Incidental Mutation 'IGL03108:Olfr535'
ID419052
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr535
Ensembl Gene ENSMUSG00000063230
Gene Nameolfactory receptor 535
SynonymsGA_x6K02T2PBJ9-42641642-42642574, MOR253-7
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.113) question?
Stock #IGL03108
Quality Score
Status
Chromosome7
Chromosomal Location140484216-140497104 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 140493121 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Serine at position 161 (N161S)
Ref Sequence ENSEMBL: ENSMUSP00000149412 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074897] [ENSMUST00000213715] [ENSMUST00000214296] [ENSMUST00000216585] [ENSMUST00000217235] [ENSMUST00000217580]
Predicted Effect possibly damaging
Transcript: ENSMUST00000074897
AA Change: N161S

PolyPhen 2 Score 0.499 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000074435
Gene: ENSMUSG00000063230
AA Change: N161S

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 4.5e-50 PFAM
Pfam:7TM_GPCR_Srsx 37 183 1.1e-8 PFAM
Pfam:7tm_1 43 292 5.8e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213339
Predicted Effect possibly damaging
Transcript: ENSMUST00000213715
AA Change: N161S

PolyPhen 2 Score 0.499 (Sensitivity: 0.88; Specificity: 0.90)
Predicted Effect possibly damaging
Transcript: ENSMUST00000214296
AA Change: N161S

PolyPhen 2 Score 0.499 (Sensitivity: 0.88; Specificity: 0.90)
Predicted Effect possibly damaging
Transcript: ENSMUST00000216585
AA Change: N161S

PolyPhen 2 Score 0.499 (Sensitivity: 0.88; Specificity: 0.90)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216962
Predicted Effect possibly damaging
Transcript: ENSMUST00000217235
AA Change: N161S

PolyPhen 2 Score 0.499 (Sensitivity: 0.88; Specificity: 0.90)
Predicted Effect possibly damaging
Transcript: ENSMUST00000217580
AA Change: N161S

PolyPhen 2 Score 0.499 (Sensitivity: 0.88; Specificity: 0.90)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130011E15Rik G A 19: 45,820,353 T633I probably damaging Het
Adgrv1 C A 13: 81,559,529 V1253F probably damaging Het
Apbb2 A G 5: 66,400,231 W296R probably damaging Het
Btbd3 T C 2: 138,284,123 V409A possibly damaging Het
C130050O18Rik A T 5: 139,415,065 D291V probably damaging Het
Catsper3 A G 13: 55,808,035 N318D probably benign Het
Chd1 T A 17: 15,725,281 D22E possibly damaging Het
Chrnb2 G A 3: 89,763,374 probably benign Het
Col24a1 G A 3: 145,323,401 G550D probably damaging Het
Cryl1 T C 14: 57,313,077 D110G probably damaging Het
Deaf1 A G 7: 141,322,961 I150T probably damaging Het
Eif3a A T 19: 60,782,309 D33E possibly damaging Het
Fabp12 C A 3: 10,250,054 G78C probably benign Het
Fat1 A G 8: 45,023,614 D1899G probably damaging Het
Galnt13 G A 2: 54,854,648 V120I probably benign Het
Ganab G A 19: 8,912,476 A635T probably damaging Het
Gm17509 G A 13: 117,220,844 probably benign Het
Gstm3 A T 3: 107,967,764 probably null Het
Hfm1 T A 5: 106,895,934 probably benign Het
Hoxd13 A C 2: 74,670,096 D327A probably damaging Het
Ints4 G T 7: 97,490,930 probably null Het
Kcna10 A T 3: 107,194,943 T297S probably benign Het
Ldb2 G A 5: 44,541,715 T127I probably damaging Het
Mapk7 T C 11: 61,491,672 D68G probably damaging Het
Msh3 A T 13: 92,221,088 probably benign Het
Muc6 A G 7: 141,637,489 S2359P possibly damaging Het
Mup6 A T 4: 60,005,990 I161F possibly damaging Het
Nup160 G A 2: 90,703,825 V665I probably benign Het
Olfr1507 T A 14: 52,490,076 D296V probably damaging Het
Olfr304 T C 7: 86,385,721 Y313C possibly damaging Het
Otog G A 7: 46,251,338 V352I probably damaging Het
Oxct1 T A 15: 4,035,282 V34D probably benign Het
Pcdhb21 T A 18: 37,515,891 probably null Het
Pcdhb8 T G 18: 37,357,246 V659G probably damaging Het
Plxnb2 T C 15: 89,158,031 N1590S probably benign Het
Rnf168 G T 16: 32,278,281 R56L possibly damaging Het
Scn8a C T 15: 100,974,615 P362S probably benign Het
Slc1a3 T A 15: 8,639,078 I468F probably damaging Het
Slc39a14 G A 14: 70,318,919 R3W probably damaging Het
Slc7a6 T A 8: 106,194,517 N373K probably damaging Het
Snrnp200 T C 2: 127,238,167 S1955P possibly damaging Het
Stat5a T A 11: 100,863,139 Y98* probably null Het
Thsd7b G T 1: 130,210,276 G1564C probably damaging Het
Zc3h13 T C 14: 75,331,766 V1351A possibly damaging Het
Other mutations in Olfr535
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00979:Olfr535 APN 7 140492701 missense probably benign 0.00
IGL01537:Olfr535 APN 7 140492838 missense probably damaging 1.00
IGL01639:Olfr535 APN 7 140493186 missense probably benign 0.09
IGL02157:Olfr535 APN 7 140492934 missense probably damaging 1.00
IGL02593:Olfr535 APN 7 140493331 missense probably benign 0.04
R1835:Olfr535 UTSW 7 140492709 missense probably benign
R2040:Olfr535 UTSW 7 140493382 missense probably benign 0.10
R3125:Olfr535 UTSW 7 140492851 missense probably benign 0.01
R4795:Olfr535 UTSW 7 140493007 missense probably damaging 1.00
R6187:Olfr535 UTSW 7 140492616 start gained probably benign
R6285:Olfr535 UTSW 7 140492713 missense possibly damaging 0.71
R6528:Olfr535 UTSW 7 140493051 missense probably damaging 1.00
R7016:Olfr535 UTSW 7 140493240 missense probably benign 0.01
R7573:Olfr535 UTSW 7 140492999 missense probably damaging 1.00
R7867:Olfr535 UTSW 7 140493136 missense probably benign 0.00
R8506:Olfr535 UTSW 7 140493423 missense probably benign
R8822:Olfr535 UTSW 7 140493013 missense possibly damaging 0.93
Posted On2016-08-02