Incidental Mutation 'IGL03113:Hsf5'
ID419293
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Hsf5
Ensembl Gene ENSMUSG00000070345
Gene Nameheat shock transcription factor family member 5
SynonymsLOC327992
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.279) question?
Stock #IGL03113
Quality Score
Status
Chromosome11
Chromosomal Location87617164-87659542 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 87657364 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Aspartic acid at position 624 (E624D)
Ref Sequence ENSEMBL: ENSMUSP00000091488 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093956]
Predicted Effect probably benign
Transcript: ENSMUST00000093956
AA Change: E624D

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000091488
Gene: ENSMUSG00000070345
AA Change: E624D

DomainStartEndE-ValueType
HSF 11 153 2.35e-9 SMART
Blast:HSF 163 423 1e-149 BLAST
low complexity region 442 457 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apof G A 10: 128,269,699 V241M probably benign Het
Arhgef10 T A 8: 14,954,505 I91N probably damaging Het
Arhgef17 G A 7: 100,929,731 T670I probably benign Het
Barhl1 T C 2: 28,915,456 D75G probably benign Het
Capn13 T C 17: 73,331,113 T432A probably benign Het
Casd1 T A 6: 4,640,951 Y691N probably damaging Het
Ccdc175 C A 12: 72,144,783 V340L probably benign Het
Cdc5l A T 17: 45,433,422 M5K possibly damaging Het
Cgn A G 3: 94,779,234 F253L probably benign Het
Csmd1 T C 8: 16,028,698 K2003R probably benign Het
Disp2 T A 2: 118,790,778 probably null Het
Dnah7a T C 1: 53,433,004 N3535D possibly damaging Het
Exoc3 G A 13: 74,193,113 Q191* probably null Het
Fstl5 T A 3: 76,429,792 Y219* probably null Het
Gad2 T A 2: 22,681,355 L435Q probably benign Het
Gcnt3 A G 9: 70,034,701 V195A probably damaging Het
Haus6 G A 4: 86,583,106 Q843* probably null Het
Hivep2 T A 10: 14,130,651 F998I probably damaging Het
Klb A G 5: 65,383,470 N969D probably benign Het
Klhl6 T A 16: 19,957,251 S186C possibly damaging Het
Klk15 T C 7: 43,938,381 F78L probably benign Het
Ldlr A G 9: 21,739,828 E514G possibly damaging Het
Map9 T A 3: 82,359,978 probably benign Het
Miga2 A T 2: 30,384,010 I99F possibly damaging Het
Morc4 T C X: 139,857,856 E189G probably benign Het
Nhlrc3 A T 3: 53,458,563 Y170N possibly damaging Het
Olfr1138 T C 2: 87,738,162 Q54R probably benign Het
Olfr1216 A G 2: 89,014,035 F10L probably damaging Het
Olfr1321 T A X: 49,727,062 N291Y probably damaging Het
Olfr401 G A 11: 74,121,703 R138Q probably benign Het
Olfr623 A T 7: 103,660,644 V202D possibly damaging Het
Olfr654 A T 7: 104,588,733 R310W probably benign Het
Olfr951 A C 9: 39,394,685 K295T probably damaging Het
Pkd1l1 G A 11: 8,834,793 T1997I probably benign Het
Poln A G 5: 34,116,862 S377P probably benign Het
Rab22a T A 2: 173,661,472 V26E probably damaging Het
Rhbdl3 T C 11: 80,353,613 V382A possibly damaging Het
Slitrk3 G T 3: 73,050,390 Q350K probably benign Het
Sult1d1 A T 5: 87,559,879 Y127* probably null Het
Vmn1r73 A T 7: 11,756,600 Y115F probably benign Het
Zfp128 T A 7: 12,890,387 D227E probably benign Het
Other mutations in Hsf5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00514:Hsf5 APN 11 87623096 missense probably damaging 0.99
IGL01726:Hsf5 APN 11 87636125 missense probably benign 0.22
IGL02480:Hsf5 APN 11 87631657 missense possibly damaging 0.67
IGL02572:Hsf5 APN 11 87631695 splice site probably benign
R0015:Hsf5 UTSW 11 87657335 missense probably benign
R0015:Hsf5 UTSW 11 87657335 missense probably benign
R1381:Hsf5 UTSW 11 87638169 missense probably benign
R1807:Hsf5 UTSW 11 87657342 missense probably benign 0.04
R1838:Hsf5 UTSW 11 87636055 missense probably benign 0.45
R2187:Hsf5 UTSW 11 87638184 missense possibly damaging 0.51
R3930:Hsf5 UTSW 11 87631682 missense probably damaging 1.00
R3931:Hsf5 UTSW 11 87631682 missense probably damaging 1.00
R4420:Hsf5 UTSW 11 87657304 missense probably benign 0.02
R4423:Hsf5 UTSW 11 87631634 missense probably damaging 0.99
R4744:Hsf5 UTSW 11 87622791 missense probably benign 0.02
R4795:Hsf5 UTSW 11 87635620 missense probably benign 0.18
R5862:Hsf5 UTSW 11 87622991 missense probably damaging 0.96
R6232:Hsf5 UTSW 11 87617294 missense probably benign 0.05
R6234:Hsf5 UTSW 11 87617294 missense probably benign 0.05
R6609:Hsf5 UTSW 11 87635953 missense probably damaging 0.99
R7821:Hsf5 UTSW 11 87638128 missense probably benign 0.04
R7989:Hsf5 UTSW 11 87635624 missense probably benign 0.07
Z1177:Hsf5 UTSW 11 87638133 nonsense probably null
Posted On2016-08-02