCm39) S758R probably damaging Het
Pced1a G A 2: 130,264,755 (GRCm39) T61I possibly damaging Het
Pik3cg T C 12: 32,250,594 (GRCm39) D731G probably damaging Het
Plxnb1 G A 9: 108,934,054 (GRCm39) D761N probably benign Het
Pmp22 T C 11: 63,049,135 (GRCm39) V126A probably benign Het
Ppp6r2 G T 15: 89,152,748 (GRCm39) R296S probably damaging Het
Prkcq A C 2: 11,265,597 (GRCm39) H438P probably damaging Het
Ryr1 T A 7: 28,774,624 (GRCm39) Y2339F probably damaging Het
Scaper T C 9: 55,765,686 (GRCm39) probably benign Het
Scp2 T A 4: 107,955,312 (GRCm39) I144F probably benign Het
Secisbp2 T C 13: 51,806,793 (GRCm39) probably null Het
Sema5a T A 15: 32,669,554 (GRCm39) Y693N probably damaging Het
Sin3b T A 8: 73,480,213 (GRCm39) I905K probably damaging Het
Slc13a3 T A 2: 165,279,227 (GRCm39) M195L probably benign Het
Stx18 G A 5: 38,293,655 (GRCm39) V294M probably damaging Het
Tbpl2 A T 2: 23,983,845 (GRCm39) N197K probably benign Het
Tdrd9 A T 12: 112,009,274 (GRCm39) H1060L probably damaging Het
Tm4sf5 G A 11: 70,396,223 (GRCm39) V23M possibly damaging Het
Tmem54 C A 4: 129,004,705 (GRCm39) L187I probably damaging Het
Tmprss5 A G 9: 49,024,528 (GRCm39) H281R possibly damaging Het
Trim30c A G 7: 104,031,820 (GRCm39) Y332H possibly damaging Het
Uba6 T A 5: 86,275,633 (GRCm39) probably benign Het
Unc80 C A 1: 66,670,613 (GRCm39) P1912Q probably damaging Het
Other mutations in Strada
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00778:Strada APN 11 106,061,976 (GRCm39) splice site probably benign
IGL00870:Strada APN 11 106,062,083 (GRCm39) missense probably damaging 1.00
IGL01564:Strada APN 11 106,064,118 (GRCm39) missense probably damaging 1.00
IGL02508:Strada APN 11 106,059,182 (GRCm39) missense probably benign 0.03
IGL02816:Strada APN 11 106,055,251 (GRCm39) unclassified probably benign
IGL03008:Strada APN 11 106,061,783 (GRCm39) missense probably damaging 1.00
R0587:Strada UTSW 11 106,061,790 (GRCm39) missense probably damaging 1.00
R1614:Strada UTSW 11 106,059,145 (GRCm39) missense probably damaging 1.00
R1764:Strada UTSW 11 106,055,010 (GRCm39) missense probably damaging 0.96
R1852:Strada UTSW 11 106,062,047 (GRCm39) missense possibly damaging 0.65
R3772:Strada UTSW 11 106,055,648 (GRCm39) missense probably damaging 0.99
R4329:Strada UTSW 11 106,077,999 (GRCm39) utr 5 prime probably benign
R4538:Strada UTSW 11 106,058,651 (GRCm39) missense probably damaging 1.00
R5532:Strada UTSW 11 106,061,843 (GRCm39) missense probably damaging 1.00
R6102:Strada UTSW 11 106,059,262 (GRCm39) missense probably benign 0.01
R6135:Strada UTSW 11 106,064,140 (GRCm39) missense probably damaging 0.99
R6337:Strada UTSW 11 106,064,143 (GRCm39) missense possibly damaging 0.80
R6773:Strada UTSW 11 106,055,733 (GRCm39) missense probably damaging 0.99
R7155:Strada UTSW 11 106,061,865 (GRCm39) missense probably damaging 1.00
R7509:Strada UTSW 11 106,077,920 (GRCm39) missense unknown
R7552:Strada UTSW 11 106,077,830 (GRCm39) missense unknown
R8510:Strada UTSW 11 106,061,984 (GRCm39) missense probably damaging 1.00
R9262:Strada UTSW 11 106,075,444 (GRCm39) missense probably damaging 1.00
R9630:Strada UTSW 11 106,077,781 (GRCm39) missense unknown
RF015:Strada UTSW 11 106,061,846 (GRCm39) missense probably damaging 0.98
Posted On 2016-08-02