Incidental Mutation 'IGL03108:Fabp12'
ID419081
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fabp12
Ensembl Gene ENSMUSG00000027530
Gene Namefatty acid binding protein 12
Synonyms1700008G05Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.080) question?
Stock #IGL03108
Quality Score
Status
Chromosome3
Chromosomal Location10244209-10301183 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 10250054 bp
ZygosityHeterozygous
Amino Acid Change Glycine to Cysteine at position 78 (G78C)
Ref Sequence ENSEMBL: ENSMUSP00000131101 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029043] [ENSMUST00000117917] [ENSMUST00000119761] [ENSMUST00000172126]
Predicted Effect probably benign
Transcript: ENSMUST00000029043
AA Change: G78C

PolyPhen 2 Score 0.120 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000029043
Gene: ENSMUSG00000027530
AA Change: G78C

DomainStartEndE-ValueType
Pfam:Lipocalin 6 132 1.4e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000117917
AA Change: G78C

PolyPhen 2 Score 0.120 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000112464
Gene: ENSMUSG00000027530
AA Change: G78C

DomainStartEndE-ValueType
Pfam:Lipocalin 6 132 1.4e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000119761
AA Change: G78C

PolyPhen 2 Score 0.120 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000112958
Gene: ENSMUSG00000027530
AA Change: G78C

DomainStartEndE-ValueType
Pfam:Lipocalin 6 132 1.4e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000172126
AA Change: G78C

PolyPhen 2 Score 0.120 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000131101
Gene: ENSMUSG00000027530
AA Change: G78C

DomainStartEndE-ValueType
Pfam:Lipocalin 6 132 1.4e-25 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130011E15Rik G A 19: 45,820,353 T633I probably damaging Het
Adgrv1 C A 13: 81,559,529 V1253F probably damaging Het
Apbb2 A G 5: 66,400,231 W296R probably damaging Het
Btbd3 T C 2: 138,284,123 V409A possibly damaging Het
C130050O18Rik A T 5: 139,415,065 D291V probably damaging Het
Catsper3 A G 13: 55,808,035 N318D probably benign Het
Chd1 T A 17: 15,725,281 D22E possibly damaging Het
Chrnb2 G A 3: 89,763,374 probably benign Het
Col24a1 G A 3: 145,323,401 G550D probably damaging Het
Cryl1 T C 14: 57,313,077 D110G probably damaging Het
Deaf1 A G 7: 141,322,961 I150T probably damaging Het
Eif3a A T 19: 60,782,309 D33E possibly damaging Het
Fat1 A G 8: 45,023,614 D1899G probably damaging Het
Galnt13 G A 2: 54,854,648 V120I probably benign Het
Ganab G A 19: 8,912,476 A635T probably damaging Het
Gm17509 G A 13: 117,220,844 probably benign Het
Gstm3 A T 3: 107,967,764 probably null Het
Hfm1 T A 5: 106,895,934 probably benign Het
Hoxd13 A C 2: 74,670,096 D327A probably damaging Het
Ints4 G T 7: 97,490,930 probably null Het
Kcna10 A T 3: 107,194,943 T297S probably benign Het
Ldb2 G A 5: 44,541,715 T127I probably damaging Het
Mapk7 T C 11: 61,491,672 D68G probably damaging Het
Msh3 A T 13: 92,221,088 probably benign Het
Muc6 A G 7: 141,637,489 S2359P possibly damaging Het
Mup6 A T 4: 60,005,990 I161F possibly damaging Het
Nup160 G A 2: 90,703,825 V665I probably benign Het
Olfr1507 T A 14: 52,490,076 D296V probably damaging Het
Olfr304 T C 7: 86,385,721 Y313C possibly damaging Het
Olfr535 A G 7: 140,493,121 N161S possibly damaging Het
Otog G A 7: 46,251,338 V352I probably damaging Het
Oxct1 T A 15: 4,035,282 V34D probably benign Het
Pcdhb21 T A 18: 37,515,891 probably null Het
Pcdhb8 T G 18: 37,357,246 V659G probably damaging Het
Plxnb2 T C 15: 89,158,031 N1590S probably benign Het
Rnf168 G T 16: 32,278,281 R56L possibly damaging Het
Scn8a C T 15: 100,974,615 P362S probably benign Het
Slc1a3 T A 15: 8,639,078 I468F probably damaging Het
Slc39a14 G A 14: 70,318,919 R3W probably damaging Het
Slc7a6 T A 8: 106,194,517 N373K probably damaging Het
Snrnp200 T C 2: 127,238,167 S1955P possibly damaging Het
Stat5a T A 11: 100,863,139 Y98* probably null Het
Thsd7b G T 1: 130,210,276 G1564C probably damaging Het
Zc3h13 T C 14: 75,331,766 V1351A possibly damaging Het
Other mutations in Fabp12
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00551:Fabp12 APN 3 10246055 splice site probably benign
IGL00957:Fabp12 APN 3 10250213 critical splice acceptor site probably null
IGL01774:Fabp12 APN 3 10247694 missense probably benign 0.00
IGL01822:Fabp12 APN 3 10246022 nonsense probably null
IGL02047:Fabp12 APN 3 10247718 splice site probably benign
IGL02164:Fabp12 APN 3 10246015 missense probably damaging 0.99
R0501:Fabp12 UTSW 3 10250143 missense probably benign 0.00
R0647:Fabp12 UTSW 3 10246036 missense possibly damaging 0.55
R1134:Fabp12 UTSW 3 10247671 missense probably benign 0.17
R2020:Fabp12 UTSW 3 10250149 missense probably benign 0.00
R5269:Fabp12 UTSW 3 10250107 missense probably benign 0.12
R7434:Fabp12 UTSW 3 10247678 missense probably benign 0.10
Posted On2016-08-02