Incidental Mutation 'IGL03113:Or3a1b'
ID 419267
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or3a1b
Ensembl Gene ENSMUSG00000070380
Gene Name olfactory receptor family 3 subfamily A member 1B
Synonyms GA_x6K02T2P1NL-4278037-4278984, Olfr401, MOR255-6
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # IGL03113
Quality Score
Status
Chromosome 11
Chromosomal Location 74012117-74013064 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 74012529 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glutamine at position 138 (R138Q)
Ref Sequence ENSEMBL: ENSMUSP00000149542 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079827] [ENSMUST00000213754]
AlphaFold Q8VFX6
Predicted Effect probably benign
Transcript: ENSMUST00000079827
AA Change: R138Q

PolyPhen 2 Score 0.125 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000078756
Gene: ENSMUSG00000070380
AA Change: R138Q

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 9.4e-51 PFAM
Pfam:7tm_1 44 293 2.2e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213754
AA Change: R138Q

PolyPhen 2 Score 0.125 (Sensitivity: 0.93; Specificity: 0.86)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apof G A 10: 128,105,568 (GRCm39) V241M probably benign Het
Arhgef10 T A 8: 15,004,505 (GRCm39) I91N probably damaging Het
Arhgef17 G A 7: 100,578,938 (GRCm39) T670I probably benign Het
Barhl1 T C 2: 28,805,468 (GRCm39) D75G probably benign Het
Capn13 T C 17: 73,638,108 (GRCm39) T432A probably benign Het
Casd1 T A 6: 4,640,951 (GRCm39) Y691N probably damaging Het
Ccdc175 C A 12: 72,191,557 (GRCm39) V340L probably benign Het
Cdc5l A T 17: 45,744,348 (GRCm39) M5K possibly damaging Het
Cgn A G 3: 94,686,544 (GRCm39) F253L probably benign Het
Csmd1 T C 8: 16,078,712 (GRCm39) K2003R probably benign Het
Disp2 T A 2: 118,621,259 (GRCm39) probably null Het
Dnah7a T C 1: 53,472,163 (GRCm39) N3535D possibly damaging Het
Exoc3 G A 13: 74,341,232 (GRCm39) Q191* probably null Het
Fstl5 T A 3: 76,337,099 (GRCm39) Y219* probably null Het
Gad2 T A 2: 22,571,367 (GRCm39) L435Q probably benign Het
Gcnt3 A G 9: 69,941,983 (GRCm39) V195A probably damaging Het
Haus6 G A 4: 86,501,343 (GRCm39) Q843* probably null Het
Hivep2 T A 10: 14,006,395 (GRCm39) F998I probably damaging Het
Hsf5 A T 11: 87,548,190 (GRCm39) E624D probably benign Het
Klb A G 5: 65,540,813 (GRCm39) N969D probably benign Het
Klhl6 T A 16: 19,776,001 (GRCm39) S186C possibly damaging Het
Klk15 T C 7: 43,587,805 (GRCm39) F78L probably benign Het
Ldlr A G 9: 21,651,124 (GRCm39) E514G possibly damaging Het
Map9 T A 3: 82,267,285 (GRCm39) probably benign Het
Miga2 A T 2: 30,274,022 (GRCm39) I99F possibly damaging Het
Morc4 T C X: 138,758,605 (GRCm39) E189G probably benign Het
Nhlrc3 A T 3: 53,365,984 (GRCm39) Y170N possibly damaging Het
Or4c111 A G 2: 88,844,379 (GRCm39) F10L probably damaging Het
Or51b6b A T 7: 103,309,851 (GRCm39) V202D possibly damaging Het
Or52u1 A T 7: 104,237,940 (GRCm39) R310W probably benign Het
Or5o1 T A X: 48,815,939 (GRCm39) N291Y probably damaging Het
Or5w15 T C 2: 87,568,506 (GRCm39) Q54R probably benign Het
Or8g32 A C 9: 39,305,981 (GRCm39) K295T probably damaging Het
Pkd1l1 G A 11: 8,784,793 (GRCm39) T1997I probably benign Het
