Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03110:Prss37'

419138

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Prss37

Ensembl Gene

ENSMUSG00000029909

Gene Name

serine protease 37

Synonyms

1700016G05Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03110

Quality Score

Status

Chromosome

Chromosomal Location

40491757-40496418 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 40495984 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 6 (Y6C)

Ref Sequence

ENSEMBL: ENSMUSP00000031967 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000031967]

AlphaFold

Q9DAA4

Predicted Effect

probably benign
Transcript: ENSMUST00000031967
AA Change: Y6C

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

SMART Domains

Protein: ENSMUSP00000031967
Gene: ENSMUSG00000029909
AA Change: Y6C

Domain	Start	End	E-Value	Type
Tryp_SPc	15	228	2.31e-15	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000148195

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000201439

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit male infertility associated with impaired zona binding and migration from the uterus into the oviduct. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acacb	A	G	5: 114,333,295 (GRCm39)	E473G	probably damaging	Het
Acp7	T	C	7: 28,310,464 (GRCm39)	M458V	probably benign	Het
Acrbp	G	T	6: 125,039,436 (GRCm39)	C485F	probably damaging	Het
Actn2	T	C	13: 12,324,493 (GRCm39)	I117V	probably benign	Het
Ahr	T	C	12: 35,554,970 (GRCm39)	E383G	probably damaging	Het
Cacna2d4	A	T	6: 119,213,698 (GRCm39)	H39L	probably benign	Het
Cdh11	G	T	8: 103,400,502 (GRCm39)	N155K	probably damaging	Het
Cldnd1	T	A	16: 58,549,959 (GRCm39)	N47K	possibly damaging	Het
Ddb1	C	T	19: 10,590,309 (GRCm39)	R279W	probably damaging	Het
Dido1	A	T	2: 180,331,135 (GRCm39)	D104E	probably damaging	Het
Dnah1	A	T	14: 30,988,674 (GRCm39)	S3386T	probably benign	Het
Galnt18	T	A	7: 111,147,920 (GRCm39)	E352V	probably benign	Het
Gm5407	T	A	16: 49,117,757 (GRCm39)		noncoding transcript	Het
Gucy1b2	T	C	14: 62,671,283 (GRCm39)		probably benign	Het
Guf1	C	A	5: 69,715,820 (GRCm39)	L87I	probably damaging	Het
Hikeshi	A	G	7: 89,585,034 (GRCm39)	S57P	probably damaging	Het
Igkv17-121	T	A	6: 68,013,851 (GRCm39)	V17D	probably damaging	Het
Itgad	T	C	7: 127,785,157 (GRCm39)	V324A	probably damaging	Het
Lama1	T	A	17: 68,105,981 (GRCm39)	L2072Q	probably benign	Het
Lrrc31	T	C	3: 30,733,415 (GRCm39)	E433G	probably benign	Het
Mrc1	T	A	2: 14,298,289 (GRCm39)	L715*	probably null	Het
Nbeal2	T	G	9: 110,460,501 (GRCm39)	K1778Q	probably damaging	Het
Or4c35	A	T	2: 89,808,493 (GRCm39)	I124F	probably damaging	Het
Or51a39	C	A	7: 102,363,090 (GRCm39)	G177C	probably damaging	Het
Or5m3	T	A	2: 85,838,942 (GRCm39)	V274E	probably damaging	Het
Ppp1r3a	T	A	6: 14,722,064 (GRCm39)		probably benign	Het
Rapgef6	A	G	11: 54,586,915 (GRCm39)	Q1602R	probably damaging	Het
Rbm15b	T	C	9: 106,763,173 (GRCm39)	T332A	probably damaging	Het
S100a7l2	C	T	3: 90,995,626 (GRCm39)	R92H	unknown	Het
Snrnp70	C	A	7: 45,026,283 (GRCm39)		probably benign	Het
Spidr	T	C	16: 15,707,618 (GRCm39)	E893G	probably damaging	Het
Stxbp2	T	C	8: 3,683,342 (GRCm39)	I74T	probably damaging	Het
Tgm2	G	A	2: 157,973,410 (GRCm39)	Q234*	probably null	Het
Thbd	T	C	2: 148,248,716 (GRCm39)	D384G	probably benign	Het
Zan	T	C	5: 137,418,278 (GRCm39)	N2940S	unknown	Het
Zmat3	T	A	3: 32,399,701 (GRCm39)	N100I	probably damaging	Het

Other mutations in Prss37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02282:Prss37	APN	6	40,492,317 (GRCm39)	missense	possibly damaging	0.81
R0201:Prss37	UTSW	6	40,493,283 (GRCm39)	missense	probably damaging	1.00
R0350:Prss37	UTSW	6	40,491,893 (GRCm39)	missense	probably damaging	0.99
R2118:Prss37	UTSW	6	40,492,294 (GRCm39)	nonsense	probably null
R2120:Prss37	UTSW	6	40,492,294 (GRCm39)	nonsense	probably null
R2124:Prss37	UTSW	6	40,492,294 (GRCm39)	nonsense	probably null
R2504:Prss37	UTSW	6	40,494,760 (GRCm39)	splice site	probably null
R4711:Prss37	UTSW	6	40,492,381 (GRCm39)	missense	probably benign	0.21
R4938:Prss37	UTSW	6	40,491,917 (GRCm39)	missense	possibly damaging	0.81
R4983:Prss37	UTSW	6	40,493,070 (GRCm39)	missense	probably benign	0.01
R6652:Prss37	UTSW	6	40,496,090 (GRCm39)	start gained	probably benign
R8111:Prss37	UTSW	6	40,494,747 (GRCm39)	missense	probably benign	0.00
R8425:Prss37	UTSW	6	40,493,052 (GRCm39)	nonsense	probably null
R8859:Prss37	UTSW	6	40,491,897 (GRCm39)	missense	probably damaging	1.00
R9297:Prss37	UTSW	6	40,491,909 (GRCm39)	missense	probably damaging	1.00
R9318:Prss37	UTSW	6	40,491,909 (GRCm39)	missense	probably damaging	1.00
R9778:Prss37	UTSW	6	40,494,713 (GRCm39)	missense	probably damaging	0.99
X0063:Prss37	UTSW	6	40,493,149 (GRCm39)	missense	possibly damaging	0.65

Posted On

2016-08-02