Incidental Mutation 'IGL03113:Morc4'
ID419272
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Morc4
Ensembl Gene ENSMUSG00000031434
Gene Namemicrorchidia 4
Synonyms5630401M14Rik, Zcwcc2, 1600017G11Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.088) question?
Stock #IGL03113
Quality Score
Status
ChromosomeX
Chromosomal Location139821632-139871677 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 139857856 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Glycine at position 189 (E189G)
Ref Sequence ENSEMBL: ENSMUSP00000084663 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033811] [ENSMUST00000087401] [ENSMUST00000165274] [ENSMUST00000171896]
Predicted Effect probably benign
Transcript: ENSMUST00000033811
AA Change: E189G

PolyPhen 2 Score 0.140 (Sensitivity: 0.92; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000033811
Gene: ENSMUSG00000031434
AA Change: E189G

DomainStartEndE-ValueType
low complexity region 6 22 N/A INTRINSIC
HATPase_c 45 138 8.17e0 SMART
low complexity region 356 366 N/A INTRINSIC
Pfam:zf-CW 421 468 8.1e-21 PFAM
low complexity region 478 491 N/A INTRINSIC
low complexity region 683 700 N/A INTRINSIC
coiled coil region 758 867 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000087401
AA Change: E189G

PolyPhen 2 Score 0.140 (Sensitivity: 0.92; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000084663
Gene: ENSMUSG00000031434
AA Change: E189G

DomainStartEndE-ValueType
low complexity region 6 22 N/A INTRINSIC
HATPase_c 45 138 8.17e0 SMART
low complexity region 356 366 N/A INTRINSIC
Pfam:zf-CW 422 467 1.6e-19 PFAM
low complexity region 478 491 N/A INTRINSIC
low complexity region 683 700 N/A INTRINSIC
coiled coil region 758 867 N/A INTRINSIC
low complexity region 876 887 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000113014
Predicted Effect probably benign
Transcript: ENSMUST00000136415
SMART Domains Protein: ENSMUSP00000132730
Gene: ENSMUSG00000031434

DomainStartEndE-ValueType
low complexity region 132 142 N/A INTRINSIC
Pfam:zf-CW 198 243 7.9e-20 PFAM
low complexity region 254 267 N/A INTRINSIC
low complexity region 459 476 N/A INTRINSIC
coiled coil region 533 641 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144481
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146914
Predicted Effect probably benign
Transcript: ENSMUST00000165274
SMART Domains Protein: ENSMUSP00000126149
Gene: ENSMUSG00000031434

DomainStartEndE-ValueType
HATPase_c 11 104 8.17e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000167664
SMART Domains Protein: ENSMUSP00000132245
Gene: ENSMUSG00000031434

DomainStartEndE-ValueType
low complexity region 91 101 N/A INTRINSIC
Pfam:zf-CW 157 202 1.6e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000171896
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] In human, the four current members of the microrchidia (morc) gene family share an N-terminal ATPase-like ATP-binding region and a CW four-cysteine zinc-finger motif. The protein encoded by this gene also has a nuclear matrix binding domain and a two-stranded coiled-coil motif near its C-terminus. This gene is widely expressed at low levels in normal tissues and has elevated expression in placenta and testis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apof G A 10: 128,269,699 V241M probably benign Het
Arhgef10 T A 8: 14,954,505 I91N probably damaging Het
Arhgef17 G A 7: 100,929,731 T670I probably benign Het
Barhl1 T C 2: 28,915,456 D75G probably benign Het
Capn13 T C 17: 73,331,113 T432A probably benign Het
Casd1 T A 6: 4,640,951 Y691N probably damaging Het
Ccdc175 C A 12: 72,144,783 V340L probably benign Het
Cdc5l A T 17: 45,433,422 M5K possibly damaging Het
Cgn A G 3: 94,779,234 F253L probably benign Het
Csmd1 T C 8: 16,028,698 K2003R probably benign Het
Disp2 T A 2: 118,790,778 probably null Het
Dnah7a T C 1: 53,433,004 N3535D possibly damaging Het
Exoc3 G A 13: 74,193,113 Q191* probably null Het
Fstl5 T A 3: 76,429,792 Y219* probably null Het
Gad2 T A 2: 22,681,355 L435Q probably benign Het
Gcnt3 A G 9: 70,034,701 V195A probably damaging Het
Haus6 G A 4: 86,583,106 Q843* probably null Het
Hivep2 T A 10: 14,130,651 F998I probably damaging Het
Hsf5 A T 11: 87,657,364 E624D probably benign Het
Klb A G 5: 65,383,470 N969D probably benign Het
Klhl6 T A 16: 19,957,251 S186C possibly damaging Het
Klk15 T C 7: 43,938,381 F78L probably benign Het
Ldlr A G 9: 21,739,828 E514G possibly damaging Het
Map9 T A 3: 82,359,978 probably benign Het
Miga2 A T 2: 30,384,010 I99F possibly damaging Het
Nhlrc3 A T 3: 53,458,563 Y170N possibly damaging Het
Olfr1138 T C 2: 87,738,162 Q54R probably benign Het
Olfr1216 A G 2: 89,014,035 F10L probably damaging Het
Olfr1321 T A X: 49,727,062 N291Y probably damaging Het
Olfr401 G A 11: 74,121,703 R138Q probably benign Het
Olfr623 A T 7: 103,660,644 V202D possibly damaging Het
Olfr654 A T 7: 104,588,733 R310W probably benign Het
Olfr951 A C 9: 39,394,685 K295T probably damaging Het
Pkd1l1 G A 11: 8,834,793 T1997I probably benign Het
Poln A G 5: 34,116,862 S377P probably benign Het
Rab22a T A 2: 173,661,472 V26E probably damaging Het
Rhbdl3 T C 11: 80,353,613 V382A possibly damaging Het
Slitrk3 G T 3: 73,050,390 Q350K probably benign Het
Sult1d1 A T 5: 87,559,879 Y127* probably null Het
Vmn1r73 A T 7: 11,756,600 Y115F probably benign Het
Zfp128 T A 7: 12,890,387 D227E probably benign Het
Other mutations in Morc4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03355:Morc4 APN X 139849682 missense probably null 1.00
R0736:Morc4 UTSW X 139854951 missense probably benign 0.14
R1710:Morc4 UTSW X 139854530 missense probably damaging 1.00
X0018:Morc4 UTSW X 139840779 missense probably damaging 0.99
Posted On2016-08-02