Incidental Mutation 'IGL03110:Olfr1032'
ID419144
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1032
Ensembl Gene ENSMUSG00000042796
Gene Nameolfactory receptor 1032
SynonymsGA_x6K02T2Q125-47485813-47486745, MOR199-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.067) question?
Stock #IGL03110
Quality Score
Status
Chromosome2
Chromosomal Location86005540-86009125 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 86008598 bp
ZygosityHeterozygous
Amino Acid Change Valine to Glutamic Acid at position 274 (V274E)
Ref Sequence ENSEMBL: ENSMUSP00000107216 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062166] [ENSMUST00000079298] [ENSMUST00000111589]
Predicted Effect probably damaging
Transcript: ENSMUST00000062166
AA Change: V274E

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000054494
Gene: ENSMUSG00000042796
AA Change: V274E

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 5.6e-50 PFAM
Pfam:7tm_1 39 288 1.1e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000079298
AA Change: V274E

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000078279
Gene: ENSMUSG00000042796
AA Change: V274E

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.3e-50 PFAM
Pfam:7tm_1 39 288 9.9e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000111589
AA Change: V274E

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000107216
Gene: ENSMUSG00000042796
AA Change: V274E

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 2.4e-50 PFAM
Pfam:7tm_1 39 288 3.5e-21 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130204L05Rik C T 3: 91,088,319 R92H unknown Het
Acacb A G 5: 114,195,234 E473G probably damaging Het
Acp7 T C 7: 28,611,039 M458V probably benign Het
Acrbp G T 6: 125,062,473 C485F probably damaging Het
Actn2 T C 13: 12,309,607 I117V probably benign Het
Ahr T C 12: 35,504,971 E383G probably damaging Het
Cacna2d4 A T 6: 119,236,737 H39L probably benign Het
Cdh11 G T 8: 102,673,870 N155K probably damaging Het
Cldnd1 T A 16: 58,729,596 N47K possibly damaging Het
Ddb1 C T 19: 10,612,945 R279W probably damaging Het
Dido1 A T 2: 180,689,342 D104E probably damaging Het
Dnah1 A T 14: 31,266,717 S3386T probably benign Het
Galnt18 T A 7: 111,548,713 E352V probably benign Het
Gm5407 T A 16: 49,297,394 noncoding transcript Het
Gucy1b2 T C 14: 62,433,834 probably benign Het
Guf1 C A 5: 69,558,477 L87I probably damaging Het
Hikeshi A G 7: 89,935,826 S57P probably damaging Het
Igkv17-121 T A 6: 68,036,867 V17D probably damaging Het
Itgad T C 7: 128,185,985 V324A probably damaging Het
Lama1 T A 17: 67,798,986 L2072Q probably benign Het
Lrrc31 T C 3: 30,679,266 E433G probably benign Het
Mrc1 T A 2: 14,293,478 L715* probably null Het
Nbeal2 T G 9: 110,631,433 K1778Q probably damaging Het
Olfr1260 A T 2: 89,978,149 I124F probably damaging Het
Olfr33 C A 7: 102,713,883 G177C probably damaging Het
Ppp1r3a T A 6: 14,722,065 probably benign Het
Prss37 T C 6: 40,519,050 Y6C probably benign Het
Rapgef6 A G 11: 54,696,089 Q1602R probably damaging Het
Rbm15b T C 9: 106,885,974 T332A probably damaging Het
Snrnp70 C A 7: 45,376,859 probably benign Het
Spidr T C 16: 15,889,754 E893G probably damaging Het
Stxbp2 T C 8: 3,633,342 I74T probably damaging Het
Tgm2 G A 2: 158,131,490 Q234* probably null Het
Thbd T C 2: 148,406,796 D384G probably benign Het
Zan T C 5: 137,420,016 N2940S unknown Het
Zmat3 T A 3: 32,345,552 N100I probably damaging Het
Other mutations in Olfr1032
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01069:Olfr1032 APN 2 86008547 missense probably damaging 1.00
IGL03167:Olfr1032 APN 2 86008167 nonsense probably null
R0206:Olfr1032 UTSW 2 86008292 missense probably damaging 1.00
R0206:Olfr1032 UTSW 2 86008292 missense probably damaging 1.00
R0919:Olfr1032 UTSW 2 86008640 missense possibly damaging 0.52
R2018:Olfr1032 UTSW 2 86008223 missense probably damaging 1.00
R2019:Olfr1032 UTSW 2 86008223 missense probably damaging 1.00
R2938:Olfr1032 UTSW 2 86008013 missense probably damaging 0.97
R3843:Olfr1032 UTSW 2 86008204 missense probably benign 0.09
R4295:Olfr1032 UTSW 2 86008270 missense probably benign 0.01
R5813:Olfr1032 UTSW 2 86008292 missense probably damaging 1.00
R6283:Olfr1032 UTSW 2 86008099 missense possibly damaging 0.73
R7031:Olfr1032 UTSW 2 86008595 missense probably benign 0.26
R7427:Olfr1032 UTSW 2 86008219 missense probably benign 0.00
R7428:Olfr1032 UTSW 2 86008219 missense probably benign 0.00
R7856:Olfr1032 UTSW 2 86008296 missense probably damaging 0.99
R8048:Olfr1032 UTSW 2 86008180 missense probably damaging 0.96
Posted On2016-08-02