Incidental Mutation 'IGL03114:Vmn2r90'
| ID |
419299 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r90
|
| Ensembl Gene |
ENSMUSG00000092120 |
| Gene Name |
vomeronasal 2, receptor 90 |
| Synonyms |
EG626942 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.139)
|
| Stock # |
IGL03114
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
17 |
| Chromosomal Location |
17924203-17954429 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 17953771 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 645
(I645T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126650
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000169805]
[ENSMUST00000231659]
[ENSMUST00000232078]
[ENSMUST00000232113]
|
| AlphaFold |
E9PXJ8 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000169805
AA Change: I645T
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000126650
Gene: ENSMUSG00000092120
AA Change: I645T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
1.8e-43 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
3e-22 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
9.8e-54 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231659
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000231940
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232078
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232113
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 56 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aadacl2fm2 |
A |
T |
3: 59,651,144 (GRCm39) |
I89F |
possibly damaging |
Het |
| Abca13 |
T |
A |
11: 9,478,999 (GRCm39) |
H4282Q |
probably benign |
Het |
| Acta2 |
A |
G |
19: 34,222,310 (GRCm39) |
|
probably null |
Het |
| Arl10 |
A |
G |
13: 54,723,579 (GRCm39) |
|
probably benign |
Het |
| Avpr1a |
A |
G |
10: 122,285,623 (GRCm39) |
Y305C |
probably damaging |
Het |
| Bmpr2 |
T |
A |
1: 59,906,603 (GRCm39) |
N565K |
probably damaging |
Het |
| Boc |
A |
T |
16: 44,307,115 (GRCm39) |
S1035R |
probably benign |
Het |
| Brd10 |
A |
T |
19: 29,694,532 (GRCm39) |
S1654T |
probably benign |
Het |
| Ccdc7a |
T |
C |
8: 129,753,170 (GRCm39) |
N187S |
possibly damaging |
Het |
| Cntn5 |
C |
T |
9: 9,748,457 (GRCm39) |
E680K |
probably damaging |
Het |
| Copa |
T |
A |
1: 171,946,835 (GRCm39) |
Y1014* |
probably null |
Het |
| Csmd3 |
A |
G |
15: 47,683,847 (GRCm39) |
S1662P |
probably damaging |
Het |
| Cyp2e1 |
T |
C |
7: 140,353,042 (GRCm39) |
F360L |
possibly damaging |
Het |
| Efnb3 |
A |
T |
11: 69,447,628 (GRCm39) |
|
probably benign |
Het |
| Egf |
A |
T |
3: 129,530,529 (GRCm39) |
L211Q |
probably damaging |
Het |
| Eno1 |
G |
A |
4: 150,325,583 (GRCm39) |
R56H |
probably benign |
Het |
| Fyb2 |
A |
G |
4: 104,852,975 (GRCm39) |
T552A |
probably damaging |
Het |
| Git2 |
G |
A |
5: 114,871,918 (GRCm39) |
|
probably benign |
Het |
| Gtf2ird2 |
A |
G |
5: 134,245,752 (GRCm39) |
|
probably null |
Het |
| Hyal4 |
A |
T |
6: 24,755,964 (GRCm39) |
I61L |
probably benign |
Het |
| Kat14 |
T |
C |
2: 144,217,885 (GRCm39) |
|
probably null |
Het |
| Kif13b |
T |
C |
14: 65,025,897 (GRCm39) |
V1418A |
probably benign |
Het |
| Lcn12 |
T |
C |
2: 25,383,274 (GRCm39) |
K35E |
probably benign |
Het |
| Lyrm7 |
G |
T |
11: 54,741,198 (GRCm39) |
N45K |
possibly damaging |
Het |
| Mical2 |
G |
T |
7: 111,996,764 (GRCm39) |
G559V |
probably damaging |
Het |
| Mtrr |
A |
T |
13: 68,712,441 (GRCm39) |
C648* |
probably null |
Het |
| Muc5b |
C |
A |
7: 141,412,556 (GRCm39) |
S1834* |
probably null |
Het |
| Mup16 |
G |
