Incidental Mutation 'IGL03108:Mup6'
ID 419053
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mup6
Ensembl Gene ENSMUSG00000078689
Gene Name major urinary protein 6
Synonyms Gm12544
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # IGL03108
Quality Score
Status
Chromosome 4
Chromosomal Location 60003481-60007274 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 60005990 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 161 (I161F)
Ref Sequence ENSEMBL: ENSMUSP00000103144 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000107517] [ENSMUST00000107520] [ENSMUST00000107521]
AlphaFold A2AV72
Predicted Effect possibly damaging
Transcript: ENSMUST00000107517
AA Change: I161F

PolyPhen 2 Score 0.554 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000103141
Gene: ENSMUSG00000078689
AA Change: I161F

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:Lipocalin 33 172 1.6e-35 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000107520
AA Change: I161F

PolyPhen 2 Score 0.554 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000103144
Gene: ENSMUSG00000078689
AA Change: I161F

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:Lipocalin 33 172 1.6e-35 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000107521
AA Change: I153F

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000103145
Gene: ENSMUSG00000078689
AA Change: I153F

DomainStartEndE-ValueType
Pfam:Lipocalin 25 164 1.4e-35 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 C A 13: 81,707,648 (GRCm39) V1253F probably damaging Het
Apbb2 A G 5: 66,557,574 (GRCm39) W296R probably damaging Het
Armh3 G A 19: 45,808,792 (GRCm39) T633I probably damaging Het
Btbd3 T C 2: 138,126,043 (GRCm39) V409A possibly damaging Het
C130050O18Rik A T 5: 139,400,820 (GRCm39) D291V probably damaging Het
Catsper3 A G 13: 55,955,848 (GRCm39) N318D probably benign Het
Chd1 T A 17: 15,945,543 (GRCm39) D22E possibly damaging Het
Chrnb2 G A 3: 89,670,681 (GRCm39) probably benign Het
Col24a1 G A 3: 145,029,162 (GRCm39) G550D probably damaging Het
Cryl1 T C 14: 57,550,534 (GRCm39) D110G probably damaging Het
Deaf1 A G 7: 140,902,874 (GRCm39) I150T probably damaging Het
Eif3a A T 19: 60,770,747 (GRCm39) D33E possibly damaging Het
Fabp12 C A 3: 10,315,114 (GRCm39) G78C probably benign Het
Fat1 A G 8: 45,476,651 (GRCm39) D1899G probably damaging Het
Galnt13 G A 2: 54,744,660 (GRCm39) V120I probably benign Het
Ganab G A 19: 8,889,840 (GRCm39) A635T probably damaging Het
Gm17509 G A 13: 117,357,380 (GRCm39) probably benign Het
Gstm3 A T 3: 107,875,080 (GRCm39) probably null Het
Hfm1 T A 5: 107,043,800 (GRCm39) probably benign Het
Hoxd13 A C 2: 74,500,440 (GRCm39) D327A probably damaging Het
Ints4 G T 7: 97,140,137 (GRCm39) probably null Het
Kcna10 A T 3: 107,102,259 (GRCm39) T297S probably benign Het
Ldb2 G A 5: 44,699,057 (GRCm39) T127I probably damaging Het
Mapk7 T C 11: 61,382,498 (GRCm39) D68G probably damaging Het
Msh3 A T 13: 92,357,596 (GRCm39) probably benign Het
Muc6 A G 7: 141,217,402 (GRCm39) S2359P possibly damaging Het
Nup160 G A 2: 90,534,169 (GRCm39) V665I probably benign Het
Or13a22 A G 7: 140,073,034 (GRCm39) N161S possibly damaging Het
Or14a258 T C 7: 86,034,929 (GRCm39) Y313C possibly damaging Het
Or4e5 T A 14: 52,727,533 (GRCm39) D296V probably damaging Het
Otog G A 7: 45,900,762 (GRCm39) V352I probably damaging Het
Oxct1 T A 15: 4,064,764 (GRCm39) V34D probably benign Het
Pcdhb21 T A 18: 37,648,944 (GRCm39) probably null Het
Pcdhb8 T G 18: 37,490,299 (GRCm39) V659G probably damaging Het
Plxnb2 T C 15: 89,042,234 (GRCm39) N1590S probably benign Het
Rnf168 G T 16: 32,097,099 (GRCm39) R56L possibly damaging Het
Scn8a C T 15: 100,872,496 (GRCm39) P362S probably benign Het
Slc1a3 T A 15: 8,668,562 (GRCm39) I468F probably damaging Het
Slc39a14 G A 14: 70,556,368 (GRCm39) R3W probably damaging Het
Slc7a6 T A 8: 106,921,149 (GRCm39) N373K probably damaging Het
Snrnp200 T C 2: 127,080,087 (GRCm39) S1955P possibly damaging Het
Stat5a T A 11: 100,753,965 (GRCm39) Y98* probably null Het
Thsd7b G T 1: 130,138,013 (GRCm39) G1564C probably damaging Het
Zc3h13 T C 14: 75,569,206 (GRCm39) V1351A possibly damaging Het
Other mutations in Mup6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01109:Mup6 APN 4 60,006,001 (GRCm39) missense probably damaging 1.00
IGL01333:Mup6 APN 4 60,005,529 (GRCm39) missense probably damaging 1.00
IGL01608:Mup6 APN 4 60,006,021 (GRCm39) missense probably benign 0.34
IGL02471:Mup6 APN 4 60,003,971 (GRCm39) splice site probably benign
IGL02932:Mup6 APN 4 60,006,009 (GRCm39) missense probably damaging 1.00
IGL03070:Mup6 APN 4 60,003,999 (GRCm39) missense probably damaging 1.00
IGL03158:Mup6 APN 4 60,005,480 (GRCm39) missense possibly damaging 0.83
R0122:Mup6 UTSW 4 60,003,995 (GRCm39) nonsense probably null
R1271:Mup6 UTSW 4 60,003,579 (GRCm39) intron probably benign
R3434:Mup6 UTSW 4 60,004,116 (GRCm39) splice site probably null
R3435:Mup6 UTSW 4 60,004,116 (GRCm39) splice site probably null
R4258:Mup6 UTSW 4 60,004,812 (GRCm39) critical splice acceptor site probably null
R4465:Mup6 UTSW 4 60,004,000 (GRCm39) missense probably damaging 1.00
R4466:Mup6 UTSW 4 60,004,000 (GRCm39) missense probably damaging 1.00
R5021:Mup6 UTSW 4 59,964,352 (GRCm39) missense probably damaging 0.99
R5272:Mup6 UTSW 4 60,005,922 (GRCm39) missense probably damaging 0.99
R6396:Mup6 UTSW 4 60,004,837 (GRCm39) missense possibly damaging 0.84
R6861:Mup6 UTSW 4 60,004,093 (GRCm39) missense probably benign 0.02
R7818:Mup6 UTSW 4 60,004,884 (GRCm39) missense probably benign 0.05
R8238:Mup6 UTSW 4 60,003,634 (GRCm39) missense probably damaging 1.00
R9294:Mup6 UTSW 4 60,004,838 (GRCm39) missense probably benign 0.16
Posted On 2016-08-02