Incidental Mutation 'IGL03112:Vmn1r178'
ID419216
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r178
Ensembl Gene ENSMUSG00000062598
Gene Namevomeronasal 1 receptor 178
SynonymsV1rd13, LOC232959
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.060) question?
Stock #IGL03112
Quality Score
Status
Chromosome7
Chromosomal Location23892009-23895622 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 23893661 bp
ZygosityHeterozygous
Amino Acid Change Glycine to Serine at position 45 (G45S)
Ref Sequence ENSEMBL: ENSMUSP00000154244 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078593] [ENSMUST00000226450] [ENSMUST00000226489] [ENSMUST00000226640] [ENSMUST00000227993]
Predicted Effect probably damaging
Transcript: ENSMUST00000078593
AA Change: G45S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000077666
Gene: ENSMUSG00000062598
AA Change: G45S

DomainStartEndE-ValueType
Pfam:TAS2R 8 297 7.9e-11 PFAM
Pfam:7tm_1 15 283 2.5e-7 PFAM
Pfam:V1R 41 296 7.8e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000226450
AA Change: G45S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably benign
Transcript: ENSMUST00000226489
Predicted Effect probably benign
Transcript: ENSMUST00000226640
Predicted Effect probably damaging
Transcript: ENSMUST00000227993
AA Change: G45S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam26b T C 8: 43,521,512 N151S probably benign Het
Adgre1 G A 17: 57,448,029 probably null Het
AI481877 G T 4: 59,049,355 Q1069K probably benign Het
Apol11a T A 15: 77,517,309 L332Q probably damaging Het
B430306N03Rik C T 17: 48,316,806 S45L probably benign Het
Cend1 G A 7: 141,427,727 T60M probably benign Het
Col6a3 C A 1: 90,811,520 E329* probably null Het
Col9a3 A G 2: 180,607,642 R266G possibly damaging Het
Defb48 C T 14: 62,984,405 probably benign Het
Eps8l2 T G 7: 141,361,736 L640R probably damaging Het
Exoc2 T A 13: 30,906,587 probably benign Het
Fam149a C T 8: 45,348,543 V514M possibly damaging Het
Fbxo25 A T 8: 13,921,034 D74V probably benign Het
Gm11733 A G 11: 117,487,140 *126W probably null Het
Grm8 C T 6: 27,363,263 C751Y probably damaging Het
Kctd16 A T 18: 40,258,800 D147V probably benign Het
Lclat1 A T 17: 73,239,747 T220S probably damaging Het
Lgi1 T A 19: 38,284,030 H116Q possibly damaging Het
Lrrc40 G A 3: 158,041,665 probably benign Het
Lsm4 T A 8: 70,678,006 I60N probably damaging Het
Morn1 T A 4: 155,093,144 Y178N probably damaging Het
Mybl2 A G 2: 163,062,536 E89G probably damaging Het
Myo18b T C 5: 112,873,990 E512G probably benign Het
Myrfl A T 10: 116,803,406 S583T probably benign Het
Nek6 A G 2: 38,560,902 I106V probably damaging Het
Oas1a A T 5: 120,898,349 D338E possibly damaging Het
Olfr1113 T A 2: 87,213,600 I236N probably damaging Het
Olfr1249 G A 2: 89,630,334 T188I probably benign Het
Olfr802 A G 10: 129,681,923 V272A probably benign Het
Pitrm1 C A 13: 6,565,008 Q508K probably benign Het
S100b A G 10: 76,259,974 D62G probably damaging Het
Sesn3 A G 9: 14,310,261 H119R probably damaging Het
Sez6l T A 5: 112,473,467 E247V probably damaging Het
Shq1 C A 6: 100,573,613 E455* probably null Het
Slc9b1 T A 3: 135,397,672 M521K probably damaging Het
Supt16 A G 14: 52,176,398 F543L probably damaging Het
Tcf25 T C 8: 123,382,519 probably benign Het
Usp48 C A 4: 137,608,064 Q183K probably damaging Het
Vmn1r237 T A 17: 21,314,106 Y30* probably null Het
Other mutations in Vmn1r178
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01697:Vmn1r178 APN 7 23893689 missense probably damaging 0.99
IGL01781:Vmn1r178 APN 7 23894009 missense probably damaging 1.00
IGL01934:Vmn1r178 APN 7 23893937 missense probably damaging 1.00
IGL02571:Vmn1r178 APN 7 23894235 missense probably damaging 0.99
IGL02727:Vmn1r178 APN 7 23894446 unclassified probably null
R0112:Vmn1r178 UTSW 7 23894184 missense possibly damaging 0.93
R0830:Vmn1r178 UTSW 7 23894027 missense possibly damaging 0.91
R1186:Vmn1r178 UTSW 7 23893892 nonsense probably null
R1340:Vmn1r178 UTSW 7 23893856 missense probably benign 0.34
R1640:Vmn1r178 UTSW 7 23894123 missense possibly damaging 0.70
R1696:Vmn1r178 UTSW 7 23894200 missense probably damaging 0.99
R1746:Vmn1r178 UTSW 7 23893904 missense probably benign 0.00
R3084:Vmn1r178 UTSW 7 23893906 missense possibly damaging 0.94
R4368:Vmn1r178 UTSW 7 23894022 missense probably damaging 1.00
R5199:Vmn1r178 UTSW 7 23894389 missense probably benign 0.11
R6380:Vmn1r178 UTSW 7 23893559 missense possibly damaging 0.62
R7000:Vmn1r178 UTSW 7 23894337 missense probably benign 0.21
R7142:Vmn1r178 UTSW 7 23893610 missense probably damaging 1.00
R7268:Vmn1r178 UTSW 7 23893953 missense probably benign 0.05
Posted On2016-08-02