A |
4: 61,436,250 (GRCm39) |
T101M |
probably benign |
Het |
| Myof |
A |
T |
19: 37,892,309 (GRCm39) |
L1148Q |
probably damaging |
Het |
| Nags |
A |
T |
11: 102,039,814 (GRCm39) |
I501F |
probably damaging |
Het |
| Nbeal1 |
A |
T |
1: 60,317,886 (GRCm39) |
Y672F |
probably damaging |
Het |
| Ncapg2 |
A |
G |
12: 116,415,993 (GRCm39) |
|
probably benign |
Het |
| Obscn |
A |
G |
11: 58,891,365 (GRCm39) |
S7056P |
unknown |
Het |
| Or52s1 |
T |
C |
7: 102,861,928 (GRCm39) |
I287T |
probably damaging |
Het |
| Pde2a |
C |
A |
7: 101,157,890 (GRCm39) |
|
probably benign |
Het |
| Piezo2 |
T |
C |
18: 63,163,343 (GRCm39) |
|
probably null |
Het |
| Pkhd1 |
C |
A |
1: 20,268,395 (GRCm39) |
D3328Y |
probably damaging |
Het |
| Plxdc2 |
T |
C |
2: 16,654,935 (GRCm39) |
V178A |
probably damaging |
Het |
| Prdx3 |
T |
C |
19: 60,861,556 (GRCm39) |
|
probably benign |
Het |
| Prkce |
T |
A |
17: 86,961,983 (GRCm39) |
D694E |
probably damaging |
Het |
| Prss1l |
T |
A |
6: 41,374,012 (GRCm39) |
C205S |
probably damaging |
Het |
| Ptdss1 |
T |
A |
13: 67,142,058 (GRCm39) |
Y405* |
probably null |
Het |
| Rad54l |
A |
T |
4: 115,955,729 (GRCm39) |
W608R |
probably damaging |
Het |
| Rassf6 |
G |
T |
5: 90,756,649 (GRCm39) |
|
probably benign |
Het |
| Sema5a |
A |
T |
15: 32,673,573 (GRCm39) |
I804F |
probably damaging |
Het |
| Slc15a2 |
A |
T |
16: 36,572,267 (GRCm39) |
I668N |
probably damaging |
Het |
| Thsd7b |
A |
G |
1: 130,116,288 (GRCm39) |
E1347G |
probably benign |
Het |
| Tmco3 |
T |
C |
8: 13,348,205 (GRCm39) |
|
probably benign |
Het |
| Ttn |
T |
C |
2: 76,551,996 (GRCm39) |
M31214V |
probably null |
Het |
| Uck1 |
G |
A |
2: 32,148,334 (GRCm39) |
R161C |
probably benign |
Het |
| Ugt2b5 |
T |
C |
5: 87,276,209 (GRCm39) |
Y355C |
probably damaging |
Het |
| Usp48 |
C |
A |
4: 137,383,436 (GRCm39) |
T1031K |
probably damaging |
Het |
| Vmn1r202 |
G |
A |
13: 22,685,640 (GRCm39) |
T259I |
probably benign |
Het |
| Vmn1r202 |
T |
A |
13: 22,685,500 (GRCm39) |
|
probably benign |
Het |
| Vps18 |
T |
C |
2: 119,124,132 (GRCm39) |
V353A |
possibly damaging |
Het |
| Vwf |
C |
T |
6: 125,576,326 (GRCm39) |
Q469* |
probably null |
Het |
|
| Other mutations in Vmn2r90 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00092:Vmn2r90
|
APN |
17 |
17,953,758 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01330:Vmn2r90
|
APN |
17 |
17,953,542 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01989:Vmn2r90
|
APN |
17 |
17,933,494 (GRCm39) |
nonsense |
probably null |
|
|
IGL02080:Vmn2r90
|
APN |
17 |
17,933,120 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02112:Vmn2r90
|
APN |
17 |
17,932,465 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02123:Vmn2r90
|
APN |
17 |
17,953,744 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02749:Vmn2r90
|
APN |
17 |
17,947,122 (GRCm39) |
makesense |
probably null |
|
|
R0131:Vmn2r90
|
UTSW |
17 |
17,932,511 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0131:Vmn2r90
|
UTSW |
17 |
17,932,511 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0132:Vmn2r90
|
UTSW |
17 |
17,932,511 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0184:Vmn2r90
|
UTSW |
17 |
17,947,139 (GRCm39) |
nonsense |
probably null |
|
|
R0379:Vmn2r90
|
UTSW |
17 |
17,948,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1022:Vmn2r90
|
UTSW |
17 |
17,948,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1024:Vmn2r90
|
UTSW |
17 |
17,948,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1897:Vmn2r90
