Incidental Mutation 'IGL03110:Olfr33'
ID419141
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr33
Ensembl Gene ENSMUSG00000066273
Gene Nameolfactory receptor 33
SynonymsMTPCR33, GA_x6K02T2PBJ9-5431102-5430146, MOR11-2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.115) question?
Stock #IGL03110
Quality Score
Status
Chromosome7
Chromosomal Location102712151-102719070 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 102713883 bp
ZygosityHeterozygous
Amino Acid Change Glycine to Cysteine at position 177 (G177C)
Ref Sequence ENSEMBL: ENSMUSP00000149588 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084817] [ENSMUST00000094124] [ENSMUST00000216312]
Predicted Effect probably damaging
Transcript: ENSMUST00000084817
AA Change: G177C

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000081877
Gene: ENSMUSG00000066273
AA Change: G177C

DomainStartEndE-ValueType
Pfam:7tm_4 37 317 2.1e-117 PFAM
Pfam:7TM_GPCR_Srsx 41 211 7.5e-11 PFAM
Pfam:7tm_1 47 299 2.4e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000094124
SMART Domains Protein: ENSMUSP00000091674
Gene: ENSMUSG00000070423

DomainStartEndE-ValueType
Pfam:7tm_4 33 311 6.2e-117 PFAM
Pfam:7TM_GPCR_Srsx 37 308 2.4e-7 PFAM
Pfam:7tm_1 43 293 2.4e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210002
Predicted Effect probably damaging
Transcript: ENSMUST00000216312
AA Change: G177C

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130204L05Rik C T 3: 91,088,319 R92H unknown Het
Acacb A G 5: 114,195,234 E473G probably damaging Het
Acp7 T C 7: 28,611,039 M458V probably benign Het
Acrbp G T 6: 125,062,473 C485F probably damaging Het
Actn2 T C 13: 12,309,607 I117V probably benign Het
Ahr T C 12: 35,504,971 E383G probably damaging Het
Cacna2d4 A T 6: 119,236,737 H39L probably benign Het
Cdh11 G T 8: 102,673,870 N155K probably damaging Het
Cldnd1 T A 16: 58,729,596 N47K possibly damaging Het
Ddb1 C T 19: 10,612,945 R279W probably damaging Het
Dido1 A T 2: 180,689,342 D104E probably damaging Het
Dnah1 A T 14: 31,266,717 S3386T probably benign Het
Galnt18 T A 7: 111,548,713 E352V probably benign Het
Gm5407 T A 16: 49,297,394 noncoding transcript Het
Gucy1b2 T C 14: 62,433,834 probably benign Het
Guf1 C A 5: 69,558,477 L87I probably damaging Het
Hikeshi A G 7: 89,935,826 S57P probably damaging Het
Igkv17-121 T A 6: 68,036,867 V17D probably damaging Het
Itgad T C 7: 128,185,985 V324A probably damaging Het
Lama1 T A 17: 67,798,986 L2072Q probably benign Het
Lrrc31 T C 3: 30,679,266 E433G probably benign Het
Mrc1 T A 2: 14,293,478 L715* probably null Het
Nbeal2 T G 9: 110,631,433 K1778Q probably damaging Het
Olfr1032 T A 2: 86,008,598 V274E probably damaging Het
Olfr1260 A T 2: 89,978,149 I124F probably damaging Het
Ppp1r3a T A 6: 14,722,065 probably benign Het
Prss37 T C 6: 40,519,050 Y6C probably benign Het
Rapgef6 A G 11: 54,696,089 Q1602R probably damaging Het
Rbm15b T C 9: 106,885,974 T332A probably damaging Het
Snrnp70 C A 7: 45,376,859 probably benign Het
Spidr T C 16: 15,889,754 E893G probably damaging Het
Stxbp2 T C 8: 3,633,342 I74T probably damaging Het
Tgm2 G A 2: 158,131,490 Q234* probably null Het
Thbd T C 2: 148,406,796 D384G probably benign Het
Zan T C 5: 137,420,016 N2940S unknown Het
Zmat3 T A 3: 32,345,552 N100I probably damaging Het
Other mutations in Olfr33
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02064:Olfr33 APN 7 102713601 missense probably damaging 1.00
IGL02349:Olfr33 APN 7 102714126 missense probably damaging 0.99
IGL02739:Olfr33 APN 7 102714314 missense possibly damaging 0.58
IGL03014:Olfr33 UTSW 7 102713546 missense probably null 0.91
R0158:Olfr33 UTSW 7 102713955 missense probably benign 0.03
R1455:Olfr33 UTSW 7 102713998 nonsense probably null
R1996:Olfr33 UTSW 7 102713792 missense probably damaging 1.00
R2032:Olfr33 UTSW 7 102713876 missense probably benign 0.00
R2152:Olfr33 UTSW 7 102713581 missense probably benign 0.01
R4852:Olfr33 UTSW 7 102713543 missense probably damaging 0.99
R4965:Olfr33 UTSW 7 102713495 missense probably damaging 1.00
R5264:Olfr33 UTSW 7 102714351 missense probably benign 0.00
R5464:Olfr33 UTSW 7 102713682 missense probably benign
R6680:Olfr33 UTSW 7 102714315 missense possibly damaging 0.70
R7195:Olfr33 UTSW 7 102713666 missense possibly damaging 0.74
R7373:Olfr33 UTSW 7 102714099 missense possibly damaging 0.53
R7391:Olfr33 UTSW 7 102713982 missense probably benign 0.02
R7872:Olfr33 UTSW 7 102714182 missense probably benign 0.01
R7948:Olfr33 UTSW 7 102713688 missense probably benign 0.00
R8097:Olfr33 UTSW 7 102713990 missense possibly damaging 0.53
Posted On2016-08-02