Incidental Mutation 'IGL03112:Apol11a'
ID419244
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Apol11a
Ensembl Gene ENSMUSG00000091650
Gene Nameapolipoprotein L 11a
SynonymsEG626615
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.053) question?
Stock #IGL03112
Quality Score
Status
Chromosome15
Chromosomal Location77508271-77518051 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 77517309 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Glutamine at position 332 (L332Q)
Ref Sequence ENSEMBL: ENSMUSP00000132565 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000172191]
Predicted Effect probably damaging
Transcript: ENSMUST00000172191
AA Change: L332Q

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000132565
Gene: ENSMUSG00000091650
AA Change: L332Q

DomainStartEndE-ValueType
Pfam:ApoL 28 328 1e-90 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam26b T C 8: 43,521,512 N151S probably benign Het
Adgre1 G A 17: 57,448,029 probably null Het
AI481877 G T 4: 59,049,355 Q1069K probably benign Het
B430306N03Rik C T 17: 48,316,806 S45L probably benign Het
Cend1 G A 7: 141,427,727 T60M probably benign Het
Col6a3 C A 1: 90,811,520 E329* probably null Het
Col9a3 A G 2: 180,607,642 R266G possibly damaging Het
Defb48 C T 14: 62,984,405 probably benign Het
Eps8l2 T G 7: 141,361,736 L640R probably damaging Het
Exoc2 T A 13: 30,906,587 probably benign Het
Fam149a C T 8: 45,348,543 V514M possibly damaging Het
Fbxo25 A T 8: 13,921,034 D74V probably benign Het
Gm11733 A G 11: 117,487,140 *126W probably null Het
Grm8 C T 6: 27,363,263 C751Y probably damaging Het
Kctd16 A T 18: 40,258,800 D147V probably benign Het
Lclat1 A T 17: 73,239,747 T220S probably damaging Het
Lgi1 T A 19: 38,284,030 H116Q possibly damaging Het
Lrrc40 G A 3: 158,041,665 probably benign Het
Lsm4 T A 8: 70,678,006 I60N probably damaging Het
Morn1 T A 4: 155,093,144 Y178N probably damaging Het
Mybl2 A G 2: 163,062,536 E89G probably damaging Het
Myo18b T C 5: 112,873,990 E512G probably benign Het
Myrfl A T 10: 116,803,406 S583T probably benign Het
Nek6 A G 2: 38,560,902 I106V probably damaging Het
Oas1a A T 5: 120,898,349 D338E possibly damaging Het
Olfr1113 T A 2: 87,213,600 I236N probably damaging Het
Olfr1249 G A 2: 89,630,334 T188I probably benign Het
Olfr802 A G 10: 129,681,923 V272A probably benign Het
Pitrm1 C A 13: 6,565,008 Q508K probably benign Het
S100b A G 10: 76,259,974 D62G probably damaging Het
Sesn3 A G 9: 14,310,261 H119R probably damaging Het
Sez6l T A 5: 112,473,467 E247V probably damaging Het
Shq1 C A 6: 100,573,613 E455* probably null Het
Slc9b1 T A 3: 135,397,672 M521K probably damaging Het
Supt16 A G 14: 52,176,398 F543L probably damaging Het
Tcf25 T C 8: 123,382,519 probably benign Het
Usp48 C A 4: 137,608,064 Q183K probably damaging Het
Vmn1r178 G A 7: 23,893,661 G45S probably damaging Het
Vmn1r237 T A 17: 21,314,106 Y30* probably null Het
Other mutations in Apol11a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01722:Apol11a APN 15 77517107 missense probably benign 0.03
R1296:Apol11a UTSW 15 77511019 splice site probably benign
R1576:Apol11a UTSW 15 77516931 missense probably damaging 1.00
R1875:Apol11a UTSW 15 77513566 missense possibly damaging 0.81
R2517:Apol11a UTSW 15 77517195 missense probably benign 0.00
R4614:Apol11a UTSW 15 77516572 missense probably benign 0.08
R4892:Apol11a UTSW 15 77516990 nonsense probably null
R5027:Apol11a UTSW 15 77516953 missense probably damaging 1.00
R5334:Apol11a UTSW 15 77516753 missense probably benign 0.14
R6208:Apol11a UTSW 15 77517041 missense probably damaging 0.99
R7883:Apol11a UTSW 15 77516574 missense probably damaging 1.00
Posted On2016-08-02