|
UTSW |
17 |
17,953,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1993:Vmn2r90
|
UTSW |
17 |
17,933,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2472:Vmn2r90
|
UTSW |
17 |
17,948,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2508:Vmn2r90
|
UTSW |
17 |
17,954,229 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2679:Vmn2r90
|
UTSW |
17 |
17,933,131 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R3409:Vmn2r90
|
UTSW |
17 |
17,953,638 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4693:Vmn2r90
|
UTSW |
17 |
17,953,956 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4797:Vmn2r90
|
UTSW |
17 |
17,932,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5258:Vmn2r90
|
UTSW |
17 |
17,933,114 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5358:Vmn2r90
|
UTSW |
17 |
17,924,412 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5445:Vmn2r90
|
UTSW |
17 |
17,954,386 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5446:Vmn2r90
|
UTSW |
17 |
17,932,464 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5567:Vmn2r90
|
UTSW |
17 |
17,932,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5680:Vmn2r90
|
UTSW |
17 |
17,947,034 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5686:Vmn2r90
|
UTSW |
17 |
17,933,712 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5751:Vmn2r90
|
UTSW |
17 |
17,954,128 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6156:Vmn2r90
|
UTSW |
17 |
17,953,606 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6185:Vmn2r90
|
UTSW |
17 |
17,953,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6450:Vmn2r90
|
UTSW |
17 |
17,953,498 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R6707:Vmn2r90
|
UTSW |
17 |
17,948,364 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6802:Vmn2r90
|
UTSW |
17 |
17,932,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6913:Vmn2r90
|
UTSW |
17 |
17,924,323 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7070:Vmn2r90
|
UTSW |
17 |
17,924,313 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7237:Vmn2r90
|
UTSW |
17 |
17,924,249 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7503:Vmn2r90
|
UTSW |
17 |
17,933,510 (GRCm39) |
missense |
not run |
|
|
R7698:Vmn2r90
|
UTSW |
17 |
17,953,596 (GRCm39) |
missense |
probably benign |
|
|
R7943:Vmn2r90
|
UTSW |
17 |
17,932,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8072:Vmn2r90
|
UTSW |
17 |
17,947,142 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8128:Vmn2r90
|
UTSW |
17 |
17,954,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8295:Vmn2r90
|
UTSW |
17 |
17,948,358 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8345:Vmn2r90
|
UTSW |
17 |
17,933,127 (GRCm39) |
nonsense |
probably null |
|
|
R8682:Vmn2r90
|
UTSW |
17 |
17,932,344 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8716:Vmn2r90
|
UTSW |
17 |
17,924,343 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9041:Vmn2r90
|
UTSW |
17 |
17,954,286 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9412:Vmn2r90
|
UTSW |
17 |
17,954,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9607:Vmn2r90
|
UTSW |
17 |
17,953,638 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9705:Vmn2r90
|
UTSW |
17 |
17,933,039 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
Z1088:Vmn2r90
|
UTSW |
17 |
17,953,879 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Vmn2r90
|
UTSW |
17 |
17,933,079 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2016-08-02 |
Incidental Mutation