Poln A G 5: 34,274,206 (GRCm39) S377P probably benign Het
Rab22a T A 2: 173,503,265 (GRCm39) V26E probably damaging Het
Rhbdl3 T C 11: 80,244,439 (GRCm39) V382A possibly damaging Het
Slitrk3 G T 3: 72,957,723 (GRCm39) Q350K probably benign Het
Sult1d1 A T 5: 87,707,738 (GRCm39) Y127* probably null Het
Vmn1r73 A T 7: 11,490,527 (GRCm39) Y115F probably benign Het
Zfp128 T A 7: 12,624,314 (GRCm39) D227E probably benign Het
Other mutations in Or3a1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00087:Or3a1b APN 11 74,012,705 (GRCm39) missense probably benign 0.00
IGL01303:Or3a1b APN 11 74,012,160 (GRCm39) missense probably damaging 1.00
IGL01397:Or3a1b APN 11 74,012,590 (GRCm39) missense probably damaging 0.97
IGL02101:Or3a1b APN 11 74,012,571 (GRCm39) nonsense probably null
IGL02121:Or3a1b APN 11 74,012,113 (GRCm39) splice site probably benign
IGL02347:Or3a1b APN 11 74,012,397 (GRCm39) missense probably benign 0.03
IGL03126:Or3a1b APN 11 74,012,610 (GRCm39) missense probably benign 0.01
IGL03302:Or3a1b APN 11 74,012,459 (GRCm39) missense possibly damaging 0.60
R0549:Or3a1b UTSW 11 74,012,301 (GRCm39) missense probably damaging 1.00
R1180:Or3a1b UTSW 11 74,012,406 (GRCm39) missense probably benign 0.28
R1350:Or3a1b UTSW 11 74,013,039 (GRCm39) missense possibly damaging 0.96
R1800:Or3a1b UTSW 11 74,012,234 (GRCm39) missense probably benign 0.00
R1808:Or3a1b UTSW 11 74,012,257 (GRCm39) missense probably damaging 0.96
R1962:Or3a1b UTSW 11 74,012,650 (GRCm39) missense probably benign 0.02
R1998:Or3a1b UTSW 11 74,012,406 (GRCm39) missense probably benign 0.28
R1999:Or3a1b UTSW 11 74,012,406 (GRCm39) missense probably benign 0.28
R2000:Or3a1b UTSW 11 74,012,406 (GRCm39) missense probably benign 0.28
R2859:Or3a1b UTSW 11 74,012,808 (GRCm39) missense probably damaging 1.00
R4914:Or3a1b UTSW 11 74,012,705 (GRCm39) missense probably benign 0.00
R4915:Or3a1b UTSW 11 74,012,705 (GRCm39) missense probably benign 0.00
R4916:Or3a1b UTSW 11 74,012,705 (GRCm39) missense probably benign 0.00
R4918:Or3a1b UTSW 11 74,012,705 (GRCm39) missense probably benign 0.00
R5292:Or3a1b UTSW 11 74,012,877 (GRCm39) missense probably damaging 0.99
R5522:Or3a1b UTSW 11 74,012,484 (GRCm39) missense probably damaging 1.00
R5761:Or3a1b UTSW 11 74,012,335 (GRCm39) missense probably damaging 0.97
R6318:Or3a1b UTSW 11 74,012,547 (GRCm39) missense possibly damaging 0.82
R6608:Or3a1b UTSW 11 74,012,454 (GRCm39) missense probably benign 0.00
R6737:Or3a1b UTSW 11 74,012,732 (GRCm39) missense probably benign
R6790:Or3a1b UTSW 11 74,012,427 (GRCm39) missense probably damaging 1.00
R7243:Or3a1b UTSW 11 74,012,559 (GRCm39) missense probably damaging 0.97
R7423:Or3a1b UTSW 11 74,012,811 (GRCm39) missense probably benign 0.01
R7517:Or3a1b UTSW 11 74,012,335 (GRCm39) missense probably damaging 0.97
R7833:Or3a1b UTSW 11 74,012,663 (GRCm39) missense probably damaging 1.00
R8241:Or3a1b UTSW 11 74,013,035 (GRCm39) missense probably benign 0.03
R8423:Or3a1b UTSW 11 74,012,492 (GRCm39) missense probably benign 0.06
R8937:Or3a1b UTSW 11 74,012,874 (GRCm39) missense probably benign 0.03
R9145:Or3a1b UTSW 11 74,012,526 (GRCm39) missense probably benign 0.01
R9725:Or3a1b UTSW 11 74,012,612 (GRCm39) missense probably benign 0.01
Posted On 2016-08-02